Today we share must-read insights from  Kather­ine Sul­li­van, Direc­tor of the Brain Fit­ness Cen­ter at Wal­ter Reed Army Med­ical Cen­ter, and Peter Kissinger, Pres­i­dent of the AAA Foun­da­tion for Traf­fic Safety. Both of them will dis­cuss their ongo­ing work and lessons learned at the upcom­ing 2011 Sharp­Brains Sum­mit (March 30th — April 1st, 2011). The inter­views below were con­ducted via email.

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Kather­ine Sul­li­van is the Direc­tor of the Brain Fit­ness Cen­ter at Wal­ter Reed Army Med­ical Center.

1. Kather­ine, how would you define “brain fit­ness” vs. “phys­i­cal fitness”?

In our con­text (help­ing active duty ser­vice mem­bers and vet­er­ans recover from cog­ni­tive dys­func­tion most asso­ci­ated with trau­matic brain injury), I’d say brain fit­ness is the out­come we work towards: the cog­ni­tive resources required to return to duty or rein­te­grate into daily and pro­fes­sional lives as much as pos­si­ble. In this sense, Read the rest of this entry »

Yes­ter­day I had the chance to chat with Yaakov Stern, lead­ing Cog­ni­tive Reserve researcher at Colum­bia Uni­ver­sity, and then with a group of 25 life­long learn­ers in Ari­zona who attended a brain fit­ness class (hello, Robert and friends!) based on our con­sumer guide The Sharp­Brains Guide to Brain Fit­ness. On reflec­tion, I found both con­ver­sa­tions to be very stim­u­lat­ing for the same rea­son: they were forward-looking, focused not so much on sta­tus quo but on how emerg­ing research, tech­nol­ogy and trends may impact our soci­ety and lives in years to come. Let’s con­tinue the con­ver­sa­tion. Let me share the 10 main trends that we analyzed/ fore­casted in our book, and then ask you, sharp read­ers, to add your own 2 cents to the dis­cus­sion. Read the rest of this entry »

The main value of the inde­pen­dent NIH panel men­tioned in the pre­vi­ous arti­cle comes from the rec­om­men­da­tions it makes for research, indus­try and gov­ern­ment to fill the gaps in the sci­en­tific evi­dence in years to come.

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In fact, hav­ing access to objec­tive, auto­mated assess­ments to help con­sumers bet­ter mon­i­tor their cog­ni­tive health and take proac­tive, informed action is the one part of the brain fit­ness puz­zle that is badly needed.

It is esti­mated that 60% of peo­ple with Alzheimer’s Dis­ease go undi­ag­nosed. Most patients today get diag­nosed with Alzheimer’s too late and based on tools which are not sen­si­tive enough to pick up on sub­tle prob­lems in think­ing and mem­ory needed to make accu­rate diag­no­sis and dis­tin­guish among dif­fer­ent mem­ory dis­or­ders. This often results in hav­ing many indi­vid­u­als with high edu­ca­tion and intel­lect appear ‘nor­mal’ when in fact they have an Alzheimer’s-induced mem­ory and cog­ni­tive slowdown.

Note: You can keep read­ing the arti­cle To Man­age Brain Fit­ness Through Life, We Need to Put Puz­zle Pieces Together in the web­site of the Amer­i­can Soci­ety of Aging (arti­cle link opens PDF). ASA recently asked me to write a cou­ple of arti­cles on lat­est brain fit­ness and cog­ni­tive health trends for their Min­dAlert ini­tia­tive, and this is the sec­ond of the two.

Press release: “Leader in cog­ni­tion mea­sure­ment inte­grates into UBC to max­i­mize mea­sure­ment pre­ci­sion of piv­otal end­points and ensure data integrity. United BioSource Cor­po­ra­tion (UBC) today announced the acqui­si­tion of CDR”

Press release (09/10/09): Here

Analy­sis for mem­bers of Sharp­Brains Net­work for Brain Fit­ness Inno­va­tion: Here

For con­text, see our pre­vi­ous arti­cle titled Com­put­er­ized Cog­ni­tive Assess­ments: oppor­tu­ni­ties and con­cerns, focused on the OptumHealth — Brain­Re­source part­ner­ship and inno­v­a­tive work by the US Army.

