Time for Sharp­Brains’ Jan­u­ary 2012 eNewslet­ter, fea­tur­ing in this occa­sion mul­ti­ple thought-provoking per­spec­tives on how emerg­ing neu­ro­science can and should make us rethink pre­vail­ing prac­tices in edu­ca­tion, healthy aging and pre­ven­tive medicine.

Fea­tured Perspectives:

• The Future of Pre­ven­tive Brain Med­i­cine: Break­ing Down the Cog­ni­tion & Alzheimer’s Dis­ease Alpha­bet Soup, by Dr. Dharma Singh Khalsa
• When 1 + 1 = 5: Dyscal­cu­lia and Work­ing Mem­ory, by Dr. Tracy Alloway
• New Review of Neu­ro­feed­back Treat­ment for ADHD — Cur­rent State of the Sci­ence, by Dr. David Rabiner
• The Busi­ness and Ethics of the Brain Fit­ness Boom, by Alvaro Fernandez
• (How to con­tribute arti­cles like these to SharpBrains.com)

New Research: 

• Brain func­tion can start declin­ing as early as age 45
• Edu­ca­tion for Men­tal Fit­ness: “A Sharper Mind, Mid­dle Age and Beyond”
• Life­long cog­ni­tive exer­cise may ward off Alzheimer’s pro­tein beta amyloid
• Cog­ni­tive Train­ing & Brain Teasers Can Increase Open­ness Among Older Adults
• Cog­ni­tive Train­ing in Mild Cog­ni­tive Impair­ment (MCI)
• Does Nin­tendo Brain Age work as a brain train­ing game?
• Brain Injury Care: Treat­ment and Reim­burse­ment Challenges

Resources:

• The Ten Habits of a Sharp Brain
• Brain Teasers and Games, for Kids and Adults
• Upcom­ing Talk & Book Sign­ing in Wash­ing­ton, DC

Have a great month of February.

Build­ing Blocks for a Bet­ter Future

The best alter­na­tive for tomor­row should be bet­ter than the best alter­na­tive avail­able today. How do we get there, when “cog­ni­tion” and “brain fit­ness” remain elu­sive con­cepts in pop­u­lar cul­ture? I believe that the lack of pub­lic edu­ca­tion is the major obsta­cle that lim­its the brain fit­ness field’s poten­tial to deliver real-world ben­e­fits, since only informed demand will ensure the ongo­ing devel­op­ment of ratio­nal, struc­tured “rules of the road.” What could be done to address this and other par­tic­u­lar obsta­cles? Read the rest of this entry »

Engag­ing peo­ple where they are in the life-course

Eighty per­cent of the 38,000 adults over age 50 who were respon­ders in the 2010 AARP Mem­ber Opin­ion Sur­vey indi­cated “stay­ing men­tally sharp” was their top ranked inter­est and con­cern (Dinger, 2010). What exactly does this phrase mean? And what role can tech­nol­ogy play in “stay­ing men­tally sharp”? Intel CEO Paul Otellini has said, “You have to start by think­ing about what peo­ple want to do… and work back­ward.” Read the rest of this entry »

As the pres­i­dent and med­ical direc­tor of the Alzheimer’s Research and Pre­ven­tion Foun­da­tion (ARPF), it’s my job to stay on top of advances in the field of Alzheimer’s research. Recently, a num­ber of arti­cles in the med­ical lit­er­a­ture have caught my atten­tion. They are focused on a par­tic­u­lar ques­tion that con­cerns most Baby Boomers like me: “Is mem­ory loss just a nor­mal part of aging?” Read the rest of this entry »

Below you can find the full tran­script of our engag­ing Q&A ses­sion today on mem­ory, mem­ory tech­niques and brain-healthy lifestyles with Dr. Gary  Small, Direc­tor of UCLA’s Mem­ory Clinic and Cen­ter on Aging, and author of The Mem­ory Bible. You can learn more about his book  Here, and learn more about upcom­ing Brain Fit­ness Q&A Ses­sions Here.

Per­haps one of the best ques­tions and answers was:

2:55
Ques­tion: Gary, you’ve worked many years in this field. Let us in on the secret. What do YOU do you, per­son­ally, to pro­mote your own brain fit­ness?
2:57
Answer: I try to get at least 30 min­utes of aer­o­bic con­di­tion­ing each day; try to min­i­mize my stress by stay­ing con­nected with fam­ily and friends; gen­er­ally eat a brain healthy diet (fish, fruits, veg­eta­bles), and try to bal­ance my online time with my offline time. Which reminds me, I think it is almost time for me to sign off line. Read the rest of this entry »

Pre­dict­ing Alzheimer’s Dis­ease More Accu­rate Through Cog­ni­tive Changes Than Bio­mark­ers (Med­ical News):

• “Mea­sur­ing people’s changes in cog­ni­tive abil­i­ties is a bet­ter pre­dic­tor of Alzheimer’s dis­ease than changes in bio­mark­ers, researchers from the Ben­ito Menni Com­plex Assis­ten­cial en Salut Men­tal, Barcelona, Spain, reported in Archives of Gen­eral Psy­chi­a­try, a JAMA journal.”
• “The inves­ti­ga­tors used a range of tests to assess Read the rest of this entry »

