Wel­come to the 8th edi­tion of Hour­glass, the blog car­ni­val devoted to biogeron­tol­ogy. Enjoy!

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Use It or Lose It

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Cog­ni­tive Enhance­ment, Health and Assessments

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The Ben­e­fits of Caloric Restric­tion Read the rest of this entry »

Con­cus­sion effect ‘spans decades’ (BBC)

- “Peo­ple con­cussed in their youth show sub­tle signs of men­tal and phys­i­cal prob­lems even more than 30 years later, say Cana­dian researchers.”

- “Dr Louis de Beau­mont, who led the study, said: “This study shows that the effects of sports con­cus­sions in early adult­hood per­sist beyond 30 years post-concussion, and that it can cause cog­ni­tive and motor func­tion alter­ations as the ath­letes age.”

- “Ath­letes should be bet­ter informed about the cumu­la­tive and per­sis­tent effects of sports con­cus­sion on men­tal and phys­i­cal processes so they know about the risk asso­ci­ated with return­ing to their sport.”

The study in question:

De Beau­mont L, The­o­ret H, Mon­geon D at al. Brain func­tion decline in healthy retired ath­letes who sus­tained their last sports con­cus­sion in early adult­hood. Brain 2009, Advanced online pub­li­ca­tion Jan­u­ary 27

Given the impor­tance of this topic, which we cov­ered in our 2008 Mar­ket Research, we are happy to read about new resources like a new book titled Sports Neu­ropsy­chol­ogy: Assess­ment and Man­age­ment of Trau­matic Brain Injury

From a recent book review by Gary S. Solomon, Ph.D.:

- “The past 15 years has yielded an explo­sion of infor­ma­tion on Read the rest of this entry »

Let me sum­ma­rize ten high­lights and reflec­tions from stim­u­lat­ing dis­cus­sions on cog­ni­tive health and assess­ments I have had this month so far.

Jan­u­ary 8-9th: Sym­po­sium on Co-Adaptive Learn­ing: Adap­tive Tech­nol­ogy for the Aging (details Here), orga­nized by the Ari­zona State University’s Cen­ter for Adap­tive Neural Systems:

1. Cog­ni­tive health is a crit­i­cal fac­tor in over­all health­care, but is often approached in a frag­mented, non-systematic way. Most speak­ers in the sym­po­sium did men­tion how cog­ni­tive health issues inter­act with their spe­cific areas of focus (aging, Parkinson’s Dis­ease, trau­matic brain injury, Alzheimer’s…) but there was a lack of a com­mon frame­work and tax­on­omy to define the prob­lem and iden­tify solu­tions and inter­ven­tions to mea­sure and help main­tain cog­ni­tive health across the lifespan.

2. For exam­ple, Parkinson’s Dis­ease. Did you know (I didn’t) that a sig­nif­i­cant per­cent­age of Parkinson’s patients have well-identified cog­ni­tive impair­ments, mostly in their exec­u­tive func­tions but also per­cep­tual problems?

3. We truly need a Cul­ture of Cog­ni­tive Health, as Ran­dal Koene pointed out.

4. May online cog­ni­tive games serve as ongo­ing, real-time assess­ment of cog­ni­tive func­tion? Misha Pavel thought so. He also added we may well see “cog­ni­tive exer­cise coaches” some­time in the horizon.

5. Skip Rizzo pre­sented how vir­tual real­ity can help address Post Trau­matic Stress Dis­or­der (PTSD) and even to admin­is­ter inno­v­a­tive cog­ni­tive assessments.

6. My pre­sen­ta­tion, titled The Emerg­ing Cog­ni­tive Fit­ness Mar­ket: Sta­tus, Trends and Chal­lenges, is avail­able Here

7. Jan­u­ary 22nd: Con­sumer Reports orga­nized a health sum­mit titled Read the rest of this entry »

How do you know when some­thing is fast mov­ing towards a Glad­wellian tip­ping point? When health insur­ance com­pa­nies and pub­lic pol­icy mak­ers launch sig­nif­i­cant initiatives.

For exam­ple, the gov­ern­ment of Ontario recently announced a $10 mil­lion invest­ment with Bay­crest Research Cen­tre who will part­ner with MaRS Ven­ture Group to develop and com­mer­cialise brain fit­ness tech­nolo­gies. The invest­ment was matched by an addi­tional $10 mil­lion from pri­vate sources.

