I hope you are hav­ing happy hol­i­days, and are get­ting ready for New Year cel­e­bra­tions. Best wishes to you and your loved ones.

Via Med­Jour­nal­Watch we just found this inter­est­ing paper,

Asso­ci­a­tions of job demands and intel­li­gence with cog­ni­tive per­for­mance among men in late life. Guy G. Pot­ter PhD^*, Michael J. Helms BS, and Brenda L. Plass­man PhD Neu­rol­ogy 2007.

- CONCLUSIONS: “Intel­lec­tu­ally demand­ing work was asso­ci­ated with greater ben­e­fit to cog­ni­tive per­for­mance in later life inde­pen­dent of related fac­tors like edu­ca­tion and intel­li­gence. The fact that indi­vid­u­als with lower intel­lec­tual apti­tude demon­strated a stronger pos­i­tive asso­ci­a­tion between work and higher cog­ni­tive per­for­mance dur­ing retire­ment sug­gests that behav­ior may enhance intel­lec­tual reserve, per­haps even years after peak intel­lec­tual activity.”

This is con­sis­tent with the Cog­ni­tive Reserve the­ory we dis­cussed in the inter­view with neu­ro­sci­en­tist Yaakov Stern:

- AF (Alvaro Fer­nan­dez): OK, so our goal is to build that Reserve of neu­rons, synapses, and skills. How can we do that? What defines “men­tally stim­u­lat­ing activ­i­ties” or good “brain exercise”?

- YS (Yaakov Stern): In sum­mary, we could say that “stim­u­la­tion” con­sists of engag­ing in activ­i­ties. In our research almost all activ­i­ties are seen to con­tribute to reserve. Some have chal­leng­ing lev­els of cog­ni­tive com­plex­ity, and some have inter­per­sonal or phys­i­cal demands. In ani­mal stud­ies, expo­sure to an enriched envi­ron­ment or increased phys­i­cal activ­ity result in increased neu­ro­ge­n­e­sis (the cre­ation of new neu­rons). You can get that stim­u­la­tion through edu­ca­tion and/ or your occu­pa­tion. There is clear research show­ing how those two ele­ments reduce the risk. Now, what is very excit­ing is that, no mat­ter one’s age, edu­ca­tion and occu­pa­tion, our level of par­tic­i­pa­tion in leisure activ­i­ties has a sig­nif­i­cant and cumu­la­tive effect. A key mes­sage here is that dif­fer­ent activ­i­ties have inde­pen­dent, syn­er­gis­tic, con­tri­bu­tions, which means the more things you do and the ear­lier you start, the bet­ter. But you are never stuck: bet­ter late than never.

- Read more on the Cog­ni­tive Reserve

In short, men­tally and socially stim­u­lat­ing activ­i­ties, through our edu­ca­tion, occu­pa­tion AND leisure activ­i­ties, con­tribute to build­ing a Cog­ni­tive Reserve in our brains that may help delay mem­ory prob­lems, Mild Cog­ni­tive Impair­ment, and Alzheimer’s related symp­toms, and help main­tain cog­ni­tive per­for­mance over­all as we age.

If you are think­ing about New Year Res­o­lu­tions, this is one more area to con­sider. Happy 2008!

Given the grow­ing num­ber of arti­cles in the pop­u­lar press men­tion­ing words such as “neu­ro­plas­tic­ity”, “fMRI” and “cog­ni­tive reserve”, let’s review some key find­ings, con­cepts and terms.

First, a pre­scient quote by Span­ish neu­ro­sci­en­tist San­ti­ago Ramon y Cajal (1852–1934): “Every man can, if he so desires, become the sculp­tor his own brain”.

Thanks to new neu­roimag­ing tech­niques, regarded “as impor­tant for neu­ro­science as tele­scopes were for astron­omy, neu­ro­sci­en­tists and cog­ni­tive psy­chol­o­gists have been find­ing that the brain has a num­ber of “core capac­i­ties” and “men­tal mus­cles” that can be exer­cised through nov­elty, vari­ety and prac­tice, and that exer­cis­ing our brain can influ­ence the gen­er­a­tion of new neu­rons and their con­nec­tions. Brain exer­cise is being rec­og­nized, there­fore, as a crit­i­cal pil­lar of brain health, together with nutri­tion, phys­i­cal exer­cise and stress management.

