We are the archi­tects and builders of our own brains.

For mil­len­nia, how­ever, we were obliv­i­ous to our enor­mous cre­ative capa­bil­i­ties. We had no idea that our brains were chang­ing in response to our actions and atti­tudes, every day of our lives. So we uncon­sciously and ran­domly shaped our brains and our lat­ter years because we believed we had an immutable brain that was at the mercy of our genes.

Noth­ing could be fur­ther from the truth. Read the rest of this entry »

Train­ing the brain is pos­si­ble because of neu­ro­plas­tic­ity. Our daily expe­ri­ences can trig­ger neu­ro­plas­tic changes in the brain, such as the growth of new brain cells (neu­rons) and new con­nec­tions (synapses) between neu­rons. Plas­tic­ity is observed at all ages but is at its peak dur­ing brain devel­op­ment, as a baby and then a child learns basic knowl­edge and skills nec­es­sary to sur­vive. We should thus expect that the brain of a baby could be eas­ily trained. This is what Wass and his col­leagues recently demon­strated in a new study with 11-month-old babies. Read the rest of this entry »

Given the grow­ing media cov­er­age men­tion­ing the terms Cog­ni­tive Reserve and Brain Reserve, you may be ask­ing your­self, “What exactly is my Cog­ni­tive (or Brain) Reserve?”

The cog­ni­tive reserve hypoth­e­sis, tested in mul­ti­ple stud­ies, states that indi­vid­u­als with more cog­ni­tive reserve can expe­ri­ence more Alzheimer’s dis­ease pathol­ogy in the brain (more plaques and tan­gles) with­out devel­op­ing Alzheimer’s dis­ease symptoms.

How does that work? Sci­en­tists are not sure but two pos­si­bil­i­ties are con­sid­ered.
1. One is that more cog­ni­tive reserve means more brain reserve, that is more neu­rons and con­nec­tions (synapses) between neu­rons. Indi­vid­u­als with more synapses would then have more synapses to lose before the crit­i­cal thresh­old for Alzheimer’s Dis­ease is reached.
2. Another pos­si­bil­ity is that more cog­ni­tive reserve means more com­pen­satory processes. The brain of indi­vid­u­als with more cog­ni­tive reserve would use more alter­na­tive net­works to com­pen­sate for the dam­ages caused by the pathol­ogy in pre­vi­ously used networks.

In a newly pub­lished study, Roe and col­leagues from Wash­ing­ton Uni­ver­sity in St. Louis, used the num­ber of years of edu­ca­tion as a mea­sure of cog­ni­tive reserve. Why years of edu­ca­tion? Because pre­vi­ous stud­ies have shown that peo­ple who have more edu­ca­tion also exhibit a greater resis­tance to Alzheimer’s symp­toms, even while patho­log­i­cal changes are occur­ring in the brain (see Ben­nett el al., 2003 or Roe, Xiong, et al., 2008).

Roe and her col­leagues stud­ied 198 indi­vid­u­als whose mean age was 67. Out of these 198 indi­vid­u­als, 161 were non­de­mented and 37 were diag­nosed with Alzheimer’s Disease.

All the par­tic­i­pants in the study took a Read the rest of this entry »

Dr. Arthur Kramer is a Pro­fes­sor in the Uni­ver­sity of Illi­nois Depart­ment of Psy­chol­ogy, the Cam­pus Neu­ro­science Pro­gram, the Beck­man Insti­tute, and the Direc­tor of the Bio­med­ical Imag­ing Cen­ter at the Uni­ver­sity of Illinois.

I am hon­ored to inter­view him today.

Dr. Kramer, thank you for your time. Let’ start by try­ing to clar­ify some exist­ing mis­con­cep­tions and con­tro­ver­sies. Based on what we know today, and your recent Nature piece (Note: ref­er­enced below), what are the 2–3 key lifestyle habits would you sug­gest to a per­son who wants to delay Alzheimer’s symp­toms and improve over­all brain health?

First, Be Active. Do phys­i­cal exer­cise. Aer­o­bic exer­cise, 30 to 60 min­utes per day 3 days per week, has been shown to have an impact in a vari­ety of exper­i­ments. And you don’t need to do some­thing stren­u­ous: even walk­ing has shown that effect. There are many open ques­tions in terms of spe­cific types of exer­cise, dura­tion, mag­ni­tude of effect but, as we wrote in our recent Nature Reviews Neu­ro­science arti­cle, there is lit­tle doubt that lead­ing a seden­tary life is bad for our cog­ni­tive health. Car­dio­vas­cu­lar exer­cise seems to have a pos­i­tive effect.