Another impor­tant devel­op­ment was the $18 mil­lion agree­ment between the Australian-based Brain Resource Com­pany (ASX:BRC) and OptumHealth in the US. This will allow for the pro­vi­sion of web-based cog­ni­tive assess­ments as part of a clinician’s deci­sion sup­port systems.

These are some ini­tia­tives cov­ered in a webi­nar Top Ten Cog­ni­tive Fit­ness Events of 2008 pre­sented in Decem­ber for Sharp­Brains’ clients. Alvaro Fer­nan­dez described the state of play and main dri­vers behind the growth of the bur­geon­ing brain fit­ness mar­ket — which I will try and sum­ma­rize here.

The key dri­vers seem to be Read the rest of this entry »

My apolo­gies for not hav­ing blogged in a few days. I landed back in San Fran­cisco today after speak­ing and par­tic­i­pat­ing in a very stim­u­lat­ing event put together by the Ari­zona State Uni­ver­sity’s Adap­tive Neural Sys­tems Cen­ter with fund­ing from the National Sci­ence Foun­da­tion.

The 2-day sym­po­sium was titled Co-Adaptive Learn­ing: Adap­tive Tech­nol­ogy for the Aging (link opens a PDF with the agenda), fea­tured impres­sive speak­ers and a highly qual­i­fied audi­ence, and cov­ered a wide array of cur­rent and future health­care and aging appli­ca­tions of neu­ro­science. The one aspect that was very mean­ing­ful for me to observe how often we dis­cussed cog­ni­tive abil­i­ties, cog­ni­tive deficits, cog­ni­tive assess­ments, cog­ni­tive enhance­ment tools (both inva­sive and non-invasive) in a vari­ety of healthy aging and clin­i­cal contexts.

I will share more about the event in the next few days, includ­ing links to the fas­ci­nat­ing work pre­sented by speak­ers, but let me know sim­ply thank the two gra­cious orga­niz­ers and hosts of the event by quot­ing the goal of their cen­ter and work:

- Jimmy Abbas, PhD: “One of the hall­marks of bio­log­i­cal sys­tems is the abil­ity to adapt. In our work, we mimic neu­ro­bi­o­log­i­cal sys­tems in order to endow tech­nol­ogy with the abil­ity to adapt, and we use tech­nol­ogy to max­i­mize adap­ta­tions in neu­ro­bi­o­log­i­cal sys­tems. With these approaches, we aim to pro­mote func­tional adap­ta­tion after disability.”

- Ranu Jung, PhD: “Our goal is to improve the qual­ity of life of indi­vid­u­als with dis­abil­i­ties by design­ing tech­niques to inves­ti­gate, replace and repair dam­aged neural sys­tems to enhance mobil­ity and func­tion­al­ity. Whether a per­son has spinal cord injury, limb loss or Parkinson’s dis­ease, mobil­ity and func­tion­al­ity mean independence.”

Links:

Cen­ter: Adap­tive Neural Sys­tems Center.

Agenda (PDF): Co-Adaptive Learn­ing: Adap­tive Tech­nol­ogy for the Aging

Dear reader and mem­ber of Sharp­Brains’ com­mu­nity,
We want to thank you for your atten­tion and sup­port in 2008, and wish you a Happy, Pros­per­ous, Healthy and Pos­i­tive 2009!

Below you have the Decem­ber edi­tion of our monthly newslet­ter. Enjoy:

Best of 2008

Top 30 Brain Fit­ness Arti­cles of 2008: We have com­piled Sharp­Brains’ 30 most pop­u­lar arti­cles, writ­ten by thir­teen Expert Con­trib­u­tors and staff mem­bers for you. Have you read them all?

November-December News: No month goes by with­out sig­nif­i­cant news in the field of cog­ni­tive fit­ness. Sum­ma­rized here are 10 recent devel­op­ments wor­thy of atten­tion, includ­ing an upcom­ing brain train­ing prod­uct for ice hockey play­ers, my lec­ture at New York Pub­lic Library, and more.

Inter­views: Videogames, Med­i­ta­tion

Are videogames good for your brain?: A land­mark study by Dr. Arthur Kramer and col­leagues has shown that play­ing a strat­egy videogame can bring a vari­ety of sig­nif­i­cant men­tal ben­e­fits to older brains. Another recent study, also by Kramer and col­leagues, does not show sim­i­lar ben­e­fits to younger brains (despite play­ing the same game). How can this be? Dr. Kramer, who has kindly agreed to serve on Sharp­Brains’ Sci­en­tific Advi­sory Board, elaborates.

