Here you have a round-up of recent news on how cog­ni­tive and affec­tive neu­ro­science find­ings are start­ing to inform edu­ca­tion and health across the lifespan:

Pedi­a­tri­cians issue a call to aid chil­dren fac­ing ‘toxic stress’ (LA Times)

Teach­ers as Brain-Changers: Neu­ro­science and Learn­ing (EdWeek) Read the rest of this entry »

Good brief arti­cle at New Sci­en­tist, Maker of cog­ni­tive train­ing game seeks FDA approval:

- “Imag­ine walk­ing away from a doctor’s office with a pre­scrip­tion to play a video game. Brain Plas­tic­ity, the devel­oper of a cog­ni­tive train­ing game, has begun talks with the Food and Drug Admin­is­tra­tion (FDA) to mar­ket the game as a ther­a­peu­tic drug.”

- “Brain Plas­tic­ity has been fine-tuning a game to help peo­ple with schiz­o­phre­nia improve the deficits in atten­tion and mem­ory that are often asso­ci­ated with the disorder.”

Think­ing glob­ally to improve men­tal health: NIH announces inter­na­tional research ini­tia­tive (press release):

- “The Grand Chal­lenges in Global Men­tal Health Ini­tia­tive, led by the National Insti­tutes of Health and the Global Alliance for Chronic Dis­eases, has iden­ti­fied the top 40 bar­ri­ers to bet­ter men­tal health around the world. Sim­i­lar to past grand chal­lenges, which Read the rest of this entry »

The use of a vari­ety of brain train­ing inter­ven­tions is grow­ing in the area of men­tal health. Emerg­ing evi­dence sug­gests that in the near future tar­geted brain train­ing may even be used to pre­vent sub­stance abuse. For exam­ple, train­ing work­ing mem­ory may reduce sub­stance abusers’ dis­count­ing of long-term rewards and pun­ish­ments — such dis­count­ing is one of the rea­sons why peo­ple sus­cep­ti­ble to addic­tions do not ben­e­fit from tra­di­tional informational/ edu­ca­tional approaches to drug prevention.

Let’s explore some expand­ing appli­ca­tions of brain train­ing, and much more, in this lat­est edi­tion of the monthly Sharp­Brains eNewslet­ter.

Brain Train­ing and Men­tal Health

ADHD: Brain Train­ing, Neu­ro­feed­back, Diet, and More: What can be done to fight ADHD and improve the lives of peo­ple suf­fer­ing from it?

Neu­ro­plas­tic­ity in the Brain of Chil­dren with Neu­ro­log­i­cal Dis­or­ders: Brain train­ing may be an option for chil­dren suf­fer­ing from Tourette Syn­drom to help reduce the symptoms.

Brain Train­ing and Schiz­o­phre­nia: Social cog­ni­tive train­ing pro­grams can boost schiz­o­phren­ics’ skills social skills.

Rethink­ing the Clas­si­fi­ca­tion of Men­tal Ill­ness: How can we rethink the clas­si­fi­ca­tion of psy­chopathol­ogy (via the new DSM-5) to reflect our cur­rent under­stand­ing of the brain as a dynamic system?

Upcom­ing events: Cog­ni­tive Reme­di­a­tion in Psy­chi­a­try (June 10th, NYC), Enter­tain­ment Soft­ware and Cog­ni­tive Neu­rother­a­peu­tics Soci­ety (Sep­tem­ber 19–20, San Francisco).

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Lifestyle for Brain Health

More Friends, Big­ger Brain: The num­ber of friends you have could be pre­dicted by the size of our amygdala!

Music and Demen­tia: Play­ing music pro­tects the brain later on. Music may also be used to teach new facts to peo­ple suf­fer­ing from dementia.

Exer­cise and Over­weight Chil­dren: Aer­o­bic exer­cise can boost over­weight chil­dren exec­u­tive functions.

