SharpBrains

This is a partial list of the literature we reviewed during the research phase of our new book, The SharpBrains Guide to Brain Fitness.  We know many friends of SharpBrains are researchers, healthcare professionals, graduate/ Ph.D. students, who want have direct access to the references (perhaps PubMed should promote itself as a never ending source of mental stimulation?), so here you have this list, organized by relevant chapter. Please note that the list below appears in the book - whose manuscript we had to close in January 2009.

Introduction

• Basak, C. et al. (2008). Can training in a real-time strategy video game attenuate cognitive decline in older adults? Psychology and Aging.
• Begley, S. (2007). Train your mind, change your brain: How a new science reveals our extraordinary potential to transform ourselves. Ballantine Books.
• DeKosky, S. T., et al. (2008). Ginkgo biloba for prevention of dementia: a randomized controlled trial. Journal of the American Medical Association, 300, 2253-2262.
• Doidge, N. (2007). The Brain that changes itself: Stories of personal triumph from the frontiers of brain science. Viking Adult.

Chapter 1. The Brain and Brain Fitness 101

• Bunge, S. A., & Wright, S. B. (2007). Neurodevelopmental changes in working memory and cognitive control. Current Opinion In Neurobiology, 17(2), 243-50.
• Damasio, A. (1995). Descartes’ error: Emotion, reason, and the human brain. Penguin Press.
• David Kolb, D. (1983). Experiential learning: Experience as the source of learning and development. FT Press.
• Draganski, B., Gaser, C., Kempermann, G., Kuhn, H. G., Winkler, J., Buchel, C., & May A. (2006). Temporal and spatial dynamics of brain structure changes during extensive learning. The Journal of Neuroscience, 261231, 6314-6317.
• Gage, F. H., Kempermann, G., & Song, H. (2007). Adult Neurogenesis. Cold Spring Harbor Laboratory Press, NY.
• Gardner, H. (1983). Frames of Mind: The theory of multiple intelligences. New York: Basic Books.
• Gaser, C. & Schlaug, G. (2003). Brain structures differ between musicians and non-musicians. The Journal of Neuroscience, 23, 9240-9245. Continue Reading »

Here you have the June edition of our monthly newsletter covering cognitive health and brain fitness topics. Please remember that you can subscribe to receive this Newsletter by email, using the box at the top of this page.

The full schedule of the SharpBrains' powered Cognitive Health Track at the Games for Health Conference, June 11-12th in Boston, is now available online. 13 sessions will feature 18 innovators and thought-leaders representing developers, universities, clinicians, consumers, insurance companies, and more. You can learn more and register.

Longevity Dividend

Ever heard of the Longevity Dividend? Perhaps Grey is the New Gold: The Kronos Longevity Research Institute has released a new report summarizing the state of aging research that includes an excellent introduction into the Longevity Dividend, a "theory that says we hope to intervene scientifically to slow the aging process, which will also delay the onset of age-related diseases. Delaying aging just seven years would slash rates of conditions like cancer, diabetes, Alzheimer’s disease and heart disease in half." With that context in mind, is the National Institute on Aging getting its fair budget share?

Resources

Visual Representation of the State of the Market 2009: Paul Van Slembrouck  summarizes and beautifully presents the main findings of our 150-page market report, The State of the Brain Fitness Market 2009. Enjoy this excellent graphic.

Book Club Discussion Guide: The goal of our just published book, The SharpBrains Guide to Brain Fitness, is to inform you, but also to open a much needed debate to contribute to our collective brain fitness. We encourage book clubs to read and discuss the book, and suggest 10 questions to kickstart the conversation. Please do send us your answers and impressions!

Education & Learning

10% Students may have working memory problems: Why does this matter?: A recent study screened over 3,000 school-aged students in schools in the UK and found that 1 in 10 was identified as having working memory difficulties. Working memory is our ability to store and manipulate information for a brief time, and difficulties in this brain function may lead into difficulties in reading and mathematics. Dr. Tracy Alloway reviews the study and elaborates.

Despite television, cell phones, and Web “twitter,” traditional reading is still an important skill. Whether it is school textbooks, tech manuals at work, or regular books, people still read, though not as much as they used to. One reason that many people don't read much is that they don't read well. For them, it is slow, hard work and they don't remember as much as they should. Students, for example,may have to read something several times before they understand and remember what they read.

Why? You would think that schools teach kids how to read well. Schools do try. I work with middle-school teachers (see http://peer.tamu.edu) and they tell me that many students are 2-3 years behind grade level in reading proficiency. No doubt, television, cell phones, and the Web are major contributors to this problem, which will apparently get worse if we don't emphasize and improve reading instruction.

