Every Mon­day dur­ing the next 10 weeks we’ll dis­cuss here what lead­ing indus­try, sci­ence and pol­icy experts –all of whom will speak at the upcom­ing 2011 Sharp­Brains Sum­mit (March 30th — April 1st, 2011)– have to say about emerg­ing oppor­tu­ni­ties and chal­lenges to address, over the next 10 years, the grow­ing brain-related soci­etal demands.

With­out fur­ther ado, here you have what four Sum­mit Speak­ers say…

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Alvaro Pascual-Leone is the Direc­tor of the Berenson-Allen Cen­ter for Non-Invasive Brain Stim­u­la­tion at Har­vard Med­ical School.

1. How would you define “brain fit­ness” vs. “phys­i­cal fit­ness”?

Phys­i­cal fit­ness can refer to an over­all or gen­eral state of health and well-being. How­ever, it is also often used more specif­i­cally to refer to the abil­ity to per­form a given activ­ity, occu­pa­tion, or sport.

Sim­i­larly brain fit­ness might be used to refer to a gen­eral state of healthy, opti­mized brain func­tion, or a more spe­cific brain-based abil­ity to process cer­tain, spe­cific infor­ma­tion, enable cer­tain motor actions, or sup­port cer­tain cog­ni­tive abil­i­ties. Impor­tantly though, I would argue Read the rest of this entry »

If you could, you would. You can, but pre­fer not to know it?

More than any other organ, your brain is up to you. You are what you think, not just what you eat. Here’s some food for thought:

Design your Mind

Set­ting cog­ni­tive and behav­ioral goals raises chal­leng­ing and wor­thy ques­tions: What do you want from your brain? Will you know it when you achieve it?

To attain the brain of our choos­ing, we must under­stand our selves and cur­rent abil­i­ties. Intro­spec­tion and curios­ity are help­ful if they trig­ger and sus­tain the effort to enrich the mind. How­ever, objec­tive infor­ma­tion which leads to informed assess­ment of brain func­tion is often lacking.

Mind your Brain

Hon­esty. Open­ness. Self-awareness.

Irrefutable virtues, but in prac­tice most peo­ple fall short. Few reg­u­larly appraise their brain skills; even so, the abil­ity to accu­rately judge one’s own men­tal per­for­mance is not guar­an­teed. I believe the first step to mind­ing the brain is shed­ding hang-ups while offer­ing and solic­it­ing frank feed­back from fam­ily and close con­fi­dants. In the clin­i­cal set­ting, rou­tine cog­ni­tive screen­ing and “men­tal check ups” are not cur­rently prac­ticed, in part due to time con­straints and lim­ited util­ity of tra­di­tional paper-and-pencil tests. From a pub­lic health per­spec­tive, the U.S. Pre­ven­ta­tive Task Force reviewed Read the rest of this entry »

You have may have seen a few weeks ago the inter­view between for­mer US pres­i­den­tial con­tender John Edwards and reporter Bob Woodruff. All the result­ing media cov­er­age cen­tered on Edwards’ dec­la­ra­tions. How­ever, there is some­thing much more remark­able that sur­faced at that inter­view: Bob Woodruff’s spec­tac­u­lar recovery.

This is the same reporter who suf­fered a severe trau­matic brain injury when a road­side bomb det­o­nated next to his vehi­cle in Jan­u­ary 29th 2006 as he was cov­er­ing news devel­op­ments in Iraq.

Today we are for­tu­nate to inter­view Lee Woodruff, Bob’s wife and pil­lar through­out his recov­ery. Lee and Bob co-wrote the fan­tas­tic book In an Instant: A Family’s Jour­ney of Love and Heal­ing.

Alvaro Fer­nan­dez: Lee, many thanks for your time. I was amazed read­ing your book, where you share your jour­ney, and then watch­ing Bob inter­view John Edwards, the best dis­play I can imag­ine of his recov­ery. Can you please sum­ma­rize for us what Bob –and you– went through since Jan­u­ary 2006?

Lee Woodruff: As you know, Bob suf­fered a life-threatening trau­matic brain injury in Iraq. He was promptly taken under mil­i­tary care and under­went a series of surg­eries for head injuries, with a joint Army & Air Force neu­ro­sur­gi­cal team in Iraq, in a US Army Med­ical Com­mand hos­pi­tal in Ger­many, and at Bethesda Naval Hos­pi­tal, back here in the US.

Dur­ing this time, span­ning around 4 months, he spent 37 days in coma, and his skull had to be sur­gi­cally rebuilt. The cog­ni­tive reha­bil­i­ta­tion process started then, at a med­ical facil­ity closer home.

Can you please explain what kind of cog­ni­tive rehab Bob has gone though-both in a for­mal way, with a ther­a­pist, and infor­mally, on his own?

The first thing I’d like to say is that rehab is a long process. Doc­tors told me that Bob, despite the sever­ity of his injuries, had bet­ter chances to recover than other vic­tims, because of the reserve of neu­rons and con­nec­tions he had built thanks to Read the rest of this entry »

You know your weight. And your phys­i­cal fit­ness. And a vari­ety of health-related metrics.

What about your brain fitness?

