Good arti­cle today in the NYT on “chemo brain” — some typ­i­cal short-term and long-term cog­ni­tive con­se­quences of chemotherapy.

The Fog That Fol­lows Chemother­apy (New York Times)

One quote is crit­i­cal — for chemo brain and also for a vari­ety of clin­i­cal con­di­tions that present asso­ci­ated cog­ni­tive impairments:

“Con­trol­ling for brain func­tion before can­cer treat­ment begins can help deter­mine cause and effect. In one study, can­cer patients took a bat­tery of neu­ropsy­cho­log­i­cal tests before start­ing chemother­apy, three weeks after com­plet­ing treat­ment, and again one year later. Although a third of the patients had signs of cog­ni­tive impair­ment before ther­apy began, the num­ber jumped to 61 per­cent after treat­ment, and half remained impaired a year later.”

As we have dis­cussed before, I believe that inex­pen­sive com­put­er­ized cog­ni­tive assess­ments will start to become widely avail­able in only a few years, to help set up indi­vid­u­al­ized cog­ni­tive base­lines and inform clin­i­cal diag­noses and treat­ments. For more, you can read Com­put­er­ized Cog­ni­tive Assess­ments: oppor­tu­ni­ties and concerns

In April 2008, Bay­crest, a lead­ing research insti­tute focused on aging and brain func­tion, received $10-million from the Ontario Gov­ern­ment to cre­ate a ground­break­ing Cen­tre for Brain Fit­ness. Its stated goal was to “develop and com­mer­cial­ize a range of prod­ucts designed to improve the brain health of aging Ontar­i­ans and oth­ers around the world”.

“Our gov­ern­ment is proud to sup­port Bay­crest and its invalu­able work, which is already lead­ing to the dis­cov­ery of impor­tant new tools and approaches to treat­ing brain dis­eases asso­ci­ated with aging,” said Min­is­ter of Research and Inno­va­tion, John Wilkinson.

We have Baycrest’s CEO with us today, to explore why Ontario and Bay­crest chose to become pio­neers in this area, and dis­cuss some of the main oppor­tu­ni­ties, and chal­lenges. Dr. William E. Reich­man is Pres­i­dent and CEO of Bay­crest. Dr. Reich­man, an internationally-known expert in geri­atric men­tal health and demen­tia, is also Pro­fes­sor of Psy­chi­a­try on the Fac­ulty of Med­i­cine at the Uni­ver­sity of Toronto.

Alvaro Fer­nan­dez: Bill, thank you for your time. Let me start by ask­ing, given that you just spoke at the recent Con­sumer Elec­tronic Show, what do you make of the grow­ing brain fit­ness field?

Bill Reich­man: it looks like a clas­sic exam­ple of a very promis­ing but still early stage field – a lot of oppor­tu­nity and enthu­si­asm, but also a lot of prod­uct claims that are not backed by solid research. Think about the phys­i­cal fit­ness anal­ogy: even today, after decades of progress, you still see peo­ple buy­ing research-based prod­ucts such as tread­mills but also all types of ran­dom machines they see on TV and have not been sub­ject to any val­i­da­tion. Sim­i­larly, con­sumers today do not know what to make of grow­ing brain fit­ness claims. As another speaker pointed out, for the indus­try to ful­fill its promise, it will need to be care­ful with research and claims, not to end up like the nutraceu­ti­cals category.

By the way, let me rec­og­nize that the work you are doing with Sharp­Brains reports and your web­site is very impor­tant to offer qual­ity information.

Thank you. Let’s step back for a moment. Tak­ing a, say, 10 years view, what is the main oppor­tu­nity that technology-based brain fit­ness can offer to society?

First of all, let me say that I think we have an oppor­tu­nity to make major progress in Brain Health in the XXI cen­tury, sim­i­lar to what hap­pened with Car­dio­vas­cu­lar Health in the XX, and tech­nol­ogy will play a cru­cial role.

Given the rapid advances we are wit­ness­ing today in the research and tech­nol­ogy are­nas, I feel con­fi­dent in say­ing that in less than 10 years we will have both valid and reli­able assess­ments of cog­ni­tive func­tions, that will be used both by Read the rest of this entry »

Con­cus­sion effect ‘spans decades’ (BBC)

- “Peo­ple con­cussed in their youth show sub­tle signs of men­tal and phys­i­cal prob­lems even more than 30 years later, say Cana­dian researchers.”

- “Dr Louis de Beau­mont, who led the study, said: “This study shows that the effects of sports con­cus­sions in early adult­hood per­sist beyond 30 years post-concussion, and that it can cause cog­ni­tive and motor func­tion alter­ations as the ath­letes age.”

