Dr. Michael Merzenich, Emer­i­tus Pro­fes­sor at UCSF, is a lead­ing pio­neer in brain plas­tic­ity research. In the late 1980s, Dr. Merzenich was on the team that invented the cochlear implant. In 1996, he was the found­ing CEO of Sci­en­tific Learn­ing Cor­po­ra­tion (Nas­daq: SCIL), and in 2004 became co-founder and Chief Sci­en­tific Offi­cer of Posit Sci­ence. He was elected to the National Acad­emy of Sci­ences in 1999 and to the Insti­tute of Med­i­cine this year. He retired as Fran­cis A. Sooy Pro­fes­sor and Co-Director of the Keck Cen­ter for Inte­gra­tive Neu­ro­science at the Uni­ver­sity of Cal­i­for­nia at San Fran­cisco in 2007. You may have learned about his work in one of PBS TV spe­cials, mul­ti­ple media appear­ances, or neuroplasticity-related books.

(Alvaro Fer­nan­dez) Dear Michael, thank you very much for agree­ing to par­tic­i­pate in the inau­gural Sharp­Brains Sum­mit in Jan­u­ary, and for your time today. In order to con­tex­tu­al­ize the Summit’s main themes, I would like to focus this inter­view on the likely big-picture impli­ca­tions dur­ing the next 5 years of your work and that of other neu­ro­plas­tic­ity research and indus­try pioneers.

Thank you for invit­ing me. I believe the Sharp­Brains Sum­mit will be very use­ful and stim­u­lat­ing, you are gath­er­ing an impres­sive group together. I am look­ing for­ward to January.

Neuroplasticity-based Tools: The New Health & Well­ness Frontier

There are many dif­fer­ent technology-free approaches to har­ness­ing –enabling, dri­ving– neu­ro­plas­tic­ity. What is the unique value that tech­nol­ogy brings to the cog­ni­tive health table?

It’s all about effi­ciency, scal­a­bil­ity, per­son­al­iza­tion, and assured effec­tive­ness. Tech­nol­ogy sup­ports the imple­men­ta­tion of near-optimally-efficient brain-training strate­gies. Through the Inter­net, it enables the low-cost dis­tri­b­u­tion of these new tools, any­where out in the world. Tech­nol­ogy also enables the per­son­al­iza­tion of brain health train­ing, by pro­vid­ing sim­ple ways to mea­sure and address indi­vid­ual needs in each person’s brain-health train­ing expe­ri­ence. It enables assess­ments of your abil­i­ties that can affirm that your own brain health issues have been effec­tively addressed.

Of course sub­stan­tial gains could also be achieved by orga­niz­ing your every­day activ­i­ties that grow your neu­ro­log­i­cal abil­i­ties and sus­tain your brain health. Still, if the ordi­nary cit­i­zen is to have any real chance of main­tain­ing their brain fit­ness, they’re going to have to spend con­sid­er­able time at the brain gym!

One espe­cially impor­tant con­tri­bu­tion of tech­nol­ogy is the scal­a­bil­ity that it pro­vides for deliv­er­ing brain fit­ness help out into the world. Think about how effi­cient the drug deliv­ery sys­tem is today. Doc­tors pre­scribe drugs, insur­ance cov­ers them, and there is a drug store in every neigh­bor­hood in almost every city in the world so that every patient has access to them. Once neuroplasticity-based tools and out­comes and stan­dard­ized, we can envi­sion a sim­i­lar sce­nario. And we don’t need all those drug stores, because we have the Internet!

Hav­ing said this, there are obvi­ous obsta­cles. One main one, in my mind, is the lack of under­stand­ing of what these new tools can do. Cog­ni­tive train­ing pro­grams, for exam­ple, seem counter-intuitive to con­sumers and many pro­fes­sion­als “ why would one try to improve speed-of-processing if all one cares about is œmem­ory? A sec­ond obvi­ous prob­lem is to get indi­vid­u­als to buy into the effort required to really change their brains for the bet­ter. That buy-in has been achieved for many indi­vid­u­als as it applies to their phys­i­cal health, but we haven’t got­ten that far yet in edu­cat­ing the aver­age older per­son that brain fit­ness train­ing is an equally effort­ful business!

