The recent dis­cov­ery that expe­ri­ence can change brain struc­ture and func­tion at any age has sparked numer­ous health, edu­ca­tion, and pro­duc­tiv­ity appli­ca­tions whose value and lim­i­ta­tions we are only start­ing to grasp.

Brain fit­ness has quickly become a main­stream aspi­ra­tion among baby boomers and elders, pri­mar­ily in North Amer­ica. It has fueled a grow­ing inter­est in brain fit­ness classes, brain fit­ness cen­ters, and brain fit­ness pro­grams, along with atten­dant oppor­tu­ni­ties and chal­lenges. An increas­ing num­ber of adults want use­ful tools to pro­tect cog­ni­tive health and performance—not nec­es­sar­ily to reverse aging—and what they are find­ing is an expand­ing and noisy mar­ket­place where they (and also pro­fes­sion­als) need to care­fully eval­u­ate their own needs and the avail­able options (Fer­nan­dez and Gold­berg, 2009). Read the rest of this entry »

Baby­boomers, wor­ried about demen­tia, are look­ing for ways to keep their brain active. Board games and brain fit­ness soft­ware pro­grams are part of the answer. How­ever it is not always easy to find and com­pare these prod­ucts. This arti­cle shows how Mar­ble: The Brain Store has devel­oped a very inter­ac­tive retail expe­ri­ence to help con­sumers find the prod­ucts that are right for them.

Note that we will have a chance to learn more about the con­cept as Lind­say Gask­ins, CEO of Mar­bles, will be speak­ing at the Sharp­Brains Sum­mit this month (March 30 — April 1).

Mar­bles is mak­ing its mark with enter­tain­ment and ser­vice. This is not a typ­i­cal game store. Employ­ees are called brain coaches, not sales asso­ciates, and are trained on how to play the hun­dreds of games and puz­zles and soft­ware in the store.

Like a book­store, Mar­bles divides its prod­ucts by sub­ject: crit­i­cal think­ing, mem­ory, coor­di­na­tion, visual per­cep­tion and word skills. The store car­ries 250 prod­ucts […] There are games for fine-motor skills, stress relief, atten­tion deficit dis­or­der, cre­ativ­ity and dyslexia, just to name a few.

As part of the research behind the book The Sharp­Brains Guide for Brain Fit­ness we inter­viewed dozens of lead­ing cog­ni­tive health and fit­ness sci­en­tists and experts world­wide to learn about their research and thoughts, and have a num­ber of take-aways to report.

What can we clearly say today that we couldn’t have said only 10 years ago? That what neu­ro­science pio­neer San­ti­ago Ramon y Cajal claimed in the XX cen­tury, “Every man can, if he so desires, become the sculp­tor his own brain”, may well become real­ity in the XXI.

And trans­form Edu­ca­tion, Health, Train­ing, and Gam­ing in the process, since Read the rest of this entry »

Have you read the cover story of the New Sci­en­tist this week: Men­tal mus­cle: six ways to boost your brain?

The arti­cle, which includes good infor­ma­tion on brain food, the value of med­i­ta­tion, etc., starts by say­ing that: “Brain train­ing doesn’t work, but there are lots of other ways to give your grey mat­ter a quick boost.” Fur­ther in the arti­cle you can read “… brain train­ing soft­ware has now been con­signed to the shelf of tech­nolo­gies that failed to live up to expectations.”

Such claims are based on the one study widely pub­li­cized ear­lier this year: the BBC “brain train­ing” exper­i­ment, pub­lished by Owen et al. (2010) in Nature.

What hap­pened to the sci­en­tific rigor asso­ci­ated with the New Scientist?

As expressed in one of our pre­vi­ous posts: “Once more, claims seem to go beyond the sci­ence back­ing them up … except that in this case it is the researchers, not the devel­op­ers, who are respon­si­ble.” (See BBC “Brain Train­ing” Exper­i­ment: the Good, the Bad, the Ugly).

Read our two pre­vi­ous posts to get to the heart of the BBC study and what it really means. As Alvaro Fer­nan­dez and Dr. Zelin­ski explore the poten­tial sci­en­tific flaws of the study, they both point out that there are very promis­ing pub­lished exam­ples of brain train­ing method­olo­gies that seem to work.

