Eric Jensen alerted me to a research study pub­lished in the Feb­ru­ary 4th Jour­nal of Neu­ro­science — Trans­gen­er­a­tional Res­cue of a Genetic Defect in Long-Term Poten­ti­a­tion and Mem­ory For­ma­tion by Juve­nile Enrich­ment. We both had the same ini­tial WOW! feel­ing that we had expe­ri­enced when we first read about the dis­cov­ery of mir­ror neu­rons a decade+ ago.

The study’s find­ings seemed to sug­gest that acquired char­ac­ter­is­tics can be genet­i­cally trans­mit­ted, a Lamar­ck­i­nan belief that had long been dis­carded by biol­o­gists. This seemed improb­a­ble, so we decided to check out what the sci­en­tific com­mu­nity thought. It’s the kind of research that edu­ca­tors cer­tainly need to under­stand because the poten­tial edu­ca­tional impli­ca­tions are pro­found, no mat­ter how this par­tic­u­lar study sorts out.

I’ve thus appended the fol­low­ing infor­ma­tion below: (1) the abstract and ref­er­ence of the orig­i­nal sttudy, (2) a link to a non-technical report in the cur­rent issue of New Sci­en­tist, (3) a link to a non– tech­ni­cal expla­na­tion of the research in Med­ical News Today, and (4) a link to a recent extended non-technical New Sci­en­tist arti­cle on the issue of non-genetic inher­i­tance. Eric will post his com­men­tary on the research in the March edi­tion of his Brighter Brain Bul­letin newsletter.

THE STUDY:

To put it sim­ply: The researchers stud­ied long-term poten­ti­a­tion (LTP), in which longer and more robust synap­tic acti­va­tion occurs. LTP is the basic mech­a­nism for learn­ing and mem­ory formation.

Juve­nile mice placed into an enriched envi­ron­ment (EE) devel­oped enhanced LTP capa­bil­i­ties that they later trans­mit­ted to their own off­spring dur­ing embryo­ge­n­e­sis (rather than through later mater­nal instruc­tion), and these effects per­sisted even when the off­spring weren’t in an EE. The study con­cluded that a stim­u­lat­ing juve­nile envi­ron­ment can thus influ­ence the com­po­si­tion of sig­nal­ing net­works that influ­ence synap­tic plas­tic­ity and mem­ory for­ma­tion in the enriched mouse, and also in its future offspring.

The prob­lem with this research appears to be over whether the trans­mit­ted effects occurred via genetic changes or through some­thing else in the mother’s uter­ine envi­ron­ment. A female’s eggs develop early in life to be dis­trib­uted later, so it’s improb­a­ble that a female’s juve­nile expe­ri­ences would alter the DNA in her eggs. A more prob­a­ble expla­na­tion may be that any changes in the mother’s brain that occur via an EE are rep­re­sented as cur­rently ill– under­stood sig­nal­ing mol­e­cules that pass through the pla­cen­tal bar­rier into the embry­onic brain.

THE SIGNIFICANCE:

For edu­ca­tors, this research sim­ply adds to our own strong belief that long-term ben­e­fits accrue from a stim­u­lat­ing early envi­ron­ment that encour­ages curios­ity and explo­ration. The research builds on Read the rest of this entry »

As you may have noticed, we just changed a few things in our site, includ­ing prepar­ing a more solid Resources sec­tion. Please take a look at the nav­i­ga­tion bar at the top.

One of the new pages, that we will update often, is an expanded Books page. Here are the books that we are rec­om­mend­ing now.

Fas­ci­nat­ing books on neu­ro­plas­tic­ity (the abil­ity of the brain to rewire itself through experience):

Train Your Mind, Change Your Brain: How a New Sci­ence Reveals Our Extra­or­di­nary Poten­tial to Trans­form Our­selves — by Sharon Begley.

