SharpBrains

(Editor's Note: I recently came across an excellent book and resource, The Alzheimer's Action Plan: The Experts' Guide to the Best Diagnosis and Treatment for Memory Problems, recently released in paperback. Dr. Murali Doraiswamy, one of the authors and leading Alzheimer's expert, kindly helped us create a 2-part article series to share with SharpBrains readers advice on a very important question, "How can we help the public at large to distinguish Alzheimer's Disease from normal aging --- so that an interest in early identification doesn't translate into unneeded worries?" What follows is an excerpt from the book, pages 72-78, discussing the Pros and Cons of the most common assessments).

---

While no single test (other than a brain biopsy, which is a very invasive and risky procedure) can conclusively prove that a person has Alzheimer’s, many tests can give us a good idea. A list of all the tests that help us assess memory and thinking problems appears at the end of this chapter. Meanwhile, let’s take a good look at the whys and hows of a thorough memory assessment.

WHAT A DIFFERENCE AN EXTRA TEST CAN MAKE

To understand why getting tested (and retested as symptoms change and the disease progresses) is important, check out the experience of Katherine, who went to the doctor complaining of a memory slowdown. She took five of the most important neuropsychological tests, which assess brain function without actually physically looking at the brain. Then she underwent brain scans, a cardiovascular workup, and blood tests to see what else was going on that might be undermining her mental function. Continue Reading »

Think about this: How can anyone take care of his or her brain when every week brings a new barrage of articles and studies which seem to contradict each other?

Do supplements improve memory? Do you need both physical and mental exercise –or is one of them enough? Which brain training approach, if any, is worth one's time and money?

We tried to address these questions, and many others, in our recent book, The SharpBrains Guide to Brain Fitness (182 pages, $24.95), that we presented at Games for Health Conference last week. The book is the result of over two years of extensive research including more than a hundred interviews with scientists, professionals and consumers, and a deep review of the scientific literature, led by neuropsychologist Elkhonon Goldberg and myself with the help of cognitive scientist Pascale Michelon. As we wrote in the Introduction, what we wanted to do first of all was to debunks these 10 myths on brain health and brain training:

Myth 1. Genes determine the fate of our brains.
Facts: Lifelong neuroplasticity allows our lifestyles and actions to play a meaningful role in how our brains physically evolve, especially given longer life expectancy.

Myth 2. Aging means automatic decline.
Facts: There is nothing inherently fixed in the precise trajectory of how brain functions evolve as we age.

Myth 3. Medication is the main hope for cognitive enhancement.
Facts: Non-invasive interventions can have comparable and more durable effects, side effect-free.

Myth 4. We will soon have a Magic Pill or General Solution to solve all our cognitive challenges.
Facts: A multi-pronged approach is recommended, centered around nutrition, stress management, and both physical and mental exercise.

Myth 5. There is only one “it” in “Use It or Lose it”.
Facts: The brain is composed of a number of specialized units. Our life and productivity depend on a variety of brain functions, not just one.

Myth 6. All brain activities or exercises are equal.
Facts: Varied and targeted exercises are the necessary ingredients in brain training so that a wide range of brain functions can be stimulated.

Myth 7. There is only one way to train your brain.
Facts: Brain functions can be impacted in a number of ways: through meditation, cognitive therapy, cognitive training.

Myth 8. We all have something called “Brain Age”.
Facts: Brain age is a fiction. No two individuals have the same brain or expression of brain functions.

Myth 9. That “brain age” can be reversed by 10, 20, 30 years.
Facts: Brain training can improve specific brain functions, but, with research available today, cannot be said to roll back one’s “brain age” by a number of years.

Myth 10. All human brains need the same brain training.
Facts: As in physical fitness, users must ask themselves: What functions do I need to improve on? In what timeframe? What is my budget?

Do you have other myths in mind you would like  us to address?

We have started to receive great feedback from the healthcare community, such as this email from a neurosurgeon in Texas:

"I really like the book, it is comprehensive without being too technical. I have recommended it to several patients. There are some other books that I expected would be greeted with enthusiasm, but were too complex for most of my patients. I think this book is right in the sweet spot".

