SharpBrains

You have survived the 2007 shopping and eating season. Congratulations! Now it's time to shift gears and focus on 2008...whether you write down some New Year resolutions or contemplate some things that you want to let go of from last year and set intentions and goals for this year - as is a friend's tradition on the winter solstice.

To summarize the key findings of the last 20 years of neuroscience research on how to "exercise our brains", there are three things that we can strive for: novelty, variety and challenge. If we do these three things, we will build new connections in our brains, be mindful and pay attention to our environment, improve cognitive abilities such as pattern-recognition, and in general contribute to our lifelong brain health.

With these three principles of brain health in mind - novelty, variety and challenge - let me suggest a few potential New Years resolutions, perhaps some unexpected, that will help you make 2008 a year of Brain Fitness: Continue Reading »

I hope you are having a joyful holiday season, and wish you a Happy and Prosperous 2008. The Brain Fitness field has made a great deal of progress in 2007, and we are looking forward the New Year.

Here you are have the Monthly Digest of our Most Popular Blog Posts. You can consider it your monthly Brain Fitness/ Exercise Newsletter.

Let me first of all introduce you to our new "Author Speaks Series", where we will give leading scientists and experts a forum to present their new brain-related books. We are honored to kickstart the series with Larry McCleary, former acting Chief of Pediatric Neurosurgery at Denver Children's Hospital. You can read Here his article on how to keep a brain-friendly lifestyle. This series will complement our ongoing Neuroscience Interview Series.

Brain Fitness in the News

Brain Fitness @ PBS: PBS featured a fantastic special program on neuroplasticity and brain fitness during the month of December. Before you ask: as of today, the DVD of the program is still not available in PBS online shop. We expect to see it there in 2-3 weeks. We will keep you informed.

The Huffington Post started featuring a column written by me: you may enjoy taking a look at Alvaro Fernandez - Living on The Huffington Post.

Jogging our Brains for Brain Vitality, Healthy Aging-and Intelligence!: a roundup of several great recent articles on memory, aging, IQ and cognitive abilities such as self-control.

Health & Wellness

Brain Training: No Magic Bullet, Yet Useful Tool. Interview with Elizabeth Zelinski: Dr. Zelinski, leading researcher of the IMPACT study, shares fascinating insights. For example: "...cognitive enhancement requires the engagement in a variety of activities, those activities must be novel, adaptive and challenging-which is why computer-based programs can be helpful. But even at a more basic level, what matters is being engaged with life, continually exposed to stimulating activities, always trying to get out of our comfort zones, doing our best at whatever we are doing. A major typical misconception is that there is only one general intelligence to care about. In reality, we have many different cognitive abilities, such as attention, memory, language, reasoning, and more, so it makes sense to have different programs designed to train and improve each of them."

How to Evaluate and Choose a Brain Fitness Program: To help you navigate the growing number of computer-based programs and games, we published this 10-Question Checklist, based on dozens of interviews with scientists, experts and consumers.

Travel and Engagement as Good Brain Exercise: As we've seen, novelty, variety and challenge are the key guidelines for "brain exercise" that help build new neural connections, force one to be mindful and pay attention, improve abilities such as pattern-recognition, and generally contribute to lifelong brain health. In this post we feature the brain building / mind expanding experience of a SharpBrains friend working in Namibia.

Alzheimer's Prevention and Diagnostic Tests: analysis of several recent articles on emerging research behind Alzheimer's diagnostic and prevention.

Corporate Wellness and Training

Cognitive Reserve and Intellectually Demanding Jobs: a recent study shows how "Intellectually demanding work was associated with greater benefit to cognitive performance in later life independent of related factors like education and intelligence."

Cognitive Health and Baby Boomers- 6 Points to Keep in Mind: based upon an excellent McKinsey report titled Serving Aging Baby Boomers, we discuss a variety a news articles, including interesting numbers, some bad news, and some good news.

Lifelong Learning Is Changing My Brain: Andreas, the neuroscience PhD student who spent last summer working with SharpBrains, writes some reflections on his experience and on how scientists and business professionals can learn from each other.

Brain Teasers

Traveler IQ Game: Check out this stimulating online game...

Events

Learning & The Brain Conference, February 5-7 2008, San Francisco: Sign up now for this great conference for educators who want to learn about the latest brain research findings and implications. I will be speaking at the conference giving an overview of innovative cognitive training programs. The organizers are offering a Special Discount for SharpBrains readers until January 25th 2008, so click here if interested.

If we don't talk beforehand...Happy New Year!

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You can also enjoy our previous editions of our Brain Fitness Newsletter:

- November Edition

- October Edition

- September Edition

- August Edition

- July Edition

Roundup of several insightful articles and recent research:

Fish Oil May Help Prevent Alzheimer's (Washington Post)

- "The omega-3 fatty acids found in fish oil might play an important role in preventing Alzheimer's disease, according to a research team at the University of California, Los Angeles (UCLA)."

