SharpBrains

Think about this: How can anyone take care of his or her brain when every week brings a new barrage of articles and studies which seem to contradict each other?

Do supplements improve memory? Do you need both physical and mental exercise –or is one of them enough? Which brain training approach, if any, is worth one's time and money?

We tried to address these questions, and many others, in our recent book, The SharpBrains Guide to Brain Fitness (182 pages, $24.95), that we presented at Games for Health Conference last week. The book is the result of over two years of extensive research including more than a hundred interviews with scientists, professionals and consumers, and a deep review of the scientific literature, led by neuropsychologist Elkhonon Goldberg and myself with the help of cognitive scientist Pascale Michelon. As we wrote in the Introduction, what we wanted to do first of all was to debunks these 10 myths on brain health and brain training:

Myth 1. Genes determine the fate of our brains.
Facts: Lifelong neuroplasticity allows our lifestyles and actions to play a meaningful role in how our brains physically evolve, especially given longer life expectancy.

Myth 2. Aging means automatic decline.
Facts: There is nothing inherently fixed in the precise trajectory of how brain functions evolve as we age.

Myth 3. Medication is the main hope for cognitive enhancement.
Facts: Non-invasive interventions can have comparable and more durable effects, side effect-free.

Myth 4. We will soon have a Magic Pill or General Solution to solve all our cognitive challenges.
Facts: A multi-pronged approach is recommended, centered around nutrition, stress management, and both physical and mental exercise.

Myth 5. There is only one “it” in “Use It or Lose it”.
Facts: The brain is composed of a number of specialized units. Our life and productivity depend on a variety of brain functions, not just one.

Myth 6. All brain activities or exercises are equal.
Facts: Varied and targeted exercises are the necessary ingredients in brain training so that a wide range of brain functions can be stimulated.

Myth 7. There is only one way to train your brain.
Facts: Brain functions can be impacted in a number of ways: through meditation, cognitive therapy, cognitive training.

Myth 8. We all have something called “Brain Age”.
Facts: Brain age is a fiction. No two individuals have the same brain or expression of brain functions.

Myth 9. That “brain age” can be reversed by 10, 20, 30 years.
Facts: Brain training can improve specific brain functions, but, with research available today, cannot be said to roll back one’s “brain age” by a number of years.

Myth 10. All human brains need the same brain training.
Facts: As in physical fitness, users must ask themselves: What functions do I need to improve on? In what timeframe? What is my budget?

Do you have other myths in mind you would like  us to address?

We have started to receive great feedback from the healthcare community, such as this email from a neurosurgeon in Texas:

"I really like the book, it is comprehensive without being too technical. I have recommended it to several patients. There are some other books that I expected would be greeted with enthusiasm, but were too complex for most of my patients. I think this book is right in the sweet spot".

And this great book review by an Internist Physician and Robert Wood Johnson Foundation Fellow, titled Is Your Brain A Couch Potato?:

“…a short, sweet, entertaining read of a complex topic, with timely (written in 1/09) reviews of 21 top technology products, as well as informed and expert predictions of where this burgeoning brain-fitness field is headed. More importantly, after you read it, you'll have a good, detailed sense of where you, personally, can act to improve your own couch-potato brain - and how to keep it fit and flexible your whole life. The SharpBrains Guide To Brain Fitness reminds of us all why books (and not just googling a topic) can be well worth your time and money. Two Stethoscopes Up - check it out. life."

—Doc Gurley, book review for SFGate.com (06/08/09)

The book:  The SharpBrains Guide to Brain Fitness (available via Amazon.com Here, review copies available upon request).

Description: While most of us have heard the phrase “use it or lose it,” very few understand what “it” means, or how to properly “use it” in order to maintain brain function and fitness. The SharpBrains Guide to Brain Fitness is an invaluable guide that helps readers navigate growing brain research and identify the lifestyle factors and products that contribute to brain health and fitness. By gathering insights from eighteen of the world’s top scientists and offering tools and detailed descriptions of over twenty products, this book is an essential guide to the field of brain fitness, neuroplasticity and cognitive health. An accessible and thought-provoking read, The SharpBrains Guide to Brain Fitness educates lifelong learners and professionals in healthcare, education, business, etc., on emerging trends and forecasts of what the future will hold.

Products Reviewed (we reviewed scientific studies published before January 2009, when the manuscript text was closed):

- Overall brain maintenance: Brain Age series (Nintendo), BrainWare Safari (Learning Enhancement Corporation), FitBrains.com (Vivity Labs), Happy-Neuron.com (Scientific Brain Training), Lumosity.com (Lumos Labs), MindFit (CogniFit), (m)Power (Dakim)

- Targeted brain workout: Classic and InSight (Posit Science), Working Memory Training JM and RM (Cogmed), DriveFit (CogniFit), Earobics (Houghton Mifflin), Fast ForWord (Scientific Learning), IntelliGym (Applied Cognitive Engineering), Vision Restpration Therapy (NovaVision)

- Emotional self-regulation: emWave PC and Personal Stress Reliever (HeartMath), Journey to the Wild Divine (Wild Divine), RESPeRATE (InterCure), StressEraser (Helicor)

This is a partial list of the literature we reviewed during the research phase of our new book, The SharpBrains Guide to Brain Fitness.  We know many friends of SharpBrains are researchers, healthcare professionals, graduate/ Ph.D. students, who want have direct access to the references (perhaps PubMed should promote itself as a never ending source of mental stimulation?), so here you have this list, organized by relevant chapter. Please note that the list below appears in the book - whose manuscript we had to close in January 2009.