And this great book review by an Internist Physician and Robert Wood Johnson Foundation Fellow, titled Is Your Brain A Couch Potato?:

“…a short, sweet, entertaining read of a complex topic, with timely (written in 1/09) reviews of 21 top technology products, as well as informed and expert predictions of where this burgeoning brain-fitness field is headed. More importantly, after you read it, you'll have a good, detailed sense of where you, personally, can act to improve your own couch-potato brain - and how to keep it fit and flexible your whole life. The SharpBrains Guide To Brain Fitness reminds of us all why books (and not just googling a topic) can be well worth your time and money. Two Stethoscopes Up - check it out. life."

—Doc Gurley, book review for SFGate.com (06/08/09)

The book:  The SharpBrains Guide to Brain Fitness (available via Amazon.com Here, review copies available upon request).

Description: While most of us have heard the phrase “use it or lose it,” very few understand what “it” means, or how to properly “use it” in order to maintain brain function and fitness. The SharpBrains Guide to Brain Fitness is an invaluable guide that helps readers navigate growing brain research and identify the lifestyle factors and products that contribute to brain health and fitness. By gathering insights from eighteen of the world’s top scientists and offering tools and detailed descriptions of over twenty products, this book is an essential guide to the field of brain fitness, neuroplasticity and cognitive health. An accessible and thought-provoking read, The SharpBrains Guide to Brain Fitness educates lifelong learners and professionals in healthcare, education, business, etc., on emerging trends and forecasts of what the future will hold.

Products Reviewed (we reviewed scientific studies published before January 2009, when the manuscript text was closed):

- Overall brain maintenance: Brain Age series (Nintendo), BrainWare Safari (Learning Enhancement Corporation), FitBrains.com (Vivity Labs), Happy-Neuron.com (Scientific Brain Training), Lumosity.com (Lumos Labs), MindFit (CogniFit), (m)Power (Dakim)

- Targeted brain workout: Classic and InSight (Posit Science), Working Memory Training JM and RM (Cogmed), DriveFit (CogniFit), Earobics (Houghton Mifflin), Fast ForWord (Scientific Learning), IntelliGym (Applied Cognitive Engineering), Vision Restpration Therapy (NovaVision)

- Emotional self-regulation: emWave PC and Personal Stress Reliever (HeartMath), Journey to the Wild Divine (Wild Divine), RESPeRATE (InterCure), StressEraser (Helicor)

Dave hosts a fun iCephalon 2009 Keynote address (AKA Encephalon 72), a collection of the best brain and mind blog posts of the last couple weeks. Enjoy!

The San Francisco Chronicle brings two great pieces today - including an excellent review of our new Book!

Is Your Brain A Couch Potato? (online book review)

"At 165 pages, we're talking a short, sweet, entertaining read of a complex topic, with timely (written in 1/09) reviews of 21 top technology products, as well as informed and expert predictions of where this burgeoning brain-fitness field is headed. More importantly, after you read it, you'll have a good, detailed sense of where you, personally, can act to improve your own couch-potato brain - and how to keep it fit and flexible your whole life. The SharpBrains Guide To Brain Fitness reminds of us all why books (and not just googling a topic) can be well worth your time and money. Two Stethoscopes Up - check it out."

Software designed to make older drivers sharper (article in print version)

- "Allstate is experimenting with the software because it wants its customers who are over 50 to become better drivers so they have fewer accidents and can drive longer, perhaps in return for lower premiums, said Tom Warden, an assistant vice president in Allstate's research and planning center."

- "Allstate found Posit after the insurance company's own scientists, who were working on the physiology and psychology of good drivers, discovered research done by Visual Awareness, a company in Alabama that has worked with State Farm and various state motor vehicle departments on expanding drivers' fields of view. Posit acquired Visual Awareness last year."

This is a partial list of the literature we reviewed during the research phase of our new book, The SharpBrains Guide to Brain Fitness.  We know many friends of SharpBrains are researchers, healthcare professionals, graduate/ Ph.D. students, who want have direct access to the references (perhaps PubMed should promote itself as a never ending source of mental stimulation?), so here you have this list, organized by relevant chapter. Please note that the list below appears in the book - whose manuscript we had to close in January 2009.

Introduction

• Basak, C. et al. (2008). Can training in a real-time strategy video game attenuate cognitive decline in older adults? Psychology and Aging.
• Begley, S. (2007). Train your mind, change your brain: How a new science reveals our extraordinary potential to transform ourselves. Ballantine Books.
• DeKosky, S. T., et al. (2008). Ginkgo biloba for prevention of dementia: a randomized controlled trial. Journal of the American Medical Association, 300, 2253-2262.
• Doidge, N. (2007). The Brain that changes itself: Stories of personal triumph from the frontiers of brain science. Viking Adult.

