I hope you are hav­ing happy hol­i­days, and are get­ting ready for New Year cel­e­bra­tions. Best wishes to you and your loved ones.

Via Med­Jour­nal­Watch we just found this inter­est­ing paper,

Asso­ci­a­tions of job demands and intel­li­gence with cog­ni­tive per­for­mance among men in late life. Guy G. Pot­ter PhD^*, Michael J. Helms BS, and Brenda L. Plass­man PhD Neu­rol­ogy 2007.

- CONCLUSIONS: “Intel­lec­tu­ally demand­ing work was asso­ci­ated with greater ben­e­fit to cog­ni­tive per­for­mance in later life inde­pen­dent of related fac­tors like edu­ca­tion and intel­li­gence. The fact that indi­vid­u­als with lower intel­lec­tual apti­tude demon­strated a stronger pos­i­tive asso­ci­a­tion between work and higher cog­ni­tive per­for­mance dur­ing retire­ment sug­gests that behav­ior may enhance intel­lec­tual reserve, per­haps even years after peak intel­lec­tual activity.”

This is con­sis­tent with the Cog­ni­tive Reserve the­ory we dis­cussed in the inter­view with neu­ro­sci­en­tist Yaakov Stern:

- AF (Alvaro Fer­nan­dez): OK, so our goal is to build that Reserve of neu­rons, synapses, and skills. How can we do that? What defines “men­tally stim­u­lat­ing activ­i­ties” or good “brain exercise”?

- YS (Yaakov Stern): In sum­mary, we could say that “stim­u­la­tion” con­sists of engag­ing in activ­i­ties. In our research almost all activ­i­ties are seen to con­tribute to reserve. Some have chal­leng­ing lev­els of cog­ni­tive com­plex­ity, and some have inter­per­sonal or phys­i­cal demands. In ani­mal stud­ies, expo­sure to an enriched envi­ron­ment or increased phys­i­cal activ­ity result in increased neu­ro­ge­n­e­sis (the cre­ation of new neu­rons). You can get that stim­u­la­tion through edu­ca­tion and/ or your occu­pa­tion. There is clear research show­ing how those two ele­ments reduce the risk. Now, what is very excit­ing is that, no mat­ter one’s age, edu­ca­tion and occu­pa­tion, our level of par­tic­i­pa­tion in leisure activ­i­ties has a sig­nif­i­cant and cumu­la­tive effect. A key mes­sage here is that dif­fer­ent activ­i­ties have inde­pen­dent, syn­er­gis­tic, con­tri­bu­tions, which means the more things you do and the ear­lier you start, the bet­ter. But you are never stuck: bet­ter late than never.

- Read more on the Cog­ni­tive Reserve

In short, men­tally and socially stim­u­lat­ing activ­i­ties, through our edu­ca­tion, occu­pa­tion AND leisure activ­i­ties, con­tribute to build­ing a Cog­ni­tive Reserve in our brains that may help delay mem­ory prob­lems, Mild Cog­ni­tive Impair­ment, and Alzheimer’s related symp­toms, and help main­tain cog­ni­tive per­for­mance over­all as we age.

If you are think­ing about New Year Res­o­lu­tions, this is one more area to con­sider. Happy 2008!

Very good arti­cle in the LA Times today. Like a Stair­Mas­ter for the brain: Can men­tal work­outs improve the mind’s agility? Baby boomer con­cerns stim­u­late an indus­try expan­sion.

The reporter, Melissa Healy, reviews the healthy aging seg­ment in the Brain Fit­ness field. A few selected quotes:

- “There is plau­si­bil­ity, both bio­log­i­cal and behav­ioral, to the claim that these may work,” says Molly Wag­ster, chief of the National Insti­tute on Aging’s neu­ropsy­chol­ogy branch. “But it is still a sit­u­a­tion of ‘buyer beware.’ ”

- “I see this as a new fron­tier of fit­ness over­all,” says Alvaro Fer­nan­dez, founder and chief exec­u­tive of the web­site Sharp­Brains .com, which tracks the busi­ness and sci­ence of brain-training. Amer­i­cans already under­stand the value of phys­i­cal fit­ness as a means of pre­serv­ing the body’s proper func­tion and pre­vent­ing age-related dis­eases, says Fer­nan­dez. He pre­dicts that cog­ni­tive fit­ness will become a goal to which Amer­i­cans equally aspire as we learn more about aging and the brain.
– (Dr. Elkhonon) Gold­berg, who pro­vides sci­en­tific advice on the web­site http://www.sharpbrains.com/, says that as neu­ro­sci­en­tists use imag­ing tech­nolo­gies to “see” the cel­lu­lar changes that come with learn­ing, he grows more con­fi­dent that well-designed train­ing pro­grams can have dis­cernible every­day effects in pre­serv­ing or repair­ing the intel­lec­tual func­tion of older adults. “This is shared hard­ware” that’s being changed in the brain, “and to the extent you some­how enhance it, that will have wide-ranging effects,” Gold­berg says. “It pro­vides a much more com­pelling raison­tre for this whole business.”