BBC “Brain Train­ing” Exper­i­ment: the Good, the Bad, the Ugly

Sci­en­tific cri­tique of BBC/ Nature Brain Train­ing Experiment

In spite of the recent eco­nomic down­turn, rev­enues for dig­i­tal tech­nolo­gies to assess, enhance and treat cog­ni­tion, or dig­i­tal brain health and fit­ness tools, grew 35% in 2009. “The con­ver­gence of demo­graphic and pol­icy trends with cog­ni­tive neu­ro­science dis­cov­er­ies and tech­no­log­i­cal inno­va­tion is giv­ing birth to a nascent mar­ket­place that can fun­da­men­tally trans­form what brain health is, how it is mea­sured, and how it is done,” says Alvaro Fer­nan­dez, mem­ber of the World Eco­nomic Forum’s Coun­cil on the Aging Soci­ety and Editor-in-Chief of the report. “This ground­break­ing report can help pio­neers shape the emerg­ing toolkit to ben­e­fit an aging soci­ety that increas­ingly seeks new ways to enhance cog­ni­tive func­tion­al­ity and men­tal well­ness across the lifespan.”

“As the brain is thrust into the cen­ter of the health­care ecosys­tem, inno­v­a­tive cog­ni­tive health and brain fit­ness appli­ca­tions will play an increas­ingly impor­tant role in defin­ing neu­ro­cen­tric health,” adds Jake Duna­gan, Research Direc­tor at the Insti­tute For The Future.

Report: Trans­form­ing Brain Health with Dig­i­tal Tools to Assess, Enhance and Treat Cog­ni­tion across the Lifes­pan: The State of the Brain Fit­ness Mar­ket 2010.

A major­ity among the 1,900+ decision-makers and early-adopters sur­veyed said they trusted the effec­tive­ness of non-invasive options above inva­sive options to enhance crit­i­cal brain func­tion­al­ity. Pro­fes­sional and intel­lec­tual chal­lenges were rated very effec­tive by 61% of respon­dents, aer­o­bic exer­cise and read­ing books by 42%, med­i­ta­tion by 38%, com­put­er­ized brain train­ing by 26%, tak­ing pre­scrip­tion drugs by 13%, tak­ing sup­ple­ments by 12%, and self-medicating with drugs by 1%.

These are among the key find­ings of a 207-page mar­ket report released today by Sharp­Brains and pre­pared in col­lab­o­ra­tion with 24 lead­ing sci­en­tists and 10 inno­v­a­tive orga­ni­za­tions — the most com­pre­hen­sive such research study done to ana­lyze emerg­ing research, tech­nolo­gies and marketplace.

“We must do for brain health in the 21st cen­tury what we largely accom­plished in car­dio­vas­cu­lar health in the past cen­tury. It’s time to take sci­en­tific insights out of the lab and to iden­tify prac­ti­cal appli­ca­tions, mak­ing the main­te­nance of good brain fit­ness a pub­lic health pri­or­ity,” indi­cates William Reich­man, MD, Pres­i­dent and CEO of Baycrest.

Other Report High­lights are: Read the rest of this entry »

In a recently pub­lished sci­en­tific study (see Hall C, et al “Cog­ni­tive activ­i­ties delay onset of mem­ory decline in per­sons who develop demen­tia” Neu­rol­ogy 2009; 73: 356–361), Hall and col­leagues exam­ined how edu­ca­tion and stim­u­lat­ing activ­i­ties may inter­act to con­tribute to cog­ni­tive reserve. The study involved 488 ini­tially healthy peo­ple, aver­age age 79, who enrolled in the Bronx Aging Study between 1980 and 1983. These indi­vid­u­als were fol­lowed for 5 years with assess­ments every 12 to 18 months (start­ing in 1980). At the start of the study, all par­tic­i­pants were asked how many cog­ni­tive activ­i­ties (read­ing, writ­ing, cross­word puz­zles, board or card games, group dis­cus­sions, or play­ing music) they par­tic­i­pated in and for how many days a week. Researchers were able to eval­u­ate the impact of self-reported par­tic­i­pa­tion these activ­i­ties on the onset of accel­er­ated mem­ory decline in 101 indi­vid­u­als who devel­oped demen­tia dur­ing the study.

Results showed that for every “activ­ity day” (par­tic­i­pa­tion in one activ­ity for one day a week) the sub­jects engaged in, they delayed for about two months the onset of rapid mem­ory loss asso­ci­ated with demen­tia. Inter­est­ingly, the pos­i­tive effect of brain-stimulating activ­i­ties in this study appeared to be inde­pen­dent of a person’s level of education.

This is great news as it sug­gests that it is never too late to try to build up brain reserve. The more brain stim­u­lat­ing activ­i­ties one does and the more often, the bet­ter for a stronger cog­ni­tive reserve.

