It is well known that phys­i­cal fit­ness train­ing can improve cog­ni­tive abil­i­ties. A small study sur­pris­ingly sug­gests that it may work both ways: Cog­ni­tive train­ing may improve seniors’ phys­i­cal fit­ness, more specif­i­cally their walking-while-talking speed. Poor gait speed (i.e., walk­ing speed) is cor­re­lated with a higher prob­a­bil­ity of falls as well as with cog­ni­tive impair­ment. This study shows thus a promis­ing exam­ple of how the ben­e­fits of cog­ni­tive train­ing can trans­fer to a cru­cial everyday-life activity .

Twenty seniors, aged 70 or older par­tic­i­pated in the study. Ten of the seniors par­tic­i­pated in a com­put­er­ized brain fit­ness pro­gram (Mind­Fit, by Cog­niFit) three times weekly Read the rest of this entry »

Think about this: How can any­one take care of his or her brain when every week brings a new bar­rage of arti­cles and stud­ies which seem to con­tra­dict each other?

Do sup­ple­ments improve mem­ory? Do you need both phys­i­cal and men­tal exer­cise or is one of them enough? Which brain train­ing approach, if any, is worth one’s time and money?

We tried to address these ques­tions, and many oth­ers, in our recent book, The Sharp­Brains Guide to Brain Fit­ness (182 pages, $24.95), that we pre­sented at Games for Health Con­fer­ence last week. The book is the result of over two years of exten­sive research includ­ing more than a hun­dred inter­views with sci­en­tists, pro­fes­sion­als and con­sumers, and a deep review of the sci­en­tific lit­er­a­ture, led by neu­ropsy­chol­o­gist Elkhonon Gold­berg and myself with the help of cog­ni­tive sci­en­tist Pas­cale Mich­e­lon. As we wrote in the Intro­duc­tion, what we wanted to do first of all was to debunks these 10 myths on brain health and brain training:

Myth 1. Genes deter­mine the fate of our brains.
Facts: Life­long neu­ro­plas­tic­ity allows our lifestyles and actions to play a mean­ing­ful role in how our brains phys­i­cally evolve, espe­cially given longer life expectancy.

Myth 2. Aging means auto­matic decline.
Facts: There is noth­ing inher­ently fixed in the pre­cise tra­jec­tory of how brain func­tions evolve as we age.

Myth 3. Med­ica­tion is the main hope for cog­ni­tive enhance­ment.
Facts: Non-invasive inter­ven­tions can have com­pa­ra­ble and more durable effects, side effect-free.

Myth 4. We will soon have a Magic Pill or Gen­eral Solu­tion to solve all our cog­ni­tive chal­lenges.
Facts: A multi-pronged approach is rec­om­mended, cen­tered around nutri­tion, stress man­age­ment, and both phys­i­cal and men­tal exercise.

Myth 5. There is only one “Use It or Lose it”.
Facts: The brain is com­posed of a num­ber of spe­cial­ized units. Our life and pro­duc­tiv­ity depend on a vari­ety of brain func­tions, not just one.

Myth 6. All brain activ­i­ties or exer­cises are equal.
Facts: Var­ied and tar­geted exer­cises are the nec­es­sary ingre­di­ents in brain train­ing so that a wide range of brain func­tions can be stimulated.

Myth 7. There is only one way to train your brain.
Facts: Brain func­tions can be impacted in a num­ber of ways: through med­i­ta­tion, cog­ni­tive ther­apy, cog­ni­tive training.

Myth 8. We all have some­thing called “Brain Age”.
Facts: Brain age is a fic­tion. No two indi­vid­u­als have the same brain or expres­sion of brain functions.

Myth 9. That “brain age”‚ can be reversed by 10, 20, 30 years.
Facts: Brain train­ing can improve spe­cific brain func­tions, but, with research avail­able today, can­not be said to roll back one “brain age”‚ by a num­ber of years.