The Brain Grows With Prac­tice…: We know that when the brain mas­ters a new skill, tar­geted brain areas/ cir­cuits get enlarged. We now know that those areas and cir­cuits even­tu­ally shrink back to nor­mal, but per­for­mance gain can be maintained!

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Food for Thought

What is Brain Fit­ness? What are Emerg­ing Oppor­tu­ni­ties to Retool Brain Health? Here are the answers by seven 2011 Sharp­Brains Sum­mit Speakers.

Nav­i­gate through the 30 most pop­u­lar arti­cles of last year in SharpBrains.com to learn more about the brain and how to maintain/ enhance brain func­tion­ing across the lifes­pan..

Brain Teaser

Can you lis­ten to these laughs and dis­tin­guish whether it is a human or a com­puter laugh­ing? Also, given how good laugh­ing is…how about try­ing this to find out how much stressed you are? You may be surprised.

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We hope you enjoyed this newslet­ter. Please do feel free to share this with friends and col­leagues via Face­book, Twit­ter and LinkedIn.

Indi­vid­u­als suf­fer­ing from schiz­o­phre­nia show social cog­ni­tive deficits, that is dif­fi­cul­ties in per­ceiv­ing and under­stand­ing the social world. Research shows that schiz­o­phre­nia is accom­pa­nied by social cog­ni­tion prob­lems such as prob­lems iden­ti­fy­ing facial expres­sions, under­stand­ing and respond­ing to social cues (e.g., body lan­guage), under­stand­ing that oth­ers have dif­fer­ent men­tal states and thoughts than one­self (also called The­ory of mind). These deficits are usu­ally per­sis­tent over time and resist phar­ma­co­log­i­cal treat­ment. Inter­est­ingly, social cog­ni­tion may be train­able. This recent arti­cle reviews the research and shows that social cog­ni­tive train­ing programs :

• pro­duce a mod­er­ate to large improve­ment in the recog­ni­tion of facial emotions
• pro­duce a smaller improve­ment in The­ory of mind
• do not improve social per­cep­tion (such as under­stand­ing voice into­na­tion or body lan­guage) Read the rest of this entry »

The 2011 Sharp­Brains Sum­mit gath­ered  more than 260 research and indus­try lead­ers in 16 coun­tries for 3 days to dis­cuss the chang­ing land­scape. Held online, par­tic­i­pants from all over the globe  attended to hear more than 40 thought lead­ers, sci­en­tists, entre­pre­neurs and pol­icy mak­ers out­line the evolv­ing mar­ket­place. Dis­cus­sion moved from cog­ni­tive fit­ness to neu­ro­plas­tic­ity, across reg­u­la­tory and pol­icy trends, and new prod­uct launches by new and estab­lished play­ers  What did we take home from the Sharp­Brains Sum­mit? Was it novel con­sumer insights aris­ing from a new retail land­scape? What of pol­icy ini­tia­tives from inno­va­tion clus­ters around the globe? Do you see a future pop­u­lated by neu­ro­science toolk­its, dri­ven by the inex­orable demo­graphic changes set to occur in the com­ing decades? Or was it a look “under the hood” of tech­nol­ogy plat­forms devel­oped by cat­e­gory lead­ers that sharp­ened our insight? Here are 10 emerg­ing themes:

1. The Need for Stan­dard­iza­tion of methodologies

A pro­fu­sion of cog­ni­tive and emo­tional health tests, bat­ter­ies and new tech­nolo­gies are crowd­ing the research envi­ron­ment. The NIH tool­box for the assess­ment of a broad range of cog­ni­tive domains Read the rest of this entry »

As announced by the NIMH a few months ago, schiz­o­phre­nia can now be con­sid­ered as a brain dis­or­der. Research is focus­ing on the cog­ni­tive deficits as the main prob­lem of the dis­or­der, prob­a­bly pre­ced­ing and per­haps lead­ing to the symp­toms of hal­lu­ci­na­tions and delusions.