- "Publishing in the Dec. 26 issue of the Journal of Neuroscience, the scientists demonstrated that the omega-3 fatty acid docosahexaenoic acid (DHA) increases the production of LR11, a protein that is found at reduced levels in Alzheimer's patients. LR11 is known to destroy the protein that forms the plaques associated with the disease, the researchers explained." 

- "Alzheimer's is a debilitating neurodegenerative disease that causes memory loss, dementia, personality change and ultimately death. The Alzheimer's Association estimates that 5.1 million Americans are currently afflicted with the disease. The association predicts that may increase to between 11 million and 16 million people by 2050."

 'Finding Alzheimer’s Before a Mind Fails' (New York Times)

- "Ms. Kerley is part of an ambitious new scientific effort to find ways to detect Alzheimer’s disease at the earliest possible moment. Although the disease may seem like a calamity that strikes suddenly in old age, scientists now think it begins long before the mind fails."

- "Many scientists believe the best hope of progress, maybe the only hope, lies in Continue Reading »

Over the last months, thanks to the traffic growth of SharpBrains.com (over 100,000 unique visitors per month these days, THANK YOU for visiting today and please come back!), a number of proactive book agents, publishers and authors have contacted us to inform us of their latest brain-related books. We have taken a look at many books, wrote reviews of The Dana Guide to Brain Health book review and Best of the Brain from Scientific American, and interviewed scientists such as Judith Beck, Robert Emmons and James Zull.

Now we are launching a new Author Speaks Series to provide a platform for leading scientists and experts writing high-quality brain-related books to reach a wide audience. We are honored to start the series with an article by Larry McCleary, M.D, former acting Chief of Pediatric Neurosurgery at Denver Children's Hospital, and author of The Brain Trust Program: A Scientifically Based Three-Part Plan to Improve Memory, Elevate Mood, Enhance Attention, Alleviate Migraine and Menopausal Symptoms, and Boost Mental Energy (Perigee Trade, 2007).

Without further ado, let's enjoy Dr. McCleary's article:

Brain Evolution and Why it is Meaningful Today to Improve Our Brain Health

You may feel overwhelmed by the stream of seemingly contradictory suggestions regarding the best way to maintain mental clarity as you age. Based on an analysis of seminal factors in the development of modern brain anatomy, I believe it is possible to make some very compelling recommendations for growing big brains, enhancing their function, and making them resistant to the aging process. These may be loosely categorized as factors pertaining to the mental or physical attributes of the brain. Although they are not truly independent entities, such a conceptualization provides a basis for the generation of brain healthy prescriptions. Diet, physical exercise, and stress reduction enhance neuronal resilience. Sleep and mental stimulation are vital for cognitive ability, learning, and memory.

Diet: Follow a modern shore-based/marine diet including seafood in its most general sense, non-starchy vegetables of all colors, berries, and eggs. Other sources of lean protein containing long-chain omega 3 fatty acids such as free range beef, chicken, bison, or elk are nutritious alternatives.

Physical exercise (Think ‘fight or flight’ activity.): Include all types. Aerobic activities such as swimming, bicycling, walking, or hiking for promotion of vascular health and weight control; resistance training for promotion of neurotrophic factors, naturally occurring compounds that make brain cells more resistant to aging, such as IGF-1 (Insulin-like growth factor-1) and BDNF (Brain-derived neurotrophic factor); and balance, coordination, and agility training such as ping-pong, balance beam, trampoline, and jumping rope to enhance cognitive speed and motor skills.

Stress Control: From an evolutionary perspective, stressors (such as meeting a cave bear) and intense physical activity (running or fighting) were brief in duration and usually occurred together. Modern stressors (psychological or emotional stress) tend to be unremitting and are generally uncoupled from the physical (fight or flight) component, meaning stress develops without any associated physical activity. Such intense physical pursuits are now called exercise. Not surprisingly, exercise is a perfect physiologic antidote for stress due to its beneficial impact on cortisol (the ‘stress’ hormone) and blood pressure and should be incorporated into any program of stress reduction.

Adequate sleep: The body needs rest, but the brain requires sleep. Acute or chronic sleep deprivation causes devastating short and long-term consequences to brain anatomy (synaptic loss) and function (memory and learning difficulties). Off-line information processing and memory consolidation are additional sleep-related benefits.

Mental stimulation: Brain-training, a cognitively challenging lifestyle, novelty, and socialization are vital for the promotion of neuronal plasticity and neurogenesis (the formation of new nerve cells and neuronal connections), the enhancement of specific brain functions such as memory, and the development of cognitive reserve –additional mental processing potential that may be brought online when needed.