Med­i­ta­tion on the Brain: Dr. Andrew New­berg pro­vides an excel­lent overview of the brain ben­e­fits of prac­tices such as med­i­ta­tion. He rec­om­mends, “look for some­thing sim­ple, easy to try first, ensur­ing the prac­tice is com­pat­i­ble with one’s beliefs and goals. You need to match prac­tice with need: under­stand the spe­cific goals you have in mind, your sched­ule and lifestyle, and find some­thing practical.“

The Need for Objec­tive Assessments

Cog­ni­tive screen­ings and Alzheimer’s Dis­ease: The Alzheimer’s Foun­da­tion of Amer­ica just released a thought­ful report advo­cat­ing for wide­spread cog­ni­tive screen­ings after the age of 65 (55 given the right con­di­tions). Sharp­Brains read­ers, probed by Dr. Joshua Stein­er­man, seem to agree.

Quan­ti­ta­tive EEG for ADHD diag­no­sis: Dr. David Rabiner reports on the find­ings from a recent study that doc­u­ments the util­ity of Quan­ti­ta­tive EEG as an objec­tive test to assist in the diag­no­sis of ADHD. If this pro­ce­dure were to become more widely used, he sug­gests, the num­ber of chil­dren and ado­les­cents who are inap­pro­pri­ately diag­nosed and treated for the dis­or­der would dimin­ish substantially.

Shall we ques­tion the brand new book of human trou­bles?: The fights over the new ver­sion of the psy­chi­atric diag­nos­tic man­ual, the DSM-V, are start­ing to come to light. Dr. Vaughan Bell won­ders why the pub­lic debate avoids the key ques­tion of whether diag­no­sis itself is use­ful for men­tal health and why psy­cho­met­rics are sim­ply ignored.

Resources for Life­long Learning

Edu­ca­tion builds Cog­ni­tive Reserve for Alzheimers Dis­ease Pro­tec­tion: Dr. Pas­cale Mich­e­lon reviews a recent study that sup­ports the Cog­ni­tive Reserve hypoth­e­sis — men­tally stim­u­lat­ing expe­ri­ences through­out life, such as for­mal edu­ca­tion, help build a reserve in our brains that con­tributes to a lower prob­a­bil­ity of devel­op­ing Alzheimer’s symptoms.

5 Tips on Life­long Learn­ing & the Adult Brain: Lau­rie Bar­tels asks us to please please 1) chal­lenge our­selves with new learn­ing, 2) remem­ber that neu­ro­plas­tic­ity and neu­ro­ge­n­e­sis are hall­marks of our brains, 3) check for mis-learning on an ongo­ing basis, 4) more visu­als, less text, 5) move it, move it — start today!

Here you have sev­eral recent arti­cles and devel­op­ments wor­thy of attention:

1) Boom times for brain train­ing games (CNN)
2) Nav­i­gat­ing the brain fit­ness land­scape: do’s and don’ts (McKnight’s Long Term Care News)
3) USA Hockey and Intel­li­gym (press release)
4) Brain Fit­ness at New York Pub­lic Library (NYPL blog)
5) McDon­nell Foun­da­tion grant har­nesses cog­ni­tive sci­ence to improve stu­dent learn­ing (press release)
6) Health insur­ance firms offer­ing online cog­ni­tive ther­apy for insom­nia (Los Ange­les Times)
7) Head­Min­der Cog­ni­tive Sta­bil­ity Index: Com­put­er­ized Neu­rocog­ni­tive … (Press release)
THE AGE OF MASS INTELLIGENCE (Intel­li­gent Life)
9) Work­ing Later in Life May Facil­i­tate Neural Health (Cere­brum)
10) The Cool Fac­tor: Never Let Them See You Sweat (New York Times)

Links, selected quotes and com­men­tary: Read the rest of this entry »

Here you have the Novem­ber edi­tion of our monthly newslet­ter cov­er­ing cog­ni­tive health and brain fit­ness top­ics. Please remem­ber that you can sub­scribe to receive this Newslet­ter by email, sim­ply by sub­mit­ting your email at the top of this page.

