Dr. Michael Merzenich, Emer­i­tus Pro­fes­sor at UCSF, is a lead­ing pio­neer in brain plas­tic­ity research. In the late 1980s, Dr. Merzenich was on the team that invented the cochlear implant. In 1996, he was the found­ing CEO of Sci­en­tific Learn­ing Cor­po­ra­tion (Nas­daq: SCIL), and in 2004 became co-founder and Chief Sci­en­tific Offi­cer of Posit Sci­ence. He was elected to the National Acad­emy of Sci­ences in 1999 and to the Insti­tute of Med­i­cine this year. He retired as Fran­cis A. Sooy Pro­fes­sor and Co-Director of the Keck Cen­ter for Inte­gra­tive Neu­ro­science at the Uni­ver­sity of Cal­i­for­nia at San Fran­cisco in 2007. You may have learned about his work in one of PBS TV spe­cials, mul­ti­ple media appear­ances, or neuroplasticity-related books.

(Alvaro Fer­nan­dez) Dear Michael, thank you very much for agree­ing to par­tic­i­pate in the inau­gural Sharp­Brains Sum­mit in Jan­u­ary, and for your time today. In order to con­tex­tu­al­ize the Summit’s main themes, I would like to focus this inter­view on the likely big-picture impli­ca­tions dur­ing the next 5 years of your work and that of other neu­ro­plas­tic­ity research and indus­try pioneers.

Thank you for invit­ing me. I believe the Sharp­Brains Sum­mit will be very use­ful and stim­u­lat­ing, you are gath­er­ing an impres­sive group together. I am look­ing for­ward to January.

Neuroplasticity-based Tools: The New Health & Well­ness Frontier

There are many dif­fer­ent technology-free approaches to har­ness­ing –enabling, dri­ving– neu­ro­plas­tic­ity. What is the unique value that tech­nol­ogy brings to the cog­ni­tive health table?

It’s all about effi­ciency, scal­a­bil­ity, per­son­al­iza­tion, and assured effec­tive­ness. Tech­nol­ogy sup­ports the imple­men­ta­tion of near-optimally-efficient brain-training strate­gies. Through the Inter­net, it enables the low-cost dis­tri­b­u­tion of these new tools, any­where out in the world. Tech­nol­ogy also enables the per­son­al­iza­tion of brain health train­ing, by pro­vid­ing sim­ple ways to mea­sure and address indi­vid­ual needs in each person’s brain-health train­ing expe­ri­ence. It enables assess­ments of your abil­i­ties that can affirm that your own brain health issues have been effec­tively addressed.

Of course sub­stan­tial gains could also be achieved by orga­niz­ing your every­day activ­i­ties that grow your neu­ro­log­i­cal abil­i­ties and sus­tain your brain health. Still, if the ordi­nary cit­i­zen is to have any real chance of main­tain­ing their brain fit­ness, they’re going to have to spend con­sid­er­able time at the brain gym!

One espe­cially impor­tant con­tri­bu­tion of tech­nol­ogy is the scal­a­bil­ity that it pro­vides for deliv­er­ing brain fit­ness help out into the world. Think about how effi­cient the drug deliv­ery sys­tem is today. Doc­tors pre­scribe drugs, insur­ance cov­ers them, and there is a drug store in every neigh­bor­hood in almost every city in the world so that every patient has access to them. Once neuroplasticity-based tools and out­comes and stan­dard­ized, we can envi­sion a sim­i­lar sce­nario. And we don’t need all those drug stores, because we have the Internet!

Hav­ing said this, there are obvi­ous obsta­cles. One main one, in my mind, is the lack of under­stand­ing of what these new tools can do. Cog­ni­tive train­ing pro­grams, for exam­ple, seem counter-intuitive to con­sumers and many pro­fes­sion­als “ why would one try to improve speed-of-processing if all one cares about is œmem­ory? A sec­ond obvi­ous prob­lem is to get indi­vid­u­als to buy into the effort required to really change their brains for the bet­ter. That buy-in has been achieved for many indi­vid­u­als as it applies to their phys­i­cal health, but we haven’t got­ten that far yet in edu­cat­ing the aver­age older per­son that brain fit­ness train­ing is an equally effort­ful business!

Tools for Safer Dri­ving: Teens and Adults

Safe dri­ving seems to be one area where the ben­e­fits are more intu­itive, which may explain the sig­nif­i­cant traction.