Myth 10. All human brains need the same brain train­ing.
Facts: As in phys­i­cal fit­ness, users must ask them­selves: What func­tions do I need to improve on? In what time­frame? What is my budget?

Do you have other myths in mind you would like  us to address?

We have started to receive great feed­back from the health­care com­mu­nity, such as this email from a neu­ro­sur­geon in Texas:

“I really like the book, it is com­pre­hen­sive with­out being too tech­ni­cal. I have rec­om­mended it to sev­eral patients. There are some other books that I expected would be greeted with enthu­si­asm, but were too com­plex for most of my patients. I think this book is right in the sweet spot”.

A short, sweet, enter­tain­ing read of a com­plex topic, with timely (writ­ten in 1/09) reviews of 21 top tech­nol­ogy prod­ucts, as well as informed and expert pre­dic­tions of where this bur­geon­ing brain-fitness field is headed. More impor­tantly, after you read it, you’ll have a good, detailed sense of where you, per­son­ally, can act to improve your own couch-potato brain — and how to keep it fit and flex­i­ble your whole life. The Sharp­Brains Guide To Brain Fit­ness reminds of us all why books (and not just googling a topic) can be well worth your time and money. Two Stetho­scopes Up — check it out. life.”

And this great book review by an Internist Physi­cian and Robert Wood John­son Foun­da­tion Fel­low, titled Is Your Brain A Couch Potato?:

Doc Gur­ley, book review for SFGate.com (06/08/09)

The book:  The Sharp­Brains Guide to Brain Fit­ness (avail­able via Amazon.com Here, review copies avail­able upon request).

Descrip­tion: While most of us have heard the phrase “use it or lose it,” very few under­stand what it means, or how to prop­erly ‚“use it”‚¬ in order to main­tain brain func­tion and fit­ness. The Sharp­Brains Guide to Brain Fit­ness is an invalu­able guide that helps read­ers nav­i­gate grow­ing brain research and iden­tify the lifestyle fac­tors and prod­ucts that con­tribute to brain health and fit­ness. By gath­er­ing insights from eigh­teen of the world’s top sci­en­tists and offer­ing tools and detailed descrip­tions of over twenty prod­ucts, this book is an essen­tial guide to the field of brain fit­ness, neu­ro­plas­tic­ity and cog­ni­tive health. An acces­si­ble and thought-provoking read, The Sharp­Brains Guide to Brain Fit­ness edu­cates life­long learn­ers and pro­fes­sion­als in health­care, edu­ca­tion, busi­ness, etc., on emerg­ing trends and fore­casts of what the future will hold.

Prod­ucts Reviewed (we reviewed sci­en­tific stud­ies pub­lished before Jan­u­ary 2009, when the man­u­script text was closed):

– Over­all brain main­te­nance: Brain Age series (Nin­tendo), Brain­Ware Safari (Learn­ing Enhance­ment Cor­po­ra­tion), FitBrains.com (Viv­ity Labs), Happy-Neuron.com (Sci­en­tific Brain Train­ing), Lumosity.com (Lumos Labs), Mind­Fit (Cog­niFit), (m)Power (Dakim)

– Tar­geted brain work­out: Clas­sic and InSight (Posit Sci­ence), Work­ing Mem­ory Train­ing JM and RM (Cogmed), Dri­ve­Fit (Cog­niFit), Earo­bics (Houghton Mif­flin), Fast For­Word (Sci­en­tific Learn­ing), Intel­li­Gym (Applied Cog­ni­tive Engi­neer­ing), Vision Rest­pra­tion Ther­apy (NovaVision)

– Emo­tional self-regulation: emWave PC and Per­sonal Stress Reliever (Heart­Math), Jour­ney to the Wild Divine (Wild Divine), RES­PeR­ATE (Inter­Cure), StressEraser (Helicor)

There’s such a flood of very sig­nif­i­cant research stud­ies, edu­ca­tional resources and arti­cles related to brain health, it’s hard to keep track — even for us!

