Below you can find the full tran­script of our engag­ing Q&A ses­sion today on mem­ory, mem­ory tech­niques and brain-healthy lifestyles with Dr. Gary  Small, Direc­tor of UCLA’s Mem­ory Clinic and Cen­ter on Aging, and author of The Mem­ory Bible. You can learn more about his book  Here, and learn more about upcom­ing Brain Fit­ness Q&A Ses­sions Here.

Per­haps one of the best ques­tions and answers was:

2:55
Ques­tion: Gary, you’ve worked many years in this field. Let us in on the secret. What do YOU do you, per­son­ally, to pro­mote your own brain fit­ness?
2:57
Answer: I try to get at least 30 min­utes of aer­o­bic con­di­tion­ing each day; try to min­i­mize my stress by stay­ing con­nected with fam­ily and friends; gen­er­ally eat a brain healthy diet (fish, fruits, veg­eta­bles), and try to bal­ance my online time with my offline time. Which reminds me, I think it is almost time for me to sign off line. Read the rest of this entry »

We just noticed that the Alliance for Aging Research offers an excel­lent list of ref­er­ences on Brain Health Research, orga­nized in these 10 sec­tions below. Enjoy!

#1 Nour­ish Your Nog­gin: Eat a Brain Healthy Diet Read the rest of this entry »

The L.A. Times reports today the neg­a­tive results of the lat­est ran­dom­ized trial test­ing the effects of DHA sup­ple­ments on Alzheimer’s symp­toms (DHA is an omega-3 fatty acid).

The study … exam­ined 402 peo­ple with mild to mod­er­ate Alzheimer’s. They were ran­domly assigned to take 2 grams a day of omega-3 cap­sules con­tain­ing docosa­hexaenoic acid (or DHA) or a placebo cap­sule. The par­tic­i­pants were fol­lowed for 18 months, and their cog­ni­tive and func­tional abil­i­ties were reassessed. They also under­went MRI to look at the brain.

There was no ben­e­fit seen in the patients tak­ing omega-3 fatty-acid sup­ple­ments in either brain vol­ume or cog­ni­tive function.

Com­ments: Does this study mean that DHA or omega-3 in gen­eral are not good for the brain? No! This study sug­gests that tak­ing DHA sup­ple­ments after Alzheimer’s diag­no­sis is not help­ful. Prior evi­dence shows that omega-3 con­sump­tion (espe­cially DHA) long before the onset of Alzheimer’s symp­toms reduces the risk of devel­op­ing the dis­ease. Indeed, sev­eral stud­ies have shown that eat­ing fish (the pri­mary source in our diet of omega-3 fatty acids) is asso­ci­ated with a reduced risk of cog­ni­tive decline or dementia.

The authors of the JAMA study also spec­u­late that DHA sup­ple­ments could be used as a treat­ment for peo­ple who have not yet been diag­nosed with Alzheimer’s but are already devel­op­ing demen­tia pathol­ogy in their brain: “Indi­vid­u­als inter­me­di­ate between healthy aging and demen­tia, such as those with mild cog­ni­tive impair­ment, might derive ben­e­fit from DHA sup­ple­men­ta­tion, although fur­ther study will be nec­es­sary to test this hypoth­e­sis.” 

You may find that too much media cov­er­age on how to take good care of our brains is con­fus­ing, if not poten­tially mis­lead­ing. In The True Story — is men­tal exer­cise good, bad, or irrel­e­vant, Dr. Pas­cale Mich­e­lon dis­sects for you a recent large study which was largely reported as bad news when in fact it brings good news (no mir­a­cles, but good news).  We hope you enjoy her insight­ful analy­sis — and all the excel­lent arti­cles that fol­low in the Sep­tem­ber edi­tion of our monthly eNewslet­ter cov­er­ing cog­ni­tive health and brain fit­ness top­ics. Please remem­ber that you can use the box in the right col­umn to sub­scribe and receive this newslet­ter via email.

Do you Mind

Dear sapi­ens sapi­ens, do you mind: Dr. Joshua Stein­er­man encour­ages you to ask your­self the tough ques­tions: Do you mind your brain? Do you know your nog­gin’? Can you claim cere­bral own­er­ship or is your men­tal a rental? Plus, why we need a new lex­i­con for pos­i­tive cog­ni­tion interventions.

Time for a Cog­ni­tive Reserve Day: with 36 mil­lion peo­ple world­wide with demen­tia today and related care costs around 1 per­cent of the world’s gross domes­tic prod­uct (GDP), and grow­ing fast, may it be time to com­ple­ment World Alzheimer’s Day with Word Cog­ni­tive Reserve’s Day?