A recent arti­cle in the Psy­chi­atric Times reviews the dif­fer­ent cog­ni­tive reme­di­a­tion tech­niques used with peo­ple suf­fer­ing from schiz­o­phre­nia. This is of inter­est to any­body work­ing on men­tal health. Indeed, as Sophia Vino­gradov, Interim Vice Chair Psy­chi­a­try at UCSF will dis­cuss dur­ing the Sharp­Brains Sum­mit (next week!) schiz­o­phre­nia is lead­ing the way in under­stand­ing how to iden­tify and address brain-based cog­ni­tive deficits asso­ci­ated with the disorder.

…most [Cog­ni­tive Reme­di­a­tion (CR) pro­grams] are now com­put­er­ized. Some  pro­grams use a mix of gen­eral edu­ca­tional soft­ware, but many train par­tic­i­pants with spe­cial­ized com­puter soft­ware designed to improve cognition.

Most CR pro­grams aim to improve the cog­ni­tive domains usu­ally asso­ci­ated with deficits in schizophrenia—for instance ver­bal and visual work­ing mem­ory, exec­u­tive func­tion, atten­tion, and pro­cess­ing speed.

CR has been demon­strated to improve over­all (global) cog­ni­tion as well as spe­cific domains, includ­ing atten­tion, exec­u­tive func­tion, work­ing mem­ory, ver­bal learn­ing and mem­ory, pro­cess­ing speed, and affect recognition.

We’re delighted to add Brain Resource to the ros­ter of Spon­sors of the upcom­ing 2011 Sharp­Brains Sum­mit, and the Cen­ter for  Tech­nol­ogy and Aging and the Brain Injury Asso­ci­a­tion of Canada to the ros­ter of Part­ners. Thank you for your sup­port! Read the rest of this entry »

Dr. Michael Merzenich, Emer­i­tus Pro­fes­sor at UCSF, is a lead­ing pio­neer in brain plas­tic­ity research. In the late 1980s, Dr. Merzenich was on the team that invented the cochlear implant. In 1996, he was the found­ing CEO of Sci­en­tific Learn­ing Cor­po­ra­tion (Nas­daq: SCIL), and in 2004 became co-founder and Chief Sci­en­tific Offi­cer of Posit Sci­ence. He was elected to the National Acad­emy of Sci­ences in 1999 and to the Insti­tute of Med­i­cine this year. He retired as Fran­cis A. Sooy Pro­fes­sor and Co-Director of the Keck Cen­ter for Inte­gra­tive Neu­ro­science at the Uni­ver­sity of Cal­i­for­nia at San Fran­cisco in 2007. You may have learned about his work in one of PBS TV spe­cials, mul­ti­ple media appear­ances, or neuroplasticity-related books.

(Alvaro Fer­nan­dez) Dear Michael, thank you very much for agree­ing to par­tic­i­pate in the inau­gural Sharp­Brains Sum­mit in Jan­u­ary, and for your time today. In order to con­tex­tu­al­ize the Summit’s main themes, I would like to focus this inter­view on the likely big-picture impli­ca­tions dur­ing the next 5 years of your work and that of other neu­ro­plas­tic­ity research and indus­try pioneers.

Thank you for invit­ing me. I believe the Sharp­Brains Sum­mit will be very use­ful and stim­u­lat­ing, you are gath­er­ing an impres­sive group together. I am look­ing for­ward to January.

Neuroplasticity-based Tools: The New Health & Well­ness Frontier

There are many dif­fer­ent technology-free approaches to har­ness­ing –enabling, dri­ving– neu­ro­plas­tic­ity. What is the unique value that tech­nol­ogy brings to the cog­ni­tive health table?

It’s all about effi­ciency, scal­a­bil­ity, per­son­al­iza­tion, and assured effec­tive­ness. Tech­nol­ogy sup­ports the imple­men­ta­tion of near-optimally-efficient brain-training strate­gies. Through the Inter­net, it enables the low-cost dis­tri­b­u­tion of these new tools, any­where out in the world. Tech­nol­ogy also enables the per­son­al­iza­tion of brain health train­ing, by pro­vid­ing sim­ple ways to mea­sure and address indi­vid­ual needs in each person’s brain-health train­ing expe­ri­ence. It enables assess­ments of your abil­i­ties that can affirm that your own brain health issues have been effec­tively addressed.