Tools for Safer Dri­ving: Teens and Adults

Safe dri­ving seems to be one area where the ben­e­fits are more intu­itive, which may explain the sig­nif­i­cant traction.

Yes, we see great poten­tial and inter­est among insur­ers for improv­ing dri­ving safety, both for seniors and teens. Appro­pri­ate cog­ni­tive train­ing can lower at-fault acci­dent rates. You can mea­sure clear ben­e­fits in rel­a­tively short time frames, so it won’t take long for insur­ers to see an eco­nomic ratio­nale to not only offer pro­grams at low cost or for free but to incen­tivize dri­vers to com­plete them. All­state, AAA, State Farm and other insur­ers are begin­ning to real­ize this poten­tial. It is impor­tant to note that typ­i­cal acci­dents among teens and seniors are dif­fer­ent, so that train­ing method­olo­gies will need to be dif­fer­ent for dif­fer­ent high-risk populations.

Yet, most dri­ving safety ini­tia­tives today still focus on edu­cat­ing dri­vers, rather that train­ing them neu­ro­log­i­cally. We mea­sure vision, for exam­ple, but com­pletely ignore atten­tional con­trol abil­i­ties, or a driver’s use­ful field of view. I expect this to change sig­nif­i­cantly over the next few years.

Long-term care and health insur­ance com­pa­nies will ulti­mately see sim­i­lar ben­e­fits, and we believe that they will fol­low a sim­i­lar course of action to reduce gen­eral med­ical and neu­rode­gen­er­a­tive dis­ease– (Mild Cog­ni­tive Impair­ment and Alzheimer’s– and Parkinsons-) related costs. In fact, many senior liv­ing com­mu­ni­ties are among the pio­neers in this field.

Boomers & Beyond: Main­tain­ing Cog­ni­tive Vitality

Main­stream media is cov­er­ing this emerg­ing cat­e­gory with thou­sands of sto­ries. But most cov­er­age seems still focused on does it work? more than “how do we define It”, what does work mean? or work for whom, and for what? Can you sum­ma­rize what recent research suggests?

We have seen clear pat­terns in the appli­ca­tion of our train­ing pro­grams, some pub­lished (like IMPACT), some unpub­lished, some with healthy adults, and some with peo­ple with mild cog­ni­tive impair­ment or early Alzheimers Dis­ease (AD). What we see in every case: Read the rest of this entry »

Not a day goes by with­out a sig­nif­i­cant depression-related announce­ment. Yes­ter­day, one could read that Older Women More Likely to Suf­fer Depres­sion (than Older Men; in the Wash­ing­ton Post). Today, we see that St. Jude Start­ing Trial On Brain Stim­u­la­tion For Depres­sion (CNN). A few days ago, Blue Cross of Cal­i­for­nia Launched Mater­nity Depres­sion Pro­gram (press release).

Time to step back and ask our­selves ques­tions such as, “What is going On”, “What is Depres­sion”, “What Treat­ments Work, and What is the Lat­est Research”. For­tu­nately, thanks to our col­lab­o­ra­tion with Greater Good Mag­a­zine, Jill Sut­tie offers a fas­ci­nat­ing answers to those questions-and more. Enjoy.

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Clos­ing the Circuit

Helen Mayberg’s research could rev­o­lu­tion­ize depres­sion treatment.

— By Jill Suttie.

At some point in their lives, 5 to 12 per­cent of Amer­i­can men and 10–25 per­cent of women will suf­fer an episode of depres­sion, mak­ing it the most com­monly diag­nosed men­tal dis­or­der today. Unlike nor­mal sad­ness, which passes with time, depres­sion feels unstop­pable and causes peo­ple to lose inter­est in nearly all activ­i­ties. Because it affects a person’s abil­ity to eat, sleep, work, and func­tion nor­mally, it exacts a huge cost on the econ­omy, esti­mated at $30 bil­lion dol­lars annu­ally. The cost in human suf­fer­ing can­not be measured.