(Editor’s note: this arti­cle belongs to the excel­lent May 2009 spe­cial issue on Aug­ment­ing Cog­ni­tion of sci­en­tific jour­nal Fron­tiers in Neu­ro­science, Vol­ume 3, Issue 1. You can order this issue, for 50 euros, here. Highly rec­om­mended for sci­en­tists and tech­ni­cal read­ers inter­ested in the sci­ence. This arti­cle, an indus­try overview, is repro­duced here with autho­riza­tion by the Fron­tiers Research Foun­da­tion).

Prepar­ing Soci­ety for the Cog­ni­tive Age

- By Alvaro Fernandez

Ground­break­ing cog­ni­tive neu­ro­science research has occurred over the last 20 years — with­out par­al­lel growth of con­sumer aware­ness and appro­pri­ate pro­fes­sional dis­sem­i­na­tion. “Cog­ni­tion” remains an elu­sive con­cept with unclear impli­ca­tions out­side the research community.

Ear­lier this year, I pre­sented a talk to health care pro­fes­sion­als at the New York Acad­emy of Med­i­cine, titled “Brain Fit­ness Soft­ware: Help­ing Con­sumers Sep­a­rate Hope from Hype”. I explained what com­put­er­ized cog­ni­tive assess­ment and train­ing tools can do (assess/enhance spe­cific cog­ni­tive func­tions), what they can­not do (reduce one’s “brain age”) and the cur­rent uncer­tain­ties about what they can do (i.e., delay Alzheimer’s symp­toms). At the same sym­po­sium, Dr. Gary Kennedy, Direc­tor of Geri­atric Psy­chi­a­try at Mon­te­fiore Med­ical Cen­ter, pro­vided guid­ance on why and how to screen for exec­u­tive func­tion deficits in the con­text of dementia.

I could per­ceive two emerg­ing trends at the event: 1) “Aug­ment­ing Cog­ni­tion” research is most com­monly framed as a health­care, often phar­ma­co­log­i­cal topic, with the tra­di­tional cog­ni­tive bias in med­i­cine of focus­ing on detec­tion and treat­ment of dis­ease, 2) In addi­tion, there is a grow­ing inter­est in non-invasive enhance­ment options and over­all lifestyle issues. Research find­ings in Aug­ment­ing Cog­ni­tion are only just begin­ning to reach the main­stream mar­ket­place, mostly through health­care chan­nels. The oppor­tu­nity is immense, but we will need to ensure the mar­ket­place matures in a ratio­nal and sus­tain­able man­ner, both through health­care and non-healthcare channels.

In Jan­u­ary 2009, we polled the 21,000 sub­scribers of Sharp­Brains’ mar­ket research eNewslet­ter to iden­tify atti­tudes and behav­iors towards the “brain fit­ness” field (a term we chose in 2006 based on a num­ber of con­sumer sur­veys and focus groups to con­nect with a wider audi­ence). Over 2,000 decision-makers and early adopters responded to the survey.

One of the key ques­tions we asked was, “What is the most impor­tant prob­lem you see in the brain fit­ness field and how do you think it can be solved?”. Some exam­ples of the sur­vey free text answers are quoted here, together with my suggestions.

Most impor­tant prob­lems in the brain fit­ness field

Pub­lic aware­ness (39%): “To get peo­ple to under­stand that hered­ity alone does not decide brain func­tion­ing”. We need to ramp up efforts to build pub­lic aware­ness and enthu­si­asm about brain research, includ­ing estab­lish­ing clear links to daily liv­ing. We can col­lab­o­rate with ini­tia­tives such as the Dana Foundation’s Brain Aware­ness Week and use the recent “Neu­ro­science Core Con­cepts” mate­ri­als devel­oped by the Soci­ety for Neu­ro­science to give talks at schools, libraries and workplaces.

Claims (21%): “The lack of stan­dards and clear def­i­n­i­tions is very con­fus­ing, and Read the rest of this entry »

Good arti­cle today in the NYT on “chemo brain” — some typ­i­cal short-term and long-term cog­ni­tive con­se­quences of chemotherapy.

