The 2011 Sharp­Brains Sum­mit gath­ered  more than 260 research and indus­try lead­ers in 16 coun­tries for 3 days to dis­cuss the chang­ing land­scape. Held online, par­tic­i­pants from all over the globe  attended to hear more than 40 thought lead­ers, sci­en­tists, entre­pre­neurs and pol­icy mak­ers out­line the evolv­ing mar­ket­place. Dis­cus­sion moved from cog­ni­tive fit­ness to neu­ro­plas­tic­ity, across reg­u­la­tory and pol­icy trends, and new prod­uct launches by new and estab­lished play­ers  What did we take home from the Sharp­Brains Sum­mit? Was it novel con­sumer insights aris­ing from a new retail land­scape? What of pol­icy ini­tia­tives from inno­va­tion clus­ters around the globe? Do you see a future pop­u­lated by neu­ro­science toolk­its, dri­ven by the inex­orable demo­graphic changes set to occur in the com­ing decades? Or was it a look “under the hood” of tech­nol­ogy plat­forms devel­oped by cat­e­gory lead­ers that sharp­ened our insight? Here are 10 emerg­ing themes:

1. The Need for Stan­dard­iza­tion of methodologies

A pro­fu­sion of cog­ni­tive and emo­tional health tests, bat­ter­ies and new tech­nolo­gies are crowd­ing the research envi­ron­ment. The NIH tool­box for the assess­ment of a broad range of cog­ni­tive domains Read the rest of this entry »

We are pleased to make eleven impor­tant announce­ments about the upcom­ing 2011 Sharp­Brains Vir­tual Sum­mit…eleven addi­tional rea­sons to con­sider reg­is­ter­ing and join­ing our event and com­mu­nity next week.

1. Intel Cor­po­ra­tion, the “Spon­sors of Tomor­row™”, and Lumos Labs have become Sum­mit Gold Sponsors.
2. Sharp­Brains will issue a Cer­tifi­cate of Atten­dance to par­tic­i­pants (20 hours of con­tin­u­ing education).
3. Jamie Wil­son shares 20 rea­sons why vir­tual con­fer­ences are the future.
4. NIH/ NIA Pro­gram Chief Molly Wag­ster will dis­cuss the new NIH Tool­box for Assess­ment of Neu­ro­log­i­cal and Behav­ioral Function.
5. Yaakov Stern (Colum­bia), David Darby (CogState), Keith Wesnes (United BioSource) and Jef­frey Kaye (Orcat­ech) will explore The Role of Cog­ni­tive Health Mon­i­tor­ing Systems.
6. Alvaro Fer­nan­dez (Sharp­Brains) and Muki Hansteen-Izora (Intel Cor­po­ra­tion) will ana­lyze The State of Inno­va­tion and Emerg­ing Marketplace.
7. You can still Reg­is­ter and obtain a com­pli­men­tary copy of Sharp­Brains’ mar­ket report The State of the Brain Fit­ness Mar­ket 2010 (which includes mar­ket data, ven­dor analy­sis, inno­va­tion case stud­ies, research briefs, and more.)
8. Michael Merzenich (UCSF), Alvaro Pascual-Leone (Har­vard), Wal­ter Green­leaf (Vir­tu­ally­Bet­ter) and Kate Sul­li­van (Wal­ter Reed) will dis­cuss how Inno­va­tion gets From Lab to Marketplace.
9. Lumos Labs, Brain Resource, Cogmed, Bay­crest, Cog­niFit, and Posit Sci­ence will present their lat­est tools and solu­tions dur­ing Expo Day.
10. A total of 19 excel­lent Sum­mit Part­ners help us expand Summit’s reach and influence.
11. We are plan­ning April/ May social gath­er­ings for Sum­mit par­tic­i­pants in 5 cities: San Fran­cisco, Los Ange­les, Wash­ing­ton DC, NYC, and Toronto, and will help facil­i­tate gath­er­ings in any city/ region with at least 10 Sum­mit participants.