Mil­lions of peo­ple diag­nosed with depres­sion turn to med­ica­tion as a treat­ment, and many of the most pop­u­lar Read the rest of this entry »

Today we are for­tu­nate to inter­view Dr. Jerri Edwards, an Asso­ciate Pro­fes­sor at Uni­ver­sity of South Florida’s School of Aging Stud­ies and Co-Investigator of the influ­en­cial ACTIVE study. Dr. Edwards was trained by Dr. Kar­lene K. Ball, and her research is aimed toward dis­cov­er­ing how cog­ni­tive abil­i­ties can be main­tained and even enhanced with advanc­ing age.

Main focus of research

Alvaro Fer­nan­dez: Please explain to our read­ers your main research areas

Jerri Edwards: I am par­tic­u­larly inter­ested in how cog­ni­tive inter­ven­tions may help older adults to avoid or at least delay func­tional dif­fi­cul­ties and thereby main­tain their inde­pen­dence longer. Much of my work has focused on the func­tional abil­ity of dri­ving includ­ing assess­ing dri­ving fit­ness among older adults and reme­di­a­tion of cog­ni­tive decline that results in dri­ving difficulties.

Some research ques­tions that inter­est me include, how can we main­tain health­ier lives longer? How can train­ing improve cog­ni­tive abil­i­ties, both to improve those abil­i­ties and also to slow-down, or delay, cog­ni­tive decline? The spe­cific cog­ni­tive abil­ity that I have stud­ied the most is pro­cess­ing speed, which is one of the cog­ni­tive skills that decline early on as we age.

ACTIVE results

Can you explain what cog­ni­tive pro­cess­ing speed is, and why it is rel­e­vant to our daily lives?

Pro­cess­ing speed is men­tal quick­ness. Just like a com­puter with a 486 proces­sor can do a lot of the same things as a com­puter with a Pen­tium 4 proces­sor, but it takes much longer, our minds tend to slow down with age as com­pared to when we were younger. We can do the same tasks, but it takes more time. Quick speed of pro­cess­ing is impor­tant for Read the rest of this entry »

We usu­ally spend more time in this blog talk­ing about brain fit­ness sci­ence, pro­grams and trends than talk­ing about peo­ple. Today we are going to change that, since we have been receiv­ing great feed­back from a num­ber of sources. While we still need to improve a lot, we can start to see the results of what we do in our “brain fit­ness cen­ter”. And we couldn’t be hap­pier about the nom­i­na­tion this week of Dr. Elkhonon Gold­berg and myself, as Sharp­Brains cofounders, for The Tech Museum Awards — Tech­nol­ogy Ben­e­fit­ing Human­ity, in the Health category.

I. Anony­mous Feed­back from an online sur­vey of our online store cus­tomers

• 58% respon­dents are Very Sat­is­fied, and 42% Sat­is­fied, with the prod­ucts and ser­vices they chose. I promise that there were more options (Dis­sat­is­fied, Very Dissatisfied)
• “As a trader, I really need to sus­tain atten­tion for long peri­ods. Your pro­gram (here) has been eye-opening and very helpful.”
• “I LOVE the pro­gram! It is fun, chal­lenges me and gives me hope for improv­ing in the areas where I have lim­i­ta­tions. Staff sup­port & edu­ca­tional infor­ma­tion has been great. It is very impor­tant to be able to talk to some­one about the ques­tions or process prob­lems that we experience…your mem­ber on-line site gives us the oppor­tu­nity to get answers & needed sup­port. Thanks for all you are doing. My hus­band and I love get­ting feed­back about our progress…it is a very pos­i­tive experience!”
• “Keep devel­op­ing pro­grams so when we fin­ish doing the Mind­Fit (here) pro­gram there will be another one to build upon the first! I am impressed at how well your pro­grams are indi­vid­u­al­ized. Good Job to all involved!”
• “Good, I enjoy the games (here) and I can tell a dif­fer­ence in my mem­ory and over­all awareness.”

II. Feed­back about our Stress Man­age­ment for Peak Per­for­mance work­shop (here)

• Accen­ture: 46 per­cent of sur­vey respon­dents Strongly Agreed that they “gained prac­ti­cal skills and knowl­edge they could start using imme­di­ately.” 69 per­cent Strongly Agreed Read the rest of this entry »