The cog­ni­tive reserve hypoth­e­sis sug­gests that indi­vid­u­als with more cog­ni­tive reserve can expe­ri­ence more Alzheimer’s dis­ease pathol­ogy in the brain (more plaques and tan­gles) with­out devel­op­ing Alzheimer’s dis­ease symptoms.

How does that work? Sci­en­tists are not sure but two pos­si­bil­i­ties are con­sid­ered.
1. One is that more cog­ni­tive reserve means more brain reserve, that is more neu­rons and con­nec­tions between neu­rons.
2. Another pos­si­bil­ity is that more cog­ni­tive reserve means more com­pen­satory processes (see my pre­vi­ous post “Edu­ca­tion builds Cog­ni­tive Reserve for Alzheimers Dis­ease Pro­tec­tion” for more details.)

Now, one may won­der about the dif­fer­ence types of men­tal stim­u­la­tion avail­able, includ­ing not only puz­zles and such, but struc­tured activ­i­ties such as brain fit­ness soft­ware and med­i­ta­tion. Do we exer­cise our brain every time we think about some­thing? What can one do to exer­cise one’s brain in ways that enhance capac­ity? Does aer­o­bic fit­ness train­ing also exer­cise one’s brain? What types of method­olo­gies and prod­ucts are avail­able? Do they “work”? Are all the same?

Those are the types of ques­tions we wanted to address in the book The Sharp­Brains Guide To Brain Fit­ness (avail­able via Amazon.com). We are proud of the recog­ni­tion the book has started to obtain, includ­ing endorse­ments by lead­ing scientists:

“The Sharp­Brains Guide to Brain Fit­ness is the only book that I know of that seam­lessly inte­grates lat­est infor­ma­tion about cog­ni­tive health across the lifes­pan, with inter­views with active researchers exam­in­ing cog­ni­tive main­te­nance and enhance­ment, along with reviews of com­mer­cial prod­ucts tar­geted to cog­ni­tive enhance­ment. The book should be very use­ful to any­one inter­ested in brain care, both health care pro­fes­sion­als and the pub­lic at large”.
— Arthur Kramer, Pro­fes­sor of Psy­chol­ogy at Uni­ver­sity of Illinois

“This Sharp­Brains book pro­vides a very valu­able ser­vice to a wide com­mu­nity inter­ested in learn­ing and brain top­ics. I found it inter­est­ing and help­ful“
- Michael Pos­ner, Emer­i­tus Pro­fes­sor of Neu­ro­science at the Uni­ver­sity of Ore­gon, and first recip­i­ent of the Dogan Prize

– Pas­cale Mich­e­lon, Ph. D., is Sharp­Brains’ Research Man­ager for Edu­ca­tional Projects. Dr. Mich­e­lon has a Ph.D. in Cog­ni­tive Psy­chol­ogy and has worked as a Research Sci­en­tist at Wash­ing­ton Uni­ver­sity in Saint Louis, in the Psy­chol­ogy Depart­ment. She con­ducted sev­eral research projects to under­stand how the brain makes use of visual infor­ma­tion and mem­o­rizes facts. She is now an Adjunct Fac­ulty at Wash­ing­ton University.

Ref­er­ences:

- Study: Hall C, et al “Cog­ni­tive activ­i­ties delay onset of mem­ory decline in per­sons who develop demen­tia” Neu­rol­ogy 2009; 73: 356–361

- Book: The Sharp­Brains Guide To Brain Fit­ness: 18 Inter­views with Sci­en­tists, Prac­ti­cal Advice, and Prod­uct Reviews, to Keep Your Brain Sharp

(Editor’s note: this arti­cle belongs to the excel­lent May 2009 spe­cial issue on Aug­ment­ing Cog­ni­tion of sci­en­tific jour­nal Fron­tiers in Neu­ro­science, Vol­ume 3, Issue 1. You can order this issue, for 50 euros, here. Highly rec­om­mended for sci­en­tists and tech­ni­cal read­ers inter­ested in the sci­ence. This arti­cle, an indus­try overview, is repro­duced here with autho­riza­tion by the Fron­tiers Research Foun­da­tion).

Prepar­ing Soci­ety for the Cog­ni­tive Age

- By Alvaro Fernandez

Ground­break­ing cog­ni­tive neu­ro­science research has occurred over the last 20 years — with­out par­al­lel growth of con­sumer aware­ness and appro­pri­ate pro­fes­sional dis­sem­i­na­tion. “Cog­ni­tion” remains an elu­sive con­cept with unclear impli­ca­tions out­side the research community.

