Every Mon­day dur­ing the next 10 weeks we’ll dis­cuss here what lead­ing indus­try, sci­ence and pol­icy experts –all of whom will speak at the upcom­ing 2011 Sharp­Brains Sum­mit (March 30th — April 1st, 2011)– have to say about emerg­ing oppor­tu­ni­ties and chal­lenges to address, over the next 10 years, the grow­ing brain-related soci­etal demands.

With­out fur­ther ado, here you have what four Sum­mit Speak­ers say…

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Alvaro Pascual-Leone is the Direc­tor of the Berenson-Allen Cen­ter for Non-Invasive Brain Stim­u­la­tion at Har­vard Med­ical School.

1. How would you define “brain fit­ness” vs. “phys­i­cal fit­ness”?

Phys­i­cal fit­ness can refer to an over­all or gen­eral state of health and well-being. How­ever, it is also often used more specif­i­cally to refer to the abil­ity to per­form a given activ­ity, occu­pa­tion, or sport.

Sim­i­larly brain fit­ness might be used to refer to a gen­eral state of healthy, opti­mized brain func­tion, or a more spe­cific brain-based abil­ity to process cer­tain, spe­cific infor­ma­tion, enable cer­tain motor actions, or sup­port cer­tain cog­ni­tive abil­i­ties. Impor­tantly though, I would argue Read the rest of this entry »

After many many months of men­tal stim­u­la­tion, phys­i­cal exer­cise and the cer­tain need for stress man­age­ment… we have just announced the release of the The State of the Brain Fit­ness Soft­ware Mar­ket 2009 report, our sec­ond annual com­pre­hen­sive mar­ket analy­sis of the US mar­ket for com­put­er­ized cog­ni­tive assess­ment and train­ing tools. In this report we esti­mate the size of the US brain fit­ness soft­ware mar­ket at $265M in 2008, up from $225M in 2007 (18% annual growth), and from $100m in 2005. Two seg­ments fuelled the mar­ket growth from 2007 to 2008: con­sumers (grew from $80m to $95m) and health­care & insur­ance providers (grew from $65m to $80m).

The 150-page report finds promis­ing research and ini­tia­tives to drive sig­nif­i­cant growth, com­bined with increased con­sumer con­fu­sion given aggres­sive mar­ket­ing claims and lack of edu­ca­tion and stan­dards. The report includes:
– The com­plete results of an exclu­sive Jan­u­ary 2009 Sur­vey with 2,000+ respon­dents
– A pro­pri­etary Mar­ket & Research Momen­tum Matrix to cat­e­go­rize 21 key ven­dors into four cat­e­gories
– 10 Research Exec­u­tive Briefs writ­ten by lead­ing sci­en­tists at promi­nent research labs
– An analy­sis of the level of clin­i­cal val­i­da­tion per prod­uct and cog­ni­tive domain

Top 10 High­lights from the report:

1) Con­sumers, seniors, com­mu­ni­ties and insur­ance providers drove year on year sus­tained growth, from $225m in 2007 to $265m in 2008. Rev­enues may reach between $1 bil­lion to $5 bil­lion by 2015, depend­ing on how impor­tant prob­lems (Pub­lic Aware­ness, Nav­i­gat­ing Claims, Research, Health Cul­ture, Lack of Assess­ment) are addressed.

2) Increased inter­est and con­fu­sion: 61% of respon­dents Strongly Agree with the state­ment Address­ing cog­ni­tive and brain health should be a health­care pri­or­ity. But, 65% Agree/Strongly Agree. I don’t really know what to expect from prod­ucts mak­ing brain claims.

3) Invest­ment in R&D seeds future growth: Land­mark invest­ments by insur­ance providers and government-funded research insti­tutes test­ing new brain fit­ness appli­ca­tions planted new seeds for future growth.

4) Becom­ing stan­dard in res­i­den­tial facil­i­ties: Over 700 res­i­den­tial facil­i­ties mostly Inde­pen­dent and Assisted Liv­ing facil­i­ties and CCRCs have installed com­put­er­ized cog­ni­tive train­ing programs.

5) Cus­tomer sat­is­fac­tion: Con­sumers seem more sat­is­fied with computer-based prod­ucts than paper-based options. But, sat­is­fac­tion dif­fers by prod­uct. When asked I got real value for my money, results were as fol­lows: Lumosity.com (65% Agree), Puz­zle Books (60%), Posit Sci­ence (52%), Nin­tendo (51%) agreed. Posit Sci­ence (53% Agree) and Lumosity.com (51%) do bet­ter than Puz­zle Books (39%) and Nin­tendo (38%) at I have seen the results I wanted.