Some of the blame can be placed on the fads in reading teaching, such as phonics and “whole language,” which sometimes are promoted by zealots who don't respect the need for both approaches. Much of the blame for poor reading skills can be laid at the feet of parents who set poor examples and, of course, on the youngsters who are too lazy to learn how to read well.

For all those who missed out on good reading skills, it is not too late. I summarize below what I think it takes to read with good speed and comprehension.

1. Read with a purpose.
2. Skim first.
3. Get the reading mechanics right.
4. Be judicious in highlighting and note taking.
5. Think in pictures.
6. Rehearse as you go along.
7. Stay within your attention span and work to increase that span.
8. Rehearse again soon.

1) Know Your Purpose

Everyone should have a purpose for their reading and think about how that purpose is being fulfilled during the actual reading. The advantage for remembering is that checking continuously for how the purpose is being fulfilled helps the reader to stay on task, to focus on the more relevant parts of the text, and to rehearse continuously as one reads. This also saves time and effort because relevant items are most attended.

Identifying the purpose should be easy if you freely choose what to read. Just ask yourself, “Why am I reading this?” If it is to be entertained or pass the time, then there is not much problem. But myriad other reasons could apply, such as:

o to understand a certain group of people, such as Muslims, Jews, Hindus, etc.
o to crystallize your political position, such as why a given government policy should be opposed.
o to develop an informed plan or proposal.
o to satisfy a requirement of an academic course or other assigned reading.

Many of us have readings assigned to us, as in a school environment. Or the boss may hand us a manual and say Continue Reading »

Welcome to the 70th edition of Encephalon, the blog carnival that offers some of the best neuroscience and psychology blog posts every other week.

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Mysteries of Brain and Mind

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On Neurons, Journeys, and Chemical Friends

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On Brain Functions

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Frontiers in Perception

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Next edition will be hosted by Neuroanthropology on Monday, May 25th. If you can't wait until to read more, you may be interested in the new in-depth feature, Cognitive Monthly, offered by Cognitive Daily blog for $2/ month. This month's issue, "The Illusion of Theater," discusses the "remarkable science behind what theatrical professionals seem, to laypeople, to do intuitively: create an environment that encourages us to believe that what we see on stage is a true representation of reality."

Working memory is our ability to store and manipulate information for a brief time. It is typically measured by dual-tasks, where the individual has to remember an item while simultaneously processing a sometimes unrelated piece of information. A widely used working memory task is the reading span task where the individual reads a sentence, verifies it, and then recalls the final word. Individual differences in working memory performance are closely related to a range of academic skills such as reading, spelling, comprehension, and mathematics. Crucially, there is emerging research that working memory predicts learning outcomes independently of IQ. One explanation for the importance of working memory in academic attainment is that because it appears to be relatively unaffected by environmental influences, such as parental educational level and financial background, it measures a student’s capacity to acquire knowledge rather than what they have already learned.

However little is known about the consequences of low working memory capacity per se, independent of other associated learning difficulties. In particular, it is not known either what proportion of students with low working memory capacities has significant learning difficulties or what their behavioral characteristics are. The aim of a recent study published in Child Development (reference below) was to provide the first systematic large-scale examination of the cognitive and behavioral characteristics of school-aged students who have been identified solely on the basis of very low working memory scores.

In screening of over 3000 school-aged students in mainstream schools, 1 in 10 was identified as having working memory difficulties. There were several key findings regarding their cognitive skills. The first is that the majority of them performed below age-expected levels in reading and mathematics. This suggests that Continue Reading »

After many many months of mental stimulation, physical exercise and the certain need for stress management... we have just announced the release of the The State of the Brain Fitness Software Market 2009 report, our second annual comprehensive market analysis of the US market for computerized cognitive assessment and training tools. In this report we estimate the size of the US brain fitness software market at $265M in 2008, up from $225M in 2007 (18% annual growth), and from $100m in 2005. Two segments fuelled the market growth from 2007 to 2008: consumers (grew from $80m to $95m) and healthcare & insurance providers (grew from $65m to $80m).