Ear­lier this year, I pre­sented a talk to health care pro­fes­sion­als at the New York Acad­emy of Med­i­cine, titled “Brain Fit­ness Soft­ware: Help­ing Con­sumers Sep­a­rate Hope from Hype”. I explained what com­put­er­ized cog­ni­tive assess­ment and train­ing tools can do (assess/enhance spe­cific cog­ni­tive func­tions), what they can­not do (reduce one’s “brain age”) and the cur­rent uncer­tain­ties about what they can do (i.e., delay Alzheimer’s symp­toms). At the same sym­po­sium, Dr. Gary Kennedy, Direc­tor of Geri­atric Psy­chi­a­try at Mon­te­fiore Med­ical Cen­ter, pro­vided guid­ance on why and how to screen for exec­u­tive func­tion deficits in the con­text of dementia.

I could per­ceive two emerg­ing trends at the event: 1) “Aug­ment­ing Cog­ni­tion” research is most com­monly framed as a health­care, often phar­ma­co­log­i­cal topic, with the tra­di­tional cog­ni­tive bias in med­i­cine of focus­ing on detec­tion and treat­ment of dis­ease, 2) In addi­tion, there is a grow­ing inter­est in non-invasive enhance­ment options and over­all lifestyle issues. Research find­ings in Aug­ment­ing Cog­ni­tion are only just begin­ning to reach the main­stream mar­ket­place, mostly through health­care chan­nels. The oppor­tu­nity is immense, but we will need to ensure the mar­ket­place matures in a ratio­nal and sus­tain­able man­ner, both through health­care and non-healthcare channels.

In Jan­u­ary 2009, we polled the 21,000 sub­scribers of Sharp­Brains’ mar­ket research eNewslet­ter to iden­tify atti­tudes and behav­iors towards the “brain fit­ness” field (a term we chose in 2006 based on a num­ber of con­sumer sur­veys and focus groups to con­nect with a wider audi­ence). Over 2,000 decision-makers and early adopters responded to the survey.

One of the key ques­tions we asked was, “What is the most impor­tant prob­lem you see in the brain fit­ness field and how do you think it can be solved?”. Some exam­ples of the sur­vey free text answers are quoted here, together with my suggestions.

Most impor­tant prob­lems in the brain fit­ness field

Pub­lic aware­ness (39%): “To get peo­ple to under­stand that hered­ity alone does not decide brain func­tion­ing”. We need to ramp up efforts to build pub­lic aware­ness and enthu­si­asm about brain research, includ­ing estab­lish­ing clear links to daily liv­ing. We can col­lab­o­rate with ini­tia­tives such as the Dana Foundation’s Brain Aware­ness Week and use the recent “Neu­ro­science Core Con­cepts” mate­ri­als devel­oped by the Soci­ety for Neu­ro­science to give talks at schools, libraries and workplaces.

Claims (21%): “The lack of stan­dards and clear def­i­n­i­tions is very con­fus­ing, and Read the rest of this entry »

My pre­sen­ta­tion to open our Games for Health Con­fer­ence track is now avail­able via SlideShare:

See Bird’s Eye View of Cog­ni­tive Health Innovation

Descrip­tion: Sci­en­tific, tech­no­log­i­cal and demo­graphic trends have con­verged to cre­ate a new $265m mar­ket in the US alone: seri­ous games, soft­ware and online appli­ca­tions that can help peo­ple of all ages assess and train cog­ni­tive abil­i­ties. Alvaro Fer­nan­dez will pro­vide a Bird’s Eye View of the sci­ence, mar­ket seg­ments and trends, com­pet­i­tive land­scape, and main chal­lenges ahead, based on The State of the Brain Fit­ness Soft­ware Mar­ket 2009 report released in May, which included Research Exec­u­tive Briefs pre­pared by 12 lead­ing sci­en­tists and a sur­vey of 2,000+ decision-makers and early adopters.

61% of respon­dents to the sur­vey Strongly Agreed with the state­ment “Address­ing cog­ni­tive and brain health should be a health­care pri­or­ity.”  But, 65% Agreed/Strongly Agreed with “I don’t really know what to expect from prod­ucts mak­ing brain claims.” In this ses­sion, Alvaro will pub­licly unveil the new book The Sharp­Brains Guide to Brain Fit­ness: 18 Inter­views with Sci­en­tists, Prac­ti­cal Advice, and Prod­uct Reviews, To Keep Your Brain Sharp, co-authored by neu­ropsy­chol­o­gist Dr. Elkhonon Gold­berg and him­self, aimed at help­ing con­sumers and pro­fes­sion­als under­stand and nav­i­gate this grow­ing field.