6) Assess­ments: Increas­ing adop­tion of computer-based cog­ni­tive assess­ments to base­line and track cog­ni­tive func­tions over time in mil­i­tary, sports, and clin­i­cal con­texts. The Alzheimer’s Foun­da­tion of Amer­ica now advo­cates for wide­spread cog­ni­tive screen­ings after 65–75.

7) Spe­cific com­put­er­ized cog­ni­tive train­ing and videogames have been shown to improve brain func­tions, but the key ques­tions are, Which ones, and Who needs what when?

Aggres­sive mar­ket­ing claims are cre­at­ing con­fu­sion and skep­ti­cism, result­ing in a dis­tract­ing con­tro­versy between two mis­lead­ing extremes: (a) buy­ing prod­uct XYZ can reju­ve­nate your brain Y years or (b) those prod­ucts don’t work; just do one more cross­word puz­zle. The upcom­ing book The Sharp­Brains Guide to Brain Fit­ness aims to help con­sumers nav­i­gate these claims.

9) Devel­op­ers can be clas­si­fied into four groups, based on a pro­pri­etary Mar­ket and Research Momen­tum Matrix: Sharp­Brains finds 4 Lead­ers, 8 High Poten­tials, 3 Cross­words 2.0, and 6 Wait & See companies.

10) Increased dif­fer­en­ti­a­tion: Lead­ing com­pa­nies are bet­ter defin­ing their value propo­si­tion and dis­tri­b­u­tion chan­nels to reach spe­cific seg­ments such as retire­ment com­mu­ni­ties, schools, or health­care providers.

Lead­ing researchers pre­pared 10 Research Exec­u­tive Briefs:
- Dr. Joshua Stein­er­man (Einstein-Monteore): Neu­ro­pro­tec­tion via cog­ni­tive activ­i­ties
– Dr. Jerri Edwards (South Florida): Assess­ments of dri­ving fit­ness
– Dr. Susanne Jaeggi and Dr. Mar­tin Buschkuehl (Bern, Michi­gan): Work­ing mem­ory train­ing and  intel­li­gence
– Dr. Torkel Kling­berg (Karolin­ska): Work­ing mem­ory train­ing, dopamine, and math
– Dr. Liz Zelin­ski (UC Davis): Audi­tory pro­cess­ing train­ing
– Dr. David Vance (UAB): Speed-of-processing train­ing
– Dr. Jerri Edwards (South Florida): Cog­ni­tive train­ing for healthy aging
– Dr. Daphne Bave­lier & Dr. Shawn Green (Rochester): Action videogames and atten­tional skills
– Dr. Arthur Kramer (Illi­nois): Strat­egy videogames and exec­u­tive func­tions
– Dr. Yaakov Stern (Colum­bia): The cog­ni­tive reserve and neu­roimag­ing
– Dr. David Rabiner (Duke): Objec­tive assess­ments for ADHD

Table of Contents

Edi­to­r­ial
Exec­u­tive Sum­mary
Chap­ter 1. Bird-Eye View of the Grow­ing Field
Chap­ter 2. Mar­ket Sur­vey on Beliefs, Atti­tudes, Pur­chase Habits
Chap­ter 3. The Emerg­ing Com­pet­i­tive Land­scape
Chap­ter 4. The Sci­ence for Brain Fit­ness and Cog­ni­tive Health
Chap­ter 5. Con­sumers  Adopt­ing Cross­words 2.0?
Chap­ter 6: Health­care and Insur­ance Providers — A Cul­ture of Cog­ni­tive Health
Chap­ter 7: K12 School Sys­tems– Ready for Change?
Chap­ter 8: Mil­i­tary, Sports Teams, Com­pa­nies,  Brain-Performance Link
Chap­ter 9: Future Direc­tions‚ Pro­jec­tions and Bottlenecks

Com­pa­nies pro­filed include: Advanced Brain Tech­nolo­gies, Applied Cog­ni­tive Engi­neer­ing, Brain Cen­ter Amer­ica, Brain Resource, CNS Vital Signs, Cogmed, Cogstate, Cog­niFit, Cog­ni­tive Drug Research, Dakim, Houghton Mif­flin, Learn­ing Enhance­ment Cor­po­ra­tion, Learn­ingRx, Lumos Labs, Mar­bles: The Brain Store, Nin­tendo, NovaV­i­sion, Posit Sci­ence, Sci­en­tific Brain Train­ing, Sci­en­tific Learn­ing, Trans­An­a­lyt­ics, vibrant­Brains, Vig­or­ous Mind, Viv­ity Labs.