- “Ath­letes should be bet­ter informed about the cumu­la­tive and per­sis­tent effects of sports con­cus­sion on men­tal and phys­i­cal processes so they know about the risk asso­ci­ated with return­ing to their sport.”

The study in question:

De Beau­mont L, The­o­ret H, Mon­geon D at al. Brain func­tion decline in healthy retired ath­letes who sus­tained their last sports con­cus­sion in early adult­hood. Brain 2009, Advanced online pub­li­ca­tion Jan­u­ary 27

Given the impor­tance of this topic, which we cov­ered in our 2008 Mar­ket Research, we are happy to read about new resources like a new book titled Sports Neu­ropsy­chol­ogy: Assess­ment and Man­age­ment of Trau­matic Brain Injury

From a recent book review by Gary S. Solomon, Ph.D.:

- “The past 15 years has yielded an explo­sion of infor­ma­tion on Read the rest of this entry »

Spec­tac­u­lar arti­cle by Dr. Denise Park in this month’s Cere­brum:

Work­ing Later in Life May Facil­i­tate Neural Health

- “Carmi Schooler at the National Insti­tutes of Health, using a tech­nique that allowed him to assess causal rela­tion­ships, found that adults who per­formed intel­lec­tu­ally chal­leng­ing jobs across their life span showed more cog­ni­tive flex­i­bil­ity in late adult­hood than those who per­formed less demand­ing jobs.“
– “Per­haps the most com­pelling evi­dence regard­ing the impact of novel expe­ri­ences on brain vol­ume and func­tion comes from a study at the Max Planck Insti­tute in Ger­many. Adults with a mean age of 59 spent three months learn­ing to jug­gle three balls. Although only about half the par­tic­i­pants were able to achieve com­pe­tence in this com­plex skill, those who suc­ceeded had increased vol­ume in a mediotem­po­ral area of the visual cor­tex as well as the nucleus accum­bens and the hip­pocam­pus, sug­gest­ing that sus­tained novel expe­ri­ence can increase the sizes of neural struc­tures. Notably, the changes in the nucleus accum­bens and hip­pocam­pus were Read the rest of this entry »

If you could, you would. You can, but pre­fer not to know it?

More than any other organ, your brain is up to you. You are what you think, not just what you eat. Here’s some food for thought:

Design your Mind

Set­ting cog­ni­tive and behav­ioral goals raises chal­leng­ing and wor­thy ques­tions: What do you want from your brain? Will you know it when you achieve it?

To attain the brain of our choos­ing, we must under­stand our selves and cur­rent abil­i­ties. Intro­spec­tion and curios­ity are help­ful if they trig­ger and sus­tain the effort to enrich the mind. How­ever, objec­tive infor­ma­tion which leads to informed assess­ment of brain func­tion is often lacking.

Mind your Brain

Hon­esty. Open­ness. Self-awareness.

Irrefutable virtues, but in prac­tice most peo­ple fall short. Few reg­u­larly appraise their brain skills; even so, the abil­ity to accu­rately judge one’s own men­tal per­for­mance is not guar­an­teed. I believe the first step to mind­ing the brain is shed­ding hang-ups while offer­ing and solic­it­ing frank feed­back from fam­ily and close con­fi­dants. In the clin­i­cal set­ting, rou­tine cog­ni­tive screen­ing and “men­tal check ups” are not cur­rently prac­ticed, in part due to time con­straints and lim­ited util­ity of tra­di­tional paper-and-pencil tests. From a pub­lic health per­spec­tive, the U.S. Pre­ven­ta­tive Task Force reviewed Read the rest of this entry »

A beau­ti­ful ini­tia­tive, fea­tured in the New York Times today:
Com­ing Full Circle:

- “In a typ­i­cal Montes­sori class­room, teach­ers use category-sorting exer­cises to help young stu­dents see pat­terns and con­nec­tions. But the par­tic­i­pants in this group were mostly in their 80s and on the other side of the cog­ni­tive devel­op­ment curve. They are res­i­dents at an assisted-living facil­ity for peo­ple with demen­tia called Hearth­stone at the Esplanade, which has six other homes in New York State and Mass­a­chu­setts. Since July the res­i­dents have par­tic­i­pated in a full-time pro­gram of Montessori-based activ­i­ties designed for peo­ple with mem­ory deficiencies.”

- “A com­mon mis­con­cep­tion about peo­ple with demen­tia, Dr. Camp said, is that they no longer learn. But they do: res­i­dents learn to find their din­ing room table, for exam­ple, well after the onset of Alzheimer’s dis­ease. And because they no longer have the higher brain func­tion they had as adults, he rea­soned, they are well suited to Montessori.”

Full arti­cle: Com­ing Full Cir­cle.

