Brain func­tion can start declin­ing ‘as early as age 45′ (BBC Health):

“The brain’s abil­ity to func­tion can start to dete­ri­o­rate as early as 45, sug­gests a study in the British Med­ical Jour­nal.  Uni­ver­sity Col­lege Lon­don researchers found a 3.6% decline in men­tal rea­son­ing in women and men aged 45–49. They assessed the mem­ory, vocab­u­lary and com­pre­hen­sion skills of 7,000 men and women aged 45 to 70 over 10 years.

The Alzheimer’s Soci­ety said research was needed into how changes in the brain could help demen­tia diag­noses.  Read the rest of this entry »

Test­ing Pro­gram Fails Sol­diers, Leav­ing Brain Injuries Unde­tected (ProPublica):

“In 2007, with road­side bombs explod­ing across Iraq, Con­gress moved to improve care for sol­diers who had suf­fered one of the war’s sig­na­ture wounds, trau­matic brain injury.

Law­mak­ers passed a mea­sure requir­ing the mil­i­tary to test sol­diers’ brain func­tion before they deployed and again when they returned. The test was sup­posed to ensure that sol­diers received proper treatment.

Instead, an inves­ti­ga­tion by ProP­ub­lica and NPR has found, the test­ing pro­gram has failed to deliver on its promise, offer­ing sol­diers the appear­ance of help, but not the real­ity. Read the rest of this entry »

Rewiring the Brain to Ease Pain (Wall Street Journal):-

“How you think about pain can have a major impact on how it feels. That’s the intrigu­ing con­clu­sion neu­ro­sci­en­tists are reach­ing as scan­ning tech­nolo­gies let them see how the brain processes pain. That’s also the prin­ci­ple behind many mind-body approaches to chronic pain that are prov­ing sur­pris­ingly effec­tive in clin­i­cal tri­als. Some are as old as med­i­ta­tion, hyp­no­sis and tai chi, while oth­ers are far more high tech.”

Link to Study Towards a physiology-based mea­sure of pain (PloS One): Read the rest of this entry »

Below you can find the full tran­script of our engag­ing Q&A ses­sion yes­ter­day on life­long cog­ni­tive fit­ness, “men­tal cap­i­tal­ism”, and more,  with Alvaro Fer­nan­dez, co-author of The Sharp­Brains Guide to Brain Fit­ness, mod­er­ated by Harry Moody, Direc­tor of Aca­d­e­mic Affairs at AARP. You learn more about upcom­ing Brain Fit­ness Q&A Ses­sions Here.

Read the rest of this entry »

Wel­come to a new edi­tion of Grand Rounds blog car­ni­val, the weekly edi­tion of what’s best in the health and med­ical blo­gos­phere. This week, twenty four blog­gers share data, insights, ques­tions, reflec­tions and more. Enjoy! Read the rest of this entry »

An impres­sive recent ref­er­ence book on the future of brain care is Inte­gra­tive Neu­ro­science and Per­son­al­ized Med­i­cine, edited by Evian Gor­don and Stephen H. Koslow (Oxford Uni­ver­sity Press; $89.95).

Book descrip­tion: This book takes an in depth and hard look at the cur­rent sta­tus and future direc­tion of treat­ment pre­dic­tive mark­ers in Per­son­al­ized Med­i­cine for the brain from the per­spec­tives of the researchers on the cut­ting edge and those involved in health­care imple­men­ta­tion. The con­tents pro­vide a com­pre­hen­sive text suit­able as both a pithy intro­duc­tion to and a clear sum­mary of the “sci­ence to solu­tions” con­tin­uum in this devel­op­ing field of Per­son­al­ized Med­i­cine and Inte­gra­tive Neu­ro­science. The sci­ence includes both mea­sures of genes using whole genome approaches and SNIPS as well as BRAIN­mark­ers of direct brain func­tion such as brain imag­ing, bio­phys­i­cal changes and objec­tive cog­ni­tive and behav­ioral mea­sure­ments. More infor­ma­tion below.