Of course sub­stan­tial gains could also be achieved by orga­niz­ing your every­day activ­i­ties that grow your neu­ro­log­i­cal abil­i­ties and sus­tain your brain health. Still, if the ordi­nary cit­i­zen is to have any real chance of main­tain­ing their brain fit­ness, they’re going to have to spend con­sid­er­able time at the brain gym!

One espe­cially impor­tant con­tri­bu­tion of tech­nol­ogy is the scal­a­bil­ity that it pro­vides for deliv­er­ing brain fit­ness help out into the world. Think about how effi­cient the drug deliv­ery sys­tem is today. Doc­tors pre­scribe drugs, insur­ance cov­ers them, and there is a drug store in every neigh­bor­hood in almost every city in the world so that every patient has access to them. Once neuroplasticity-based tools and out­comes and stan­dard­ized, we can envi­sion a sim­i­lar sce­nario. And we don’t need all those drug stores, because we have the Internet!

Hav­ing said this, there are obvi­ous obsta­cles. One main one, in my mind, is the lack of under­stand­ing of what these new tools can do. Cog­ni­tive train­ing pro­grams, for exam­ple, seem counter-intuitive to con­sumers and many pro­fes­sion­als “ why would one try to improve speed-of-processing if all one cares about is œmem­ory? A sec­ond obvi­ous prob­lem is to get indi­vid­u­als to buy into the effort required to really change their brains for the bet­ter. That buy-in has been achieved for many indi­vid­u­als as it applies to their phys­i­cal health, but we haven’t got­ten that far yet in edu­cat­ing the aver­age older per­son that brain fit­ness train­ing is an equally effort­ful business!

Tools for Safer Dri­ving: Teens and Adults

Safe dri­ving seems to be one area where the ben­e­fits are more intu­itive, which may explain the sig­nif­i­cant traction.

Yes, we see great poten­tial and inter­est among insur­ers for improv­ing dri­ving safety, both for seniors and teens. Appro­pri­ate cog­ni­tive train­ing can lower at-fault acci­dent rates. You can mea­sure clear ben­e­fits in rel­a­tively short time frames, so it won’t take long for insur­ers to see an eco­nomic ratio­nale to not only offer pro­grams at low cost or for free but to incen­tivize dri­vers to com­plete them. All­state, AAA, State Farm and other insur­ers are begin­ning to real­ize this poten­tial. It is impor­tant to note that typ­i­cal acci­dents among teens and seniors are dif­fer­ent, so that train­ing method­olo­gies will need to be dif­fer­ent for dif­fer­ent high-risk populations.

Yet, most dri­ving safety ini­tia­tives today still focus on edu­cat­ing dri­vers, rather that train­ing them neu­ro­log­i­cally. We mea­sure vision, for exam­ple, but com­pletely ignore atten­tional con­trol abil­i­ties, or a driver’s use­ful field of view. I expect this to change sig­nif­i­cantly over the next few years.

Long-term care and health insur­ance com­pa­nies will ulti­mately see sim­i­lar ben­e­fits, and we believe that they will fol­low a sim­i­lar course of action to reduce gen­eral med­ical and neu­rode­gen­er­a­tive dis­ease– (Mild Cog­ni­tive Impair­ment and Alzheimer’s– and Parkinsons-) related costs. In fact, many senior liv­ing com­mu­ni­ties are among the pio­neers in this field.

Boomers & Beyond: Main­tain­ing Cog­ni­tive Vitality

Main­stream media is cov­er­ing this emerg­ing cat­e­gory with thou­sands of sto­ries. But most cov­er­age seems still focused on does it work? more than “how do we define It”, what does work mean? or work for whom, and for what? Can you sum­ma­rize what recent research suggests?