Related posts:

- Alzheimer’s Risk and Pre­ven­tion: the Cog­ni­tive Reserve

- Your com­ments on cog­ni­tive train­ing, Posit Sci­ence, Alzheimer’s Aus­tralia, geron­tol­ogy, games

James Zull is a pro­fes­sor of Biol­ogy. He is also Direc­tor Emer­i­tus of the Uni­ver­sity Cen­ter for Inno­va­tion in Teach­ing and Edu­ca­tion at Case West­ern Reserve Uni­ver­sity in Ohio. These roles most assuredly coa­lesced in his 2002 book, The Art of Chang­ing the Brain: Enrich­ing the Prac­tice of Teach­ing by Explor­ing the Biol­ogy of Learn­ing.

This is a book for both teach­ers and par­ents (because par­ents are also teach­ers!) Writ­ten with the earnest­ness of first-person expe­ri­ence and reflec­tion, and a life­time of exper­tise in biol­ogy, Zull makes a well-rounded case for his ideas. He offers those ideas for your perusal, pro­vid­ing much sup­port­ing evi­dence, but he doesn’t try to ram them into your psy­che. Rather, he prac­tices what he preaches by engag­ing you with sto­ries, inform­ing you with fact, and encour­ag­ing your think­ing by the way he posits his ideas.

I have read a num­ber of books that trans­late cur­rent brain research into prac­tice while pro­vid­ing prac­ti­cal sug­ges­tions for teach­ers to imple­ment. This is the first book I have read that pro­vides a bio­log­i­cal, and clearly ratio­nal, overview of learn­ing and the brain. Zull pro­vokes you into think­ing Read the rest of this entry »

A round-up of inter­ested news dur­ing the month:

1) Train­ing Young Brains to Behave (New York Times)

2) Head Games (OpEd in New York Times)

3) Will Geron­tol­ogy rec­og­nize the Brain? (Amer­i­can Soci­ety on Aging event)

4) Brain func­tion gets a boost from walk­ing (Los Ange­les Times)

5) An idea whose time has (finally) come (McKnight’s Long Term Care News)

6) Train your brain (Finan­cial Times Germany)

7) Toman auge ejer­ci­cios que adies­tran la mente (Mile­nio, Mexico)

Trois nou­vellestudes IDATE : Seri­ous Games (Publi-News, France)

Links and com­men­tary below. Read the rest of this entry »

A cou­ple of recent stud­ies have rein­forced the life­long poten­tial for brain plas­tic­ity (the abil­ity of the brain to rewire itself through expe­ri­ence) and the impor­tance of phys­i­cal exer­cise for cog­ni­tive vital­ity. One study focused on 1) adults over 50 with mild cog­ni­tive impair­ment, the other one on 2) stroke survivors.

1)  Mem­ory prob­lems: Adults 50-years-old and over with mild cog­ni­tive impair­ment (an advanced form of mem­ory prob­lems, but pre-dementia) were asked to exer­cise for three 50-minute ses­sions per week for 24 weeks (a total of 60 hours). Results: there were small, but mea­sur­able, cog­ni­tive ben­e­fits even 18 months after Read the rest of this entry »

Try eat­ing food with one chop stick.

It is pos­si­ble, for cer­tain types of food. But prob­a­bly not the best approach.

Let’s now talk brain health.

Dr. Larry McCleary is a for­mer act­ing Chief of Pedi­atric Neu­ro­surgery at Den­ver Children’s Hos­pi­tal, and author of the The Brain Trust Pro­gram (Perigee Trade, 2007). He agreed to help us answer an impor­tant, yet often neglected, ques­tion: Given That We Are Our Brains, How do We Nour­ish Them?

Alvaro: Dr. McCleary, Why did a for­mer neu­ro­sur­geon such as your­self develop an inter­est in brain health pub­lic education?

Dr. McCleary: For two rea­sons … I am a Boomer and am try­ing to max­i­mize my own brain health. Also, there is much excit­ing research doc­u­ment­ing how we can be proac­tive in this regard. This infor­ma­tion needs to be dis­sem­i­nated and I would like to help in this process.

And what is the sin­gle most impor­tant brain-related idea or con­cept that you would like every per­son in the planet to fully understand?

The most impor­tant take home mes­sage about brain health is that we now know that no mat­ter what your brain sta­tus or age, there is much you can do to sig­nif­i­cantly improve brain func­tion and slow brain aging. Based on emerg­ing infor­ma­tion, what is espe­cially nice is the fact that unlike many things in life our brain health is largely under own control.

What are the most impor­tant ele­ments to nour­ish our brains as we age?

I approach this ques­tion much like an ath­lete pre­pares for com­pe­ti­tion. They uti­lize a holis­tic approach. Read the rest of this entry »