The Fog That Fol­lows Chemother­apy (New York Times)

One quote is crit­i­cal — for chemo brain and also for a vari­ety of clin­i­cal con­di­tions that present asso­ci­ated cog­ni­tive impairments:

“Con­trol­ling for brain func­tion before can­cer treat­ment begins can help deter­mine cause and effect. In one study, can­cer patients took a bat­tery of neu­ropsy­cho­log­i­cal tests before start­ing chemother­apy, three weeks after com­plet­ing treat­ment, and again one year later. Although a third of the patients had signs of cog­ni­tive impair­ment before ther­apy began, the num­ber jumped to 61 per­cent after treat­ment, and half remained impaired a year later.”

As we have dis­cussed before, I believe that inex­pen­sive com­put­er­ized cog­ni­tive assess­ments will start to become widely avail­able in only a few years, to help set up indi­vid­u­al­ized cog­ni­tive base­lines and inform clin­i­cal diag­noses and treat­ments. For more, you can read Com­put­er­ized Cog­ni­tive Assess­ments: oppor­tu­ni­ties and concerns

Here you have the June edi­tion of our monthly newslet­ter cov­er­ing cog­ni­tive health and brain fit­ness top­ics. Please remem­ber that you can sub­scribe to receive this Newslet­ter by email, using the box at the top of this page.

The full sched­ule of the Sharp­Brains’ pow­ered Cog­ni­tive Health Track at the Games for Health Con­fer­ence, June 11-12th in Boston, is now avail­able online. 13 ses­sions will fea­ture 18 inno­va­tors and thought-leaders rep­re­sent­ing devel­op­ers, uni­ver­si­ties, clin­i­cians, con­sumers, insur­ance com­pa­nies, and more. You can learn more and reg­is­ter.

Longevity Div­i­dend

Ever heard of the Longevity Div­i­dend? Per­haps Grey is the New Gold: The Kro­nos Longevity Research Insti­tute has released a new report sum­ma­riz­ing the state of aging research that includes an excel­lent intro­duc­tion into the Longevity Div­i­dend, a “the­ory that says we hope to inter­vene sci­en­tif­i­cally to slow the aging process, which will also delay the onset of age-related dis­eases. Delay­ing aging just seven years would slash rates of con­di­tions like can­cer, dia­betes, Alzheimer’s dis­ease and heart dis­ease in half.” With that con­text in mind, is the National Insti­tute on Aging get­ting its fair bud­get share?

Resources

Visual Rep­re­sen­ta­tion of the State of the Mar­ket 2009: Paul Van Slem­brouck sum­ma­rizes and beau­ti­fully presents the main find­ings of our 150-page mar­ket report, The State of the Brain Fit­ness Mar­ket 2009. Enjoy this excel­lent graphic.

Book Club Dis­cus­sion Guide: The goal of our just pub­lished book, The Sharp­Brains Guide to Brain Fit­ness, is to inform you, but also to open a much needed debate to con­tribute to our col­lec­tive brain fit­ness. We encour­age book clubs to read and dis­cuss the book, and sug­gest 10 ques­tions to kick­start the con­ver­sa­tion. Please do send us your answers and impressions!

Edu­ca­tion & Learning

10% Stu­dents may have work­ing mem­ory prob­lems: Why does this mat­ter?: A recent study screened over 3,000 school-aged stu­dents in schools in the UK and found that 1 in 10 was iden­ti­fied as hav­ing work­ing mem­ory dif­fi­cul­ties. Work­ing mem­ory is our abil­ity to store and manip­u­late infor­ma­tion for a brief time, and dif­fi­cul­ties in this brain func­tion may lead into dif­fi­cul­ties in read­ing and math­e­mat­ics. Dr. Tracy Alloway reviews the study and elaborates.

Brain-fitness games join work­place, as well as senior cen­ter, arse­nals (MarketWatch)

- “Con­sumers and retire­ment homes have made brain-fitness games and exer­cises a com­mer­cial hit, but now some insur­ers and employ­ers are incor­po­rat­ing them into well­ness pro­grams that pro­mote health not just for the body but also for the mind.”