We have seen clear pat­terns in the appli­ca­tion of our train­ing pro­grams, some pub­lished (like IMPACT), some unpub­lished, some with healthy adults, and some with peo­ple with mild cog­ni­tive impair­ment or early Alzheimers Dis­ease (AD). What we see in every case: Read the rest of this entry »

(Editor’s Note: given the grow­ing media atten­tion to three appar­ently sep­a­rate worlds –cog­ni­tive enhance­ment via drugs, brain fit­ness train­ing soft­ware, com­put­er­ized neu­rocog­ni­tive assessments-, I found it refresh­ing to see our co-founder Elkhonon Gold­berg intro­duce the topic of cog­notropic drugs with an inte­gra­tive per­spec­tive in the much updated new edi­tion of his clas­sic book, now titled The New Exec­u­tive Brain: Frontal Lobes In A Com­plex World. Below goes an excerpt).

For many neu­ropsy­chol­o­gists, like myself, sci­ence is a labor of love, but see­ing patients is bread and but­ter. Tra­di­tion­ally, the clin­i­cal con­tri­bu­tion of neu­ropsy­chol­ogy has been mostly diag­nos­tic, with pre­cious lit­tle to offer patients by way of treat­ment. Neu­ropsy­chol­ogy is not the only clin­i­cal dis­ci­pline for years con­signed to help­less voyeurism. Every dis­ci­pline con­cerned with cog­ni­tion shares this hum­bling predica­ment. A psy­chi­a­trist treat­ing a schiz­o­phrenic patient or a depressed patient finds him– or her­self in a sim­i­lar posi­tion. There are ample phar­ma­co­log­i­cal tools to treat the patient’s psy­chosis or mood, but very few to treat the patient’s cog­ni­tion. Even though psy­chi­a­trists increas­ingly rec­og­nize that cog­ni­tive impair­ment is often more debil­i­tat­ing in their patients than psy­chosis or mood dis­or­der, tra­di­tion­ally, very lit­tle direct effort has been aimed at improv­ing cognition.

A neu­rol­o­gist treat­ing a patient recov­er­ing from the effects of head injury does not fare much bet­ter. There are ade­quate means to con­trol the patient’s seizures but not his or her cog­ni­tive changes, despite the fact that cog­ni­tive impair­ment is usu­ally far more debil­i­tat­ing than an occa­sional seizure. Soci­ety has been so pre­oc­cu­pied with sav­ing lives, treat­ing hal­lu­ci­na­tions, con­trol­ling seizures, and lift­ing depres­sion that cog­ni­tion (mem­ory, atten­tion, plan­ning, prob­lem solv­ing) has been largely ignored. Granted, var­i­ous neu­rolep­tics, anti­con­vul­sants, anti­de­pres­sants, seda­tives, and stim­u­lants do have an effect on cog­ni­tion, but it is an ancil­lary effect of a drug designed to treat some­thing else.

Alzheimer’s dis­ease and other demen­tias have been society’s wake-up call. Here, in the most afflu­ent coun­try in the most afflu­ent of times, human minds were suc­cumb­ing to decay before human bod­ies, a sharp chal­lenge to the tacit pop­u­lar belief that the “body is frail but soul is for­ever.” This pro­vided an impe­tus for the devel­op­ment of an entirely new class of drugs, which can be termed famil­ially as “cog­notropic.” Their pri­mary and explicit pur­pose is to improve cognition.

Since med­ical and pub­lic pre­oc­cu­pa­tion with demen­tia focuses on mem­ory, most of the phar­ma­co­log­i­cal efforts have been directed at improv­ing mem­ory. At the time of this writ­ing, a hand­ful of drugs known as “Alzheimer’s drugs” or “mem­ory enhancers” have been approved by the U.S. Food and Drug Admin­is­tra­tion (FDA). In real­ity, both des­ig­na­tions are some­what mis­lead­ing. The drugs in ques­tion are Read the rest of this entry »