Food for Thought

Debunk­ing learn­ing styles: a recent arti­cle in The New York Times debunks many old myths about learn­ing and learn­ing styles, sum­ma­riz­ing emerg­ing cog­ni­tive neu­ro­science findings.

Sci­ence for the Peo­ple: quick now — think of a ques­tion, any ques­tion, that comes to mind. Chances are some one in the excel­lent ros­ter of 28 sci­ence blog­gers who took part in Sharp­Brains’ edi­tion of Sci­en­tia Pro Pub­lica blog car­ni­val answered it.

Food for Thought — II

‘West­ern’ Style Diet Increases Risk of ADHD: Dr. David Rabiner reports how, on the one hand, a recent large study track­ing 1172 Aus­tralian ado­les­cents and their par­ents found that dietary fac­tors can play an impor­tant role in the devel­op­ment of atten­tion deficits, at least for some children.

A Con­trolled Trial of Herbal Treat­ment for ADHD: on the other hand, Dr. Rabiner adds, a recent randomized-controlled trial sup­ports the idea that appro­pri­ately pre­pared and tar­geted herbal com­pounds have the poten­tial to be ther­a­peu­tic and reduce atten­tion deficit symptoms.

Shap­ing the Future

Q&A about the new Sharp­Brains Coun­cil for Brain Fit­ness Inno­va­tion: we have received many good ques­tions about the new Sharp­Brains Coun­cil … here you are our answers.

Meet the Experts: since 2006 we have inter­viewed dozens of experts on the future of cog­ni­tive enhance­ment and men­tal health, build­ing up the foun­da­tion for the type of inno­va­tion the Sharp­Brains Coun­cil wants to fos­ter. Here you can find what 26 leading-edge sci­en­tists and experts believe and why.

Get­ting ther­apy through your iPhone: The Daily Beast (a great new media out­let) just pub­lished this excel­lent arti­cle on an emerg­ing “small rev­o­lu­tion” in men­tal health care.

Brain Teaser

Brain Teaser: are you ready to test your men­tal rota­tion skills?

Please feel free to share this monthly eNewslet­ter to friends and col­leagues. Have a great month of October!

Wel­come to the XL edi­tion of Sci­en­tia Pro Pub­lica (or, since we are try­ing to speak Eng­lish, the 40th edi­tion of “Sci­ence for the Peo­ple”), the rotat­ing blog car­ni­val that show­cases the finest sci­ence, med­ical and envi­ron­ment writ­ing pub­lished in the blogosphere.

Quick now — ask a ques­tion, any ques­tion, that comes to mind. Chances are some­one in this excel­lent ros­ter of sci­ence blog­gers has antic­i­pated it and pro­vided an answer below. Enjoy!

About our­selves

1. Why do I feel bet­ter after I exer­cise (pic: brainblogger)
2. Can thought­ful blog­ging and read­ing build brain reserve and delay dementia
3. What’s the bor­der­line between high and low func­tion­ing — autism research examples
4. Can we learn to multi-task more effectively
5. Should you mind your brain

About our bod­ies Read the rest of this entry »

I recently reported on an intrigu­ing study exam­in­ing the impact of an herbal treat­ment for youth with ADHD. Results from this randomized-controlled trial were quite promis­ing and con­sis­tent with the idea that some indi­vid­u­als with ADHD have defi­cien­cies in essen­tial nutri­ents that com­pro­mise healthy brain devel­op­ment and result in ADHD symp­toms. This idea has sparked the long-standing debate about whether dietary fac­tors play an impor­tant role in the devel­op­ment of ADHD, at least for some chil­dren, and led to many stud­ies of this issue.
Although results of these stud­ies elude any sim­ple con­clu­sions, dietary fac­tors do appear to con­tribute to ADHD symp­toms in some individuals.

Some have argued that research on the rela­tion­ship between diet and ADHD is more impor­tant than ever because the diets of chil­dren in West­ern coun­tries have shown steady increases in the amounts of heav­ily processed foods rich in sat­u­rated fats, salt, and sug­ars accom­pa­nied by decreases in omega-3 fatty acids, fiber, and folate. Is it pos­si­ble that such ‘West­ern’ style diets are asso­ci­ated with an increased risk of ADHD, and per­haps a con­tribut­ing fac­tor to the high preva­lence of the disorder?