(Editor’s note: Path­ways respon­si­ble for higher-order think­ing in the pre­frontal cor­tex (PFC), or exec­u­tive cen­ter of the brain, remain vul­ner­a­ble through­out life—during crit­i­cal early-life devel­op­men­tal win­dows, when the PFC fully matures in the early 20s, and finally from declines asso­ci­ated with old age. At all ages, phys­i­cal activ­ity and PFC-navigated social con­nec­tions are essen­tial com­po­nents to main­tain­ing brain health. The Expe­ri­ence Corps, a community-based social-engagement pro­gram, part­ners seniors with local schools to pro­mote purpose-driven involve­ment. Par­tic­i­pat­ing seniors have exhib­ited imme­di­ate short-term gains in brain regions vul­ner­a­ble to aging, such as the PFC, indi­cat­ing that peo­ple with the most to lose have the most to gain from envi­ron­men­tal enrichment.)

Over the last decade, sci­en­tists made two key dis­cov­er­ies that reframed our under­stand­ing of the adult brain’s poten­tial to ben­e­fit from life­long envi­ron­men­tal enrich­ment. First, they learned that the adult brain remains plas­tic; it can gen­er­ate new neu­rons in response to phys­i­cal activ­ity and new expe­ri­ences. Sec­ond, they con­firmed the impor­tance of social con­nect­ed­ness to late-life cog­ni­tive, psy­cho­log­i­cal, and phys­i­cal health. The inte­gra­tion of these find­ings with our under­stand­ing of indi­vid­u­als’ devel­op­men­tal needs through­out life under­scores the impor­tance of the “social brain.” The pre­frontal cor­tex (PFC) is par­tic­u­larly inte­gral to nav­i­gat­ing com­plex social behav­iors and hier­ar­chies over the life course. Read the rest of this entry »

(Editor’s Note: this timely new report illus­trates the need for inno­v­a­tive brain fit­ness inter­ven­tions focused on main­tain­ing if not enhanc­ing tar­geted cog­ni­tive func­tion­al­ity, such as dri­ving safety or finan­cial decision-making, lever­ag­ing life­long neu­ro­plas­tic­ity and cog­ni­tive reserve. What the report presents as inex­orable, some­what genet­i­cally pre-programmed decline, it is not.)

BMO Retire­ment Insti­tute Report: Boomers’ Abil­ity to Make Finan­cial Deci­sions Often Declines With Age (Mar­ket Watch):

- “The BMO Retire­ment Insti­tute released a report today which raises aware­ness of the poten­tial impact on aging Cana­di­ans of declin­ing cog­ni­tive abil­i­ties — often caused by Alzheimer’s dis­ease and other forms of demen­tia — and describes how this decline can affect their abil­ity to make finan­cial deci­sions.” Read the rest of this entry »

Very inter­est­ing new data rein­forc­ing two main themes we have been ana­lyz­ing for a while:
1) We bet­ter start pay­ing seri­ous atten­tion (and R&D dol­lars) to lifestyle-based and non-invasive cog­ni­tive and emo­tional health inter­ven­tions, which are mostly ignored in favor of inva­sive, drug-based options
2) Inter­ven­tions will need to be per­son­al­ized. The study below ana­lyzes data at the coun­try level, but the same logic applies to the indi­vid­ual level

Many fear Alzheimer’s, want to be tested: sur­vey (Reuters):

- “The tele­phone sur­vey of 2,678 adults aged 18 and older in the United States, France, Ger­many, Spain and Poland was con­ducted by researchers at the Har­vard School of Pub­lic Health and Read the rest of this entry »

Every Mon­day dur­ing the next 10 weeks we’ll dis­cuss here what lead­ing indus­try, sci­ence and pol­icy experts –all of whom will speak at the upcom­ing 2011 Sharp­Brains Sum­mit (March 30th — April 1st, 2011)– have to say about emerg­ing oppor­tu­ni­ties and chal­lenges to address, over the next 10 years, the grow­ing brain-related soci­etal demands.

With­out fur­ther ado, here you have what four Sum­mit Speak­ers say…

—

Alvaro Pascual-Leone is the Direc­tor of the Berenson-Allen Cen­ter for Non-Invasive Brain Stim­u­la­tion at Har­vard Med­ical School.

1. How would you define “brain fit­ness” vs. “phys­i­cal fit­ness”?

Phys­i­cal fit­ness can refer to an over­all or gen­eral state of health and well-being. How­ever, it is also often used more specif­i­cally to refer to the abil­ity to per­form a given activ­ity, occu­pa­tion, or sport.

Sim­i­larly brain fit­ness might be used to refer to a gen­eral state of healthy, opti­mized brain func­tion, or a more spe­cific brain-based abil­ity to process cer­tain, spe­cific infor­ma­tion, enable cer­tain motor actions, or sup­port cer­tain cog­ni­tive abil­i­ties. Impor­tantly though, I would argue Read the rest of this entry »