The combination of these recommendations, each of which was instrumental in the transformation from primitive to modern nervous systems, provides a template for the most logical approach for enhancing mental function and resisting neurodegeneration as we travel through life.

The Evolutionary Rationale

The human brain clearly has the genetic potential for dramatic expansion. This was illustrated about Continue Reading »

I hope you are having happy holidays, and are getting ready for New Year celebrations. Best wishes to you and your loved ones. 

Via MedJournalWatch we just found this interesting paper, 

Associations of job demands and intelligence with cognitive performance among men in late life. Guy G. Potter PhD^*, Michael J. Helms BS, and Brenda L. Plassman PhD Neurology 2007.

- CONCLUSIONS: "Intellectually demanding work was associated with greater benefit to cognitive performance in later life independent of related factors like education and intelligence. The fact that individuals with lower intellectual aptitude demonstrated a stronger positive association between work and higher cognitive performance during retirement suggests that behavior may enhance intellectual reserve, perhaps even years after peak intellectual activity."

This is consistent with the Cognitive Reserve theory we discussed in the interview with neuroscientist Yaakov Stern:

- AF (Alvaro Fernandez): OK, so our goal is to build that Reserve of neurons, synapses, and skills. How can we do that? What defines "mentally stimulating activities" or good "brain exercise"?

- YS (Yaakov Stern): In summary, we could say that "stimulation" consists of engaging in activities. In our research almost all activities are seen to contribute to reserve. Some have challenging levels of cognitive complexity, and some have interpersonal or physical demands. In animal studies, exposure to an enriched environment or increased physical activity result in increased neurogenesis (the creation of new neurons). You can get that stimulation through education and/ or your occupation. There is clear research showing how those two elements reduce the risk. Now, what is very exciting is that, no matter one's age, education and occupation, our level of participation in leisure activities has a significant and cumulative effect. A key message here is that different activities have independent, synergistic, contributions, which means the more things you do and the earlier you start, the better. But you are never stuck: better late than never.

- Read more on the Cognitive Reserve

In short, mentally and socially stimulating activities, through our education, occupation AND leisure activities, contribute to building a Cognitive Reserve in our brains that may help delay memory problems, Mild Cognitive Impairment, and Alzheimer's related symptoms, and help maintain cognitive performance overall as we age.

If you are thinking about New Year Resolutions, this is one more area to consider. Happy 2008!

A quick note to alert you of two very interesting, growing, and somehow linked debates:

1) Very insightful article on The Aging of the Baby Boomers: What Does It Mean for the Legal Profession (thank you, Stephanie!). Some quotes:

- "As I pen this article, it seems as though I’m writing about someone else—the older worker. Age and aging, it seems, are in the eye of the one looking back at you in the mirror. I have this theory, especially as it pertains to men, that when we look in the mirror, we still see that 20 year-old stud who can leap tall buildings. But I know that my vertical leap is not what it used to be. The reality of aging in the legal profession is upon me and those of our generation."

- "Also, the perception of how old is old varies depending on the job or profession. For example, Continue Reading »

Sharon Begley, Newsweek’s science reporter, recently wrote that

- “With the nation’s 78 million baby boomers approaching the age of those dreaded “where did I leave my keys?” moments, it’s no wonder the market for computer-based brain training has shot up from essentially zero in 2005 to $80 million this year, according to the consulting firm SharpBrains.”

- “Now comes the largest and most rigorous study of a commercially-available training program, and it shows that there is hope for aging brains. This morning, at the meeting of the Gerontological Society of America, scientists are presenting data showing that after eight weeks of daily one-hour sessions with Brain Fitness 2.0 from Posit Science, elderly volunteers got measurably better in their brain’s speed and accuracy of processing. “

We recently had the chance to interview Dr. Elizabeth Zelinski of the University of Southern California Andrus Gerontology Center, who led the IMPACT (Improvement in Memory with Plasticity-based Adaptive Cognitive Training) Study Sharon Begley refers to in the quote above. 

First, some context on this study, which is by far the largest high-quality study of its kind. The study was prospective, randomized, controlled, and used a double blind trial. 524 healthy adults 65-year-old and over were divided into two groups. One received an hour a day of training for eight to ten weeks, and the other spent the same amount of time watching educational DVDs. The IMPACT study, funded by Posit Science corporation, was performed in multiple locations, including the Mayo Clinic, USCF, and San Francisco Veteran Affairs Medical Center.

The discussion centers at his point on the initial results that were presented Gerontological Society of America (the study hasn't been published yet).

Alvaro Fernandez: Dr. Zelinski. Thank you for being with us. Could you start by setting the context and providing an overview of how human cognitive abilities typically evolve as we age – based on insights from your Long Beach Longitudinal Study?