Please visit the 2011 Sharp­Brains Sum­mit web­site to Learn More and Reg­is­ter.

Also, please fol­low us via Twit­ter and spread the word about the Sum­mit using hash­tag #svs11

We look for­ward to “meet­ing” many of you next week! Please remem­ber you can enter dis­count code sharp2011 in order to get 15% off reg­is­tra­tion fees.

Dr. Michael Merzenich, Emer­i­tus Pro­fes­sor at UCSF, is a lead­ing pio­neer in brain plas­tic­ity research. In the late 1980s, Dr. Merzenich was on the team that invented the cochlear implant. In 1996, he was the found­ing CEO of Sci­en­tific Learn­ing Cor­po­ra­tion (Nas­daq: SCIL), and in 2004 became co-founder and Chief Sci­en­tific Offi­cer of Posit Sci­ence. He was elected to the National Acad­emy of Sci­ences in 1999 and to the Insti­tute of Med­i­cine this year. He retired as Fran­cis A. Sooy Pro­fes­sor and Co-Director of the Keck Cen­ter for Inte­gra­tive Neu­ro­science at the Uni­ver­sity of Cal­i­for­nia at San Fran­cisco in 2007. You may have learned about his work in one of PBS TV spe­cials, mul­ti­ple media appear­ances, or neuroplasticity-related books.

(Alvaro Fer­nan­dez) Dear Michael, thank you very much for agree­ing to par­tic­i­pate in the inau­gural Sharp­Brains Sum­mit in Jan­u­ary, and for your time today. In order to con­tex­tu­al­ize the Summit’s main themes, I would like to focus this inter­view on the likely big-picture impli­ca­tions dur­ing the next 5 years of your work and that of other neu­ro­plas­tic­ity research and indus­try pioneers.

Thank you for invit­ing me. I believe the Sharp­Brains Sum­mit will be very use­ful and stim­u­lat­ing, you are gath­er­ing an impres­sive group together. I am look­ing for­ward to January.

Neuroplasticity-based Tools: The New Health & Well­ness Frontier

There are many dif­fer­ent technology-free approaches to har­ness­ing –enabling, dri­ving– neu­ro­plas­tic­ity. What is the unique value that tech­nol­ogy brings to the cog­ni­tive health table?

It’s all about effi­ciency, scal­a­bil­ity, per­son­al­iza­tion, and assured effec­tive­ness. Tech­nol­ogy sup­ports the imple­men­ta­tion of near-optimally-efficient brain-training strate­gies. Through the Inter­net, it enables the low-cost dis­tri­b­u­tion of these new tools, any­where out in the world. Tech­nol­ogy also enables the per­son­al­iza­tion of brain health train­ing, by pro­vid­ing sim­ple ways to mea­sure and address indi­vid­ual needs in each person’s brain-health train­ing expe­ri­ence. It enables assess­ments of your abil­i­ties that can affirm that your own brain health issues have been effec­tively addressed.

Of course sub­stan­tial gains could also be achieved by orga­niz­ing your every­day activ­i­ties that grow your neu­ro­log­i­cal abil­i­ties and sus­tain your brain health. Still, if the ordi­nary cit­i­zen is to have any real chance of main­tain­ing their brain fit­ness, they’re going to have to spend con­sid­er­able time at the brain gym!

One espe­cially impor­tant con­tri­bu­tion of tech­nol­ogy is the scal­a­bil­ity that it pro­vides for deliv­er­ing brain fit­ness help out into the world. Think about how effi­cient the drug deliv­ery sys­tem is today. Doc­tors pre­scribe drugs, insur­ance cov­ers them, and there is a drug store in every neigh­bor­hood in almost every city in the world so that every patient has access to them. Once neuroplasticity-based tools and out­comes and stan­dard­ized, we can envi­sion a sim­i­lar sce­nario. And we don’t need all those drug stores, because we have the Internet!