Yes, we see great poten­tial and inter­est among insur­ers for improv­ing dri­ving safety, both for seniors and teens. Appro­pri­ate cog­ni­tive train­ing can lower at-fault acci­dent rates. You can mea­sure clear ben­e­fits in rel­a­tively short time frames, so it won’t take long for insur­ers to see an eco­nomic ratio­nale to not only offer pro­grams at low cost or for free but to incen­tivize dri­vers to com­plete them. All­state, AAA, State Farm and other insur­ers are begin­ning to real­ize this poten­tial. It is impor­tant to note that typ­i­cal acci­dents among teens and seniors are dif­fer­ent, so that train­ing method­olo­gies will need to be dif­fer­ent for dif­fer­ent high-risk populations.

Yet, most dri­ving safety ini­tia­tives today still focus on edu­cat­ing dri­vers, rather that train­ing them neu­ro­log­i­cally. We mea­sure vision, for exam­ple, but com­pletely ignore atten­tional con­trol abil­i­ties, or a driver’s use­ful field of view. I expect this to change sig­nif­i­cantly over the next few years.

Long-term care and health insur­ance com­pa­nies will ulti­mately see sim­i­lar ben­e­fits, and we believe that they will fol­low a sim­i­lar course of action to reduce gen­eral med­ical and neu­rode­gen­er­a­tive dis­ease– (Mild Cog­ni­tive Impair­ment and Alzheimer’s– and Parkinsons-) related costs. In fact, many senior liv­ing com­mu­ni­ties are among the pio­neers in this field.

Boomers & Beyond: Main­tain­ing Cog­ni­tive Vitality

Main­stream media is cov­er­ing this emerg­ing cat­e­gory with thou­sands of sto­ries. But most cov­er­age seems still focused on does it work? more than “how do we define It”, what does work mean? or work for whom, and for what? Can you sum­ma­rize what recent research suggests?

We have seen clear pat­terns in the appli­ca­tion of our train­ing pro­grams, some pub­lished (like IMPACT), some unpub­lished, some with healthy adults, and some with peo­ple with mild cog­ni­tive impair­ment or early Alzheimers Dis­ease (AD). What we see in every case: Read the rest of this entry »

We are excited to invite you to the first vir­tual, global Sharp­Brains Sum­mit (Jan­u­ary 18-20th, 2010). The Sharp­Brains Sum­mit will fea­ture a dream team of over 25 speak­ers who are lead­ers in indus­try and research from 7 coun­tries, to dis­cuss emerg­ing research, tools and best prac­tices for cog­ni­tive health and per­for­mance. This inau­gural event will expose health and insur­ance providers, devel­op­ers, inno­va­tors at For­tune 500 com­pa­nies, investors and researchers, to the oppor­tu­ni­ties, part­ner­ships, trends, and stan­dards of the rapidly evolv­ing cog­ni­tive fit­ness field.

Reg­is­ter Today

Learn more and reg­is­ter Here today, at dis­counted early-bird rates, to receive these benefits:

• Learn: Full access to all Con­fer­ence live ses­sions, and Down­load­able Record­ings and Handouts
• See: lat­est tech­nolo­gies and prod­ucts dur­ing Expo Day
• Con­nect and Dis­cuss: become a mem­ber of the Sharp­Brains Net­work for Brain Fit­ness Inno­va­tion (members-only LinkedIn Group) through the end of 2010, access online chats dur­ing the sum­mit, meet other reg­is­trants in your city
• Under­stand the Big Pic­ture: access 10 Research Exec­u­tive Briefs pre­pared by lead­ing scientists

On top of those early-bird dis­counts, we offer an addi­tional 15% dis­count for Sharp­Brains read­ers who want Reg­u­lar Admis­sion. Dis­count code: sharp2010. You can reg­is­ter Here.

