(Editor’s Note: In 1990, Con­gress des­ig­nated the 1990s the “Decade of the Brain.” Pres­i­dent George H. W. Bush pro­claimed, “A new era of dis­cov­ery is dawn­ing in brain research.” Dur­ing the ensu­ing decade, sci­en­tists greatly advanced our under­stand­ing of the brain. The edi­tors of Cere­brum asked the direc­tors of seven brain-related insti­tutes at the National Insti­tutes of Health (NIH) to iden­tify the biggest advances, great­est dis­ap­point­ments, and missed oppor­tu­ni­ties of brain research in the past decade—the decade after the “Decade of the Brain.” They also asked them what looks most promis­ing for the com­ing decade, the 2010s. Experts focused on research that might change how doc­tors diag­nose and treat human brain disorders.)

Neu­ro­science is at a his­toric turn­ing point. Today, a full decade after the “Decade of the Brain,” a con­tin­u­ous stream of advances is shat­ter­ing long-held notions about how the human brain works and what hap­pens when it doesn’t. These advances are also reshap­ing the land­scapes of other fields, from psy­chol­ogy to eco­nom­ics, edu­ca­tion and the law.

Until the Decade of the Brain, sci­en­tists believed that, once devel­op­ment was over, the adult brain under­went very few changes. This per­cep­tion con­tributed to polar­iz­ing per­spec­tives on whether genet­ics or envi­ron­ment deter­mines a person’s tem­pera­ment and per­son­al­ity, apti­tudes, and vul­ner­a­bil­ity to men­tal dis­or­ders. But dur­ing the past two decades, neu­ro­sci­en­tists have steadily built the case that the human brain, even when fully mature, is far more plastic—changing and malleable—than we orig­i­nally thought.1 It turns out that the brain (at all ages) is highly respon­sive to envi­ron­men­tal stim­uli and that con­nec­tions between neu­rons are dynamic and can rapidly change within min­utes of stimulation.

Neu­ro­plas­tic­ity is mod­u­lated in part by Read the rest of this entry »

Dr. Michael Merzenich, Emer­i­tus Pro­fes­sor at UCSF, is a lead­ing pio­neer in brain plas­tic­ity research. In the late 1980s, Dr. Merzenich was on the team that invented the cochlear implant. In 1996, he was the found­ing CEO of Sci­en­tific Learn­ing Cor­po­ra­tion (Nas­daq: SCIL), and in 2004 became co-founder and Chief Sci­en­tific Offi­cer of Posit Sci­ence. He was elected to the National Acad­emy of Sci­ences in 1999 and to the Insti­tute of Med­i­cine this year. He retired as Fran­cis A. Sooy Pro­fes­sor and Co-Director of the Keck Cen­ter for Inte­gra­tive Neu­ro­science at the Uni­ver­sity of Cal­i­for­nia at San Fran­cisco in 2007. You may have learned about his work in one of PBS TV spe­cials, mul­ti­ple media appear­ances, or neuroplasticity-related books.

(Alvaro Fer­nan­dez) Dear Michael, thank you very much for agree­ing to par­tic­i­pate in the inau­gural Sharp­Brains Sum­mit in Jan­u­ary, and for your time today. In order to con­tex­tu­al­ize the Summit’s main themes, I would like to focus this inter­view on the likely big-picture impli­ca­tions dur­ing the next 5 years of your work and that of other neu­ro­plas­tic­ity research and indus­try pioneers.

Thank you for invit­ing me. I believe the Sharp­Brains Sum­mit will be very use­ful and stim­u­lat­ing, you are gath­er­ing an impres­sive group together. I am look­ing for­ward to January.

Neuroplasticity-based Tools: The New Health & Well­ness Frontier

There are many dif­fer­ent technology-free approaches to har­ness­ing –enabling, dri­ving– neu­ro­plas­tic­ity. What is the unique value that tech­nol­ogy brings to the cog­ni­tive health table?

It’s all about effi­ciency, scal­a­bil­ity, per­son­al­iza­tion, and assured effec­tive­ness. Tech­nol­ogy sup­ports the imple­men­ta­tion of near-optimally-efficient brain-training strate­gies. Through the Inter­net, it enables the low-cost dis­tri­b­u­tion of these new tools, any­where out in the world. Tech­nol­ogy also enables the per­son­al­iza­tion of brain health train­ing, by pro­vid­ing sim­ple ways to mea­sure and address indi­vid­ual needs in each person’s brain-health train­ing expe­ri­ence. It enables assess­ments of your abil­i­ties that can affirm that your own brain health issues have been effec­tively addressed.

Of course sub­stan­tial gains could also be achieved by orga­niz­ing your every­day activ­i­ties that grow your neu­ro­log­i­cal abil­i­ties and sus­tain your brain health. Still, if the ordi­nary cit­i­zen is to have any real chance of main­tain­ing their brain fit­ness, they’re going to have to spend con­sid­er­able time at the brain gym!

