SharpBrains

This is a partial list of the literature we reviewed during the research phase of our new book, The SharpBrains Guide to Brain Fitness.  We know many friends of SharpBrains are researchers, healthcare professionals, graduate/ Ph.D. students, who want have direct access to the references (perhaps PubMed should promote itself as a never ending source of mental stimulation?), so here you have this list, organized by relevant chapter. Please note that the list below appears in the book - whose manuscript we had to close in January 2009.

Introduction

• Basak, C. et al. (2008). Can training in a real-time strategy video game attenuate cognitive decline in older adults? Psychology and Aging.
• Begley, S. (2007). Train your mind, change your brain: How a new science reveals our extraordinary potential to transform ourselves. Ballantine Books.
• DeKosky, S. T., et al. (2008). Ginkgo biloba for prevention of dementia: a randomized controlled trial. Journal of the American Medical Association, 300, 2253-2262.
• Doidge, N. (2007). The Brain that changes itself: Stories of personal triumph from the frontiers of brain science. Viking Adult.

Chapter 1. The Brain and Brain Fitness 101

• Bunge, S. A., & Wright, S. B. (2007). Neurodevelopmental changes in working memory and cognitive control. Current Opinion In Neurobiology, 17(2), 243-50.
• Damasio, A. (1995). Descartes’ error: Emotion, reason, and the human brain. Penguin Press.
• David Kolb, D. (1983). Experiential learning: Experience as the source of learning and development. FT Press.
• Draganski, B., Gaser, C., Kempermann, G., Kuhn, H. G., Winkler, J., Buchel, C., & May A. (2006). Temporal and spatial dynamics of brain structure changes during extensive learning. The Journal of Neuroscience, 261231, 6314-6317.
• Gage, F. H., Kempermann, G., & Song, H. (2007). Adult Neurogenesis. Cold Spring Harbor Laboratory Press, NY.
• Gardner, H. (1983). Frames of Mind: The theory of multiple intelligences. New York: Basic Books.
• Gaser, C. & Schlaug, G. (2003). Brain structures differ between musicians and non-musicians. The Journal of Neuroscience, 23, 9240-9245. Continue Reading »

You may be reading all about brain fitness and brain training. It seems every week brings a new barrage of articles and studies which often contradict what you read the month before: Does Gingko Biloba help delay Alzheimer’s Disease? Can physical exercise help you stay sharp as you age? Which computer-based “brain fitness programs”, if any, are worth your money?

All this coverage reflects very exciting scientific findings but also poses a key dilemma: How to become an informed lifelong learner and consumer when there are few and contradictory authoritative guidelines?

The SharpBrains Guide to Brain Fitness (to be published in May 2009; $24.95) aims to fill that void. This guide is the result of over a year of extensive research including more than a hundred interviews with scientists, professionals and consumers, and a deep literature review. Below you have some of the main findings from our effort. The guide not only covers these aspects in more depth and offers practical guidance, but also includes 18 interviews with prominent scientists to help you understand the research better.

Can we introduce you to your Brain?

The Guide will start at the obvious starting point: The Human Brain. In order to make informed decisions about brain health, one needs to first understand the basic organization of the human brain and how it tends to change as we get older.

• The brain is composed of a number of regions serving distinct functions. Forget IQ: our life and productivity depend on a variety of brain functions, not just one.

• There is nothing inherently fixed in the trajectory of how brain functions evolve as we age. Your lifestyle, actions, and even thoughts, do matter.

The 4 Pillars of Brain Maintenance

Neuroplasticity is the lifelong capacity of the brain to change and rewire itself in response to the stimulation of learning and experience. The latest scientific research shows that specific lifestyles and actions can, no matter our age, improve the health and level of functioning of our brains.

What factors seem to have the most influence? Continue Reading »

The growing field of cognitive training (one of the tools for brain fitness) can appear very confusing as the media keeps reporting contradictory claims. These claims are often based on press releases, without a deeper evaluation of the scientific evidence.

Let’s take a couple of recent examples, in successive days:

“It doesn’t work!” type of headline:
Reuters (Feb. 10, 2009) — Formal brain exercise won't help healthy seniors: research
“Healthy older people shouldn't bother spending money on computer games and websites promising to ward off mental decline, the author of a review of scientific evidence for the benefits of these "brain exercise" programs says”.

“It works!” type of headline:
ScienceDaily (Feb. 11, 2009) — Computer Exercises Improve Memory And Attention, Study Suggests
“According to the researchers, participants who used the Brain Fitness Program also scored as well as those ten years younger, on average, on memory and attention tests for which they did not train.”

So… does structured brain exercise / cognitive training work or not?

The problem may in fact reside in asking this very question in the first place, as Alvaro pointed out a while ago in his article “Alzheimer's Disease: too serious to play with headlines“.

We need a more nuanced set of questions.

Why? Because:
1. Cognition is made of several different abilities (working memory, attention, executive functions such as decision-making, etc)
2. Available training programs do not all train the same abilities
3. Users of training programs do not all have the same needs or goals
4. We need to differentiate between enhancing cognitive functions and delaying the onset of cognitive deficits such as Alzheimer’s.