The 150-page report finds promising research and initiatives to drive significant growth, combined with increased consumer confusion given aggressive marketing claims and lack of education and standards. The report includes:
- The complete results of an exclusive January 2009 Survey with 2,000+ respondents
- A proprietary Market & Research Momentum Matrix to categorize 21 key vendors into four categories
- 10 Research Executive Briefs written by leading scientists at prominent research labs
- An analysis of the level of clinical validation per product and cognitive domain

Top 10 Highlights from the report:

1) Consumers, seniors’ communities and insurance providers drove year on year sustained growth, from $225m in 2007 to $265m in 2008. Revenues may reach between $1 billion to $5 billion by 2015, depending on how important problems (Public Awareness, Navigating Claims, Research, Health Culture, Lack of Assessment) are addressed.

2) Increased interest and confusion: 61% of respondents Strongly Agree with the statement “Addressing cognitive and brain health should be a healthcare priority.” But, 65% Agree/Strongly Agree “I don't really know what to expect from products making brain claims.”

3) Investment in R&D seeds future growth: Landmark investments by insurance providers and government-funded research institutes testing new brain fitness applications planted new seeds for future growth.

4) Becoming standard in residential facilities: Over 700 residential facilities – mostly Independent and Assisted Living facilities and CCRCs – have installed computerized cognitive training programs.

5) Customer satisfaction: Consumers seem more satisfied with computer-based products than paper-based options. But, satisfaction differs by product. When asked “I got real value for my money”, results were as follows: Lumosity.com (65% Agree), Puzzle Books (60%), Posit Science (52%), Nintendo (51%) agreed. Posit Science (53% Agree) and Lumosity.com (51%) do better than Puzzle Books (39%) and Nintendo (38%) at “I have seen the results I wanted.”

6) Assessments: Increasing adoption of computer-based cognitive assessments to baseline and track cognitive functions over time in military, sports, and clinical contexts. The Alzheimer’s Foundation of America now advocates for widespread cognitive screenings after 65-75.

7) Specific computerized cognitive training and videogames have been shown to improve brain functions, but the key questions are, “Which ones”, and “Who needs what when?”

8) Aggressive marketing claims are creating confusion and skepticism, resulting in a distracting controversy between two misleading extremes: (a) “buying product XYZ can rejuvenate your brain Y years” or (b) “those products don’t work; just do one more crossword puzzle.” The upcoming book The SharpBrains Guide to Brain Fitness aims to help consumers navigate these claims.

9) Developers can be classified into four groups, based on a proprietary Market and Research Momentum Matrix: SharpBrains finds 4 Leaders, 8 High Potentials, 3 Crosswords 2.0, and 6 Wait & See companies.

10) Increased differentiation: Leading companies are better defining their value proposition and distribution channels to reach specific segments such as retirement communities, schools, or healthcare providers.

Leading researchers prepared 10 Research Executive Briefs:
- Dr. Joshua Steinerman (Einstein-Montefiore): Neuroprotection via cognitive activities
- Dr. Jerri Edwards (South Florida): Assessments of driving fitness
- Dr. Susanne Jaeggi and Dr. Martin Buschkuehl (Bern, Michigan): Working memory training and fluid intelligence
- Dr. Torkel Klingberg (Karolinska): Working memory training, dopamine, and math
- Dr. Liz Zelinski (UC Davis): Auditory processing training
- Dr. David Vance (UAB): Speed-of-processing training
- Dr. Jerri Edwards (South Florida): Cognitive training for healthy aging
- Dr. Daphne Bavelier & Dr. Shawn Green (Rochester): Action videogames and attentional skills
- Dr. Arthur Kramer (Illinois): Strategy videogames and executive functions
- Dr. Yaakov Stern (Columbia): The cognitive reserve and neuroimaging
- Dr. David Rabiner (Duke): Objective assessments for ADHD

Table of Contents

Editorial
Executive Summary
Chapter 1. Bird’s-Eye View of the Growing Field
Chapter 2. Market Survey on Beliefs, Attitudes, Purchase Habits
Chapter 3. The Emerging Competitive Landscape
Chapter 4. The Science for Brain Fitness and Cognitive Health
Chapter 5. Consumers – Adopting Crosswords 2.0?
Chapter 6: Healthcare and Insurance Providers - A Culture of Cognitive Health
Chapter 7: K12 School Systems- Ready for Change?
Chapter 8: Military, Sports Teams, Companies – Brain-Performance Link
Chapter 9: Future Directions – Projections and Bottlenecks

Companies profiled include: Advanced Brain Technologies, Applied Cognitive Engineering, Brain Center America, Brain Resource, CNS Vital Signs, Cogmed, Cogstate, CogniFit, Cognitive Drug Research, Dakim, Houghton Mifflin, Learning Enhancement Corporation, LearningRx, Lumos Labs, Marbles: The Brain Store, Nintendo, NovaVision, Posit Science, Scientific Brain Training, Scientific Learning, TransAnalytics, vibrantBrains, Vigorous Mind, Vivity Labs.