- “Improv­ing brain health can result in less pre­sen­teeism, the ten­dency to be at work but be dis­tracted and not able to focus,” he added. “If you look at dis­abil­ity costs, absen­teeism and pre­sen­teeism account for most of the med­ical costs, and that’s a good rea­son for employ­ers to be focused on brain health.” (accord­ing to Dr. Eugene Baker, vice pres­i­dent at OptumHealth’s Behav­ioral Solu­tions division)”

The arti­cle reviews inno­v­a­tive prac­tices at OptumHealth, Nation­wide Auto Insur­ance Com­pany, Humana, Penn Treaty Amer­i­can Corp, All­state, and the US Army. I am glad to see the media start to notice the impor­tance of cog­ni­tive assess­ments and the grow­ing activ­ity by insur­ers. Read the rest of this entry »

In April 2008, Bay­crest, a lead­ing research insti­tute focused on aging and brain func­tion, received $10-million from the Ontario Gov­ern­ment to cre­ate a ground­break­ing Cen­tre for Brain Fit­ness. Its stated goal was to “develop and com­mer­cial­ize a range of prod­ucts designed to improve the brain health of aging Ontar­i­ans and oth­ers around the world”.

“Our gov­ern­ment is proud to sup­port Bay­crest and its invalu­able work, which is already lead­ing to the dis­cov­ery of impor­tant new tools and approaches to treat­ing brain dis­eases asso­ci­ated with aging,” said Min­is­ter of Research and Inno­va­tion, John Wilkinson.

We have Baycrest’s CEO with us today, to explore why Ontario and Bay­crest chose to become pio­neers in this area, and dis­cuss some of the main oppor­tu­ni­ties, and chal­lenges. Dr. William E. Reich­man is Pres­i­dent and CEO of Bay­crest. Dr. Reich­man, an internationally-known expert in geri­atric men­tal health and demen­tia, is also Pro­fes­sor of Psy­chi­a­try on the Fac­ulty of Med­i­cine at the Uni­ver­sity of Toronto.

Alvaro Fer­nan­dez: Bill, thank you for your time. Let me start by ask­ing, given that you just spoke at the recent Con­sumer Elec­tronic Show, what do you make of the grow­ing brain fit­ness field?

Bill Reich­man: it looks like a clas­sic exam­ple of a very promis­ing but still early stage field – a lot of oppor­tu­nity and enthu­si­asm, but also a lot of prod­uct claims that are not backed by solid research. Think about the phys­i­cal fit­ness anal­ogy: even today, after decades of progress, you still see peo­ple buy­ing research-based prod­ucts such as tread­mills but also all types of ran­dom machines they see on TV and have not been sub­ject to any val­i­da­tion. Sim­i­larly, con­sumers today do not know what to make of grow­ing brain fit­ness claims. As another speaker pointed out, for the indus­try to ful­fill its promise, it will need to be care­ful with research and claims, not to end up like the nutraceu­ti­cals category.

By the way, let me rec­og­nize that the work you are doing with Sharp­Brains reports and your web­site is very impor­tant to offer qual­ity information.

Thank you. Let’s step back for a moment. Tak­ing a, say, 10 years view, what is the main oppor­tu­nity that technology-based brain fit­ness can offer to society?

First of all, let me say that I think we have an oppor­tu­nity to make major progress in Brain Health in the XXI cen­tury, sim­i­lar to what hap­pened with Car­dio­vas­cu­lar Health in the XX, and tech­nol­ogy will play a cru­cial role.

Given the rapid advances we are wit­ness­ing today in the research and tech­nol­ogy are­nas, I feel con­fi­dent in say­ing that in less than 10 years we will have both valid and reli­able assess­ments of cog­ni­tive func­tions, that will be used both by Read the rest of this entry »

Wel­come to the 8th edi­tion of Hour­glass, the blog car­ni­val devoted to biogeron­tol­ogy. Enjoy!

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Use It or Lose It

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Cog­ni­tive Enhance­ment, Health and Assessments

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The Ben­e­fits of Caloric Restric­tion Read the rest of this entry »