Let’s illustrate these points, by Continue Reading »

Study Questions Effectiveness Of $80 Million Per Year 'Brain Exercise Products Industry for Elderly (Science Daily)

- "There is much research on the benefits of cognitive rehabilitation strategies among elderly who already experience mild cognitive impairment (MCI) or Alzheimer's disease, as well as on the positive impact of physical exercise. The researchers, however, wanted to evaluate current research that would focus on the impact of cognitive interventions in the healthy elderly population."

- "...they concluded that there was no evidence indicating that structured cognitive intervention programs had an impact on the progression of dementia in the healthy elderly population"

Comment:  we have not reviewed the analysis yet, so cannot comment in depth. However, just from the press release, we see a few potential problems in how the study was framed, reducing its practical value: Continue Reading »

Dear reader and member of SharpBrains' community,
We want to thank you for your attention and support in 2008, and wish you a Happy, Prosperous, Healthy and Positive 2009!

Below you have the December edition of our monthly newsletter. Enjoy:

Best of 2008

Top 30 Brain Fitness Articles of 2008: We have compiled SharpBrains' 30 most popular articles, written by thirteen Expert Contributors and staff members for you. Have you read them all?

November-December News: No month goes by without significant news in the field of cognitive fitness. Summarized here are 10 recent developments worthy of attention, including an upcoming brain training product for ice hockey players, my lecture at New York Public Library, and more.

Interviews: Videogames, Meditation

Are videogames good for your brain?: A landmark study by Dr. Arthur Kramer and colleagues has shown that playing a strategy videogame can bring a variety of significant mental benefits to older brains. Another recent study, also by Kramer and colleagues, does not show similar benefits to younger brains (despite playing the same game). How can this be? Dr. Kramer, who has kindly agreed to serve on SharpBrains' Scientific Advisory Board, elaborates.

Meditation on the Brain: Dr. Andrew Newberg provides an excellent overview of the brain benefits of practices such as meditation. He recommends, "look for something simple, easy to try first, ensuring the practice is compatible with one's beliefs and goals. You need to match practice with need: understand the specific goals you have in mind, your schedule and lifestyle, and find something practical."

The Need for Objective Assessments

Cognitive screenings and Alzheimer's Disease: The Alzheimer's Foundation of America just released a thoughtful report advocating for widespread cognitive screenings after the age of 65 (55 given the right conditions). SharpBrains readers, probed by Dr. Joshua Steinerman, seem to agree.

Quantitative EEG for ADHD diagnosis: Dr. David Rabiner reports on the findings from a recent study that documents the utility of Quantitative EEG as an objective test to assist in the diagnosis of ADHD. If this procedure were to become more widely used, he suggests, the number of children and adolescents who are inappropriately diagnosed and treated for the disorder would diminish substantially.

Shall we question the brand new book of human troubles?: The fights over the new version of the psychiatric diagnostic manual, the DSM-V, are starting to come to light. Dr. Vaughan Bell wonders why the public debate avoids the key question of whether diagnosis itself is useful for mental health and why psychometrics are simply ignored.

Resources for Lifelong Learning

Education builds Cognitive Reserve for Alzheimers Disease Protection: Dr. Pascale Michelon reviews a recent study that supports the Cognitive Reserve hypothesis - mentally stimulating experiences throughout life, such as formal education, help build a reserve in our brains that contributes to a lower probability of developing Alzheimer's symptoms.

5 Tips on Lifelong Learning & the Adult Brain: Laurie Bartels asks us to please please 1) challenge ourselves with new learning, 2) remember that neuroplasticity and neurogenesis are hallmarks of our brains, 3) check for mis-learning on an ongoing basis, 4) more visuals, less text, 5) move it, move it - start today!

Learning & the Brain is a conference that gets marked on my calendar annually because I always return home having either been exposed to new information, or with a new perspective on an old topic. Last month’s conference in Cambridge, MA, themed Using Emotions Research to Enhance Learning & Achievement, was no exception. As with previous conferences, in addition to the many keynote sessions, I focused on the adult learning strand, since so much of my time is spent providing professional development for, and collaborating with adults. Here are five conference cues as they relate to education.

1. CHALLENGE YOURSELF WITH NEW LEARNING

Aaron Nelson stated that our memory starts to decline between ages twenty-five and thirty, or to phrase it a bit more positively, Sam Wang says our memory peaks around age thirty. On the other end of the age spectrum, according to Ken Kosik, there is unequivocal evidence that education protects against Alzheimer's. Both Nelson and Kosik mentioned the theory of cognitive reserve, which translates roughly to the more we learn, the more connections we create, and therefore the greater the neuronal buffer we have to draw upon as we age.

Elkhonon Goldberg, at last April's conference, stated that “as one ages, the domain of the novel shrinks, and the domain of what is known grows". He cautioned the audience to beware of being on mental autopilot. Thus, the goal is not to simply get better at doing more of the same. The type of learning that makes a difference consists specifically of new, novel challenges. The result of such engagement is that Continue Reading »

Given the growing media coverage mentioning the terms Cognitive Reserve and Brain Reserve, you may be asking yourself, "What exactly is my Cognitive (or Brain) Reserve?"