Hav­ing said this, there are obvi­ous obsta­cles. One main one, in my mind, is the lack of under­stand­ing of what these new tools can do. Cog­ni­tive train­ing pro­grams, for exam­ple, seem counter-intuitive to con­sumers and many pro­fes­sion­als “ why would one try to improve speed-of-processing if all one cares about is œmem­ory? A sec­ond obvi­ous prob­lem is to get indi­vid­u­als to buy into the effort required to really change their brains for the bet­ter. That buy-in has been achieved for many indi­vid­u­als as it applies to their phys­i­cal health, but we haven’t got­ten that far yet in edu­cat­ing the aver­age older per­son that brain fit­ness train­ing is an equally effort­ful business!

Tools for Safer Dri­ving: Teens and Adults

Safe dri­ving seems to be one area where the ben­e­fits are more intu­itive, which may explain the sig­nif­i­cant traction.

Yes, we see great poten­tial and inter­est among insur­ers for improv­ing dri­ving safety, both for seniors and teens. Appro­pri­ate cog­ni­tive train­ing can lower at-fault acci­dent rates. You can mea­sure clear ben­e­fits in rel­a­tively short time frames, so it won’t take long for insur­ers to see an eco­nomic ratio­nale to not only offer pro­grams at low cost or for free but to incen­tivize dri­vers to com­plete them. All­state, AAA, State Farm and other insur­ers are begin­ning to real­ize this poten­tial. It is impor­tant to note that typ­i­cal acci­dents among teens and seniors are dif­fer­ent, so that train­ing method­olo­gies will need to be dif­fer­ent for dif­fer­ent high-risk populations.

Yet, most dri­ving safety ini­tia­tives today still focus on edu­cat­ing dri­vers, rather that train­ing them neu­ro­log­i­cally. We mea­sure vision, for exam­ple, but com­pletely ignore atten­tional con­trol abil­i­ties, or a driver’s use­ful field of view. I expect this to change sig­nif­i­cantly over the next few years.

Long-term care and health insur­ance com­pa­nies will ulti­mately see sim­i­lar ben­e­fits, and we believe that they will fol­low a sim­i­lar course of action to reduce gen­eral med­ical and neu­rode­gen­er­a­tive dis­ease– (Mild Cog­ni­tive Impair­ment and Alzheimer’s– and Parkinsons-) related costs. In fact, many senior liv­ing com­mu­ni­ties are among the pio­neers in this field.

Boomers & Beyond: Main­tain­ing Cog­ni­tive Vitality

Main­stream media is cov­er­ing this emerg­ing cat­e­gory with thou­sands of sto­ries. But most cov­er­age seems still focused on does it work? more than “how do we define It”, what does work mean? or work for whom, and for what? Can you sum­ma­rize what recent research suggests?

We have seen clear pat­terns in the appli­ca­tion of our train­ing pro­grams, some pub­lished (like IMPACT), some unpub­lished, some with healthy adults, and some with peo­ple with mild cog­ni­tive impair­ment or early Alzheimers Dis­ease (AD). What we see in every case: Read the rest of this entry »

Dr. Arthur Kramer is a Pro­fes­sor in the Uni­ver­sity of Illi­nois Depart­ment of Psy­chol­ogy, the Cam­pus Neu­ro­science Pro­gram, the Beck­man Insti­tute, and the Direc­tor of the Bio­med­ical Imag­ing Cen­ter at the Uni­ver­sity of Illinois.

I am hon­ored to inter­view him today.

Dr. Kramer, thank you for your time. Let’ start by try­ing to clar­ify some exist­ing mis­con­cep­tions and con­tro­ver­sies. Based on what we know today, and your recent Nature piece (Note: ref­er­enced below), what are the 2–3 key lifestyle habits would you sug­gest to a per­son who wants to delay Alzheimer’s symp­toms and improve over­all brain health?