Let me intro­duce and quote some of the top Brain Health Stud­ies, Arti­cles and Resources pub­lished in March:

1) Cog­ni­tive Decline Begins In Late 20s, Study Sug­gests (Sci­ence Daily)

- “These pat­terns sug­gest that some types of men­tal flex­i­bil­ity decrease rel­a­tively early in adult­hood, but that how much knowl­edge one has, and the effec­tive­ness of inte­grat­ing it with one’s abil­i­ties, may increase through­out all of adult­hood if there are no patho­log­i­cal dis­eases,” Salt­house said.

- How­ever, Salt­house points out that there is a great deal of vari­ance from per­son to person

2) Cere­brum 2009: Emerg­ing Ideas in Brain Sci­ence — new book by the Dana Foun­da­tion that “explores the cut­ting edge of brain research and its impli­ca­tions in our every­day lives, in lan­guage under­stand­able to the gen­eral reader.”

A cou­ple of excel­lent chap­ters of direct rel­e­vance to everyone’s brain health are:
– Chap­ter 4: A Road Paved by Rea­son, by Eliz­a­beth Nor­ton Lasley

- Chap­ter 10: Neural Health: Is It Facil­i­tated by Work Force Par­tic­i­pa­tion?, by Denise Park, Ph.D

3) Stay­ing Sharp DVD Pro­gram: “Dr. Jor­dan Graf­man, chief of the Cog­ni­tive Neu­ro­science Sec­tion at the National Insti­tute of Neu­ro­log­i­cal Dis­or­ders and Stroke out­side of Wash­ing­ton, DC, and a mem­ber of the Dana Alliance for Brain Ini­tia­tives, is your guide as we cover what to expect from the aging brain and what we can do to ‘stay sharp.’

For a free DVD of this pro­gram you can con­tact stayingsharp@dana.org. (they say free in their web­site, I don’t know if that includes ship­ping & handling)

4) Dri­vers to be tested on cog­ni­tive abil­ity start­ing at age 75 (Japan Times)

The out­line of a cog­ni­tive test that dri­vers aged 75 or over will be required to take from June when renew­ing their licenses was released Thursday…The test is intended to reduce the num­ber of traf­fic acci­dents involv­ing elderly dri­vers by mea­sur­ing their cog­ni­tive level.

5) Phys­i­cal Fit­ness Improves Spa­tial Mem­ory, Increases Size Of Brain Struc­ture (Sci­ence Daily)

- “Now researchers have found that elderly adults who are more phys­i­cally fit tend to have big­ger hip­pocampi and bet­ter spa­tial mem­ory than those who are less fit.”

6) Brain Train­ers: A Work­out for the Mind (Sci­en­tific Amer­i­can Mind)

“I recently tried out eight of the lat­est brain fit­ness pro­grams, train­ing with each for a week. The pro­grams ranged widely in focus, qual­ity and how fun they were to use. “Like phys­i­cal exer­cise equip­ment, a brain exer­cise pro­gram doesn’t do you any good if you don’t use it, says Andrew J. Carle, direc­tor of the Pro­gram in Assisted Living/Senior Hous­ing Admin­is­tra­tion at George Mason Uni­ver­sity. And peo­ple tend not to use bor­ing equip­ment. “I remem­ber when Nor­dic­Track was the biggest thing out there. Every­one ran out and bought one, and 90 per­cent of them ended up as a clothes rack in the back of your bedroom.

The reporter used: Posit Science’s Brain Fit­ness Pro­gram Clas­sic, Hap­pyNeu­ron, Nin­tendo BrainAge, CogniFit’s MindFit/ Cog­niFit Per­sonal Coach, Lumos­ity, MyBrain­Trainer, Brain­Twister, Cogmed Work­ing Mem­ory Training.