This impor­tant ques­tion was exam­ined in a study pub­lished recently online in the Jour­nal of Atten­tion Dis­or­ders [Howard et. al. (2010). ADHD is asso­ci­ated with a “West­ern” dietary pat­tern in ado­les­cents. Jour­nal of Atten­tion Dis­or­ders]. Par­tic­i­pants were 1172 14 year-old Aus­tralian ado­les­cents and their par­ents who had been recruited into the study and fol­lowed since the moth­ers were between 16 and 20 weeks preg­nant. Read the rest of this entry »

In a recently pub­lished sci­en­tific study (see Hall C, et al “Cog­ni­tive activ­i­ties delay onset of mem­ory decline in per­sons who develop demen­tia” Neu­rol­ogy 2009; 73: 356–361), Hall and col­leagues exam­ined how edu­ca­tion and stim­u­lat­ing activ­i­ties may inter­act to con­tribute to cog­ni­tive reserve. The study involved 488 ini­tially healthy peo­ple, aver­age age 79, who enrolled in the Bronx Aging Study between 1980 and 1983. These indi­vid­u­als were fol­lowed for 5 years with assess­ments every 12 to 18 months (start­ing in 1980). At the start of the study, all par­tic­i­pants were asked how many cog­ni­tive activ­i­ties (read­ing, writ­ing, cross­word puz­zles, board or card games, group dis­cus­sions, or play­ing music) they par­tic­i­pated in and for how many days a week. Researchers were able to eval­u­ate the impact of self-reported par­tic­i­pa­tion these activ­i­ties on the onset of accel­er­ated mem­ory decline in 101 indi­vid­u­als who devel­oped demen­tia dur­ing the study.

Results showed that for every “activ­ity day” (par­tic­i­pa­tion in one activ­ity for one day a week) the sub­jects engaged in, they delayed for about two months the onset of rapid mem­ory loss asso­ci­ated with demen­tia. Inter­est­ingly, the pos­i­tive effect of brain-stimulating activ­i­ties in this study appeared to be inde­pen­dent of a person’s level of education.

This is great news as it sug­gests that it is never too late to try to build up brain reserve. The more brain stim­u­lat­ing activ­i­ties one does and the more often, the bet­ter for a stronger cog­ni­tive reserve.

The cog­ni­tive reserve hypoth­e­sis sug­gests that indi­vid­u­als with more cog­ni­tive reserve can expe­ri­ence more Alzheimer’s dis­ease pathol­ogy in the brain (more plaques and tan­gles) with­out devel­op­ing Alzheimer’s dis­ease symptoms.

How does that work? Sci­en­tists are not sure but two pos­si­bil­i­ties are con­sid­ered.
1. One is that more cog­ni­tive reserve means more brain reserve, that is more neu­rons and con­nec­tions between neu­rons.
2. Another pos­si­bil­ity is that more cog­ni­tive reserve means more com­pen­satory processes (see my pre­vi­ous post “Edu­ca­tion builds Cog­ni­tive Reserve for Alzheimers Dis­ease Pro­tec­tion” for more details.)

Now, one may won­der about the dif­fer­ence types of men­tal stim­u­la­tion avail­able, includ­ing not only puz­zles and such, but struc­tured activ­i­ties such as brain fit­ness soft­ware and med­i­ta­tion. Do we exer­cise our brain every time we think about some­thing? What can one do to exer­cise one’s brain in ways that enhance capac­ity? Does aer­o­bic fit­ness train­ing also exer­cise one’s brain? What types of method­olo­gies and prod­ucts are avail­able? Do they “work”? Are all the same?

Those are the types of ques­tions we wanted to address in the book The Sharp­Brains Guide To Brain Fit­ness (avail­able via Amazon.com). We are proud of the recog­ni­tion the book has started to obtain, includ­ing endorse­ments by lead­ing scientists:

“The Sharp­Brains Guide to Brain Fit­ness is the only book that I know of that seam­lessly inte­grates lat­est infor­ma­tion about cog­ni­tive health across the lifes­pan, with inter­views with active researchers exam­in­ing cog­ni­tive main­te­nance and enhance­ment, along with reviews of com­mer­cial prod­ucts tar­geted to cog­ni­tive enhance­ment. The book should be very use­ful to any­one inter­ested in brain care, both health care pro­fes­sion­als and the pub­lic at large”.
— Arthur Kramer, Pro­fes­sor of Psy­chol­ogy at Uni­ver­sity of Illinois

“This Sharp­Brains book pro­vides a very valu­able ser­vice to a wide com­mu­nity inter­ested in learn­ing and brain top­ics. I found it inter­est­ing and help­ful“
- Michael Pos­ner, Emer­i­tus Pro­fes­sor of Neu­ro­science at the Uni­ver­sity of Ore­gon, and first recip­i­ent of the Dogan Prize

– Pas­cale Mich­e­lon, Ph. D., is Sharp­Brains’ Research Man­ager for Edu­ca­tional Projects. Dr. Mich­e­lon has a Ph.D. in Cog­ni­tive Psy­chol­ogy and has worked as a Research Sci­en­tist at Wash­ing­ton Uni­ver­sity in Saint Louis, in the Psy­chol­ogy Depart­ment. She con­ducted sev­eral research projects to under­stand how the brain makes use of visual infor­ma­tion and mem­o­rizes facts. She is now an Adjunct Fac­ulty at Wash­ing­ton University.