To see slides, check out Bird’s Eye View of Cog­ni­tive Health Innovation

Enjoy the 4th of July!

You may be read­ing all about brain fit­ness and brain train­ing. It seems every week brings a new bar­rage of arti­cles and stud­ies which often con­tra­dict what you read the month before: Does Gingko Biloba help delay Alzheimer’s Dis­ease? Can phys­i­cal exer­cise help you stay sharp as you age? Which computer-based “brain fit­ness pro­grams”, if any, are worth your money?

All this cov­er­age reflects very excit­ing sci­en­tific find­ings but also poses a key dilemma: How to become an informed life­long learner and con­sumer when there are few and con­tra­dic­tory author­i­ta­tive guidelines?

The Sharp­Brains Guide to Brain Fit­ness (to be pub­lished in May 2009; $24.95) aims to fill that void. This guide is the result of over a year of exten­sive research includ­ing more than a hun­dred inter­views with sci­en­tists, pro­fes­sion­als and con­sumers, and a deep lit­er­a­ture review. Below you have some of the main find­ings from our effort. The guide not only cov­ers these aspects in more depth and offers prac­ti­cal guid­ance, but also includes 18 inter­views with promi­nent sci­en­tists to help you under­stand the research better.

Can we intro­duce you to your Brain?

The Guide will start at the obvi­ous start­ing point: The Human Brain. In order to make informed deci­sions about brain health, one needs to first under­stand the basic orga­ni­za­tion of the human brain and how it tends to change as we get older.

* The brain is com­posed of a num­ber of regions serv­ing dis­tinct func­tions. For­get IQ: our life and pro­duc­tiv­ity depend on a vari­ety of brain func­tions, not just one.

* There is noth­ing inher­ently fixed in the tra­jec­tory of how brain func­tions evolve as we age. Your lifestyle, actions, and even thoughts, do matter.

The 4 Pil­lars of Brain Maintenance

Neu­ro­plas­tic­ity is the life­long capac­ity of the brain to change and rewire itself in response to the stim­u­la­tion of learn­ing and expe­ri­ence. The lat­est sci­en­tific research shows that spe­cific lifestyles and actions can, no mat­ter our age, improve the health and level of func­tion­ing of our brains.

What fac­tors seem to have the most influ­ence? Read the rest of this entry »

Ben Sawyer and I just agreed to cre­ate a new Cog­ni­tive Health track –Pow­ered by Sharp­Brains– at the 5th Annual Games for Health Con­fer­ence. I will host the 11-session track, cov­er­ing a vari­ety of cog­ni­tive health and brain fit­ness top­ics and an overview of Sharp­Brains’ upcom­ing report The State of the Brain Fit­ness Soft­ware Mar­ket 2009.

When and where: June 11-12th at the Hyatt Har­bor­side Hotel in Boston, MA.

Con­text: The Games for Health Con­fer­ence is pro­duced by The Seri­ous Games Ini­tia­tive and sup­ported by the Robert Wood John­son Foun­da­tion. The con­fer­ence brings together researchers, med­ical pro­fes­sion­als, decision-makers at health­care and insur­ance providers, inno­va­tors and game devel­op­ers. I have attended a few times, and have always been impressed by the cal­iber of both speak­ers and every­one in the audi­ence. Really a very good crowd.

Some options to participate?

1) Attend: The cur­rent price is $379, with a 15% dis­count if you use code “sharp09” (with­out quo­ta­tion) when you reg­is­ter Here. Spe­cial price for stu­dents is $200.

Please note that the Cog­ni­tive Health track is being sched­uled now — we will announce the detailed agenda dur­ing the month of May.

2) Speak: We are look­ing for inno­va­tors, researchers and decision-makers who would like to speak about their ongo­ing projects related to the use of games and other computer-based tech­nolo­gies for cog­ni­tive health.

If inter­ested, please Con­tact Us, by May 1st, a cou­ple of para­graphs sum­ma­riz­ing a) your project, bio and orga­ni­za­tion, b) what key lessons learned and impres­sions you would share if given 20 minutes.

3) Advertise/ Sponsor/ Exhibit: To inquire about options, please con­tact Beth Bryant, one of the con­fer­ence orga­niz­ers, at bbryant at dmill.com

We are proud to col­lab­o­rate with The Games for Health Con­fer­ence and expand the Cog­ni­tive Health dialogue!