First, Be Active. Do phys­i­cal exer­cise. Aer­o­bic exer­cise, 30 to 60 min­utes per day 3 days per week, has been shown to have an impact in a vari­ety of exper­i­ments. And you don’t need to do some­thing stren­u­ous: even walk­ing has shown that effect. There are many open ques­tions in terms of spe­cific types of exer­cise, dura­tion, mag­ni­tude of effect but, as we wrote in our recent Nature Reviews Neu­ro­science arti­cle, there is lit­tle doubt that lead­ing a seden­tary life is bad for our cog­ni­tive health. Car­dio­vas­cu­lar exer­cise seems to have a pos­i­tive effect.

Sec­ond, Main­tain Life­long Intel­lec­tual Engage­ment. There is abun­dant prospec­tive obser­va­tional research show­ing that doing more men­tally stim­u­lat­ing activ­i­ties reduces the risk of devel­op­ing Alzheimer’s symptoms.

Let me add, given all media hype, that no “brain game” in par­tic­u­lar has been shown to have a long-term impact on Alzheimer’s or the main­te­nance of cog­ni­tion across extended peri­ods of time. It is too early for that-and con­sumers should be aware of that fact. It is true that some com­pa­nies are being more science-based than oth­ers but, in my view, the consumer-oriented field is grow­ing faster than the research is.

Ide­ally, com­bine both phys­i­cal and men­tal stim­u­la­tion along with social inter­ac­tions. Why not take a good walk with friends to dis­cuss a book? We lead very busy lives, so the more inte­grated and inter­est­ing activ­i­ties are, the more likely we will do them.

Read the rest of this entry »

The Dana Foun­da­tion kindly sent us a copy of the great book Best of the Brain from Sci­en­tific Amer­i­can, a col­lec­tion of 21 superb arti­cles pub­lished pre­vi­ously in Sci­en­tific Amer­i­can mag­a­zine. A very nicely edited and illus­trated book, this is a must for any­one who enjoys learn­ing about the brain and spec­u­lat­ing about what the future will bring us.

Some essays, like the ones by Eric Kan­del (The New Sci­ence of Mind), Fred Gage (Brain, Repair Your­self), Carl Zim­mer (The Neu­ro­bi­ol­ogy of the Self) and that by Steven Hol­lon, Michael Thase and John Markowitz (Treat­ing Depres­sion: Pills or Talk), are both intel­lec­tual feasts and very rel­e­vant to brain fit­ness. And finally start­ing to per­co­late into main­stream consciousness.

Let me quote some quotes and reflec­tions as I was read­ing the book a cou­ple of days ago, in the court­yard of a beau­ti­ful French cafe in Berkeley:

1) On Brain Plas­tic­ity (the abil­ity of the brain to rewire itself), Fred Gage says: “Within the past 5 years, how­ever, neu­ro­sci­en­tists have dis­cov­ered that the brain does indeed change through­out life-…The new cells and con­nec­tions that we and oth­ers have doc­u­mented may pro­vide the extra capac­ity the brain requires for the vari­ety of chal­lenges that indi­vid­u­als face through­out life. Such plas­tic­ity offers a pos­si­ble mech­a­nism through which the brain might be induced to repair itself after injury or dis­ease. It might even open the prospect of enhanc­ing an already healthy brain’s power to think and abil­ity to feel”

2)  and How Expe­ri­ence affects Brain Struc­ture: Under the sec­tion title “A Brain Work­out”, Fred Gage says “One of the mot strik­ing aspects of neu­ro­ge­n­e­sis (Note: the cre­ation of new neu­rons) is that expe­ri­ence can reg­u­late the rate of cell divi­sion, the sur­vival of new­born neu­rons and their abil­ity to inte­grate into the exist­ing neural circuits…The best way to aug­ment brain func­tion might not involve drugs or cell implants but lifestyle changes.”

3) Biol­ogy of Mind: Eric Kan­del pro­vides a won­der­ful overview of the most Read the rest of this entry »