The arti­cle adds that “Amer­i­cans this year are expected to invest $225 mil­lion in these pro­grams — up from just $70 mil­lion in 2003 — in an effort to tune up the brain, strengthen the mem­ory and fore­stall or reverse the cog­ni­tive slip­page that often comes with age, psy­chi­atric dis­ease, stroke or med­ical treatments.”

Our break­down for those 2007 US pre­dic­tions are as fol­lows: $80m for the Con­sumer seg­ment, $60m in K12 Edu­ca­tion, $50m in Clin­i­cal appli­ca­tions, and $35m in the Cor­po­rate seg­ment. The Con­sumer seg­ment, with a healthy aging value propo­si­tion, is the most recent one but the most rapidly growing.

Read the full arti­cle: Like a Stair­Mas­ter for the brain.

PS: the arti­cle also says “In the last three years, these brainpower-boosting pro­grams have pro­lif­er­ated, with names like Mind­Fit, Happy Neu­ron, Brain Fit­ness and Lumos­ity.”.. if there are reporters read­ing this, please avoid future con­fu­sion by nam­ing Posit Science’s pro­gram “Posit Sci­ence Brain Fit­ness Pro­gram 2.0″. Brain Fit­ness refers to the full category.

Very intense week, and very fun. I will be writ­ing more about this week’s 3 speak­ing events, but let me say now that our key messages

1) our brains remain flex­i­ble dur­ing our lifetimes,

2) we can refine our brains with tar­geted practice,

3) good brain exer­cise, or “men­tal cross-training”, requires nov­elty, vari­ety, and increas­ing level of chal­lenge (but with­out cre­at­ing too much stress),

are being very well accepted from both healthy aging and work­place pro­duc­tiv­ity points of view. We have ONE brain: health and pro­duc­tiv­ity are 2 sides of the same coin.

If you want to make sure we learn more about our brains, you can help fel­low blog­ger Shel­ley Batts get a col­lege schol­ar­ship by voting here. She has a great neu­ro­science blog, is now final­ist in a com­pe­ti­tion to win a nice schol­ar­ship, and needs out help.

Have some more time? You can watch this excellent 90-second video of cog­ni­tive neu­ro­sci­en­tist Dr Lisa Sak­sida doing yoga in front of the fire while explain­ing the nature of Brain and Mind (via Mind­Hacks). Quotes:

“I wish peo­ple under­stood that there is no mind/brain dual­ity. Specif­i­cally, I wish peo­ple under­stood that there is no such thing as a purely psy­cho­log­i­cal dis­or­der. Every event in your psy­cho­log­i­cal life, and there­fore every psy­cho­log­i­cal change, is reducible in the­ory to events and changes in your brain. We should there­fore not judge peo­ple dif­fer­ently, accord­ing to whether they are con­sid­ered to have a ‘psy­cho­log­i­cal’ as opposed to a ‘neu­ro­log­i­cal’ problem.”

“Of course, a lack of mind/brain split does not mean that we should aban­don all talk of psy­chol­ogy. Psy­chol­ogy and neu­ro­science are two ways of study­ing the same thing, and both are essen­tial for under­stand­ing the human condition.”

For more, check the posts in these always great blog car­ni­vals (selected col­lec­tions of blog posts by a num­ber of blog­gers around spe­cific topics)

Tan­gled Bank (sci­ence in general)

Encephalon (neu­ro­science)

Credit: Photo of Neu­rons by sym­pha­nee via flickr

The Aspen Health Forum gath­ered an impres­sive group of around 250 peo­ple to dis­cuss the most press­ing issues in Health and Med­ical Sci­ence (check out the Pro­gram and the Speak­ers bios), on Octo­ber 3-6th. It was the first con­fer­ence, by the way, where I have heard a speaker say: “I resus­ci­tated a woman yesterday”.

Key high­lights and trends:

1– Global health prob­lems require the atten­tion of the sci­en­tific com­mu­nity. Richard Klaus­ner encour­aged the sci­en­tific com­mu­nity to focus on Global Prob­lems: mater­nal mor­tal­ity rates, HIV/ AIDS, nutri­tion, can­cer, clean water.  Bill Frist, for­mer Sen­ate Major­ity Leader, added to that list the increas­ing epi­demic risks of global zootic dis­eases (trans­mit­ted between humans and ani­mals), sup­ported by 2 inter­est­ing data points: at any one moment, there are 500,000 peo­ple fly­ing world­wide; in a year, air­lines trans­port the equiv­a­lent of 2 bil­lion passengers.