 

The Brain That Changes Itself: Sto­ries of Per­sonal Tri­umph from the Fron­tiers of Brain Sci­ence — by Nor­man Doidge.

 

Great pop­u­lar sci­ence books by Read the rest of this entry »

Here you are have the Monthly Digest of our Most Pop­u­lar Blog Posts. You can con­sider it your monthly Brain Exer­cise Magazine.

Grat­i­tude is a very impor­tant emo­tion to cul­ti­vate, as Pro­fes­sor Robert Emmons tells us in this inter­view, based on his last book. Please take some time to read it, and to find at least one thing you are thank­ful for-it will be good for your health.

We are grate­ful about a very stim­u­lat­ing November:

Brain Fit­ness Mar­ket News

10 Neu­rotech­nol­ogy Trends: a lead­ing indus­try orga­ni­za­tion released their Top 10 Neu­roTrends for 2007, and brain fit­ness mat­ters appeared in 3 of them.

Thank Boomers for Buff­ing Up Brain Mar­ket: great overview of the mar­ket from a tech­nol­ogy point of view, quot­ing our mar­ket pro­jec­tions. To clar­ify the num­bers men­tioned: we project $225m in the US alone for the brain fit­ness soft­ware mar­ket (grow­ing from $70m in 2003), broken-down as fol­lows: $80m for the Con­sumer seg­ment, $60m in K12 Edu­ca­tion, $50m in Clin­i­cal appli­ca­tions, and $35m in the Cor­po­rate seg­ment. The Con­sumer seg­ment, with a healthy aging value propo­si­tion, is the most recent one but the most rapidly grow­ing.

Exer­cise On the Brain: a NYT OpEd: a widely read opin­ion piece in the New York Times, writ­ten by 2 neu­ro­sci­en­tists, that some­how seems to miss the research behind the value of men­tal stim­u­la­tion and cog­ni­tive train­ing. Other neu­ro­science teams and us write let­ters to the edi­tor that go unpub­lished. Should you have any con­tacts with jour­nal­ists, please ask them to con­tact us: we are always happy to serve as a resource to the media.

Posit Sci­ence @ GSA: well-designed Brain Train­ing Works: a timely heads up on how well-designed computer-based pro­grams can be a great com­ple­ment to other inter­ven­tions. We will be inter­view­ing the lead­ing researcher behind that study dur­ing the next 2 weeks, so keep tuned!

Brain and Mind News and Arti­cles: a vari­ety of links to good media reports, includ­ing a spec­tac­u­lar spe­cial on mem­ory in National Geographic.

News You Can Use

Mar­ian Dia­mond on the brain: lead­ing neu­ro­sci­en­tist Mar­ian Dia­mond, now 81, shares her pre­scrip­tion for life­long brain health– diet, exer­cise, chal­lenge, new­ness and ten­der lov­ing care.

From Med­i­ta­tion to MBSR (Mind­ful­ness Based Stress Reduc­tion): a report on the ben­e­fits of med­i­ta­tion and how it is becom­ing more main­stream in medicine.

Teasers

50 Mind and Brain Games for adults: you may have seen these teasers, but we want to alert you we have opened a new sec­tion in the site where you can eas­ily find our grow­ing col­lec­tion of teasers

Your Haiku, please?: a friendly chal­lenge to your brain.

Edu­ca­tion and Life­long Learning

Carol Dweck on Mind­sets, Learn­ing and Intel­li­gence: we found a fas­ci­nat­ing inter­view on the impor­tance on hav­ing a growth and learn­ing ori­ented mind­set. Both for kids and adults.

Is Intel­li­gence Innate and Fixed?: some reflec­tions based on biology.

Cor­po­rate Train­ing, Well­ness and Leadership

Cog­ni­tive Fit­ness and The Future of Work: an excel­lent con­cept map on how neu­ro­science may influ­ence the work­place of the future, drawn in real time as I spoke at an Insti­tute for the Future event.