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36-Hour Offer

Dr. Evian Gor­don will speak at the upcom­ing 2011 Sharp­Brains Sum­mit: Retool­ing Brain Health for the 21st Cen­tury (March 30th — April 1st) and his firm, Brain Resource, is among Sum­mit Spon­sors. Thanks to his sup­port, we are pleased to announce the fol­low­ing offer: TEN pro­fes­sion­als who reg­is­ter to attend the 2011 Sharp­Brains Sum­mit over the next 36 hours, from now until Fri­day March 4th, 7pm US Pacific Time, will each receive a com­pli­men­tary hard­copy of the book Inte­gra­tive Neu­ro­science and Per­son­al­ized Med­i­cine. If more than ten peo­ple reg­is­ter by then, we will select ten names at random.

We are also pleased to announce the addi­tion of 12 new Speak­ers and Mod­er­a­tors to the 2011 Sharp­Brains Sum­mit — the result­ing agenda is turn­ing out to be noth­ing short of spec­tac­u­lar (in our, yes, a bit biased judgment):

• Alexan­dra More­house, CMO, AAA North California
• Dr. Evian Gor­don, CEO, Brain Resource
• Kath­leen Herath, Asst Vice Pres­i­dent, Nation­wide Insurance
• Dr. David Tal, Direc­tor, A.G.E. Mat­ters Clinic
• Paula Psyl­lakis, Senior Pol­icy Advi­sor, Ontario Min­istry of Research and Innovation
• Veronika Litin­ski, Advi­sor, MaRS Life Sci­ences and Health Care
• Dr. Joshua Stein­er­man, Assis­tant Pro­fes­sor, Albert Ein­stein Col­lege of Medicine
• Dr. Jef­frey Kaye, Direc­tor, NIA — ORCATECH
• Dr. John Rep­pas, Pol­icy Direc­tor, Neu­rotech­nol­ogy Indus­try Organization
• Dr. Justin Mar­ley, Chair Men­tal Health Infor­mat­ics Group, UK Royal Col­lege of Psychiatrists
• Dr. David Darby, Chief Med­ical Offi­cer, Cogstate
• Dr. John Hart, Med­ical Sci­ence Direc­tor, Cen­ter for Brain Health at UT-Dallas

-> Learn More and Reg­is­ter to Par­tic­i­pate in the Sum­mit Here, and get a chance at get­ting a com­pli­men­tary copy of the book Inte­gra­tive Neu­ro­science and Per­son­al­ized Med­i­cine!

Read the rest of this entry »

Every Mon­day dur­ing the next 10 weeks we’ll dis­cuss here what lead­ing indus­try, sci­ence and pol­icy experts –all of whom will speak at the upcom­ing 2011 Sharp­Brains Sum­mit (March 30th — April 1st, 2011)– have to say about emerg­ing oppor­tu­ni­ties and chal­lenges to address, over the next 10 years, the grow­ing brain-related soci­etal demands.

With­out fur­ther ado, here you have what four Sum­mit Speak­ers say…

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Alvaro Pascual-Leone is the Direc­tor of the Berenson-Allen Cen­ter for Non-Invasive Brain Stim­u­la­tion at Har­vard Med­ical School.

1. How would you define “brain fit­ness” vs. “phys­i­cal fit­ness”?

Phys­i­cal fit­ness can refer to an over­all or gen­eral state of health and well-being. How­ever, it is also often used more specif­i­cally to refer to the abil­ity to per­form a given activ­ity, occu­pa­tion, or sport.