One espe­cially impor­tant con­tri­bu­tion of tech­nol­ogy is the scal­a­bil­ity that it pro­vides for deliv­er­ing brain fit­ness help out into the world. Think about how effi­cient the drug deliv­ery sys­tem is today. Doc­tors pre­scribe drugs, insur­ance cov­ers them, and there is a drug store in every neigh­bor­hood in almost every city in the world so that every patient has access to them. Once neuroplasticity-based tools and out­comes and stan­dard­ized, we can envi­sion a sim­i­lar sce­nario. And we don’t need all those drug stores, because we have the Internet!

Hav­ing said this, there are obvi­ous obsta­cles. One main one, in my mind, is the lack of under­stand­ing of what these new tools can do. Cog­ni­tive train­ing pro­grams, for exam­ple, seem counter-intuitive to con­sumers and many pro­fes­sion­als “ why would one try to improve speed-of-processing if all one cares about is œmem­ory? A sec­ond obvi­ous prob­lem is to get indi­vid­u­als to buy into the effort required to really change their brains for the bet­ter. That buy-in has been achieved for many indi­vid­u­als as it applies to their phys­i­cal health, but we haven’t got­ten that far yet in edu­cat­ing the aver­age older per­son that brain fit­ness train­ing is an equally effort­ful business!

Tools for Safer Dri­ving: Teens and Adults

Safe dri­ving seems to be one area where the ben­e­fits are more intu­itive, which may explain the sig­nif­i­cant traction.

Yes, we see great poten­tial and inter­est among insur­ers for improv­ing dri­ving safety, both for seniors and teens. Appro­pri­ate cog­ni­tive train­ing can lower at-fault acci­dent rates. You can mea­sure clear ben­e­fits in rel­a­tively short time frames, so it won’t take long for insur­ers to see an eco­nomic ratio­nale to not only offer pro­grams at low cost or for free but to incen­tivize dri­vers to com­plete them. All­state, AAA, State Farm and other insur­ers are begin­ning to real­ize this poten­tial. It is impor­tant to note that typ­i­cal acci­dents among teens and seniors are dif­fer­ent, so that train­ing method­olo­gies will need to be dif­fer­ent for dif­fer­ent high-risk populations.

Yet, most dri­ving safety ini­tia­tives today still focus on edu­cat­ing dri­vers, rather that train­ing them neu­ro­log­i­cally. We mea­sure vision, for exam­ple, but com­pletely ignore atten­tional con­trol abil­i­ties, or a driver’s use­ful field of view. I expect this to change sig­nif­i­cantly over the next few years.

Long-term care and health insur­ance com­pa­nies will ulti­mately see sim­i­lar ben­e­fits, and we believe that they will fol­low a sim­i­lar course of action to reduce gen­eral med­ical and neu­rode­gen­er­a­tive dis­ease– (Mild Cog­ni­tive Impair­ment and Alzheimer’s– and Parkinsons-) related costs. In fact, many senior liv­ing com­mu­ni­ties are among the pio­neers in this field.

Boomers & Beyond: Main­tain­ing Cog­ni­tive Vitality

Main­stream media is cov­er­ing this emerg­ing cat­e­gory with thou­sands of sto­ries. But most cov­er­age seems still focused on does it work? more than “how do we define It”, what does work mean? or work for whom, and for what? Can you sum­ma­rize what recent research suggests?

We have seen clear pat­terns in the appli­ca­tion of our train­ing pro­grams, some pub­lished (like IMPACT), some unpub­lished, some with healthy adults, and some with peo­ple with mild cog­ni­tive impair­ment or early Alzheimers Dis­ease (AD). What we see in every case: Read the rest of this entry »

Here you have sev­eral recent arti­cles and devel­op­ments wor­thy of attention:

1) Boom times for brain train­ing games (CNN)
2) Nav­i­gat­ing the brain fit­ness land­scape: do’s and don’ts (McKnight’s Long Term Care News)
3) USA Hockey and Intel­li­gym (press release)
4) Brain Fit­ness at New York Pub­lic Library (NYPL blog)
5) McDon­nell Foun­da­tion grant har­nesses cog­ni­tive sci­ence to improve stu­dent learn­ing (press release)
6) Health insur­ance firms offer­ing online cog­ni­tive ther­apy for insom­nia (Los Ange­les Times)
7) Head­Min­der Cog­ni­tive Sta­bil­ity Index: Com­put­er­ized Neu­rocog­ni­tive … (Press release)
THE AGE OF MASS INTELLIGENCE (Intel­li­gent Life)
9) Work­ing Later in Life May Facil­i­tate Neural Health (Cere­brum)
10) The Cool Fac­tor: Never Let Them See You Sweat (New York Times)

Links, selected quotes and com­men­tary: Read the rest of this entry »

Dr. Arthur Kramer is a Pro­fes­sor in the Uni­ver­sity of Illi­nois Depart­ment of Psy­chol­ogy, the Cam­pus Neu­ro­science Pro­gram, the Beck­man Insti­tute, and the Direc­tor of the Bio­med­ical Imag­ing Cen­ter at the Uni­ver­sity of Illinois.

