SharpBrains

This is a partial list of the literature we reviewed during the research phase of our new book, The SharpBrains Guide to Brain Fitness.  We know many friends of SharpBrains are researchers, healthcare professionals, graduate/ Ph.D. students, who want have direct access to the references (perhaps PubMed should promote itself as a never ending source of mental stimulation?), so here you have this list, organized by relevant chapter. Please note that the list below appears in the book - whose manuscript we had to close in January 2009.

Introduction

• Basak, C. et al. (2008). Can training in a real-time strategy video game attenuate cognitive decline in older adults? Psychology and Aging.
• Begley, S. (2007). Train your mind, change your brain: How a new science reveals our extraordinary potential to transform ourselves. Ballantine Books.
• DeKosky, S. T., et al. (2008). Ginkgo biloba for prevention of dementia: a randomized controlled trial. Journal of the American Medical Association, 300, 2253-2262.
• Doidge, N. (2007). The Brain that changes itself: Stories of personal triumph from the frontiers of brain science. Viking Adult.

Chapter 1. The Brain and Brain Fitness 101

• Bunge, S. A., & Wright, S. B. (2007). Neurodevelopmental changes in working memory and cognitive control. Current Opinion In Neurobiology, 17(2), 243-50.
• Damasio, A. (1995). Descartes’ error: Emotion, reason, and the human brain. Penguin Press.
• David Kolb, D. (1983). Experiential learning: Experience as the source of learning and development. FT Press.
• Draganski, B., Gaser, C., Kempermann, G., Kuhn, H. G., Winkler, J., Buchel, C., & May A. (2006). Temporal and spatial dynamics of brain structure changes during extensive learning. The Journal of Neuroscience, 261231, 6314-6317.
• Gage, F. H., Kempermann, G., & Song, H. (2007). Adult Neurogenesis. Cold Spring Harbor Laboratory Press, NY.
• Gardner, H. (1983). Frames of Mind: The theory of multiple intelligences. New York: Basic Books.
• Gaser, C. & Schlaug, G. (2003). Brain structures differ between musicians and non-musicians. The Journal of Neuroscience, 23, 9240-9245. Continue Reading »

Brain-fitness games join workplace, as well as senior center, arsenals (MarketWatch)

- "Consumers and retirement homes have made brain-fitness games and exercises a commercial hit, but now some insurers and employers are incorporating them into wellness programs that promote health not just for the body but also for the mind."

- "Improving brain health can result in less presenteeism, the tendency to be at work but be distracted and not able to focus," he added. "If you look at disability costs, absenteeism and presenteeism account for most of the medical costs, and that's a good reason for employers to be focused on brain health." (according to Dr. Eugene Baker, vice president at OptumHealth's Behavioral Solutions division)"

The article reviews innovative practices at OptumHealth, Nationwide Auto Insurance Company, Humana, Penn Treaty American Corp, Allstate, and the US Army. I am glad to see the media start to notice the importance of cognitive assessments and the growing activity by insurers. Continue Reading »

Stanford Issues Findings from Cognitive and Brain Experts Urging Consumer Caution on Memory Fitness Products (press release)

- "Fear of memory loss, mental impairment and Alzheimer's disease lead many consumers to search for products --- from supplements to software --- that claim to ward off such ailments," Laura L. Carstensen, founding director of the Stanford Center on Longevity, said. "Such products are becoming more prolific, but this burgeoning industry is completely unregulated and the claims can range from reasonable though untested, to blatantly false. It is important for consumers to proceed with caution before buying into many of these product claims. There is no magic bullet solution for cognitive decline."

- The Summit's (Note: held in April 2008) statement points out that "it would be wrong to conclude that nothing can be done to improve mental fitness." But goes on to "strongly encourage research that compares the efficacy and the cost-effectiveness of different approaches to maintaining cognitive fitness."

Round-up of April articles and news on neuroscience, brain development and cognitive health:

Games for Health Conferences to host new Cognitive Health Track:

For the first time, a new Cognitive Health track -Powered by SharpBrains- will cover eleven brain fitness and cognitive health topics during the 5th Annual Games for Health Conference. The current price is $379, with a 15% discount if you use code "sharp09" (without quotation) when you register Here. Details: June 11-12th at the Hyatt Harborside Hotel in Boston, MA.