More on the report by click­ing on The State of the Brain Fit­ness Soft­ware Mar­ket 2009.

As men­tioned before, the World Eco­nomic Forum asked me to write “an 800 words sum­mary of your most com­pelling action­able idea on the chal­lenges of geron­tol­ogy”, in prepa­ra­tion for the Inau­gural Sum­mit of the Global Agenda that will take place Novem­ber 7 to 9th in Dubai.A good num­ber of Sharp­Brains read­ers and clients offered their insights — and expressed an inter­est in read­ing the draft. So below you have — a pro­posal to cre­ate a Global Con­sor­tium for Neu­rocog­ni­tive Fit­ness Inno­va­tion, build­ing on our exist­ing mar­ket research and advi­sory ser­vices work. Your thoughts?

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The Con­text

Grow­ing Demands on Our Brains: Pic­ture 6.7 bil­lion Prim­i­tive Brains inhab­it­ing a Knowl­edge Soci­ety where life­long learn­ing and mas­ter­ing con­stant change in com­plex envi­ron­ments are crit­i­cal for pro­duc­tive work, health and per­sonal fulfillment.

Wel­come to Planet Earth, 2008.

Fur­ther stretched by increased longevity: Now pic­ture close to 1 bil­lion of those brains over the age of 60 – and please remem­ber that, less than 100 years ago, life expectancy was between 30 to 40 years. The rapidly evolv­ing Knowl­edge Soci­ety is plac­ing new and enor­mous demands on our “prim­i­tive” human brains. And the longer our lifes­pans, the more obvi­ous the “cog­ni­tive gap”. Hence, from a health point of view, the grow­ing Read the rest of this entry »

Brain-fitness plan can improve mem­ory (Syd­ney Morn­ing Her­ald), reports on the recent endorse­ment of Posit Science’s pro­grams (Posit Sci­ence Pro­gram Clas­sic, focused on audi­tory pro­cess­ing train­ing, and Posit Sci­ence Cor­tex^™ with InSight^™, on visual pro­cess­ing). Quotes: Read the rest of this entry »

Some recent brain train­ing and health news:

1) A Promis­ing Debut for Com­put­er­ized Therapies

2) Fit­ness pro­tects brain in Alzheimer’s patients

3) Brain Fit­ness Pro­gram Clas­sic comes to Mac

4) Posit Sci­ence gains own­er­ship of Sci­en­tific Learn­ing (NSDQ: SCIL) BrainConnection.

5) Brain train­ing on your mobile

6) You must remem­ber this: how the mind works

Here you have the links and my com­men­tary for these news: Read the rest of this entry »

Two inter­est­ing com­pany press releases, one yes­ter­day one today, show­ing how cog­ni­tive inter­ven­tions may be help­ful no mat­ter our age, from kids to seniors, as long as we under­stand what those “tools” are sup­posed to do and don’t expect, or are promised, miracles:

Dakim® , Inc. Secures $10.6 Mil­lion Series C Fund­ing Led by Galen Partners

- “an inno­va­tor in brain fit­ness tech­nol­ogy solu­tions, today announced Read the rest of this entry »

Sharon Beg­ley, Newsweek’s sci­ence reporter, recently wrote that

- “With the nation’s 78 mil­lion baby boomers approach­ing the age of those dreaded ‘“where did I leave my keys?” moments, it’s no won­der the mar­ket for computer-based brain train­ing has shot up from essen­tially zero in 2005 to $80 mil­lion this year, accord­ing to the con­sult­ing firm SharpBrains.

- “Now comes the largest and most rig­or­ous study of a commercially-available train­ing pro­gram, and it shows that there is hope for aging brains. This morn­ing, at the meet­ing of the Geron­to­log­i­cal Soci­ety of Amer­ica, sci­en­tists are pre­sent­ing data show­ing that after eight weeks of daily one-hour ses­sions with Brain Fit­ness 2.0 from Posit Sci­ence, elderly vol­un­teers got mea­sur­ably bet­ter in their brain’s speed and accu­racy of processing.