Emo­tional Intel­li­gence and Faces: how many uni­ver­sal emo­tions and facial expres­sions are there?

Events

Use It or Lose It, and Cells that Fire together Wire together: I spoke at the Ital­ian Con­sulate in San Fran­cisco, where we explored some of the basic con­cepts we should all know about how our brains and mind work.

Let me prac­tice the Grat­i­tude concept…Thank You for your atten­tion and participation!

You can also enjoy our pre­vi­ous edi­tions of this monthly digest:

- Octo­ber

- Sep­tem­ber

- August

- July

Quotes from a great arti­cle, Pro­fes­sor, 81, proves brain stays young:

- In 1960, Dia­mond became the first female fac­ulty mem­ber in Cal’s sci­ence depart­ment, achiev­ing full pro­fes­sor­ship in 1974. She still teaches anatomy with her 81st birth­day two weeks away.

- Dia­mond, a pro­fes­sor of anatomy at UC Berke­ley, deter­mined that the brain can stay young through stim­u­la­tion, which can be achieved through her five-point plan: diet, exer­cise, chal­lenge, new­ness and ten­der lov­ing care.

- Using her plan, how is she challenged?

- “Every stu­dent who sits in that chair,” she said, point­ing across the desk in her fifth-floor office in the Life Sci­ences Build­ing on cam­pus. “They come in here ask­ing ques­tions, and you bet­ter have the answers.”

- What new­ness, then, is in her life?

- “I have grand­chil­dren,” she said. “What could be bet­ter, decid­ing new things for them, to stim­u­late their brains.”

- She has four chil­dren, four grand­chil­dren and a hus­band, Arnold Schei­del, who teaches anatomy at UCLA. They see each other on school weekends,

- Dia­mond feels her own brain growing.

Keep read­ing here.

Related resources

A pre­vi­ous post list­ing a num­ber of her essays: Mar­ian Dia­mond and the Brain Revolution

Her great book Magic Trees of the Mind: How to Nur­ture Your Child’s Intel­li­gence, Cre­ativ­ity, and Healthy Emo­tions from Birth Through Ado­les­cence, by Berkeley’s Mar­ian Dia­mond and Janet L. Hopson.

We had a very fun ses­sion titled Teach­ing Brain Fit­ness in Your Com­mu­nity at an Amer­i­can Soci­ety on Aging (ASA) con­fer­ence for health pro­fes­sion­als a cou­ple of weeks ago. Full house, with over 60 atten­dants and very good par­tic­i­pa­tion, show­ing great inter­est in the topic. I can’t wait to see the evaluations.

These are some of the resources I promised as a follow-up, which can be use­ful to every­one inter­ested in our field:

Good gen­eral arti­cles in the busi­ness and gen­eral media:

Change or Die

Want a sharp mind for your golden years? Start now

You’re Wiser Now

On how new neu­rons are born and grow in the adult brain:

Salk Sci­en­tists Demon­strate For The First Time That Newly Born Brain Cells Are Func­tional In The Adult Brain

Old Brains, New Tricks

On the sur­pris­ing plas­tic­ity and devel­op­ment poten­tial through­out life:

Brain Plas­tic­ity, Lan­guage Pro­cess­ing and Reading

Jug­gling Jug­gles the Brain

Suc­cess­ful Aging of the Healthy Brain

Other impor­tant aspects:

Stress and the Brain

Exer­cise and the Brain

Humor, Laugh­ter and The Brain

On the impor­tance and impact of men­tal stim­u­la­tion and train­ing: Read the rest of this entry »

Alvaro and I had the good for­tune to attend a great con­fer­ence last week called Learn­ing & The Brain: Enhanc­ing Cog­ni­tion and Emo­tions for Learn­ing. It was a fas­ci­nat­ing mix of neu­ro­sci­en­tists and edu­ca­tors talk­ing with and lis­ten­ing to each other. Some top­ics were meant to be applied today, but many were food for thought — insight on where sci­ence and edu­ca­tion are headed and how they influ­ence each other.