More on the report by clicking on The State of the Brain Fitness Software Market 2009.

Round-up of recent articles on neuroscience, brain development and cognitive health:

Encephalon 68: A carnival of neuroscience:

Chris hosts a great collection of neuroscience and psychology posts in his signature Q&A style.

Bilingual Babies Get Head Start --- Before They Can Talk:

- Unlike the monolingual group, the bilingual group was able to successfully learn a new sound type and use it to predict where each character would pop up.

- The bilingual babies' skill applies to more than just switching between languages. Mehler likened this apparently enhanced cognitive ability to a brain selecting "the right tool for the right operation"—also called executive function.

- In this basic process, the brain, ever flexible, nimbly switches from one learned response to another as situations change.

- Monolingual babies hone this ability later in their young lives, Mehler suggests."

Study shows how kids' stress hurts memory:

"Now, research is providing what could be crucial clues to explain how childhood poverty translates into dimmer chances of success: Chronic stress from growing up poor appears to have a direct impact on the brain, leaving children with impairment in at least one key area - working memory."

Returning troops getting tested for brain injuries:

- "More than 150,000 service members from the Marines, Air Force, Army and Navy have undergone the testing that became mandatory last year. Those who suffer a concussion or similar head injury will get a follow-up test."

Diabetes 'impact on brain power':

- "Failure to control type 2 diabetes may have a long-term impact on the brain, research has suggested.

- Lead researcher Dr Jackie Price said: "Either hypos lead to cognitive decline, or cognitive decline makes it more difficult for people to manage their diabetes, which in turn causes more hypos.

- "A third explanation could be that a third unidentified factor is causing both the hypos and the cognitive decline."

There's such a flood of very significant research studies, educational resources and articles related to brain health, it's hard to keep track - even for us!

Let me introduce and quote some of the top Brain Health Studies, Articles and Resources published in March:

1) Cognitive Decline Begins In Late 20s, Study Suggests (Science Daily)

- "These patterns suggest that some types of mental flexibility decrease relatively early in adulthood, but that how much knowledge one has, and the effectiveness of integrating it with one's abilities, may increase throughout all of adulthood if there are no pathological diseases," Salthouse said.

- However, Salthouse points out that there is a great deal of variance from person to person

2) Cerebrum 2009: Emerging Ideas in Brain Science - new book by the Dana Foundation that "explores the cutting edge of brain research and its implications in our everyday lives, in language understandable to the general reader."

A couple of excellent chapters of direct relevance to everyone's brain health are:
- Chapter 4: A Road Paved by Reason, by Elizabeth Norton Lasley

- Chapter 10: Neural Health: Is It Facilitated by Work Force Participation?, by Denise Park, Ph.D

3) Staying Sharp DVD Program: "Dr. Jordan Grafman, chief of the Cognitive Neuroscience Section at the National Institute of Neurological Disorders and Stroke outside of Washington, DC, and a member of the Dana Alliance for Brain Initiatives, is your guide as we cover what to expect from the aging brain and what we can do to 'stay sharp.'

For a free DVD of this program you can contact stayingsharp@dana.org. (they say free in their website, I don't know if that includes shipping & handling)

4) Drivers to be tested on cognitive ability starting at age 75 (Japan Times)

The outline of a cognitive test that drivers aged 75 or over will be required to take from June when renewing their licenses was released Thursday...The test is intended to reduce the number of traffic accidents involving elderly drivers by measuring their cognitive level.

5) Physical Fitness Improves Spatial Memory, Increases Size Of Brain Structure (Science Daily)

- "Now researchers have found that elderly adults who are more physically fit tend to have bigger hippocampi and better spatial memory than those who are less fit."

6) Brain Trainers: A Workout for the Mind (Scientific American Mind)

"I recently tried out eight of the latest brain fitness programs, training with each for a week. The programs ranged widely in focus, quality and how fun they were to use. “Like physical exercise equipment, a brain exercise program doesn’t do you any good if you don’t use it,” says Andrew J. Carle, director of the Program in Assisted Living/Senior Housing Administration at George Mason University. And people tend not to use boring equipment. “I remember when NordicTrack was the biggest thing out there. Everyone ran out and bought one, and 90 percent of them ended up as a clothes rack in the back of your bedroom.”

The reporter used: Posit Science's Brain Fitness Program Classic, HappyNeuron, Nintendo BrainAge, CogniFit's MindFit/ CogniFit Personal Coach, Lumosity, MyBrainTrainer, BrainTwister, Cogmed Working Memory Training.