Elizabeth Zelinski: Of course. The first concept to understand is that different cognitive skills evolve over the lifespan in different ways. Some that rely on experience, such as vocabulary, actually improve as we age. Some tend to decline gradually, starting in our late 20s. This happens, for example, with processing speed (how long it takes us to process and respond to information), memory, and reasoning. We could summarize this phenomenon by saying that as we age we get better at dealing with the familiar, but worse at dealing with the new. We can always learn, but at a slower pace.

Are there any specific tipping or inflection points in this trend, any age when the rate of decline is more pronounced?

We don’t have a clear answer to that. It depends a lot on the individual. In general it is a gradual, cumulative process, so that by age 70 we statistically see clear age declines. Which, for example, is a strong factor determining why older adults struggle to adapt to new technologies, but why trying to learn them provides needed mental stimulation. Now we know that genes only account for a portion of this decline. Much of it depends on our environment, lifestyle and actions.

Can you summarize what a healthy individual can do to slow down this process of decline, and help stay healthy and productive as long as possible?

One general recommendation is to do everything we can to prevent or delay disease processes, such as diabetes or high-blood pressure, that have a negative effect on our brains. For example, it is a tragedy in our society that we usually reduce our levels of physical exercise drastically after we leave school.

Let me then ask: what are the relative virtues of physical vs. mental exercise?

Great question! That in fact leads into my second recommendation. Aerobic exercise has been shown to Continue Reading »

Just came across this very stimulating and fun Traveler IQ interactive game...enjoy!

Link: Traveler IQ Challenge

Note: at the bottom of the page you can select a variety of challenges (flags of the world, UNESCO sites, North America...) My favourite: Photos of the World.

Neuroplasticity is defined as "the ability of the brain to rewire itself through experience". 

We typically summarize a lot of brain research by encouraging SharpBrains readers is to seek for novelty, variety and challenge, as guidelines for "brain exercise" that will help build new connections in the brain, force one to be mindful and pay attention, improve abilities such as pattern-recognition, and in general contribute to lifelong brain health.

A friend just sent an update on her amazing experience in Namibia (the pic on the right shows the entrance to the University of Namibia) that shows how Travel and Engagement with meaningful projects can provide superb mental stimulation, or "brain exercise". This is relevant at all ages, and we are encouraged to see organizations such as Civic Ventures and Elderhostel that offer opportunities for baby boomers and older adults who want to maintain active minds.

Try picturing in your mind, as you read this, all her different brain areas that are getting needed stimulation through her Namibia experience.

UPDATE: my friend just wrote to expand on the "be mindful" angle by saying that "it definitely requires purposeful processing of the information that you are consuming in order to make it a useful brain exercise. For example, I always try to journal or write thoughtful emails about my experience in order to try to best understand it." Great point.

With her permission, here you have: 

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Dear Friends,

I am just returning from Namibia and am buzzing with excitement about all of the opportunities for us to make an impact there when we return with our students next Spring.

Namibia is very different than I expected. It was the last country in Africa to gain independence from colonialism, gaining independence just 20 years ago. Thus, it is much more developed than any African country that I have visited, with relatively good infrastructure and no exis ting debt. That said, the legacies of apartheid can still be felt in today's society, and the people are very clearly dealing constantly with issues of race and identity. One of the most interesting experiences that I had was attending a "braai" (the Namibian version of a barbecue which basically consists of Continue Reading »

Quick: say the color in which each word in this graphic is displayed (don't just read the word!):

Here you have a round-up of some great recent articles on memory, aging, and cognitive abilities such as self-control:

1) How to Boost Your Willpower (New York Times).

- "The video watchers were later given a concentration test in which they were asked to identify the color in which words were displayed. (Note: now you see why we started with that brain exercise...) The word “red,” for instance, might appear in blue ink. The video watchers who had stifled their responses did the worst on the test, suggesting that their self-control had already been depleted by the film challenge."  

- "Finally, some research suggests that people struggling with self-control should start small. A few studies show that people who were instructed for two weeks to make small changes like improving their posture or brushing their teeth with their opposite hand improved their scores on laboratory tests of self-control. The data aren’t conclusive, but they do suggest that the quest for self-improvement should start small. A vow to stop swearing, to make the bed every day or to give up just one food may be a way to strengthen your self-control, giving you more willpower reserves for bigger challenges later."

Comment: learning, building abilities, are processes that require practice and growing levels of difficulty. Like training our muscles in the gym. So the advice to start small and progressively do more makes sense. Many times the enemy of learning is the stress and anxiety we provoke by trying to do too many things at the same time...

 

2) Jogging Your Memory (Newsweek) Thanks Chris for alerting us!

- "No one should expect miracles soon, if at all. But the deeper scientists peer into the workings of memory, the better they understand Continue Reading »