Sec­ond, Main­tain Life­long Intel­lec­tual Engage­ment. There is abun­dant prospec­tive obser­va­tional research show­ing that doing more men­tally stim­u­lat­ing activ­i­ties reduces the risk of devel­op­ing Alzheimer’s symptoms.

Let me add, given all media hype, that no “brain game” in par­tic­u­lar has been shown to have a long-term impact on Alzheimer’s or the main­te­nance of cog­ni­tion across extended peri­ods of time. It is too early for that-and con­sumers should be aware of that fact. It is true that some com­pa­nies are being more science-based than oth­ers but, in my view, the consumer-oriented field is grow­ing faster than the research is.

Ide­ally, com­bine both phys­i­cal and men­tal stim­u­la­tion along with social inter­ac­tions. Why not take a good walk with friends to dis­cuss a book? We lead very busy lives, so the more inte­grated and inter­est­ing activ­i­ties are, the more likely we will do them.

Read the rest of this entry »

We had the for­tune to inter­view Dr. Brett Steen­barger on Enhanc­ing Trader Per­for­mance and The Psy­chol­ogy of Trad­ing as we launched our Neu­ro­science Inter­view Series.

Below, Expert Con­trib­u­tor Dr. Jan­ice Dorn pro­vides an in-depth brain-based dis­cus­sion of the topic, con­clud­ing that “The brain is the most pow­er­ful struc­ture in the known uni­verse and the only trad­ing tool that the trader needs to become an expert.”

No mat­ter whether you are a Pro or Ama­teur Trader…this will cer­tainly exer­cise your brain! (Dr. Dorn is prepar­ing more arti­cles on trad­ing per­for­mance and the brain…so stay tuned).

This is Your Brain On Trading

– By Dr. Jan­ice Dorn

The open­ing bell sounds, and sixty mil­lion traders enter the great­est arena in the world to do bat­tle with each other. They put their money, beliefs and skills on the line as they make deci­sions to buy and sell. Wel­come to the finan­cial mar­kets where bil­lions of dol­lars are won and lost every day. Volatil­ity com­pels all to engage their brains in the con­tin­u­ous process of deci­sion mak­ing. What sep­a­rates the win­ning from los­ing traders is the way they use their most pow­er­ful trad­ing tool—the human brain.

Read the rest of this entry »

Stephanie West Allen, our lawyer-blogger friend and Dr. Jef­frey M. Schwartz, a research psy­chi­a­trist at the School of Med­i­cine at the Uni­ver­sity of Cal­i­for­nia at Los Ange­les and a neu­ro­plas­tic­ity expert, have writ­ten a thought-provoking arti­cle for The Com­plete Lawyer.

See Arti­cle: Exer­cise Mind Hygiene On A Daily Basis. Excerpt:

- “Here’s an exam­ple of a Golden Moment of Choice: You have decided that you are going to keep your promise and get home each evening in time to put the kids to bed. When 7 p.m. rolls around, you rec­og­nize that you can move in one of two direc­tions: you can keep work­ing or get going. Because of your habit of work­ing very late, the synapses in your brain have been forged to sup­port your habit, and you feel the urge to stay. This phys­i­o­log­i­cal com­po­nent of your habit­ual behav­ior is mak­ing your deci­sion dif­fi­cult. Nev­er­the­less, you decide to leave. Now, each time you make this new choice, it will be eas­ier: You will be lay­ing down “going-home-to-the-kids” synapses to sup­port the new behav­ior (and you will be using self-directed neuroplasticity).

- Our abil­ity to step back and see that we have the choice is key. Often we do not even get that far: 7 p.m. comes and goes with­out our real­iz­ing that it’s a GMC. In order to improve your abil­ity to observe your­self and your choices, you need to develop your self-awareness”.

Arti­cle: Exer­cise Mind Hygiene On A Daily Basis

Read­ing this, and with a wife  and 6-week-old baby start­ing to fall asleep, reminds me of something…

how to say, “Good night, dear Blog!”

Below you have a very insight­ful arti­cle on stress by one of our new Expert Con­trib­u­tors, Gre­gory Kel­let, a researcher at UCSF. Enjoy! (Credit for Pic of Vic­to­ria Crater in Mars: Mars Recon­nais­sance Orbiter, via Wikipedia).