7) The Lat­est in Men­tal Health: Work­ing Out at the ‘Brain Gym’ (Wall Street Journal)

- “Mar­shall Kahn, an 82-year-old fam­ily doc­tor in Fuller­ton, Calif., says he got such a boost from brain exer­cises he started doing at a “Nifty after Fifty” club that he decided to start see­ing patients again part-time. “Doing all the men­tal exer­cise,” he says, “I real­ized I’ve still got it.”

Debate Over Drugs For ADHD Reignites (Wash­ing­ton Post)

- “New data from a large fed­eral study have reignited a debate over the effec­tive­ness of long-term drug treat­ment of chil­dren with hyper­ac­tiv­ity or attention-deficit dis­or­der, and have drawn accu­sa­tions that some mem­bers of the research team have sought to play down evi­dence that med­ica­tions do lit­tle good beyond 24 months.”

- “The study also indi­cated that long-term use of the drugs can stunt children’s growth.”

Adap­tive train­ing leads to sus­tained enhance­ment of poor work­ing mem­ory in chil­dren (Devel­op­men­tal Science)

Abstract: Work­ing mem­ory plays a cru­cial role in sup­port­ing learn­ing, with poor progress in read­ing and math­e­mat­ics char­ac­ter­iz­ing chil­dren with low mem­ory skills. This study inves­ti­gated whether these prob­lems can be over­come by a train­ing pro­gram designed to boost work­ing mem­ory. Chil­dren with low work­ing mem­ory skills were assessed on mea­sures of work­ing mem­ory, IQ and aca­d­e­mic attain­ment before and after train­ing on either adap­tive or non-adaptive ver­sions of the pro­gram. Adap­tive train­ing that taxed work­ing mem­ory to its lim­its was asso­ci­ated with sub­stan­tial and sus­tained gains in work­ing mem­ory, with age-appropriate lev­els achieved by the major­ity of chil­dren. Math­e­mat­i­cal abil­ity also improved sig­nif­i­cantly 6 months fol­low­ing adap­tive train­ing. These find­ings indi­cate that com­mon impair­ments in work­ing mem­ory and asso­ci­ated learn­ing dif­fi­cul­ties may be over­come with this behav­ioral treatment.

9) Brain cor­tex thin­ning linked to inher­ited depres­sion (Los Ange­les Times)

- “On aver­age, peo­ple with a fam­ily his­tory of depres­sion appear to have brains that are 28% thin­ner in the right cor­tex — the out­er­most layer of the brain — than those with no known fam­ily his­tory of the dis­ease. That cor­ti­cal thin­ning, said the researchers, is on a scale sim­i­lar to that seen in patients with Alzheimer’s dis­ease or schizophrenia.”

Crisp CNN article:

Boom times for brain train­ing games

Includ­ing my final quote “[Brain fit­ness] is not just some fad. The mar­ket is much deeper than Nintendo.”

The “brain fit­ness cen­ter” financed by Ontario is Bay­crest. Com­pa­nies men­tioned: Mind­fit, Posit Sci­ence, Nin­tendo, All­state, Brain­Builder, MyBrainTrainer.

The reporter and I also dis­cussed in depth the need for bet­ter con­sumer edu­ca­tion and pro­fes­sional devel­op­ment, so peo­ple can make informed deci­sions, and for cog­ni­tive assess­ments to serve as inde­pen­dent base­line, help iden­tify pri­or­i­ties and mea­sure results. Please note that our mar­ket esti­mates do include rev­enues of com­put­er­ized cog­ni­tive assess­ments, today mostly used in clin­i­cal tri­als, and within the mil­i­tary and sports teams.

