Rewiring the Brain to Ease Pain (Wall Street Journal):-

“How you think about pain can have a major impact on how it feels. That’s the intrigu­ing con­clu­sion neu­ro­sci­en­tists are reach­ing as scan­ning tech­nolo­gies let them see how the brain processes pain. That’s also the prin­ci­ple behind many mind-body approaches to chronic pain that are prov­ing sur­pris­ingly effec­tive in clin­i­cal tri­als. Some are as old as med­i­ta­tion, hyp­no­sis and tai chi, while oth­ers are far more high tech.”

Link to Study Towards a physiology-based mea­sure of pain (PloS One): Read the rest of this entry »

‘Chemo Brain’: MRI Shows Brain Changes After Chemother­apy (Medscape):

- “Breast can­cer sur­vivors who have been treated with chemother­apy show sig­nif­i­cant changes in brain activ­ity, mea­sured by func­tional mag­netic res­o­nance imag­ing (fMRI), accord­ing to a study pub­lished in the Novem­ber issue of the Archives of Neu­rol­ogy.”

- “The find­ing val­i­dates patients’ claims of reduced cog­ni­tive func­tion after receiv­ing chemother­apy, a phe­nom­e­non referred to as “chemo brain,” said lead author Shelli R. Kesler, PhD, from Stan­ford Uni­ver­sity School of Med­i­cine in California.”

Link to study Pre­frontal Cor­tex and Exec­u­tive Func­tion Impair­ments in Pri­mary Breast Can­cer (Archives of Neu­rol­ogy): Read the rest of this entry »

In two inno­v­a­tive pilot stud­ies, Ian Gotlib and his col­leagues at Stan­ford Uni­ver­sity, Cal­i­for­nia, showed that brain train­ing can be used to help elim­i­nate depres­sion, even before it starts. They stud­ied young girls (10 to 14 year old) whose moth­ers were depressed and who thus were at higher risk of devel­op­ing depres­sion them­selves later-on. The girls had not expe­ri­enced depres­sion per se but already showed behav­iors typ­i­cal of depressed brains, such as over­re­ac­tion to neg­a­tive stim­uli. Read the rest of this entry »

NIH-funded study finds dyslexia not tied to IQ (NIH press release):

At left, brain areas active in typ­i­cally devel­op­ing read­ers engaged in a rhyming task. Shown at right is the brain area acti­vated in poor read­ers involved in the same task.

- “Regard­less of high or low over­all scores on an IQ test, chil­dren with dyslexia show sim­i­lar pat­terns of brain activ­ity, accord­ing to researchers sup­ported by the National Insti­tutes of Health. The results call into ques­tion the dis­crep­ancy model — the prac­tice of clas­si­fy­ing a child as dyslexic on the basis of a lag between read­ing abil­ity and over­all IQ scores.”

- “In many school sys­tems, the dis­crep­ancy model is the cri­te­rion for Read the rest of this entry »

Cog­ni­tive per­for­mance can be improved but peo­ple vary in their abil­ity to do so. It is not clear yet how to assess who will ben­e­fit the most from train­ing and the cog­ni­tive tests used in the past were not very good at pre­dict­ing this.

Dr. Kramer and his col­leagues recently showed that the brain activ­ity in a spe­cific part of the brain (the dor­sal stria­tum) at the start of train­ing in a com­plex video-game could accu­rately pre­dict how well peo­ple will ben­e­fit from the train­ing. Thirty-four young adults with lit­tle expe­ri­ence in play­ing video games were trained to play a com­plex video game Read the rest of this entry »

This is a par­tial list of the lit­er­a­ture we reviewed dur­ing the research phase of our new book, The Sharp­Brains Guide to Brain Fit­ness.  We know many friends of Sharp­Brains are researchers, health­care pro­fes­sion­als, graduate/ Ph.D. stu­dents, who want have direct access to the ref­er­ences (per­haps PubMed should pro­mote itself as a never end­ing source of men­tal stim­u­la­tion?), so here you have this list, orga­nized by rel­e­vant chap­ter. Please note that the list below appears in the book — whose man­u­script we had to close in Jan­u­ary 2009.