Agenda/ Speak­ers

Mon­day, Jan­u­ary 18th, 2010:

(Pre­lim­i­nary sched­ule, US Pacific Time)

8–9.15am. Cog­ni­tion & Neu­ro­plas­tic­ity: The New Health­care Frontier

• Alvaro Fer­nan­dez, SharpBrains
• David White­house, OptumHealth Behav­ioral Solutions
• William Reich­man, Baycrest
• P Murali Doraiswamy, Duke University

9.30-11am. Tools for Safer Dri­ving: The Oppor­tu­nity with Teenagers and Adults

• Steven Aldrich, Posit Science
• Shlomo Breznitz, CogniFit
• Jerri Edwards, Uni­ver­sity of South Florida
• Peter Chris­tian­son, Young Dri­vers of Canada

Noon-1.30pm. Baby Boomers and Beyond: Main­tain­ing Cog­ni­tive Vitality

• Kunal Sarkar, Lumos Labs
• Eliz­a­beth Zelin­ski, USC Davis School of Geron­tol­ogy Read the rest of this entry »

Three excel­lent new edi­tions of these blog carnivals:

- Encephalon at Neu­roskep­tic: brain and mind topics.

- Grand Rounds at Run­ning a Hos­pi­tal: over­all health and med­i­cine, this week with spe­cial theme “when things go awry”.

- Change of Shift at Emergi­Blog: nurs­ing and related health­care topics.

Increased longevity has gen­er­ated many ques­tions and much inter­est in healthy aging and retire­ment lifestyles over the recent decades. As Amer­i­cans become edu­cated regard­ing lifestyle choices that con­tribute to both phys­i­cal and men­tal health, the def­i­n­i­tion of healthy aging has expanded to include brain health.

The notion of retire­ment as a time of with­drawal from soci­ety, to be spent on rest and repose reflected the think­ing of a pre­vi­ous era when peo­ple expected shorter life spans. It is now known that the human brain ben­e­fits from envi­ron­ments rich in novel and com­plex stim­uli, and that by actively par­tic­i­pat­ing in soci­ety and tak­ing on per­son­ally rel­e­vant roles, peo­ple find mean­ing and pur­pose, which gives them a rea­son to get up in the morn­ing and pur­sue new challenges.

This year, the MetLife Mature Mar­ket Insti­tute pub­lished a research study titled Dis­cov­er­ing What Mat­ters: Bal­anc­ing Money, Med­i­cine and Mean­ing. The study explored how peo­ple rebal­ance their pri­or­i­ties over time and jug­gle var­i­ous com­pet­ing aspects of life includ­ing money, med­i­cine (a metaphor for health) and mean­ing, in order to live the Good Life.  Hav­ing pur­pose was found to Read the rest of this entry »

In April 2008, Bay­crest, a lead­ing research insti­tute focused on aging and brain func­tion, received $10-million from the Ontario Gov­ern­ment to cre­ate a ground­break­ing Cen­tre for Brain Fit­ness. Its stated goal was to “develop and com­mer­cial­ize a range of prod­ucts designed to improve the brain health of aging Ontar­i­ans and oth­ers around the world”.

“Our gov­ern­ment is proud to sup­port Bay­crest and its invalu­able work, which is already lead­ing to the dis­cov­ery of impor­tant new tools and approaches to treat­ing brain dis­eases asso­ci­ated with aging,” said Min­is­ter of Research and Inno­va­tion, John Wilkinson.

We have Baycrest’s CEO with us today, to explore why Ontario and Bay­crest chose to become pio­neers in this area, and dis­cuss some of the main oppor­tu­ni­ties, and chal­lenges. Dr. William E. Reich­man is Pres­i­dent and CEO of Bay­crest. Dr. Reich­man, an internationally-known expert in geri­atric men­tal health and demen­tia, is also Pro­fes­sor of Psy­chi­a­try on the Fac­ulty of Med­i­cine at the Uni­ver­sity of Toronto.

Alvaro Fer­nan­dez: Bill, thank you for your time. Let me start by ask­ing, given that you just spoke at the recent Con­sumer Elec­tronic Show, what do you make of the grow­ing brain fit­ness field?

Bill Reich­man: it looks like a clas­sic exam­ple of a very promis­ing but still early stage field – a lot of oppor­tu­nity and enthu­si­asm, but also a lot of prod­uct claims that are not backed by solid research. Think about the phys­i­cal fit­ness anal­ogy: even today, after decades of progress, you still see peo­ple buy­ing research-based prod­ucts such as tread­mills but also all types of ran­dom machines they see on TV and have not been sub­ject to any val­i­da­tion. Sim­i­larly, con­sumers today do not know what to make of grow­ing brain fit­ness claims. As another speaker pointed out, for the indus­try to ful­fill its promise, it will need to be care­ful with research and claims, not to end up like the nutraceu­ti­cals category.