Pre­vi­ous beliefs about our brain and how it works have been proven false. Some beliefs that have been debunked include claims that adult brains can not cre­ate new neu­rons (shown to be false by Berke­ley sci­en­tists Mar­ian Dia­mond and Mark Rosen­zweig, and Salk Institute’s Fred Gage), notions that work­ing mem­ory has a max­i­mum limit of 6 or 7 items (debunked by Karolin­ska Insti­tute Torkel Kling­berg), and assump­tions that the brain’s basic processes can not be reor­ga­nized by repeated prac­tice (UCSF’s Drs. Paula Tal­lal and Michael Merzenich). The “men­tal mus­cles” we can train include atten­tion, stress and emo­tional man­age­ment, mem­ory, visual/ spa­tial, audi­tory processes and lan­guage, motor coor­di­na­tion and exec­u­tive func­tions like plan­ning and problem-solving.

Men­tal stim­u­la­tion is impor­tant if done in the right sup­port­ive and engag­ing envi­ron­ment. Stanford’s Robert Sapol­sky has proven that chronic stress and cor­ti­cal inhi­bi­tion, which may be aggra­vated due to imposed men­tal stim­u­la­tion, may prove coun­ter­pro­duc­tive. Hav­ing the right moti­va­tion is essential.

A sur­pris­ing and promis­ing area of sci­en­tific inquiry is Mindfulness-Based Stress Reduc­tion (MBSR). An increas­ing num­ber of neu­ro­sci­en­tists (such as Uni­ver­sity of Wisconsin-Madison’s Richard David­son) are inves­ti­gat­ing the abil­ity of trained med­i­ta­tors to develop and sus­tain atten­tion and visu­al­iza­tions and to work pos­i­tively with pow­er­ful emo­tional states and stress through the directed men­tal processes of med­i­ta­tion practices.

And now, some keywords:

Brain Fit­ness Pro­gram: struc­tured set of brain exer­cises, usu­ally computer-based, designed to train spe­cific brain areas and processes in tar­geted ways.

Chronic Stress: ongo­ing, long-term stress, which blocks the for­ma­tion of new neu­rons and Read the rest of this entry »

Here is ques­tion 21 from Brain Fit­ness 101: Answers to Your Top 25 Ques­tions.

Ques­tion:

I am busy exec­u­tive with a chal­leng­ing job. How is brain fit­ness rel­e­vant to me?

Key Points:

• Reduce your stress to improve con­cen­tra­tion and learn­ing readi­ness and reduce distractions.
• Increase your men­tal stim­u­la­tion to help main­tain a healthy, flex­i­ble brain.

Answer:

Exec­u­tives, or any­one involved in com­plex and rapidly evolv­ing envi­ron­ments, need to make pres­sured deci­sions based on sound logic, instead of emo­tional impulses. It is not easy to deal with the frus­tra­tion, for exam­ple, when Read the rest of this entry »

We have explained before how men­tal stim­u­la­tion is impor­tant if done in the right sup­port­ive and engag­ing envi­ron­ment. Stanford’s Robert Sapol­sky and oth­ers’ have shown that chronic stress and cor­ti­cal inhi­bi­tion, which may be aggra­vated due to imposed men­tal stim­u­la­tion, may prove coun­ter­pro­duc­tive. Hav­ing the right moti­va­tion is essential.

A promis­ing area of sci­en­tific inquiry for stress man­age­ment’ is Mindfulness-Based Stress Reduc­tion (MBSR).’ You may have read about it in Sharon Begley’s’ Train Your Mind, Change Your Brain’ book. An increas­ing num­ber of neu­ro­sci­en­tists (such as UMass Med­ical School’s Jon Kabat-Zinn and Uni­ver­sity of Wisconsin-Madison’s Richard David­son) have been inves­ti­gat­ing the abil­ity of trained med­i­ta­tors to develop and sus­tain atten­tion and visu­al­iza­tions and to work pos­i­tively with pow­er­ful emo­tional states and stress through the directed men­tal processes of med­i­ta­tion prac­tices. And have put their research into prac­tice for the ben­e­fit of many hos­pi­tal patients through their MSBR programs.

A Stan­ford psy­chol­o­gist and friend recently alerted me to a sim­i­lar pro­gram orga­nized Read the rest of this entry »