Chapter 1. The Brain and Brain Fitness 101

• Bunge, S. A., & Wright, S. B. (2007). Neurodevelopmental changes in working memory and cognitive control. Current Opinion In Neurobiology, 17(2), 243-50.
• Damasio, A. (1995). Descartes’ error: Emotion, reason, and the human brain. Penguin Press.
• David Kolb, D. (1983). Experiential learning: Experience as the source of learning and development. FT Press.
• Draganski, B., Gaser, C., Kempermann, G., Kuhn, H. G., Winkler, J., Buchel, C., & May A. (2006). Temporal and spatial dynamics of brain structure changes during extensive learning. The Journal of Neuroscience, 261231, 6314-6317.
• Gage, F. H., Kempermann, G., & Song, H. (2007). Adult Neurogenesis. Cold Spring Harbor Laboratory Press, NY.
• Gardner, H. (1983). Frames of Mind: The theory of multiple intelligences. New York: Basic Books.
• Gaser, C. & Schlaug, G. (2003). Brain structures differ between musicians and non-musicians. The Journal of Neuroscience, 23, 9240-9245. Continue Reading »

Brain-fitness games join workplace, as well as senior center, arsenals (MarketWatch)

- "Consumers and retirement homes have made brain-fitness games and exercises a commercial hit, but now some insurers and employers are incorporating them into wellness programs that promote health not just for the body but also for the mind."

- "Improving brain health can result in less presenteeism, the tendency to be at work but be distracted and not able to focus," he added. "If you look at disability costs, absenteeism and presenteeism account for most of the medical costs, and that's a good reason for employers to be focused on brain health." (according to Dr. Eugene Baker, vice president at OptumHealth's Behavioral Solutions division)"

The article reviews innovative practices at OptumHealth, Nationwide Auto Insurance Company, Humana, Penn Treaty American Corp, Allstate, and the US Army. I am glad to see the media start to notice the importance of cognitive assessments and the growing activity by insurers. Continue Reading »

The Neuroanthropology blog team has just published one of the most complete and high-quality editions of Encephalon brain & mind blog carnival in months. Enjoy!:
Encephalon #71: Big Night

Round-up of recent articles on neuroscience, brain development and cognitive health:

Encephalon 68: A carnival of neuroscience:

Chris hosts a great collection of neuroscience and psychology posts in his signature Q&A style.

Bilingual Babies Get Head Start --- Before They Can Talk:

- Unlike the monolingual group, the bilingual group was able to successfully learn a new sound type and use it to predict where each character would pop up.

- The bilingual babies' skill applies to more than just switching between languages. Mehler likened this apparently enhanced cognitive ability to a brain selecting "the right tool for the right operation"—also called executive function.

- In this basic process, the brain, ever flexible, nimbly switches from one learned response to another as situations change.

- Monolingual babies hone this ability later in their young lives, Mehler suggests."

Study shows how kids' stress hurts memory:

"Now, research is providing what could be crucial clues to explain how childhood poverty translates into dimmer chances of success: Chronic stress from growing up poor appears to have a direct impact on the brain, leaving children with impairment in at least one key area - working memory."

Returning troops getting tested for brain injuries:

- "More than 150,000 service members from the Marines, Air Force, Army and Navy have undergone the testing that became mandatory last year. Those who suffer a concussion or similar head injury will get a follow-up test."

Diabetes 'impact on brain power':

- "Failure to control type 2 diabetes may have a long-term impact on the brain, research has suggested.

- Lead researcher Dr Jackie Price said: "Either hypos lead to cognitive decline, or cognitive decline makes it more difficult for people to manage their diabetes, which in turn causes more hypos.

- "A third explanation could be that a third unidentified factor is causing both the hypos and the cognitive decline."

This is one of the slides I created recently for my talks, and it seems to be getting the point across.

Your answer?

The follow-up question: is your job and life more similar to the constant problem-solving and mental challenge of the cab driver, or to the routine or the bus driver?

Pascale wrote an excellent article on this, check it out: Brain Plasticity - How learning changes your brain.

Have a good Good Friday/ Passover/ holiday/ weekend!

Three excellent new editions of these blog carnivals:

- Encephalon at Neuroskeptic: brain and mind topics.

- Grand Rounds at Running a Hospital: overall health and medicine, this week with special theme "when things go awry".

- Change of Shift at EmergiBlog: nursing and related healthcare topics.