Thank you for your inter­est, atten­tion and par­tic­i­pa­tion in our Sharp­Brains com­mu­nity. As always, we appre­ci­ate your com­ments and suggestions.

Sum­mit of the Global Agenda

How can we per­suade busi­ness lead­ers, policy-makers and researchers of the urgency to develop and pro­mote an inte­grated “Healthy Liv­ing” agenda focused on main­tain­ing life­long phys­i­cal and cog­ni­tive health, vs. the usual mind­set focused on deal­ing with spe­cific dis­eases and prob­lems once they arise?

In The Future of the Aging Soci­ety: Bur­den or Human Cap­i­tal?, I sum­ma­rize some of the key themes dis­cussed at the World Eco­nomic Forum event in Dubai on Novem­ber 7-9th. The world is aging — and in health­ier ways. But our health­care and retire­ment sys­tems are on track to go bank­rupt — their premises are out­dated. The cur­rent disease-based research agenda com­pounds the prob­lem. Solu­tions? 1) Pro­mote Healthy Lifestyles that help Main­tain Phys­i­cal and Cog­ni­tive Func­tional Abil­i­ties, 2) Redesign Envi­ron­ments to Fos­ter Health, Engage­ment and Finan­cial Secu­rity, 3) Develop an Inte­grated Healthy Liv­ing & Aging Research Agenda. Specif­i­cally, we could work with the UN and Global 2000 com­pa­nies to move for­ward a new agenda.

Planet Earth 2.0: A New Oper­at­ing Sys­tem: Imag­ine see­ing a top sheik in Dubai, wrapped in tra­di­tional Arab cloth­ing, exclaim “Yes We Can (a la Obama) in front of the 800 global experts, adding that “we build the future with our own hands. Some of the atten­dants of the World Eco­nomic Forum’s Sum­mit of the Global Agenda urged us to “reboot” the sys­tem. More than a “reboot”, we may have to upgrade to a new global “Yes We Can” oper­at­ing system.

Brain Fit­ness Research

Neu­ro­plas­tic­ity and the Brain That Changes Itself: Lau­rie Bar­tels reviews the excel­lent book by Nor­man Doidge, explain­ing that “the neu­ro­science behind Doidge’s book involves neu­ro­plas­tic­ity, which is the brain’s abil­ity to rewire itself. This means that the brain  is our intel­li­gence,  is not some­thing fixed in con­crete but rather a chang­ing, learn­ing entity.”

Can We Pick Your Brain re: Cog­ni­tive Assess­ments?: In our view, a crit­i­cal com­po­nent in the matu­rity of the brain fit­ness mar­ket will be the avail­abil­ity of inex­pen­sive, valid and reli­able objec­tive cog­ni­tive assess­ments,  to help mea­sure how our brain func­tions change over time and iden­tify pri­or­i­ties for tar­geted improve­ments. Dr. Joshua Stein­er­man asks if you would be up for them?

Use It (Prop­erly) or Lose It

Phys­i­cal and men­tal exer­cise to pre­vent cog­ni­tive decline: The Amer­i­can Med­ical News, a weekly news­pa­per for physi­cians pub­lished by the Amer­i­can Med­ical Asso­ci­a­tion, just pub­lished an excel­lent arti­cle on the impor­tance of phys­i­cal and men­tal exer­cise. We are very happy to see efforts like these to train physi­cians and health pro­fes­sion­als in gen­eral,  given that most of them were trained under a very dif­fer­ent under­stand­ing of the brain than the one we have today.

Brain Fit­ness 2: Sight & Sound: PBS recently announced the sec­ond install­ment of their pop­u­lar Brain Fit­ness Pro­gram show, to start air­ing soon.

MetaCar­ni­val #1: a con­ver­sa­tion across the blo­gos­phere: We often insist on “Nov­elty, Vari­ety and Chal­lenge” as key ingre­di­ents for good “brain exer­cise”. There are many ways to mix those ingre­di­ents — you may enjoy this one, the first inter­dis­ci­pli­nary gath­er­ing of blogs and blog car­ni­vals cov­er­ing health, sci­ence, anthro­pol­ogy, gen­eral advice and more.

Top 15 Brain Teasers and Games for Men­tal Exer­cise: Over the last 2 years we have pub­lished close to 100 puz­zles, teasers, rid­dles, and every kind of men­tal exer­cise (with­out count­ing our in-depth inter­views with top neu­ro­sci­en­tists). Which ones have proven most stim­u­lat­ing for you. Let us know. Here is a selec­tion of our Top 15 teasers.