Bilingual Babies Get Head Start --- Before They Can Talk:

- "Unlike the monolingual group, the bilingual group was able to successfully learn a new sound type and use it to predict where each character would pop up...The bilingual babies' skill applies to more than just switching between languages. Mehler likened this apparently enhanced cognitive ability to a brain selecting "the right tool for the right operation"—also called executive function."

- "In this basic process, the brain, ever flexible, nimbly switches from one learned response to another as situations change...Monolingual babies hone this ability later in their young lives, Mehler suggests."

Study shows how kids' stress hurts memory:

"Now, research is providing what could be crucial clues to explain how childhood poverty translates into dimmer chances of success: Continue Reading »

Round-up of recent articles on neuroscience, brain development and cognitive health:

Encephalon 68: A carnival of neuroscience:

Chris hosts a great collection of neuroscience and psychology posts in his signature Q&A style.

Bilingual Babies Get Head Start --- Before They Can Talk:

- Unlike the monolingual group, the bilingual group was able to successfully learn a new sound type and use it to predict where each character would pop up.

- The bilingual babies' skill applies to more than just switching between languages. Mehler likened this apparently enhanced cognitive ability to a brain selecting "the right tool for the right operation"—also called executive function.

- In this basic process, the brain, ever flexible, nimbly switches from one learned response to another as situations change.

- Monolingual babies hone this ability later in their young lives, Mehler suggests."

Study shows how kids' stress hurts memory:

"Now, research is providing what could be crucial clues to explain how childhood poverty translates into dimmer chances of success: Chronic stress from growing up poor appears to have a direct impact on the brain, leaving children with impairment in at least one key area - working memory."

Returning troops getting tested for brain injuries:

- "More than 150,000 service members from the Marines, Air Force, Army and Navy have undergone the testing that became mandatory last year. Those who suffer a concussion or similar head injury will get a follow-up test."

Diabetes 'impact on brain power':

- "Failure to control type 2 diabetes may have a long-term impact on the brain, research has suggested.

- Lead researcher Dr Jackie Price said: "Either hypos lead to cognitive decline, or cognitive decline makes it more difficult for people to manage their diabetes, which in turn causes more hypos.

- "A third explanation could be that a third unidentified factor is causing both the hypos and the cognitive decline."

There's such a flood of very significant research studies, educational resources and articles related to brain health, it's hard to keep track - even for us!

Let me introduce and quote some of the top Brain Health Studies, Articles and Resources published in March:

1) Cognitive Decline Begins In Late 20s, Study Suggests (Science Daily)

- "These patterns suggest that some types of mental flexibility decrease relatively early in adulthood, but that how much knowledge one has, and the effectiveness of integrating it with one's abilities, may increase throughout all of adulthood if there are no pathological diseases," Salthouse said.

- However, Salthouse points out that there is a great deal of variance from person to person

2) Cerebrum 2009: Emerging Ideas in Brain Science - new book by the Dana Foundation that "explores the cutting edge of brain research and its implications in our everyday lives, in language understandable to the general reader."

A couple of excellent chapters of direct relevance to everyone's brain health are:
- Chapter 4: A Road Paved by Reason, by Elizabeth Norton Lasley

- Chapter 10: Neural Health: Is It Facilitated by Work Force Participation?, by Denise Park, Ph.D

3) Staying Sharp DVD Program: "Dr. Jordan Grafman, chief of the Cognitive Neuroscience Section at the National Institute of Neurological Disorders and Stroke outside of Washington, DC, and a member of the Dana Alliance for Brain Initiatives, is your guide as we cover what to expect from the aging brain and what we can do to 'stay sharp.'

For a free DVD of this program you can contact stayingsharp@dana.org. (they say free in their website, I don't know if that includes shipping & handling)

4) Drivers to be tested on cognitive ability starting at age 75 (Japan Times)

The outline of a cognitive test that drivers aged 75 or over will be required to take from June when renewing their licenses was released Thursday...The test is intended to reduce the number of traffic accidents involving elderly drivers by measuring their cognitive level.

5) Physical Fitness Improves Spatial Memory, Increases Size Of Brain Structure (Science Daily)

- "Now researchers have found that elderly adults who are more physically fit tend to have bigger hippocampi and better spatial memory than those who are less fit."