Ref­er­ences:

- Study: Hall C, et al “Cog­ni­tive activ­i­ties delay onset of mem­ory decline in per­sons who develop demen­tia” Neu­rol­ogy 2009; 73: 356–361

- Book: The Sharp­Brains Guide To Brain Fit­ness: 18 Inter­views with Sci­en­tists, Prac­ti­cal Advice, and Prod­uct Reviews, to Keep Your Brain Sharp

Sev­eral months ago we came across an excel­lent resource for cognitive/ brain fit­ness aimed at help­ing com­pa­nies offer qual­ity brain health infor­ma­tion to their employees.

While it is true that we often tend to believe all this “brain fit­ness” stuff is most rel­e­vant to our par­ents and/ or grand­par­ents, trust me, if you are read­ing this, you need it. Every­one with a brain can ben­e­fit from learn­ing about how his or her brain works and how to main­tain it with proper care.

And, from a company’s point of view, aren’t “tal­ent” and “human cap­i­tal” really all about brain fit­ness and cog­ni­tive performance?

The Con­fer­ence Board and the Dana Alliance for Brain Ini­tia­tives (descrip­tions below) pub­lished in 2008 a 44-page book­let to “teach sim­ple, prac­ti­cal strate­gies for incor­po­rat­ing brain-friendly prac­tices into day-to-day life”.  Your Brain at work: Mak­ing the sci­ence of cog­ni­tive fit­ness to work for you is the first of three planned book­lets on cog­ni­tive fitness.

The Con­fer­ence Board and the Dana Alliance have allowed Sharp­Brains to share the fol­low­ing Action Plan with our read­ers, straight from Your Brain at work brochure. At the bot­tom of this post we also share instruc­tions on how indi­vid­u­als and com­pa­nies can get their own copies of this excel­lent brochure. Read the rest of this entry »

We just received these two very thought-provoking essays on Alzheimer’s Dis­ease and brain health, as part of a writ­ing work­shop, led by Susan Hill in Lake­land, Florida, with a group of grade 9–11 homeschoolers.

With­out fur­ther ado, here you are both Essays:

Essay A. Pre­vent­ing Alzheimer’s at Work

– By Josh H

5,000,000: that is the num­ber of peo­ple in the United States alone who are affected by Alzheimer’s dis­ease. Research has shown that those who held jobs such as san­i­ta­tion work­ers or trash col­lec­tors in their 30s, 40s, and 50s are more at risk for Alzheimer’s dis­ease than peo­ple who held jobs such as doc­tors or sci­en­tists at the same age. If every­one knew this, the world would ben­e­fit, and it could impact the lives of everyone.

Read the rest of this entry »

Over the last months, thanks to the traf­fic growth of SharpBrains.com (over 100,000 unique vis­i­tors per month these days, THANK YOU for vis­it­ing today and please come back!), a num­ber of proac­tive book agents, pub­lish­ers and authors have con­tacted us to inform us of their lat­est brain-related books. We have taken a look at many books, wrote reviews of The Dana Guide to Brain Health book review‚ and Best of the Brain from Sci­en­tific Amer­i­can, and inter­viewed sci­en­tists such as Judith Beck, Robert Emmons and James Zull.

Now we are launch­ing a new Author Speaks Series to pro­vide a plat­form for lead­ing sci­en­tists and experts writ­ing high-quality brain-related books to reach a wide audi­ence. We are hon­ored to start the series with an arti­cle by Larry McCleary, M.D, for­mer act­ing Chief of Pedi­atric Neu­ro­surgery at Den­ver Children’s Hos­pi­tal, and author of The Brain Trust Pro­gram: A Sci­en­tif­i­cally Based Three-Part Plan to Improve Mem­ory, Ele­vate Mood, Enhance Atten­tion, Alle­vi­ate Migraine and Menopausal Symp­toms, and Boost Men­tal Energy (Perigee Trade, 2007).