Using dra­matic new imag­ing tech­niques, such as fMRIs, PET, and SPECT, neu­ro­sci­en­tists are gain­ing valu­able infor­ma­tion about learn­ing. This pio­neer­ing knowl­edge is lead­ing not only to new ped­a­go­gies, but also to new med­ica­tions, brain enhance­ment tech­nolo­gies, and ther­a­pies.… The Con­fer­ence cre­ates an inter­dis­ci­pli­nary forum — a meet­ing place for neu­ro­sci­en­tists, edu­ca­tors, psy­chol­o­gists, clin­i­cians, and par­ents — to exam­ine these new research find­ings with respect to their applic­a­bil­ity in the class­room and clin­i­cal practice.

Take-aways

• Humans are a mix­ture of cog­ni­tion and emo­tion, and both ele­ments are essen­tial to func­tion and learn properly
• Edu­ca­tors and pub­lic pol­icy mak­ers need to learn more about the brain, how it grows, and how to cul­ti­vate it
• Stu­dents of all ages need to be both chal­lenged and nur­tured in order to succeed
• Peo­ple learn dif­fer­ently — try to teach and learn through as many dif­fer­ent modal­i­ties as pos­si­ble (engage lan­guage, motor skills, artis­tic cre­ation, social inter­ac­tion, sen­sory input, etc.)
• While short-term stress can heighten your cog­ni­tive abil­i­ties, long term stress kills you — you need to find bal­ance and release
• Test anx­i­ety and sub­se­quent poor test results can be improved with behav­ioral train­ing with feed­back based on heart rate variability
• Dr. Robert Sapol­sky is a very very enlight­en­ing and fun speaker
• Allow time for rest and con­sol­i­da­tion of learned material
• Emo­tional mem­o­ries are eas­ier to remember
• Con­fer­ences like these per­form a real ser­vice in fos­ter­ing dia­logues between sci­en­tists and educators

Read the rest of this entry »

Con­tin­u­ing with the theme of a Week of Sci­ence spon­sored by Just Sci­ence, we will high­light some of the key points in: Appel­hans BM, Luecken LJ. Heart Rate Vari­abil­ity as an Index of Reg­u­lated Emo­tional Respond­ing. Review of Gen­eral Psy­chol­ogy. 2006;10:229–240.

Defin­ing Heart Rate Vari­abil­ity
Effec­tive emo­tional reg­u­la­tion depends on being able to flex­i­bly adjust your phys­i­o­log­i­cal response to a chang­ing environment.

“… heart rate vari­abil­ity (HRV) is a mea­sure of the con­tin­u­ous inter­play between sym­pa­thetic and parasym­pa­thetic influ­ences on heart rate that yields infor­ma­tion about auto­nomic flex­i­bil­ity and thereby rep­re­sents the capac­ity for reg­u­lated emo­tional responding.”

“HRV reflects the degree to which car­diac activ­ity can be mod­u­lated to meet chang­ing sit­u­a­tional demands.”

The sym­pa­thetic (SNS) and parasym­pa­thetic (PNS) branches of the auto­nomic ner­vous sys­tem (ANS) antag­o­nis­ti­cally influ­ence the lengths of time between con­sec­u­tive heart­beats. Faster heart rates, which can be due to increased SNS and/or lower PNS activ­ity, cor­re­spond to a shorter inter­beat inter­val while slower heart rates have a longer inter­beat inter­val, which can be attrib­uted to increased PNS and/or decreased SNS activity.

The frequency-based HRV analy­ses are based on the fact that the vari­a­tions in heart rate pro­duced by SNS and PNS activ­ity occur at dif­fer­ent speeds, or fre­quen­cies. SNS is slow act­ing and medi­ated by nor­ep­i­neph­rine while PNS influ­ence is fast act­ing and medi­ated by acetylcholine.

Read the rest of this entry »