I have fallen behind on answer­ing a few excel­lent recent com­ments –on cog­ni­tive train­ing over­all, Posit Sci­ence and Alzheimer’s Aus­tralia, geron­tol­ogy and the brain, the value of videogames-, so let me address them here:

1) Nicks says (Brain Fit­ness Pro­grams For Seniors Hous­ing, Health­care and Insur­ance Providers: Eval­u­a­tion Checklist)

“This report is inter­est­ing and it addresses many very impor­tant ques­tions that cog­ni­tive neu­ropsy­chol­o­gists, such as myself have. I feel that many of the prod­ucts on the mar­ket now make claims which are gen­er­ally unsubstantiated.

I find it con­cern­ing that many of these pro­grammes have been mar­keted to tar­get older adults in par­tic­u­lar with­out mak­ing any spe­cific state­ment on whether the activ­i­ties are ben­e­fi­cial and have been sup­ported with empir­i­cal research.

i have recently con­ducted a cog­ni­tive inter­ven­tion study which used a large array of out­come mea­sures which focus on Read the rest of this entry »

From the web­site of the invest­ing ven­ture cap­i­tal firm, Milk Capital:

Milk Cap­i­tal invests USD 5 mil­lion in CogniFit

–July 31st, 2008. “Milk Cap­i­tal invest USD 5M in Cog­nifit, a com­pany spe­cial­ized in cog­ni­tive and brain soft­ware The solu­tions devel­oped by Cog­niFit are designed to be applied to a large num­ber of fields, such as health­care, dri­ving, edu­ca­tion, sport and many oth­ers. The field of appli­ca­tions is almost unlim­ited as it is only restricted by the capac­i­ties of the brain.”

-“Since its estab­lish­ment in 1999, as a start-up in the Ofer Group’s Incu­ba­tor, Naiot, Cog­niFit attracted 4.2M$. The com­pany has grown sig­nif­i­cantly and today, its soft­ware is dis­trib­uted in a large num­ber of coun­tries, from the United States through France to New Zealand, and has been trans­lated into ten lan­guages. This 5M$ invest­ment of MILK CAPITAL should drive the devel­op­ment of Cog­niFit all the more than the com­pany intends to con­quer new mar­kets by means of new prod­ucts and appli­ca­tions all over the world.”

Pre­vi­ous post on one of CogniFit’s prod­ucts, Dri­ve­Fit: Dri­ve­Fit; Brain Fit­ness Pro­gram for Dri­ving.

Other recent ven­ture rounds in the brain fit­ness soft­ware space:

- Feb­ru­ary 2008: Dakim raises $10,6 mil­lion
– June 2008: Lumos Labs (Lumos­ity) raises $3 millions

I spoke at the MIT Club of North­ern Cal­i­for­nia in Feb­ru­ary to pro­vide an overview of the fas­ci­nat­ing land­scape. The write-up: Brain Train­ing Games: Con­text, Trends, Ques­tions.

For in-depth infor­ma­tion on the whole cat­e­gory –size, cus­tomer seg­ments, player land­scape, clin­i­cal val­i­da­tion, trends– you may enjoy our Mar­ket Report.

Some recent brain train­ing and health news:

1) A Promis­ing Debut for Com­put­er­ized Therapies

2) Fit­ness pro­tects brain in Alzheimer’s patients

3) Brain Fit­ness Pro­gram Clas­sic comes to Mac

4) Posit Sci­ence gains own­er­ship of Sci­en­tific Learn­ing (NSDQ: SCIL) BrainConnection.

5) Brain train­ing on your mobile

6) You must remem­ber this: how the mind works

Here you have the links and my com­men­tary for these news: Read the rest of this entry »

Press release: Here

– “Lumos Labs, devel­oper of Lumosity.com, the lead­ing web-based provider of scientifically-tested brain train­ing games, today announced that it has raised $3 mil­lion of equity financ­ing from Pequot Ven­tures, Nor­west Ven­ture Part­ners (NVP), and exist­ing investors includ­ing Michael Dear­ing. The investor group brings exper­tise that will cat­alyze the ongo­ing devel­op­ment of Lumosity.com and sup­port Lumos Labs mis­sion to improve lives by enhanc­ing brain fitness.