With­out fur­ther ado, let’s enjoy Dr. McCleary’s article:

Brain Evo­lu­tion and Why it is Mean­ing­ful Today to Improve Our Brain Health

You may feel over­whelmed by the stream of seem­ingly con­tra­dic­tory sug­ges­tions regard­ing the best way to main­tain men­tal clar­ity as you age. Based on an analy­sis of sem­i­nal fac­tors in the devel­op­ment of mod­ern brain anatomy, I believe it is pos­si­ble to make some very com­pelling rec­om­men­da­tions for grow­ing big brains, enhanc­ing their func­tion, and mak­ing them resis­tant to the aging process. These may be loosely cat­e­go­rized as fac­tors per­tain­ing to the men­tal or phys­i­cal attrib­utes of the brain. Although they are not truly inde­pen­dent enti­ties, such a con­cep­tu­al­iza­tion pro­vides a basis for the gen­er­a­tion of brain healthy pre­scrip­tions. Diet, phys­i­cal exer­cise, and stress reduc­tion enhance neu­ronal resilience. Sleep and men­tal stim­u­la­tion are vital for cog­ni­tive abil­ity, learn­ing, and memory.

Diet: Fol­low a mod­ern shore-based/marine diet includ­ing seafood in its most gen­eral sense, non-starchy veg­eta­bles of all col­ors, berries, and eggs. Other sources of lean pro­tein con­tain­ing long-chain omega 3 fatty acids such as free range beef, chicken, bison, or elk are nutri­tious alternatives.

Phys­i­cal exer­cise (Think fight or flight — activ­ity.): Include all types. Aer­o­bic activ­i­ties such as swim­ming, bicy­cling, walk­ing, or hik­ing for pro­mo­tion of vas­cu­lar health and weight con­trol; resis­tance train­ing for pro­mo­tion of neu­rotrophic fac­tors, nat­u­rally occur­ring com­pounds that make brain cells more resis­tant to aging, such as IGF-1 (Insulin-like growth factor-1) and BDNF (Brain-derived neu­rotrophic fac­tor); and bal­ance, coor­di­na­tion, and agility train­ing such as ping-pong, bal­ance beam, tram­po­line, and jump­ing rope to enhance cog­ni­tive speed and motor skills.

Stress Con­trol: From an evo­lu­tion­ary per­spec­tive, stres­sors (such as meet­ing a cave bear) and intense phys­i­cal activ­ity (run­ning or fight­ing) were brief in dura­tion and usu­ally occurred together. Mod­ern stres­sors (psy­cho­log­i­cal or emo­tional stress) tend to be unremit­ting and are gen­er­ally uncou­pled from the phys­i­cal (fight or flight) com­po­nent, mean­ing stress devel­ops with­out any asso­ci­ated phys­i­cal activ­ity. Such intense phys­i­cal pur­suits are now called exer­cise. Not sur­pris­ingly, exer­cise is a per­fect phys­i­o­logic anti­dote for stress due to its ben­e­fi­cial impact on cor­ti­sol (the stress hor­mone) and blood pres­sure and should be incor­po­rated into any pro­gram of stress reduction.

Ade­quate sleep: The body needs rest, but the brain requires sleep. Acute or chronic sleep depri­va­tion causes dev­as­tat­ing short and long-term con­se­quences to brain anatomy (synap­tic loss) and func­tion (mem­ory and learn­ing dif­fi­cul­ties). Off-line infor­ma­tion pro­cess­ing and mem­ory con­sol­i­da­tion are addi­tional sleep-related benefits.

Men­tal stim­u­la­tion: Brain-training, a cog­ni­tively chal­leng­ing lifestyle, nov­elty, and social­iza­tion are vital for the pro­mo­tion of neu­ronal plas­tic­ity and neu­ro­ge­n­e­sis (the for­ma­tion of new nerve cells and neu­ronal con­nec­tions), the enhance­ment of spe­cific brain func­tions such as mem­ory, and the devel­op­ment of cog­ni­tive reserve — addi­tional men­tal pro­cess­ing poten­tial that may be brought online when needed.

The com­bi­na­tion of these rec­om­men­da­tions, each of which was instru­men­tal in the trans­for­ma­tion from prim­i­tive to mod­ern ner­vous sys­tems, pro­vides a tem­plate for the most log­i­cal approach for enhanc­ing men­tal func­tion and resist­ing neu­rode­gen­er­a­tion as we travel through life.

The Evo­lu­tion­ary Rationale

The human brain clearly has the genetic poten­tial for dra­matic expan­sion. This was illus­trated about Read the rest of this entry »