2– “Let’s get real…Ideology kills”. Mary Robin­son, for­mer Pres­i­dent of Ire­land, on what it takes to stop HIV/ AIDS: “I am from Ire­land, a Catholic coun­try. And I am Catholic. But I can see how ide­ol­ogy kills..we need more empa­thy with real­ity, and to work with local women in those coun­tries who need things like female con­doms.” She was implic­itly crit­i­ciz­ing the large bud­get devoted to unre­al­is­tic absti­nence pro­grams. This ses­sion included a fas­ci­nat­ing exchange where Bill Frist rose from the audi­ence to defend the role of US aid, explain­ing how 60% of retro­vi­ral drugs in African coun­tries have been funded by the Amer­i­can tax­payer, high­light­ing Pres­i­dent Bush’s courage to make HIV/AIDS a top agenda item in many devel­op­ing coun­tries, and crit­i­ciz­ing other coun­tries for not doing enough. Which made Nobel Prize Lau­re­ate Peter Agre, also in the audi­ence, stand up and encour­age the US to really step up to the plate and devote 1% of the GDP to aid, as a num­ber of Euro­pean coun­tries do, instead of 0.1%.

3– Where is the new “Sput­nik”?: Basic sci­ence is cru­cial for inno­va­tion and for eco­nomic growth, but it is often under­ap­pre­ci­ated. Sci­en­tists are not “nerds”, as some­times they are por­trayed in pop­u­lar cul­ture, but peo­ple with a deep curios­ity and drive to solve a Big prob­lem. Many of the speak­ers had been inspired by the Sput­nik and the Apollo mis­sions to become sci­en­tists, at a time when the pro­fes­sion was con­sid­ered cool. Two Nobel Prize Lau­re­ates (Peter Agre, Michael Bishop), talked about their lives and careers try­ing to demys­tify what it takes to be a sci­en­tist and to win a Nobel Prize. Both are grate­ful to the tax­pay­ers dol­lars that funded their research, and insist we must do a bet­ter job at explain­ing the sci­en­tific process to soci­ety at large. Both are proud of hav­ing attended small lib­eral arts col­leges, and hav­ing evolved from there, fueled by their great curios­ity and unpre­dictable, serendip­i­tous paths, into launch­ing new sci­en­tific and med­ical fields.  Bishop listed a num­ber of times where he made deci­sions that were con­sid­ered “career sui­cide” by men­tors and col­leagues, and men­tioned “I was con­fused” around 15 times in 15 minutes…down to earth and inspiring.

4– We need a true Health Care Cul­ture: Mark Ganz sum­ma­rized it best by explain­ing how his health provider group improved care when they rede­fined them­selves from “we are 7,000 employ­ees” to “we are a 3 mil­lion strong com­mu­nity”, mov­ing from Read the rest of this entry »

Grow­ing media atten­tion on the brain fit­ness field. At least on the “Healthy Aging” seg­ment (I pre­dict the media with catch up soon with devel­op­ments in other areas, from cog­ni­tive train­ing for kids and adults with ADD/ ADHD to stroke and TBI reha­bil­i­ta­tion, to peak per­for­mance for cor­po­rate training).

First, a superb arti­cle by Leslie Walker at the Wash­ing­ton Post: Cross-Training Your Brain to Main­tain Its Strength

Quotes:  “A grow­ing body of research sug­gests that men­tal activ­ity in mid­dle age and ear­lier can help later in life. As a result, Web sites such as HappyNeuron.com are spring­ing up to offer online games to peo­ple of all ages, while blogs like SharpBrains.com pro­vide com­men­tary on the fledg­ling indus­try.” (Note: we can also pro­vide com­men­tary on the commentary!)

“Peo­ple who engage in very chal­leng­ing tasks — not just in work but dur­ing leisure activ­i­ties such as read­ing, cross­word puz­zles, bridge, chess and travel — tend to slow down their men­tal aging process very sig­nif­i­cantly,” says Breznitz, who is also a mem­ber of Israel’s leg­is­la­ture and has devel­oped a brain-training pro­gram called MindFit.”

“Also con­tribut­ing to the brain work­out boom are state-of-the-art imag­ing tech­niques that have allowed sci­en­tists to val­i­date a the­ory devel­oped decades ago. By tak­ing detailed pic­tures of brain neu­rons, sci­en­tists watch parts of the brain that had seemed dor­mant light up and assume new respon­si­bil­i­ties in response to stim­uli. The­o­ret­i­cally, this means brain decay can be halted or even reversed.”