By the way, let me rec­og­nize that the work you are doing with Sharp­Brains reports and your web­site is very impor­tant to offer qual­ity information.

Thank you. Let’s step back for a moment. Tak­ing a, say, 10 years view, what is the main oppor­tu­nity that technology-based brain fit­ness can offer to society?

First of all, let me say that I think we have an oppor­tu­nity to make major progress in Brain Health in the XXI cen­tury, sim­i­lar to what hap­pened with Car­dio­vas­cu­lar Health in the XX, and tech­nol­ogy will play a cru­cial role.

Given the rapid advances we are wit­ness­ing today in the research and tech­nol­ogy are­nas, I feel con­fi­dent in say­ing that in less than 10 years we will have both valid and reli­able assess­ments of cog­ni­tive func­tions, that will be used both by Read the rest of this entry »

A cou­ple of very well curated col­lec­tions of recent blog posts:

Encephalon #64: hosted by Neu­r­o­critic, cov­er­ing neu­ro­science and psy­chol­ogy. Please make sure to visit when you have some time to spare…because you will quickly become addicted to the qual­ity con­tent and superb presentation.

It’s Grand Rounds, What Do You Think? GOSH!: hosted by Kim at Emergi­Blog, with an inter­dis­ci­pli­nary, “Napoleon Dyna­mite”, frame. Doesn’t seem to make sense? well, pay a visit.

Just a quick heads up: the MetLife Mature Mar­ket Insti­tute has pub­lished a new report: titled Dis­cov­er­ing What Mat­ters: Bal­anc­ing Money, Med­i­cine and Meaning.

Descrip­tion: “The adage that money can’t buy hap­pi­ness is sup­ported ana­lyt­i­cally by new research demon­strat­ing the impor­tance of hav­ing pur­pose in one’s life and that the most con­tent peo­ple focus on the non-financial essen­tials in their lives, even dur­ing dif­fi­cult eco­nomic times.  Liv­ing the “good life” for middle-aged and older Amer­i­cans is equated with spend­ing time with fam­ily and friends, a pre­vi­ously unquan­ti­fied find­ing, accord­ing to the MetLife Mature Mar­ket Institute’s lat­est study, Dis­cov­er­ing What Mat­ters: Bal­anc­ing Money, Med­i­cine and Mean­ing, pro­duced in con­junc­tion with lead­ing author, life coach, and exec­u­tive edu­ca­tor, Richard Lei­der.  They describe the good life in terms of hav­ing health, a finan­cial safety net and the time to do what is impor­tant to them.”

Report is avail­able Here (PDF, 69 kb).

Will com­ment in a few days, when I get the chance to take a look at it. Have a nice weekend!

“If Dr. Rob can inter­view Santa, why can’t I inter­view a select group of health & med­ical blog­gers? They will have some good ideas to share”.

So did President-elect Obama came to real­ize a few days ago. After his peo­ple kindly con­tacted our peo­ple, we felt com­pelled to grant him open access to our col­lec­tive wis­dom. With­out fur­ther ado, below you have Grand Rounds 5:12 — a Q&A ses­sion led by the incom­ing Pres­i­dent on how to reform (for the bet­ter, we hope) healthcare.

On Health Insurance

Q:  How does the blo­gos­phere per­ceive the prob­lem of hav­ing a sig­nif­i­cant group of peo­ple uninsured?

Health Insur­ance Col­orado: a grow­ing eco­nomic bur­den, which may lead to emer­gency rooms turn­ing peo­ple away if they are unable to pro­vide proof of health insurance.

Dr Rich: well, a recent arti­cle in the Jour­nal of the Amer­i­can Med­ical Asso­ci­a­tion showed how over­crowd­ing in Amer­i­can emer­gency rooms is NOT due to the unin­sured. Rather, it is due to insured Amer­i­cans who can­not get in to see their pri­mary care physi­cians. We may need improved care both for the insured and unin­sured groups.

Insure­Blog: I’d sec­ond that. Lack of health insur­ance is a major prob­lem but is it really our Biggest Problem?

It’s All about Attitude

Q: You may have heard my cam­paign mantra, “Yes We Can”. Can I count on your support?