The cognitive reserve hypothesis, tested in multiple studies, states that individuals with more cognitive reserve can experience more Alzheimer’s disease pathology in the brain (more plaques and tangles) without developing Alzheimer’s disease symptoms.

How does that work? Scientists are not sure but two possibilities are considered.
1. One is that more cognitive reserve means more brain reserve, that is more neurons and connections (synapses) between neurons. Individuals with more synapses would then have more synapses to lose before the critical threshold for Alzheimer’s Disease is reached.
2. Another possibility is that more cognitive reserve means more compensatory processes. The brain of individuals with more cognitive reserve would use more alternative networks to compensate for the damages caused by the pathology in previously used networks.

In a newly published study, Roe and colleagues from Washington University in St. Louis, used the number of years of education as a measure of cognitive reserve. Why years of education? Because previous studies have shown that people who have more education also exhibit a greater resistance to Alzheimer’s symptoms, even while pathological changes are occurring in the brain (see Bennett el al., 2003 or Roe, Xiong, et al., 2008).

Roe and her colleagues studied 198 individuals whose mean age was 67. Out of these 198 individuals, 161 were nondemented and 37 were diagnosed with Alzheimer’s Disease.

All the participants in the study took a Continue Reading »

We offered some Brain Fitness Predictions in our Market Report , including...

"7. Doctors and pharmacists will help patients navigate through the overwhelming range of available products and interpret the results of cognitive assessments. This will require significant professional development efforts, given that most doctors today were trained under a very different understanding of the brain than the one we have today."

The American Medical News, a weekly newspaper for physicians published by the American Medical Association, just published an excellent article along those lines:

Steps to a nimble mind: Physical and mental exercise help keep the brain fit
-- Neuroscience is uncovering techniques to prevent cognitive decline.

A few quotes:

- It's an example that highlights a wave of new thinking about the importance of brain fitness.

- Until recently, conventional wisdom held that our brains were intractable, hard-wired computers. What we were born with was all we got. Age wore down memory and the ability to understand, and few interventions could reverse this process. But increasingly, evidence suggests that physical and mental exercise can alter specific brain regions, making radical improvements in cognitive function.

- With nearly 72 million Americans turning 65 over the next two decades, physicians need the tools to handle growing patient concerns about how to best maintain brain health. Armed with this new brand of science, frontline physicians will be better equipped to address the needs of aging baby boomers, already in the throes of the brain fitness revolution.

- "Encourage them to exercise the brain in novel and complex ways," he says.

Full article: here

One of the physicians quoted in the article is Gary J. Kennedy, MD, Director of the Division of Geriatric Psychiatry at Montefiore Medical Center in NYC and a professor in the Dept. of Psychiatry and Behavioral Sciences at Albert Einstein College of Medicine.

To put the AMA article in better perspective for SharpBrains readers, we asked Dr. Kennedy a few follow-up questions. Below you have his questions.

Alvaro Fernandez (AF): Can you summarize how cognitive functions tend to evolve as we age?

Gary Kennedy (GK): As we age cognitive functions that rely on Continue Reading »

As mentioned before, the World Economic Forum asked me to write "an 800 words summary of your most compelling actionable idea on the challenges of gerontology", in preparation for the Inaugural Summit of the Global Agenda that will take place November 7 to 9th in Dubai.A good number of SharpBrains readers and clients offered their insights - and expressed an interest in reading the draft. So below you have - a proposal to create a Global Consortium for Neurocognitive Fitness Innovation, building on our existing market research and advisory services work. Your thoughts?

-----

The Context

Growing Demands on Our Brains: Picture 6.7 billion Primitive Brains inhabiting a Knowledge Society where lifelong learning and mastering constant change in complex environments are critical for productive work, health and personal fulfillment.

Welcome to Planet Earth, 2008.

Further stretched by increased longevity: Now picture close to 1 billion of those brains over the age of 60 – and please remember that, less than 100 years ago, life expectancy was between 30 to 40 years. The rapidly evolving Knowledge Society is placing new and enormous demands on our “primitive” human brains. And the longer our lifespans, the more obvious the “cognitive gap”. Hence, from a health point of view, the growing Continue Reading »

A couple of recent research findings are making the media rounds, bringing much needed attention to the high Alzheimer's rates among Latinos and to preventive approaches based on the Cognitive Reserve - such as, what jobs we choose:

More Alzheimer's risk for Hispanics, studies find (International Herald Tribune):

- Studies suggest that many Hispanics may have more risk factors for developing dementia than other groups, and a significant number appear to be getting Alzheimer's earlier. And surveys indicate that Latinos, less likely to see doctors because of financial and language barriers, more often mistake dementia symptoms for normal aging, delaying diagnosis.

- "This is the tip of the iceberg of a huge public health challenge," said Yanira Cruz, president of the National Hispanic Council on Aging. "We really need to Continue Reading »