“The brain is con­stantly rewiring and recal­i­brat­ing itself in response to what you do,” says Henry Mah­ncke, who holds a PhD in neu­ro­science and is vice pres­i­dent of Posit Sci­ence, the San Fran­cisco devel­oper of the Brain Fit­ness soft­ware. “It remakes itself into a more effi­cient oper­a­tion to do the things you ask it to do.”

Com­ments: the arti­cle touches many key points. I espe­cially enjoy the quote “To be effec­tive, sci­en­tists say men­tal activ­ity must become pro­gres­sively more chal­leng­ing. Oth­er­wise, the brain adjusts and learns to per­form repet­i­tive tasks with less effort”, a key mes­sage I make often in my lec­tures to explain why well-designed pro­grams can be more effec­tive than doing cross­word puz­zle num­ber 512,789. The arti­cle also relates how many retire­ment com­mu­ni­ties and senior cen­ters and indi­vid­u­als are try­ing out the new brain fit­ness pro­grams com­ing to mar­ket, and shows some healthy skep­ti­cism on the state of the research. Now, this is an invi­ta­tion to the reporter to inter­view neu­ropsy­chol­o­gist Dr. Elkhonon Gold­berg to get the full pic­ture of the sci­ence behind the field, since these pro­grams haven’t appeared in a vac­uum. Our 10-Question Eval­u­a­tion Check­list can pro­vide use­ful guid­ance to any­one con­sid­er­ing a program.

Boomers use online brain games to stave off demen­tia (AccountingWeb)

Quotes: “The Inter­net offers a plethora of brain games for those who don’t sub­scribe to a daily news­pa­per or don’t want to pur­chase games. AARP, for exam­ple, offers plenty of free games on its site. More games appear at SharpBrains.com, includ­ing a page that con­tains the Top Ten Neu­ro­science Brain­teasers, and you can sign up to have the Col­lege Board e-mail you the SAT ques­tion of the day.”

“The gen­er­a­tion that refuses to age is not going to sit back and wait for Alzheimer’s Dis­ease and other signs of demen­tia to take hold. Instead, savvy Baby Boomers are expand­ing their minds (no, not the way they did in the 60s) with the aid of the com­puter, puz­zles, and games. A brain health move­ment is sweep­ing Read the rest of this entry »

There has been an inter­est­ing dis­cus­sion about the issues related to the aging of the legal pro­fes­sion. Stephanie intro­duced us to the arti­cle “the Gray­ing Bar: let’s not for­get the ethics” by David Giacalone.

In short: sta­tis­tics about the increas­ing ratio of lawyers over 70 in active prac­tice, on the one hand, and the gen­eral inci­dence of Alzheimer’s and other demen­tias, on the other, lead David to point out an increas­ing like­li­hood that some lawyers may be prac­tic­ing in less than ideal con­di­tions for their clients, beyond a rea­son­able “brain age”. The ques­tion then becomes: who and how can solve this prob­lem, which is only going to grow given demo­graphic trends?.

We are not legal experts, but would like to inform the debate by offer­ing 10 con­sid­er­a­tions on healthy aging and job per­for­mance from a neu­ropsy­cho­log­i­cal point of view, that apply to all occupations:

1– We should talk more about change than about decline, as Sharon Beg­ley wrote recently in her great arti­cle on The Upside of Aging — WSJ.com (sub­scrip­tion required).

We dis­cussed some of these effects with Dr. Elkhonon Gold­berg, who wrote his great book The Wis­dom Para­dox pre­cisely on this point, at The Exec­u­tive Brain and How our Minds Can Grow Stronger.

2– Some skills improve as we age: In our “Exer­cis­ing Our Brains” Classes, we typ­i­cally explain how some areas typ­i­cally improve as we age, such as self-regulation, emo­tional func­tion­ing and Wis­dom (which means mov­ing from Prob­lem solv­ing to Pat­tern recog­ni­tion). As a lawyer accu­mu­lates more cases under his/ her belt, he or she devel­ops an auto­matic “intu­ition” for solu­tions and strate­gies. As long as the envi­ron­ment doesn’t change too rapidly, this grow­ing wis­dom is very valuable.

3– …whereas, yes, oth­ers typ­i­cally decline: Read the rest of this entry »

Here is ques­tion 18 of 25 from Brain Fit­ness 101: Answers to Your Top 25 Ques­tions.

Ques­tion:
Is phys­i­cal fit­ness impor­tant to your brain fitness?

Key Points:

• Exer­cise improves learn­ing through increased blood sup­ply and growth hormones.
• Exer­cise is an anti-depressant by reduc­ing stress and pro­mot­ing neurogenesis.
• Exer­cise pro­tects the brain from dam­age and dis­ease, as well as speed­ing the recovery.
• Exer­cise ben­e­fits you the most when you start young.

Answer:
Read the rest of this entry »