Intro­duc­tion

Basak, C. et al. (2008). Can train­ing in a real-time strat­egy video game atten­u­ate cog­ni­tive decline in older adults? Psy­chol­ogy and Aging.
Beg­ley, S. (2007). Train your mind, change your brain: How a new sci­ence reveals our extra­or­di­nary poten­tial to trans­form our­selves. Bal­lan­tine Books.
DeKosky, S. T., et al. (2008). Ginkgo biloba for pre­ven­tion of demen­tia: a ran­dom­ized con­trolled trial. Jour­nal of the Amer­i­can Med­ical Asso­ci­a­tion, 300, 2253–2262.
Doidge, N. (2007). The Brain that changes itself: Sto­ries of per­sonal tri­umph from the fron­tiers of brain sci­ence. Viking Adult.

Chap­ter 1. The Brain and Brain Fit­ness 101

Bunge, S. A., & Wright, S. B. (2007). Neu­rode­vel­op­men­tal changes in work­ing mem­ory and cog­ni­tive con­trol. Cur­rent Opin­ion In Neu­ro­bi­ol­ogy, 17(2), 243–50.
Dama­sio, A. (1995). Descartes error: Emo­tion, rea­son, and the human brain. Pen­guin Press.
David Kolb, D. (1983). Expe­ri­en­tial learn­ing: Expe­ri­ence as the source of learn­ing and devel­op­ment. FT Press.
Dra­gan­ski, B., Gaser, C., Kem­per­mann, G., Kuhn, H. G., Win­kler, J., Buchel, C., & May A. (2006). Tem­po­ral and spa­tial dynam­ics of brain struc­ture changes dur­ing exten­sive learn­ing. The Jour­nal of Neu­ro­science, 261231, 6314–6317.
Gage, F. H., Kem­per­mann, G., & Song, H. (2007). Adult Neu­ro­ge­n­e­sis. Cold Spring Har­bor Lab­o­ra­tory Press, NY.
Gard­ner, H. (1983). Frames of Mind: The the­ory of mul­ti­ple intel­li­gences. New York: Basic Books.
Gaser, C. & Schlaug, G. (2003). Brain struc­tures dif­fer between musi­cians and non-musicians. The Jour­nal of Neu­ro­science, 23, 9240–9245. Read the rest of this entry »

Today’s kids are into multi-tasking. This is the gen­er­a­tion hooked on iPods, IM’ing, video games — not to men­tion TV! Many peo­ple in my gen­er­a­tion think it is won­der­ful that kids can do all these things simul­ta­ne­ously and are impressed with their competence.

Well, as a teacher of such kids when they reach col­lege, I am not impressed. Col­lege stu­dents these days have short atten­tion spans and have trou­ble con­cen­trat­ing. They got this way in sec­ondary school. I see this in the middle-school out­reach pro­gram I help run. At this age kids are really wrapped up in multi-tasking at the expense of focus.

Accord­ing to a Kaiser Fam­ily Foun­da­tion study last year, school kids in all grades beyond the sec­ond grade com­mit­ted, on aver­age, more than six hours per day to TV or videos, music, video games, and com­put­ers. Almost one-third reported that “most of the time” they did their home­work while chat­ting on the phone, surf­ing the Web, send­ing instant mes­sages, watch­ing TV, or lis­ten­ing to music.

Kids think that this enter­tain­ment while study­ing helps their learn­ing. It prob­a­bly does make learn­ing less tedious, but it clearly makes learn­ing less effi­cient and less effec­tive. Multi-tasking vio­lates every­thing we know about how mem­ory works. Now we have objec­tive sci­en­tific evi­dence that Read the rest of this entry »

Michael I. Pos­ner is a promi­nent sci­en­tist in the field of cog­ni­tive neu­ro­science. He is cur­rently an emer­i­tus pro­fes­sor of neu­ro­science at the Uni­ver­sity of Ore­gon (Depart­ment of Psy­chol­ogy, Insti­tute of Cog­ni­tive and Deci­sion Sci­ences). In August 2008, the Inter­na­tional Union of Psy­cho­log­i­cal Sci­ence made him the first recip­i­ent of the Dogan Prize “in recog­ni­tion of a con­tri­bu­tion that rep­re­sents a major advance in psy­chol­ogy by a scholar or team of schol­ars of high inter­na­tional reputation.”