7) The Latest in Mental Health: Working Out at the 'Brain Gym' (Wall Street Journal)

- "Marshall Kahn, an 82-year-old family doctor in Fullerton, Calif., says he got such a boost from brain exercises he started doing at a "Nifty after Fifty" club that he decided to start seeing patients again part-time. "Doing all the mental exercise," he says, "I realized I've still got it."

8) Debate Over Drugs For ADHD Reignites (Washington Post)

- "New data from a large federal study have reignited a debate over the effectiveness of long-term drug treatment of children with hyperactivity or attention-deficit disorder, and have drawn accusations that some members of the research team have sought to play down evidence that medications do little good beyond 24 months."

- "The study also indicated that long-term use of the drugs can stunt children's growth."

8) Adaptive training leads to sustained enhancement of poor working memory in children (Developmental Science)

Abstract: Working memory plays a crucial role in supporting learning, with poor progress in reading and mathematics characterizing children with low memory skills. This study investigated whether these problems can be overcome by a training program designed to boost working memory. Children with low working memory skills were assessed on measures of working memory, IQ and academic attainment before and after training on either adaptive or non-adaptive versions of the program. Adaptive training that taxed working memory to its limits was associated with substantial and sustained gains in working memory, with age-appropriate levels achieved by the majority of children. Mathematical ability also improved significantly 6 months following adaptive training. These findings indicate that common impairments in working memory and associated learning difficulties may be overcome with this behavioral treatment.

9) Brain cortex thinning linked to inherited depression (Los Angeles Times)

- "On average, people with a family history of depression appear to have brains that are 28% thinner in the right cortex --- the outermost layer of the brain --- than those with no known family history of the disease. That cortical thinning, said the researchers, is on a scale similar to that seen in patients with Alzheimer's disease or schizophrenia."

Here you have the presentation I delivered on Tuesday at ETech 2009 (this year's O'Reilly Emerging Technology Conference):

Emerging Research and Technology for Life Hacking/ Brain Training

(click to open presentation in new window)

Description: Life hacking. Brain training. They are one and the same. The brain’s frontal lobes enable our goal-oriented behavior, supporting “executive functions,” such as decision-making, attention, emotional self-regulation, goal-setting, and working memory. These functions can be enhanced with targeted practice – such as life hacking. This session will provide an overview of the cognitive neuroscience underpinning life hacking, and review the state-of-the-art of non-invasive tools for brain training: neurofeedback, biofeedback, software applications, cognitive simulations, Transcranial Magnetic Stimulation, and plain-old meditation.

It was great to meet fellow bloggers and presenters, such as Shelley Batts of Of Two Minds and Chris Patil of Ouroboros, and very inquisite and throughful audience members. Getting ready to speak at ASA/ NCOA and IHRSA next week!

Today we continue the conversation with Maggie Jackson, author of Distracted: The Erosion of Attention and the Coming Dark Age.

You can read part 1 here.

Q - In your Harvard Management Update interview, you said that "When what we pay attention to is driven by the last email we received, the trivial and the crucial occupy the same plane." As well, it seems to be that a problem is our culture's over-idealization of "always on" and "road warrior" habits, which distract from the importance of executive functions such as paying attention to one's environment, setting up goals and plans, executing on them, measuring results, and internalizing learning. How can companies better equip their employees for future success? Can you offer some examples of companies who have positive cultures that encourage and reward employees fully put their frontal lobes into good use?

A – As I mentioned above, we are working and living in ways that undermine our ability to strategize, focus, reflect, innovate. Skimming, multitasking and speed all have a place in 21st-century life. But we can’t let go of deeper skills of focus and thinking and relating, or we’ll create a society of misunderstanding and shallow thinking.

To create workplaces that foster strategic thinking, deep social connection and innovation, we need to take three steps:

First, question the values that venerate McThinking and undermine attention. Recently, my morning paper carried a front-page story about efforts “in an age of impatience” to create a quick-boot computer. “It’s ridiculous to ask people to wait a couple of minutes to start up their computer,” explained one tech executive. The first hand up in the classroom, the hyper business-man or –woman who can’t sit still, much less listen – these are icons of success in American society. Still, many of us are beginning to question our adoration of instant gratification and hyper-mobility.

Second, we need to set the stage for focus individually and collectively by rewriting our climate of distraction and inattention. To help, some companies and business leaders are experimenting with “white space” – the creation of physical spaces or times on the calendar for uninterrupted, unwired thinking and Continue Reading »