Sim­i­larly brain fit­ness might be used to refer to a gen­eral state of healthy, opti­mized brain func­tion, or a more spe­cific brain-based abil­ity to process cer­tain, spe­cific infor­ma­tion, enable cer­tain motor actions, or sup­port cer­tain cog­ni­tive abil­i­ties. Impor­tantly though, I would argue Read the rest of this entry »

Dr. John Docherty is an Adjunct Pro­fes­sor of Psy­chi­a­try at the Weill Med­ical Col­lege, Cor­nell Uni­ver­sity, Direc­tor of Post Grad­u­ate Edu­ca­tion there, and Chief Med­ical Offi­cer of Brain Resource. Trained as a clin­i­cal research fel­low in neu­ropsy­chophar­ma­col­ogy at NIMH, he later returned as Chief of the Psy­choso­cial Treat­ments Research Branch, respon­si­ble for all fed­er­ally sup­ported psy­choso­cial treat­ment research in men­tal health nation­wide. He over­saw the land­mark National Col­lab­o­ra­tive Study of the Treat­ment of Depres­sion and served as a mem­ber and Chair­man for over 10 years on the NIMH and then NIDA Treat­ment Research IRGs. Dr. Docherty has wide expe­ri­ence in suc­cess­fully imple­ment­ing inno­va­tion in both clin­i­cal oper­a­tions and man­aged health care. He founded North­east Psy­chi­atric Asso­ciates in 1985. As National Med­ical Direc­tor for National Med­ical Enter­prises, he over­saw med­ical con­trol and qual­ity improve­ment in 74 hos­pi­tals in 34 states. He was the Exec­u­tive Vice-President and Chief Med­ical Offi­cer for Merit Behav­ioral Care, which then cov­ered 30 mil­lion peo­ple. In 1998, he founded Com­pre­hen­sive Neu­ro­Science (CNS). Its Care Man­age­ment Tech­nolo­gies are cur­rently imple­mented in 17 state Med­ic­aid plans. Dr Docherty has received numer­ous hon­ors and awards and has authored over 100 sci­en­tific publications.

(Editor’s note: this inter­view with Dr. John Docherty was orig­i­nally pub­lished in Sharp­Brains’ mar­ket report Trans­form­ing Brain Health with Dig­i­tal Tools to Assess, Enhance and Treat Cog­ni­tion across the Lifes­pan, pub­lished in July 2010)

Alvaro Fer­nan­dez: Dr. Docherty, it is a plea­sure to be with you today to dis­cuss the main theme of Sharp­Brains’ 2010 mar­ket report – how the con­ver­gence of sci­en­tific find­ings and tech­nol­ogy plat­forms and tools is reshap­ing how as a soci­ety and as indi­vid­u­als we will take care of cog­ni­tion and men­tal well­ness along the life­course, giv­ing birth to the emerg­ing dig­i­tal brain health and fit­ness mar­ket. Can you first briefly dis­cuss your career tra­jec­tory and your cur­rent role at Brain Resource?

Dr. John Docherty: Sure. The main theme of my work since the 1960s has remained the same, “How do we put knowl­edge into effec­tive use to improve men­tal health?” Over the last cen­tury, med­i­cine made tremen­dous progress in gen­er­at­ing sci­en­tific and clin­i­cal knowl­edge. Basic research dis­cov­ery sci­ence and clin­i­cal treat­ment devel­op­ment sci­ence have made great progress. Within Psy­chi­a­try there was stan­dard set­ting advance in the 1960’s through the NIMH-VA coop­er­a­tive stud­ies to the method­ol­ogy of assess­ing the effi­cacy of psy­chophar­ma­co­log­i­cal drugs. This work estab­lished prin­ci­ples adopted for the study of med­ica­tions in the other areas of med­i­cine. The study of psy­chother­apy, how­ever, lagged in devel­op­ment. In my role of Chief of the Psy­choso­cial Treat­ments Branch of the NIMH , I helped con­tribute to the advance of that work by sup­port­ing the efforts of an extra­or­di­nary group of indi­vid­u­als led by Irene Waskow who car­ried out the TDCRP. This study estab­lished the method­olo­gies that made pos­si­ble the effec­tive sci­en­tific study of the effi­cacy of psy­chother­a­pies. The evi­dence base and of such treat­ments as CBT, DBT, Moti­va­tional Enhance­ment Treat­ment and other evidence-based psy­chother­a­pies derives directly from this study and its sem­i­nal influ­ence. This was a con­tri­bu­tion to the sci­ence of Clin­i­cal Treat­ment Devel­op­ment research.