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“My brain is fried, toast, fraz­zled, burnt out. How many times have you said or heard one ver­sion or another of these state­ments. Most of us think we are being fig­u­ra­tive when we utter such phrases, but research shows that the bio­log­i­cal con­se­quences of sus­tained high lev­els of stress may have us being more accu­rate than we would like to think.

Crash Course on Stress

Our bod­ies are a com­plex bal­anc­ing act between sys­tems work­ing full time to keep us alive and well. This bal­anc­ing act is con­stantly adapt­ing to the myr­iad of changes occur­ring every sec­ond within our­selves and our envi­ron­ments. When it gets dark our pupils dilate, when we get hot we sweat, when we smell food we sali­vate, and so forth. This con­stant bal­anc­ing act main­tains a range of sta­bil­ity in the body via change; and is often referred to as allosta­sis. Any change which threat­ens this bal­ance can be referred to as allo­sta­tic load or stress.

Allo­sta­tic load/stress is part of being alive. For exam­ple just by get­ting up in the morn­ing, we all expe­ri­ence a very impor­tant need to increase our heart rate and blood pres­sure in order to feed our newly ele­vated brain. Although usu­ally man­age­able, this is a change which the body needs to adapt to and, by our def­i­n­i­tion, a stressor.

Stress is only a prob­lem when this allo­sta­tic load becomes over­load. When change is exces­sive or Read the rest of this entry »

Today we have the plea­sure to have Dr. Pas­cale Mich­e­lon, one of our new Expert Con­trib­u­tors, write her first arti­cle here. Enjoy, and please com­ment so we hear your thoughts and engage in a nice conversation.

(Btw, if you notice some sim­i­lar­ity between the col­ors in the fMRI scan below and the look & feel of this site…well, the rea­son is that those orange-grey fMRI col­ors were our inspi­ra­tion! the orange color denotes the most brain activation).

- Alvaro

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You have prob­a­bly heard about CAT and MRI scans (pro­duced thanks to machines like the one to the top right). So you know that these are tech­niques that doc­tors and sci­en­tists use to look inside the brain.

You have prob­a­bly also heard about brain fit­ness and how impor­tant it is to keep a healthy brain to be pro­tected against age-related and disease-related brain damages.

The ques­tion we ask here is the fol­low­ing: Can we use brain scans to eval­u­ate how fit the brain is? Before we try to answer this ques­tion let’s start with the basics and try to under­stand how brain scans work.

Brain imag­ing, also called neu­roimag­ing, allows one to Read the rest of this entry »

Over the last months, thanks to the traf­fic growth of SharpBrains.com (over 100,000 unique vis­i­tors per month these days, THANK YOU for vis­it­ing today and please come back!), a num­ber of proac­tive book agents, pub­lish­ers and authors have con­tacted us to inform us of their lat­est brain-related books. We have taken a look at many books, wrote reviews of The Dana Guide to Brain Health book review‚ and Best of the Brain from Sci­en­tific Amer­i­can, and inter­viewed sci­en­tists such as Judith Beck, Robert Emmons and James Zull.

Now we are launch­ing a new Author Speaks Series to pro­vide a plat­form for lead­ing sci­en­tists and experts writ­ing high-quality brain-related books to reach a wide audi­ence. We are hon­ored to start the series with an arti­cle by Larry McCleary, M.D, for­mer act­ing Chief of Pedi­atric Neu­ro­surgery at Den­ver Children’s Hos­pi­tal, and author of The Brain Trust Pro­gram: A Sci­en­tif­i­cally Based Three-Part Plan to Improve Mem­ory, Ele­vate Mood, Enhance Atten­tion, Alle­vi­ate Migraine and Menopausal Symp­toms, and Boost Men­tal Energy (Perigee Trade, 2007).

With­out fur­ther ado, let’s enjoy Dr. McCleary’s article:

Brain Evo­lu­tion and Why it is Mean­ing­ful Today to Improve Our Brain Health

You may feel over­whelmed by the stream of seem­ingly con­tra­dic­tory sug­ges­tions regard­ing the best way to main­tain men­tal clar­ity as you age. Based on an analy­sis of sem­i­nal fac­tors in the devel­op­ment of mod­ern brain anatomy, I believe it is pos­si­ble to make some very com­pelling rec­om­men­da­tions for grow­ing big brains, enhanc­ing their func­tion, and mak­ing them resis­tant to the aging process. These may be loosely cat­e­go­rized as fac­tors per­tain­ing to the men­tal or phys­i­cal attrib­utes of the brain. Although they are not truly inde­pen­dent enti­ties, such a con­cep­tu­al­iza­tion pro­vides a basis for the gen­er­a­tion of brain healthy pre­scrip­tions. Diet, phys­i­cal exer­cise, and stress reduc­tion enhance neu­ronal resilience. Sleep and men­tal stim­u­la­tion are vital for cog­ni­tive abil­ity, learn­ing, and memory.