We recently had the chance to inter­view Dr. Eliz­a­beth Zelin­ski of the Uni­ver­sity of South­ern Cal­i­for­nia Andrus Geron­tol­ogy Cen­ter, who led the IMPACT (Improve­ment in Mem­ory with Plasticity-based Adap­tive Cog­ni­tive Train­ing) Study Sharon Beg­ley refers to in the quote above.

First, some con­text on this study, which is by far the largest high-quality study of its kind. The study was prospec­tive, ran­dom­ized, con­trolled, and used a dou­ble blind trial. 524 healthy adults 65-year-old and over were divided into two groups. One received an hour a day of train­ing for eight to ten weeks, and the other spent the same amount of time watch­ing edu­ca­tional DVDs. The IMPACT study, funded by Posit Sci­ence cor­po­ra­tion, was per­formed in mul­ti­ple loca­tions, includ­ing the Mayo Clinic, USCF, and San Fran­cisco Vet­eran Affairs Med­ical Center.

The dis­cus­sion cen­ters at his point on the ini­tial results that were pre­sented Geron­to­log­i­cal Soci­ety of Amer­ica (the study hasn’t been pub­lished yet).

Alvaro Fer­nan­dez: Dr. Zelin­ski. Thank you for being with us. Could you start by set­ting the con­text and pro­vid­ing an overview of how human cog­ni­tive abil­i­ties typ­i­cally evolve as we age based on insights from your Long Beach Lon­gi­tu­di­nal Study?

Eliz­a­beth Zelin­ski: Of course. The first con­cept to under­stand is that dif­fer­ent cog­ni­tive skills evolve over the lifes­pan in dif­fer­ent ways. Some that rely on expe­ri­ence, such as vocab­u­lary, actu­ally improve as we age. Some tend to decline grad­u­ally, start­ing in our late 20s. This hap­pens, for exam­ple, with pro­cess­ing speed (how long it takes us to process and respond to infor­ma­tion), mem­ory, and rea­son­ing. We could sum­ma­rize this phe­nom­e­non by say­ing that as we age we get bet­ter at deal­ing with the famil­iar, but worse at deal­ing with the new. We can always learn, but at a slower pace.

Are there any spe­cific tip­ping or inflec­tion points in this trend, any age when the rate of decline is more pronounced?

We don’t have a clear answer to that. It depends a lot on the indi­vid­ual. In gen­eral it is a grad­ual, cumu­la­tive process, so that by age 70 we sta­tis­ti­cally see clear age declines. Which, for exam­ple, is a strong fac­tor deter­min­ing why older adults strug­gle to adapt to new tech­nolo­gies, but why try­ing to learn them pro­vides needed men­tal stim­u­la­tion. Now we know that genes only account for a por­tion of this decline. Much of it depends on our envi­ron­ment, lifestyle and actions.

Can you sum­ma­rize what a healthy indi­vid­ual can do to slow down this process of decline, and help stay healthy and pro­duc­tive as long as possible?

One gen­eral rec­om­men­da­tion is to do every­thing we can to pre­vent or delay dis­ease processes, such as dia­betes or high-blood pres­sure, that have a neg­a­tive effect on our brains. For exam­ple, it is a tragedy in our soci­ety that we usu­ally reduce our lev­els of phys­i­cal exer­cise dras­ti­cally after we leave school.

Let me then ask: what are the rel­a­tive virtues of phys­i­cal vs. men­tal exercise?

Great ques­tion! That in fact leads into my sec­ond rec­om­men­da­tion. Aer­o­bic exer­cise has been shown to Read the rest of this entry »

Newsweek’s Sharon Beg­ley writes a great note on Brain Train­ing: How It Works based on ini­tial data pre­sented at the Geron­to­log­i­cal Soci­ety of Amer­ica over the week­end. Some quotes:

- With the nation’s 78 mil­lion baby boomers approach­ing the age of those dreaded “where did I leave my keys? moments, it’s no won­der the mar­ket for computer-based brain train­ing has shot up from essen­tially zero in 2005 to $80 mil­lion this year, accord­ing to the con­sult­ing firm SharpBrains.