Dr. Pos­ner, many thanks for your time today. I really enjoyed the James Arthur Lec­ture mono­graph on Evo­lu­tion and Devel­op­ment of Self-Regulation that you deliv­ered last year. Could you pro­vide a sum­mary of the research you presented?

I would empha­size that we human beings can reg­u­late our thoughts, emo­tions, and actions to a greater degree than other pri­mates. For exam­ple, we can choose to pass up an imme­di­ate reward for a larger, delayed reward.

We can plan ahead, resist dis­trac­tions, be goal-oriented. These human char­ac­ter­is­tics appear to depend upon what we often call “self-regulation.” What is excit­ing these days is that progress in neu­roimag­ing and in genet­ics make it pos­si­ble to think about self-regulation in terms of spe­cific brain-based networks.

Can you explain what self-regulation is?

All par­ents have seen this in their kids. Par­ents can see the remark­able trans­for­ma­tion as their chil­dren develop the abil­ity to reg­u­late emo­tions and to per­sist with goals in the face of dis­trac­tions. That abil­ity is usu­ally labeled ‚ self-regulation.

The other main area of your research is atten­tion. Can you explain the brain-basis for what we usu­ally call “attention”?

I have been inter­ested in how the atten­tion sys­tem devel­ops in infancy and early childhood.

One of our major find­ings, thanks to neu­roimag­ing, is that there is not one sin­gle “atten­tion”, but three sep­a­rate func­tions of atten­tion with three sep­a­rate under­ly­ing brain net­works: alert­ing, ori­ent­ing, and exec­u­tive atten­tion. Read the rest of this entry »

After about age 50, most peo­ple begin to expe­ri­ence a decline in mem­ory capa­bil­ity. Why is that? One obvi­ous answer is that the small arter­ies of the brain begin to clog up, often as a result of a life­time of eat­ing the wrong things and a lack of exer­cise. If that life­time has been stress­ful, many neu­rons may have been killed by stress hor­mones. Given the most recent sci­en­tific lit­er­a­ture, reviewed in my book Thank You, Brain, For All You Remem­ber. What You For­got Was My Fault, dead neu­rons can’t be replaced, except in the hip­pocam­pus, which is for­tu­nate for mem­ory because the hip­pocam­pus is essen­tial for mak­ing cer­tain kinds of mem­o­ries per­ma­nent. Another cause is incip­i­ent Alzheimer’s dis­ease; autop­sies show that many peo­ple have the lesions of the dis­ease but have never shown symp­toms, pre­sum­ably because a life­time of excep­tional men­tal activ­ity has built up a “cog­ni­tive reserve.

So is there any­thing you can do about it besides exer­cise like crazy, eat healthy foods that you don’t like all that much, pop your statin pills, and take up yoga?

Yes. In short: focus, focus, focus.

Chang­ing think­ing styles can help. Research shows that Read the rest of this entry »

Iron­i­cally, Marc at the blog titled Neu­ro­sci­en­tif­i­cally Chal­lenged has just released one of the best edi­tions of Encephalon blog car­ni­val. Pay a visit only when you have some time to spare with a col­lec­tion of excel­lent and very well pre­sented neu­ro­science, med­i­cine and psy­chol­ogy blog posts, on top­ics rang­ing from fMRI to gene ther­apy and neuroplasticity.

Visit #49 Encephalon edi­tion at Neu­ro­sci­en­tif­i­cally Challenged.

Also, you may enjoy tak­ing a look at past edi­tions and cal­en­dar for future ones at Encephalon home page: Encephalon Archives & Cal­en­dar.