I am hon­ored to inter­view him today.

Dr. Kramer, thank you for your time. Let’ start by try­ing to clar­ify some exist­ing mis­con­cep­tions and con­tro­ver­sies. Based on what we know today, and your recent Nature piece (Note: ref­er­enced below), what are the 2–3 key lifestyle habits would you sug­gest to a per­son who wants to delay Alzheimer’s symp­toms and improve over­all brain health?

First, Be Active. Do phys­i­cal exer­cise. Aer­o­bic exer­cise, 30 to 60 min­utes per day 3 days per week, has been shown to have an impact in a vari­ety of exper­i­ments. And you don’t need to do some­thing stren­u­ous: even walk­ing has shown that effect. There are many open ques­tions in terms of spe­cific types of exer­cise, dura­tion, mag­ni­tude of effect but, as we wrote in our recent Nature Reviews Neu­ro­science arti­cle, there is lit­tle doubt that lead­ing a seden­tary life is bad for our cog­ni­tive health. Car­dio­vas­cu­lar exer­cise seems to have a pos­i­tive effect.

Sec­ond, Main­tain Life­long Intel­lec­tual Engage­ment. There is abun­dant prospec­tive obser­va­tional research show­ing that doing more men­tally stim­u­lat­ing activ­i­ties reduces the risk of devel­op­ing Alzheimer’s symptoms.

Let me add, given all media hype, that no “brain game” in par­tic­u­lar has been shown to have a long-term impact on Alzheimer’s or the main­te­nance of cog­ni­tion across extended peri­ods of time. It is too early for that-and con­sumers should be aware of that fact. It is true that some com­pa­nies are being more science-based than oth­ers but, in my view, the consumer-oriented field is grow­ing faster than the research is.

Ide­ally, com­bine both phys­i­cal and men­tal stim­u­la­tion along with social inter­ac­tions. Why not take a good walk with friends to dis­cuss a book? We lead very busy lives, so the more inte­grated and inter­est­ing activ­i­ties are, the more likely we will do them.

Read the rest of this entry »

Phys­i­cal fit­ness. Cognitive/ brain fit­ness. Both require nov­elty, vari­ety and chal­lenge. Pro­fes­sor Schlomo Breznitz, a sci­en­tific and busi­ness leader in the cog­ni­tive fit­ness field, explains why, elo­quently, below. Per­haps “we want change” really means “we need change”. Enjoy!

————————

Why are every­day life chal­lenges not suf­fi­cient to keep our brains fit?

– By Prof. Shlomo Breznitz

Often, when describ­ing the ben­e­fits of Mind­Fit to brain health, I am asked by peo­ple in the audi­ence whether this soft­ware is really needed. After all, so they argue, life pro­vides con­tin­ues cog­ni­tive chal­lenges, which should suf­fice for ensur­ing brain fit­ness. From the moment we wake up until we go to sleep our brains have to attend to com­plex stim­uli, plan many activ­i­ties, some of them quite com­plex, and carry us through what­ever the day offers. These tasks should pro­vide suf­fi­cient “brain exer­cise” with­out the need to engage in spe­cific men­tal workout.

This line of argu­ment sounds oddly famil­iar, since it is an exact dupli­ca­tion of claims made in the recent past against the need for phys­i­cal exer­cise. One jumps into the car and from the car and per­haps even climbs a few stairs before sit­ting in the chair, which should be enough to burn the calo­ries and keep fit.

Read the rest of this entry »

If you are in the Bay Area, we hope to see you at this event! Feel free to for­ward the invi­ta­tion below to any­one you know who may be interested.

---

The grow­ing move­ment for improv­ing brain health has brought many inter­ested pro­fes­sion­als and inter­ested com­mu­nity mem­bers to the table. Shar­ing our infor­ma­tion, activ­i­ties, and planned events to pro­mote brain health increases the power of our reach.

Please join us on May 16, 2007 from noon to 1:30pm for a com­pli­men­tary gath­er­ing co-sponsored by:

• The Amer­i­can Soci­ety on Aging (Nancy Cerid­wyn will make some remarks),
• The Osher Life­long Learn­ing Insti­tutes (OLLI) at San Fran­cisco State Uni­ver­sity and Uni­ver­sity of Cal­i­for­nia at Berke­ley, and
• Sharp­Brains.

Dr. Elkhonon Gold­berg, well-known neu­ro­sci­en­tist and author of The Wis­dom Para­dox: How Your Mind Can Grow Stronger as Your Brain Grows Older and Alvaro Fer­nan­dez, CEO and Co-Founder of Sharp­Brains and instruc­tor of the Exer­cis­ing Our Brains class, will pro­vide an overview of the sci­ence and trends behind the emerg­ing brain fit­ness field.

Please bring infor­ma­tion on your work and events to share with oth­ers inter­ested in brain health.

Where: SFSU OLLI (835 Mar­ket Street, 6th Floor, San Fran­cisco, Room 675)
When: Wednes­day, May 16, 12–1:30 pm
What: A chance for net­work­ing with Read the rest of this entry »