ButY­ouDont­Look­Sick: Yes. If Leslie Hunt can talk so openly about her chronic ill­ness (Lupus) yet ful­fill her Amer­i­can Idol dreams, we can ful­fill our dreams too.

Notes of an Anes­the­sioboist: you are talk­ing to the group of pro­fes­sion­als will­ing to self-experiment with our own body for the ben­e­fit of sci­ence and our patients.

Med­views: My wife, son, and I signed up to work as med­ical vol­un­teers for your upcom­ing inauguration.

Emergi­Blog: I am on board too. But, please, remem­ber that car­ing is the essence of nurs­ing. And that is why my patients will always be my patients and never my  clients.

Neu­roan­thro­pol­ogy: Mr. President-elect, it seems to me that, despite all our good inten­tions, bal­anc­ing the bud­get and mul­ti­ple com­pet­ing pri­or­i­ties will be a chal­lenge. May I sug­gest you start prac­tic­ing some capoeira for equi­lib­rium training?

Shrink Rap: Happy to help. Now, we will need to pro­tect some time for qual­ity sleep time.

Train­ing

Q: I am encour­aged by your words. How can my team and I bet­ter sup­port you in your daily activities?

Aequa­nim­i­tas: we need more role mod­els for us to “learn to think, observe, and com­pare” and that the patient is our “first, last, and only teacher”.

Mud­phud­der: Couldn’t agree more. We need Read the rest of this entry »

I will be host­ing the Decem­ber 9th edi­tion of Grand Rounds blog car­ni­val. Please email me your excel­lent health & med­i­cine posts, indi­cat­ing Grand Rounds in the sub­ject line:

afer­nan­dez at sharp­brains dot com

Thank you!

We offered some Brain Fit­ness Pre­dic­tions in our Mar­ket Report , including…

“7. Doc­tors and phar­ma­cists will help patients nav­i­gate through the over­whelm­ing range of avail­able prod­ucts and inter­pret the results of cog­ni­tive assess­ments. This will require sig­nif­i­cant pro­fes­sional devel­op­ment efforts, given that most doc­tors today were trained under a very dif­fer­ent under­stand­ing of the brain than the one we have today.”

The Amer­i­can Med­ical News, a weekly news­pa­per for physi­cians pub­lished by the Amer­i­can Med­ical Asso­ci­a­tion, just pub­lished an excel­lent arti­cle along those lines:

Steps to a nim­ble mind: Phys­i­cal and men­tal exer­cise help keep the brain fit
– Neu­ro­science is uncov­er­ing tech­niques to pre­vent cog­ni­tive decline.

A few quotes:

- It’s an exam­ple that high­lights a wave of new think­ing about the impor­tance of brain fitness.

- Until recently, con­ven­tional wis­dom held that our brains were intractable, hard-wired com­put­ers. What we were born with was all we got. Age wore down mem­ory and the abil­ity to under­stand, and few inter­ven­tions could reverse this process. But increas­ingly, evi­dence sug­gests that phys­i­cal and men­tal exer­cise can alter spe­cific brain regions, mak­ing rad­i­cal improve­ments in cog­ni­tive function.

- With nearly 72 mil­lion Amer­i­cans turn­ing 65 over the next two decades, physi­cians need the tools to han­dle grow­ing patient con­cerns about how to best main­tain brain health. Armed with this new brand of sci­ence, front­line physi­cians will be bet­ter equipped to address the needs of aging baby boomers, already in the throes of the brain fit­ness revolution.

- “Encour­age them to exer­cise the brain in novel and com­plex ways,” he says.

Full arti­cle: here

One of the physi­cians quoted in the arti­cle is Gary J. Kennedy, MD, Direc­tor of the Divi­sion of Geri­atric Psy­chi­a­try at Mon­te­fiore Med­ical Cen­ter in NYC and a pro­fes­sor in the Dept. of Psy­chi­a­try and Behav­ioral Sci­ences at Albert Ein­stein Col­lege of Medicine.

To put the AMA arti­cle in bet­ter per­spec­tive for Sharp­Brains read­ers, we asked Dr. Kennedy a few follow-up ques­tions. Below you have his questions.

Alvaro Fer­nan­dez (AF): Can you sum­ma­rize how cog­ni­tive func­tions tend to evolve as we age?

Gary Kennedy (GK): As we age cog­ni­tive func­tions that rely on Read the rest of this entry »