Two recent announce­ments bring out how the assess­ment of cog­ni­tive abil­i­ties, or brain func­tions, is increas­ingly being done thanks to new com­put­er­ized options:

1) Last week, OptumHealth announced an exclu­sive 3-year agree­ment (esti­mated at $18m) with the Aus­tralian com­pany Brain Resource. OptumHealth will be embed­ding the Brain Resource plat­form into their over­all Behav­ioral Solu­tions program.

- OptumHealth Behav­ioral Solu­tions will work with Brain Resource to pro­vide clin­i­cians with a Web-based assess­ment that mea­sures gen­eral cog­ni­tion (how peo­ple process infor­ma­tion) and social cog­ni­tion (how peo­ple man­age their emo­tions). This 40-minute assess­ment is based on well-known and val­i­dated tests of mem­ory, atten­tion, exec­u­tive func­tion, and response speed, and mood, social skills and emo­tional resilience.

Read the rest of this entry »

July is shap­ing up to be a fas­ci­nat­ing month, full of cog­ni­tive health research reports and appli­ca­tions. Here you have a roundup, cov­er­ing food for the brain, cog­ni­tive assess­ments, men­tal train­ing and DNA, and more.

1) Brain foods: the effects of nutri­ents on brain func­tion (Nature Neuroscience)

The Aspen Health Forum gath­ered an impres­sive group of around 250 peo­ple to dis­cuss the most press­ing issues in Health and Med­ical Sci­ence (check out the Pro­gram and the Speak­ers bios), on Octo­ber 3-6th. It was the first con­fer­ence, by the way, where I have heard a speaker say: “I resus­ci­tated a woman yesterday”.

Key high­lights and trends:

1– Global health prob­lems require the atten­tion of the sci­en­tific com­mu­nity. Richard Klaus­ner encour­aged the sci­en­tific com­mu­nity to focus on Global Prob­lems: mater­nal mor­tal­ity rates, HIV/ AIDS, nutri­tion, can­cer, clean water.  Bill Frist, for­mer Sen­ate Major­ity Leader, added to that list the increas­ing epi­demic risks of global zootic dis­eases (trans­mit­ted between humans and ani­mals), sup­ported by 2 inter­est­ing data points: at any one moment, there are 500,000 peo­ple fly­ing world­wide; in a year, air­lines trans­port the equiv­a­lent of 2 bil­lion passengers.

2– “Let’s get real…Ideology kills”. Mary Robin­son, for­mer Pres­i­dent of Ire­land, on what it takes to stop HIV/ AIDS: “I am from Ire­land, a Catholic coun­try. And I am Catholic. But I can see how ide­ol­ogy kills..we need more empa­thy with real­ity, and to work with local women in those coun­tries who need things like female con­doms.” She was implic­itly crit­i­ciz­ing the large bud­get devoted to unre­al­is­tic absti­nence pro­grams. This ses­sion included a fas­ci­nat­ing exchange where Bill Frist rose from the audi­ence to defend the role of US aid, explain­ing how 60% of retro­vi­ral drugs in African coun­tries have been funded by the Amer­i­can tax­payer, high­light­ing Pres­i­dent Bush’s courage to make HIV/AIDS a top agenda item in many devel­op­ing coun­tries, and crit­i­ciz­ing other coun­tries for not doing enough. Which made Nobel Prize Lau­re­ate Peter Agre, also in the audi­ence, stand up and encour­age the US to really step up to the plate and devote 1% of the GDP to aid, as a num­ber of Euro­pean coun­tries do, instead of 0.1%.

3– Where is the new “Sput­nik”?: Basic sci­ence is cru­cial for inno­va­tion and for eco­nomic growth, but it is often under­ap­pre­ci­ated. Sci­en­tists are not “nerds”, as some­times they are por­trayed in pop­u­lar cul­ture, but peo­ple with a deep curios­ity and drive to solve a Big prob­lem. Many of the speak­ers had been inspired by the Sput­nik and the Apollo mis­sions to become sci­en­tists, at a time when the pro­fes­sion was con­sid­ered cool. Two Nobel Prize Lau­re­ates (Peter Agre, Michael Bishop), talked about their lives and careers try­ing to demys­tify what it takes to be a sci­en­tist and to win a Nobel Prize. Both are grate­ful to the tax­pay­ers dol­lars that funded their research, and insist we must do a bet­ter job at explain­ing the sci­en­tific process to soci­ety at large. Both are proud of hav­ing attended small lib­eral arts col­leges, and hav­ing evolved from there, fueled by their great curios­ity and unpre­dictable, serendip­i­tous paths, into launch­ing new sci­en­tific and med­ical fields.  Bishop listed a num­ber of times where he made deci­sions that were con­sid­ered “career sui­cide” by men­tors and col­leagues, and men­tioned “I was con­fused” around 15 times in 15 minutes…down to earth and inspiring.

4– We need a true Health Care Cul­ture: Mark Ganz sum­ma­rized it best by explain­ing how his health provider group improved care when they rede­fined them­selves from “we are 7,000 employ­ees” to “we are a 3 mil­lion strong com­mu­nity”, mov­ing from Read the rest of this entry »