- Now comes the largest and most rig­or­ous study of a commercially-available train­ing pro­gram, and it shows that there is hope for aging brains. This morn­ing, at the meet­ing of the Geron­to­log­i­cal Soci­ety of Amer­ica, sci­en­tists are pre­sent­ing data show­ing that after eight weeks of daily one-hour ses­sions with Brain Fit­ness 2.0 from Posit Sci­ence, elderly vol­un­teers got mea­sur­ably bet­ter in their brain’s speed and accu­racy of pro­cess­ing. And unlike every other train­ing pro­gram tested before, the improve­ments “gen­er­al­ize to broad mea­sures of cog­ni­tion and are notice­able in every­day life,” Eliz­a­beth Zelin­ski of the Uni­ver­sity of South­ern Cal­i­for­nia, who led the IMPACT (Improve­ment in Mem­ory with Plasticity-based Adap­tive Cog­ni­tive Train­ing) Study, reports.

- For the IMPACT study, 468 par­tic­i­pants, all healthy adults 65 and over, were divided into two groups. One received an hour a day of train­ing on Brain­Fit­ness for eight to ten weeks, and the other (the con­trol group) got the same amount of computer-based learn­ing. That choice of con­trol group is sig­nif­i­cant. It means that Brain Fit­ness was being com­pared not to star­ing into space or some sim­i­larly unhelp­ful activ­ity, but to one that might rea­son­ably be expected to improve men­tal ability.

- Because the Brain Fit­ness group showed greater improve­ments than the con­trols, includ­ing on tasks that the computer-based exer­cises did not explic­itly tar­get, it sug­gests that the audi­tory train­ing has altered some­thing fun­da­men­tal in the brain and not just spe­cific cir­cuits for, say, memory.

Read full post: Brain Train­ing: How It Works

The Geron­to­log­i­cal Soci­ety of Amer­ica press release includes

- Researchers released ini­tial data today at the 60th Annual Meet­ing of The Geron­to­log­i­cal Soci­ety of Amer­ica (GSA) that showed that doing the right kind of brain exer­cise can enhance mem­ory and other cog­ni­tive abil­i­ties of older adults.

- “We pre­sented these impor­tant results at the Annual Meet­ing of GSA, because aging experts need to spread the word that cog­ni­tive decline is not an inevitable part of aging, said Dr. Zelin­ski. “Doing the prop­erly designed cog­ni­tive activ­i­ties can actu­ally enhance abil­i­ties as you age.”

I will be inter­view­ing Eliz­a­beth Zelin­ski as part of our Neu­ro­science Inter­view Series, so keep tuned.

One clar­i­fi­ca­tion: this is not the first study to show how cog­ni­tive train­ing can gen­er­al­ize beyond the tasks directly trained. Oth­ers have already shown an effect on cog­ni­tive abil­i­ties and even on real-world tasks, on a vari­ety of age groups and trained func­tions. But the size of it (468 par­tic­i­pants) makes it by far the largest that does so, and the effects are very sig­nif­i­cant and promising.

Sev­eral recent sto­ries on brain train­ing and SharpBrains:

1) New brain games may improve mind fit­ness by Kevin Koster­man (U of Wis­con­sin Oshkosh’s Advance-Titan)

“Any­time we learn, we are train­ing, chang­ing, our brain,” Fer­nan­dez said. “The three key core ele­ments for effec­tive brain exer­cise are nov­elty, vari­ety and con­stant chal­lenge, sim­i­lar to increas­ing the level in machines we find in gyms.”

2) “Train­ing the Brain as pos­si­ble as Train­ing the Body”, جريدة النهار by Hanadi El Diri (Anna­har, one of the most pres­ti­gious papers in the Mid­dle East. The text is in Arabic.)

3) “Train your brain” by Mark Muck­en­fuss (The Press-Enterprise in River­side and San Bernardino)

“We can­not promise to peo­ple you will only keep get­ting bet­ter until you are 200 years old. But I think peo­ple still under­es­ti­mate how flex­i­ble the brain really is.”

The Smart­Brains [sic] pro­gram com­bines men­tal exer­cises with a stress reduc­tion pro­gram. Too much stress, says Fer­nan­dez, has been shown to be dam­ag­ing not only to per­for­mance, but to the brain itself.
With all of the avail­able pro­grams for stim­u­lat­ing the brain, he says, it is impor­tant to shop care­fully. A crit­i­cal ele­ment, he says, is how clients or par­tic­i­pants are evaluated.

“Make sure they have a cred­i­ble assess­ment that helps you find your strengths and weak­nesses and that they have pro­grams that address (those areas),” he says. “Assess­ments that give you 50 (as an age-equivalent grade) and a week later you’re 32, that’s not a valu­able assessment.”