6) Brain Trainers: A Workout for the Mind (Scientific American Mind)

"I recently tried out eight of the latest brain fitness programs, training with each for a week. The programs ranged widely in focus, quality and how fun they were to use. “Like physical exercise equipment, a brain exercise program doesn’t do you any good if you don’t use it,” says Andrew J. Carle, director of the Program in Assisted Living/Senior Housing Administration at George Mason University. And people tend not to use boring equipment. “I remember when NordicTrack was the biggest thing out there. Everyone ran out and bought one, and 90 percent of them ended up as a clothes rack in the back of your bedroom.”

The reporter used: Posit Science's Brain Fitness Program Classic, HappyNeuron, Nintendo BrainAge, CogniFit's MindFit/ CogniFit Personal Coach, Lumosity, MyBrainTrainer, BrainTwister, Cogmed Working Memory Training.

7) The Latest in Mental Health: Working Out at the 'Brain Gym' (Wall Street Journal)

- "Marshall Kahn, an 82-year-old family doctor in Fullerton, Calif., says he got such a boost from brain exercises he started doing at a "Nifty after Fifty" club that he decided to start seeing patients again part-time. "Doing all the mental exercise," he says, "I realized I've still got it."

8) Debate Over Drugs For ADHD Reignites (Washington Post)

- "New data from a large federal study have reignited a debate over the effectiveness of long-term drug treatment of children with hyperactivity or attention-deficit disorder, and have drawn accusations that some members of the research team have sought to play down evidence that medications do little good beyond 24 months."

- "The study also indicated that long-term use of the drugs can stunt children's growth."

8) Adaptive training leads to sustained enhancement of poor working memory in children (Developmental Science)

Abstract: Working memory plays a crucial role in supporting learning, with poor progress in reading and mathematics characterizing children with low memory skills. This study investigated whether these problems can be overcome by a training program designed to boost working memory. Children with low working memory skills were assessed on measures of working memory, IQ and academic attainment before and after training on either adaptive or non-adaptive versions of the program. Adaptive training that taxed working memory to its limits was associated with substantial and sustained gains in working memory, with age-appropriate levels achieved by the majority of children. Mathematical ability also improved significantly 6 months following adaptive training. These findings indicate that common impairments in working memory and associated learning difficulties may be overcome with this behavioral treatment.

9) Brain cortex thinning linked to inherited depression (Los Angeles Times)

- "On average, people with a family history of depression appear to have brains that are 28% thinner in the right cortex --- the outermost layer of the brain --- than those with no known family history of the disease. That cortical thinning, said the researchers, is on a scale similar to that seen in patients with Alzheimer's disease or schizophrenia."

Physical Fitness Improves Spatial Memory, Increases Size Of Brain Structure (Science Daily)

- "Now researchers have found that elderly adults who are more physically fit tend to have bigger hippocampi and better spatial memory than those who are less fit."

- "Certain activities are believed to modify hippocampus size in humans. For example, a study of London taxi drivers found that the posterior portion of the hippocampus was larger in experienced taxi drivers than in other subjects. And a study of German medical students found that the same region of the hippocampus increased in size as they studied for their final exams."

- "Studies also have found that the hippocampus shrinks with age, a process that coincides with small but significant cognitive declines. The rate at which this occurs, however, differs among individuals."

Related articles:

Physical Exercise and Brain Health

Brain Plasticity: How learning changes your brain

Two recent scientific studies published by Dr. Arthur Kramer and colleagues present fascinating results. The two studies are:

1) Basak C, et al "Can training in a real-time strategy video game attenuate cognitive decline in older adults?" Psychol Aging 2008; DOI: 10.1037/a0013494.

2) Boot, W. R., Kramer, A. F., Simons, D. J., Fabiani, M. & Gratton, G. (2008) The effects of video game playing on attention, memory, and executive control. Acta Psychologica, 129, 387-398.

Let's first review the first study, a significant experiment in that it showed wide cognitive benefits in adults over 60 years old who played a strategy videogame (Rise of Nations) for 23 hours.