I would say that my major inter­est, how­ever, has been in the next step, the sci­ence of knowl­edge trans­fer. There has been and remains a long and costly (in terms par­tic­u­larly of unnec­es­sary suf­fer­ing) lag between the devel­op­ment of new knowl­edge and its com­mon and effec­tive use in practice.

In order the help the field moved for­ward, I have worked for the last 20 years in the devel­op­ment and imple­men­ta­tion of meth­ods to effec­tively trans­fer knowl­edge into prac­tice. Read the rest of this entry »

Nice week­end read­ing mate­r­ial — recent news reiforc­ing emerg­ing trends on phys­i­cal, cog­ni­tive and emo­tional fit­ness, but with new twists.

Fit teens could be smarter teens

“Researchers from Swe­den and USC exam­ined data on 1.2 mil­lion Swedish men born between 1950 and 1976 who also enlisted for the country’s manda­tory mil­i­tary ser­vice. They looked at the par­tic­i­pants’ global intel­li­gence scores as well as log­i­cal, visu­ospa­tial, ver­bal and tech­ni­cal scores. The greater the car­dio­vas­cu­lar fit­ness, the higher the cog­ni­tive scores at age 18. The asso­ci­a­tion between mus­cle strength and global intel­li­gence, in con­trast, was weak.”

UPMC Health Plan Offers Brain Fit­ness Soft­ware to Improve Health

“UPMC Health Plan announced today that it has signed an agree­ment to offer award-winning brain fit­ness soft­ware from Posit Sci­ence®, at no cost, to all UPMC for Life Medicare Advan­tage mem­bers. This brain train­ing pro­gram is a new part of the UPMC Health Plan well­ness ser­vices, which focus on both mind and body fitness.

The brain fit­ness soft­ware, known as the Insight™ Brain Fit­ness Pro­gram, is a suite of five game-like com­puter exer­cises that make brain train­ing chal­leng­ing and effec­tive. The pro­gram engages the brain’s nat­ural plas­tic­ity (the brain’s abil­ity to rewire itself) to improve basic brain function.”

Brain-fitness indus­try grows as baby-boomers work to stay sharp.

“When we’re younger we’re learn­ing quite inten­sively,” she said. “By mid­dle age, we’re not learn­ing inten­sively any­more and just using skills we’ve already mas­tered. That’s why it’s impor­tant to stretch your brain.”

Brain fit­ness games also have the poten­tial to improve one’s emo­tional health, said Mark Bald­win, a psy­chol­ogy pro­fes­sor at McGill Uni­ver­sity in Montreal.

Bald­win has devel­oped a num­ber of com­puter games based on keep­ing a brain active phys­i­o­log­i­cally, to improve it psychologically.

“It’s about prac­tis­ing or using games to train ben­e­fi­cial habits of thought, ” he said.

Good arti­cle today in the NYT on “chemo brain” — some typ­i­cal short-term and long-term cog­ni­tive con­se­quences of chemotherapy.

The Fog That Fol­lows Chemother­apy (New York Times)

One quote is crit­i­cal — for chemo brain and also for a vari­ety of clin­i­cal con­di­tions that present asso­ci­ated cog­ni­tive impairments:

“Con­trol­ling for brain func­tion before can­cer treat­ment begins can help deter­mine cause and effect. In one study, can­cer patients took a bat­tery of neu­ropsy­cho­log­i­cal tests before start­ing chemother­apy, three weeks after com­plet­ing treat­ment, and again one year later. Although a third of the patients had signs of cog­ni­tive impair­ment before ther­apy began, the num­ber jumped to 61 per­cent after treat­ment, and half remained impaired a year later.”

As we have dis­cussed before, I believe that inex­pen­sive com­put­er­ized cog­ni­tive assess­ments will start to become widely avail­able in only a few years, to help set up indi­vid­u­al­ized cog­ni­tive base­lines and inform clin­i­cal diag­noses and treat­ments. For more, you can read Com­put­er­ized Cog­ni­tive Assess­ments: oppor­tu­ni­ties and concerns