Diet: Fol­low a mod­ern shore-based/marine diet includ­ing seafood in its most gen­eral sense, non-starchy veg­eta­bles of all col­ors, berries, and eggs. Other sources of lean pro­tein con­tain­ing long-chain omega 3 fatty acids such as free range beef, chicken, bison, or elk are nutri­tious alternatives.

Phys­i­cal exer­cise (Think fight or flight — activ­ity.): Include all types. Aer­o­bic activ­i­ties such as swim­ming, bicy­cling, walk­ing, or hik­ing for pro­mo­tion of vas­cu­lar health and weight con­trol; resis­tance train­ing for pro­mo­tion of neu­rotrophic fac­tors, nat­u­rally occur­ring com­pounds that make brain cells more resis­tant to aging, such as IGF-1 (Insulin-like growth factor-1) and BDNF (Brain-derived neu­rotrophic fac­tor); and bal­ance, coor­di­na­tion, and agility train­ing such as ping-pong, bal­ance beam, tram­po­line, and jump­ing rope to enhance cog­ni­tive speed and motor skills.

Stress Con­trol: From an evo­lu­tion­ary per­spec­tive, stres­sors (such as meet­ing a cave bear) and intense phys­i­cal activ­ity (run­ning or fight­ing) were brief in dura­tion and usu­ally occurred together. Mod­ern stres­sors (psy­cho­log­i­cal or emo­tional stress) tend to be unremit­ting and are gen­er­ally uncou­pled from the phys­i­cal (fight or flight) com­po­nent, mean­ing stress devel­ops with­out any asso­ci­ated phys­i­cal activ­ity. Such intense phys­i­cal pur­suits are now called exer­cise. Not sur­pris­ingly, exer­cise is a per­fect phys­i­o­logic anti­dote for stress due to its ben­e­fi­cial impact on cor­ti­sol (the stress hor­mone) and blood pres­sure and should be incor­po­rated into any pro­gram of stress reduction.

Ade­quate sleep: The body needs rest, but the brain requires sleep. Acute or chronic sleep depri­va­tion causes dev­as­tat­ing short and long-term con­se­quences to brain anatomy (synap­tic loss) and func­tion (mem­ory and learn­ing dif­fi­cul­ties). Off-line infor­ma­tion pro­cess­ing and mem­ory con­sol­i­da­tion are addi­tional sleep-related benefits.

Men­tal stim­u­la­tion: Brain-training, a cog­ni­tively chal­leng­ing lifestyle, nov­elty, and social­iza­tion are vital for the pro­mo­tion of neu­ronal plas­tic­ity and neu­ro­ge­n­e­sis (the for­ma­tion of new nerve cells and neu­ronal con­nec­tions), the enhance­ment of spe­cific brain func­tions such as mem­ory, and the devel­op­ment of cog­ni­tive reserve — addi­tional men­tal pro­cess­ing poten­tial that may be brought online when needed.

The com­bi­na­tion of these rec­om­men­da­tions, each of which was instru­men­tal in the trans­for­ma­tion from prim­i­tive to mod­ern ner­vous sys­tems, pro­vides a tem­plate for the most log­i­cal approach for enhanc­ing men­tal func­tion and resist­ing neu­rode­gen­er­a­tion as we travel through life.

The Evo­lu­tion­ary Rationale

The human brain clearly has the genetic poten­tial for dra­matic expan­sion. This was illus­trated about Read the rest of this entry »

Who has not heard “Use It or Lose It”. Now, what is “It”? Last week I gave a talk at the Ital­ian Con­sulate in San Fran­cisco, and one of the areas atten­dants seemed to enjoy the most was learn­ing about what our brains are and how they work, peak­ing into the “black box” of our minds. With­out under­stand­ing at least the basics, how can we make good deci­sions about our own brain health and fitness?

Let’s review at a glance:

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The brain is com­posed of 3 main sub-systems

The brain is com­posed of 3 “brains” or main sub-systems, each named after the evo­lu­tion­ary moment in which the sub-system is believed to have appeared. Read the rest of this entry »