Playing computer games improves brain power of older adults, claim scientists (Telegraph)

- The team at the University of Illinois recruited 40 adults over 60 years old, half of whom were asked to play a computer game called Rise of Nations, a role-playing game in which you have to build your own empire.

- Game players have to build cities, feed and employ their people, maintain an adequate military and expand their territory.

- Both groups were assessed before, during and after the video game training on a variety of tests.

- As a group, the "gamers" became significantly better – and faster – at Continue Reading »

The Alzheimer's Foundation of America just released a thoughtful report advocating for widespread cognitive screenings after the age of 65 (55 given the right conditions).

According to the press release,

- "The report shatters unsubstantiated criticism and instead emphasizes the safety and cost-effectiveness of these tools and calls on Congress to develop a national dementia screening policy."

- “Lifting the barriers to early detection is long overdue,” Hall said. “Conversations about brain health are not taking place. We must educate and empower consumers to talk openly about memory concerns, particularly with primary care providers, so they get the attention and quality of life they deserve.”

- "Demand for screenings is evidenced by the success of AFA’s recent sixth annual National Memory Screening Day held on November 18, during which an estimated 50,000 people were given free confidential memory screenings at nearly 2,200 community sites nationwide. During last year’s event, approximately 16 percent of individuals who had a face-to-face screening scored positive and were referred to their primary care providers for follow-up. An AFA survey of participants revealed that fewer than one in four with self-reported memory complaints had previously discussed them with their physicians despite recent visits."

Excellent report available: here

Please note that the Alzheimer's Association recently argued in the opposite direction (no screenings) - which probably triggered this response.

We see emerging trends that suggest the position in favor of cognitive assessments may in fact gather momentum over the next few years: widespread computerized cognitive screenings in the US Army, insurance companies like OptumHealth adding such tools to its clinical decision-making systems, polls such as the American Society of Aging's a couple of years ago indicating a very strong demand for an "annual mental check-up", the availability of useful assessment tools and research-based preventive advice.

The starting point is to understand what those assessments are NOT: they are not diagnostic tools. When used properly, they can be used as a baseline to track performance in a variety of cognitive domains over time, so that both the individual AND the physician are not blinded by a one-time assessment, comparing an individual with his or her peers (instead of his or her past performance) when serious symptoms have frequently already been going on for a while.

Our contributor  Dr. Joshua Silverman, from Albert Einstein College of Medicine, recently generated a nice debate on the topic by asking our readers their reaction to these 3 questions: Continue Reading »

We offered some Brain Fitness Predictions in our Market Report , including...

"7. Doctors and pharmacists will help patients navigate through the overwhelming range of available products and interpret the results of cognitive assessments. This will require significant professional development efforts, given that most doctors today were trained under a very different understanding of the brain than the one we have today."

The American Medical News, a weekly newspaper for physicians published by the American Medical Association, just published an excellent article along those lines:

Steps to a nimble mind: Physical and mental exercise help keep the brain fit
-- Neuroscience is uncovering techniques to prevent cognitive decline.

A few quotes:

- It's an example that highlights a wave of new thinking about the importance of brain fitness.

- Until recently, conventional wisdom held that our brains were intractable, hard-wired computers. What we were born with was all we got. Age wore down memory and the ability to understand, and few interventions could reverse this process. But increasingly, evidence suggests that physical and mental exercise can alter specific brain regions, making radical improvements in cognitive function.

- With nearly 72 million Americans turning 65 over the next two decades, physicians need the tools to handle growing patient concerns about how to best maintain brain health. Armed with this new brand of science, frontline physicians will be better equipped to address the needs of aging baby boomers, already in the throes of the brain fitness revolution.

- "Encourage them to exercise the brain in novel and complex ways," he says.

Full article: here

One of the physicians quoted in the article is Gary J. Kennedy, MD, Director of the Division of Geriatric Psychiatry at Montefiore Medical Center in NYC and a professor in the Dept. of Psychiatry and Behavioral Sciences at Albert Einstein College of Medicine.

To put the AMA article in better perspective for SharpBrains readers, we asked Dr. Kennedy a few follow-up questions. Below you have his questions.

Alvaro Fernandez (AF): Can you summarize how cognitive functions tend to evolve as we age?

Gary Kennedy (GK): As we age cognitive functions that rely on Continue Reading »