Final Details

Please share this newslet­ter with your friends and col­leagues if you haven’t done so already.

Have a Happy Thanksgiving!

We offered some Brain Fit­ness Pre­dic­tions in our Mar­ket Report , including…

“7. Doc­tors and phar­ma­cists will help patients nav­i­gate through the over­whelm­ing range of avail­able prod­ucts and inter­pret the results of cog­ni­tive assess­ments. This will require sig­nif­i­cant pro­fes­sional devel­op­ment efforts, given that most doc­tors today were trained under a very dif­fer­ent under­stand­ing of the brain than the one we have today.”

The Amer­i­can Med­ical News, a weekly news­pa­per for physi­cians pub­lished by the Amer­i­can Med­ical Asso­ci­a­tion, just pub­lished an excel­lent arti­cle along those lines:

Steps to a nim­ble mind: Phys­i­cal and men­tal exer­cise help keep the brain fit
– Neu­ro­science is uncov­er­ing tech­niques to pre­vent cog­ni­tive decline.

A few quotes:

- It’s an exam­ple that high­lights a wave of new think­ing about the impor­tance of brain fitness.

- Until recently, con­ven­tional wis­dom held that our brains were intractable, hard-wired com­put­ers. What we were born with was all we got. Age wore down mem­ory and the abil­ity to under­stand, and few inter­ven­tions could reverse this process. But increas­ingly, evi­dence sug­gests that phys­i­cal and men­tal exer­cise can alter spe­cific brain regions, mak­ing rad­i­cal improve­ments in cog­ni­tive function.

- With nearly 72 mil­lion Amer­i­cans turn­ing 65 over the next two decades, physi­cians need the tools to han­dle grow­ing patient con­cerns about how to best main­tain brain health. Armed with this new brand of sci­ence, front­line physi­cians will be bet­ter equipped to address the needs of aging baby boomers, already in the throes of the brain fit­ness revolution.

- “Encour­age them to exer­cise the brain in novel and com­plex ways,” he says.

Full arti­cle: here

One of the physi­cians quoted in the arti­cle is Gary J. Kennedy, MD, Direc­tor of the Divi­sion of Geri­atric Psy­chi­a­try at Mon­te­fiore Med­ical Cen­ter in NYC and a pro­fes­sor in the Dept. of Psy­chi­a­try and Behav­ioral Sci­ences at Albert Ein­stein Col­lege of Medicine.

To put the AMA arti­cle in bet­ter per­spec­tive for Sharp­Brains read­ers, we asked Dr. Kennedy a few follow-up ques­tions. Below you have his questions.

Alvaro Fer­nan­dez (AF): Can you sum­ma­rize how cog­ni­tive func­tions tend to evolve as we age?

Gary Kennedy (GK): As we age cog­ni­tive func­tions that rely on Read the rest of this entry »

If you could, you would. You can, but pre­fer not to know it?

More than any other organ, your brain is up to you. You are what you think, not just what you eat. Here’s some food for thought:

Design your Mind

Set­ting cog­ni­tive and behav­ioral goals raises chal­leng­ing and wor­thy ques­tions: What do you want from your brain? Will you know it when you achieve it?

To attain the brain of our choos­ing, we must under­stand our selves and cur­rent abil­i­ties. Intro­spec­tion and curios­ity are help­ful if they trig­ger and sus­tain the effort to enrich the mind. How­ever, objec­tive infor­ma­tion which leads to informed assess­ment of brain func­tion is often lacking.

Mind your Brain

Hon­esty. Open­ness. Self-awareness.

Irrefutable virtues, but in prac­tice most peo­ple fall short. Few reg­u­larly appraise their brain skills; even so, the abil­ity to accu­rately judge one’s own men­tal per­for­mance is not guar­an­teed. I believe the first step to mind­ing the brain is shed­ding hang-ups while offer­ing and solic­it­ing frank feed­back from fam­ily and close con­fi­dants. In the clin­i­cal set­ting, rou­tine cog­ni­tive screen­ing and “men­tal check ups” are not cur­rently prac­ticed, in part due to time con­straints and lim­ited util­ity of tra­di­tional paper-and-pencil tests. From a pub­lic health per­spec­tive, the U.S. Pre­ven­ta­tive Task Force reviewed Read the rest of this entry »