– “Lumos Labs is at the cen­ter of a boom­ing inter­est in cog­ni­tive exer­cise and the emerg­ing sci­ence about the remark­able plas­tic­ity of the brain, said Amish Jani of Pequot Ven­tures. Lumosity.com has seen tremen­dous demand from users and part­ners alike by lever­ag­ing the power of the web to deliver a unique plat­form for brain fitness.

Great news for the sec­tor. The more tools avail­able for lead­ing men­tally stim­u­lat­ing lives, the bet­ter we will all be.

Lumosity.com (click Here to get a sense of their games) pro­vides a great user expe­ri­ence at a rea­son­able cost. From an investor’s per­spec­tive, we believe Lumos Labs is a very seri­ous con­tender in the brain fit­ness space, and it has indeed been exe­cut­ing a very smart online strategy.

Now, I am not sure what “scientifically-tested brain train­ing games” really means. While prepar­ing our Brain Fit­ness Soft­ware Mar­ket Report we reviewed all pub­lished research on the effi­cacy behind dif­fer­ent pro­grams, and didn’t find any for Lumos­ity (which has some very inter­est­ing inter­nal, but not pub­lished, data).

We gave Lumos­ity a score of 2 ouf of 10 in Clin­i­cal Val­i­da­tion (with Nin­tendo Brain Age get­ting a score of 1, and NovaV­i­sion, cleared by the FDA for use with stroke/ TBI patients, get­ting a 5).

Read the rest of this entry »

Dri­ving as Next Brain Fit­ness Application? 

Last month, at the MIT/ Smart­Sil­vers event where we pre­sented our Brain Fit­ness Mar­ket Report, we dis­cussed what spe­cific appli­ca­tions, beyond the cur­rent empha­sis on healthy aging, might take com­put­er­ized cog­ni­tive train­ing to a new level.  

Assess­ing and improv­ing dri­ving skills would be a top can­di­date, given both the well-defined nature of the need and the appear­ance of pro­grams with grow­ing evi­dence (both sci­en­tific and real-world) behind.

The New York Times Asks… 

Along these lines, the New York Times just published this arti­cle: Are You a Good Dri­ver? Here’s How to Find Out. A few quotes:

- “COULD a video game make you a bet­ter dri­ver? More impor­tant, could com­puter soft­ware pre­vent teenagers from mak­ing fatal mis­takes or even weed out older dri­vers whose debil­i­ties make them crash-prone?”

Read the rest of this entry »

Phys­i­cal fit­ness. Cognitive/ brain fit­ness. Both require nov­elty, vari­ety and chal­lenge. Pro­fes­sor Schlomo Breznitz, a sci­en­tific and busi­ness leader in the cog­ni­tive fit­ness field, explains why, elo­quently, below. Per­haps “we want change” really means “we need change”. Enjoy!

————————

Why are every­day life chal­lenges not suf­fi­cient to keep our brains fit?

– By Prof. Shlomo Breznitz

Often, when describ­ing the ben­e­fits of Mind­Fit to brain health, I am asked by peo­ple in the audi­ence whether this soft­ware is really needed. After all, so they argue, life pro­vides con­tin­ues cog­ni­tive chal­lenges, which should suf­fice for ensur­ing brain fit­ness. From the moment we wake up until we go to sleep our brains have to attend to com­plex stim­uli, plan many activ­i­ties, some of them quite com­plex, and carry us through what­ever the day offers. These tasks should pro­vide suf­fi­cient “brain exer­cise” with­out the need to engage in spe­cific men­tal workout.

This line of argu­ment sounds oddly famil­iar, since it is an exact dupli­ca­tion of claims made in the recent past against the need for phys­i­cal exer­cise. One jumps into the car and from the car and per­haps even climbs a few stairs before sit­ting in the chair, which should be enough to burn the calo­ries and keep fit.

Read the rest of this entry »