Introduction

• Basak, C. et al. (2008). Can training in a real-time strategy video game attenuate cognitive decline in older adults? Psychology and Aging.
• Begley, S. (2007). Train your mind, change your brain: How a new science reveals our extraordinary potential to transform ourselves. Ballantine Books.
• DeKosky, S. T., et al. (2008). Ginkgo biloba for prevention of dementia: a randomized controlled trial. Journal of the American Medical Association, 300, 2253-2262.
• Doidge, N. (2007). The Brain that changes itself: Stories of personal triumph from the frontiers of brain science. Viking Adult.

Chapter 1. The Brain and Brain Fitness 101

• Bunge, S. A., & Wright, S. B. (2007). Neurodevelopmental changes in working memory and cognitive control. Current Opinion In Neurobiology, 17(2), 243-50.
• Damasio, A. (1995). Descartes’ error: Emotion, reason, and the human brain. Penguin Press.
• David Kolb, D. (1983). Experiential learning: Experience as the source of learning and development. FT Press.
• Draganski, B., Gaser, C., Kempermann, G., Kuhn, H. G., Winkler, J., Buchel, C., & May A. (2006). Temporal and spatial dynamics of brain structure changes during extensive learning. The Journal of Neuroscience, 261231, 6314-6317.
• Gage, F. H., Kempermann, G., & Song, H. (2007). Adult Neurogenesis. Cold Spring Harbor Laboratory Press, NY.
• Gardner, H. (1983). Frames of Mind: The theory of multiple intelligences. New York: Basic Books.
• Gaser, C. & Schlaug, G. (2003). Brain structures differ between musicians and non-musicians. The Journal of Neuroscience, 23, 9240-9245. Continue Reading »

Brain-fitness games join workplace, as well as senior center, arsenals (MarketWatch)

- "Consumers and retirement homes have made brain-fitness games and exercises a commercial hit, but now some insurers and employers are incorporating them into wellness programs that promote health not just for the body but also for the mind."

- "Improving brain health can result in less presenteeism, the tendency to be at work but be distracted and not able to focus," he added. "If you look at disability costs, absenteeism and presenteeism account for most of the medical costs, and that's a good reason for employers to be focused on brain health." (according to Dr. Eugene Baker, vice president at OptumHealth's Behavioral Solutions division)"

The article reviews innovative practices at OptumHealth, Nationwide Auto Insurance Company, Humana, Penn Treaty American Corp, Allstate, and the US Army. I am glad to see the media start to notice the importance of cognitive assessments and the growing activity by insurers. Continue Reading »

After many many months of mental stimulation, physical exercise and the certain need for stress management... we have just announced the release of the The State of the Brain Fitness Software Market 2009 report, our second annual comprehensive market analysis of the US market for computerized cognitive assessment and training tools. In this report we estimate the size of the US brain fitness software market at $265M in 2008, up from $225M in 2007 (18% annual growth), and from $100m in 2005. Two segments fuelled the market growth from 2007 to 2008: consumers (grew from $80m to $95m) and healthcare & insurance providers (grew from $65m to $80m).

The 150-page report finds promising research and initiatives to drive significant growth, combined with increased consumer confusion given aggressive marketing claims and lack of education and standards. The report includes:
- The complete results of an exclusive January 2009 Survey with 2,000+ respondents
- A proprietary Market & Research Momentum Matrix to categorize 21 key vendors into four categories
- 10 Research Executive Briefs written by leading scientists at prominent research labs
- An analysis of the level of clinical validation per product and cognitive domain

Top 10 Highlights from the report:

1) Consumers, seniors’ communities and insurance providers drove year on year sustained growth, from $225m in 2007 to $265m in 2008. Revenues may reach between $1 billion to $5 billion by 2015, depending on how important problems (Public Awareness, Navigating Claims, Research, Health Culture, Lack of Assessment) are addressed.

2) Increased interest and confusion: 61% of respondents Strongly Agree with the statement “Addressing cognitive and brain health should be a healthcare priority.” But, 65% Agree/Strongly Agree “I don't really know what to expect from products making brain claims.”

3) Investment in R&D seeds future growth: Landmark investments by insurance providers and government-funded research institutes testing new brain fitness applications planted new seeds for future growth.

4) Becoming standard in residential facilities: Over 700 residential facilities – mostly Independent and Assisted Living facilities and CCRCs – have installed computerized cognitive training programs.

5) Customer satisfaction: Consumers seem more satisfied with computer-based products than paper-based options. But, satisfaction differs by product. When asked “I got real value for my money”, results were as follows: Lumosity.com (65% Agree), Puzzle Books (60%), Posit Science (52%), Nintendo (51%) agreed. Posit Science (53% Agree) and Lumosity.com (51%) do better than Puzzle Books (39%) and Nintendo (38%) at “I have seen the results I wanted.”

6) Assessments: Increasing adoption of computer-based cognitive assessments to baseline and track cognitive functions over time in military, sports, and clinical contexts. The Alzheimer’s Foundation of America now advocates for widespread cognitive screenings after 65-75.

7) Specific computerized cognitive training and videogames have been shown to improve brain functions, but the key questions are, “Which ones”, and “Who needs what when?”

8) Aggressive marketing claims are creating confusion and skepticism, resulting in a distracting controversy between two misleading extremes: (a) “buying product XYZ can rejuvenate your brain Y years” or (b) “those products don’t work; just do one more crossword puzzle.” The upcoming book The SharpBrains Guide to Brain Fitness aims to help consumers navigate these claims.

9) Developers can be classified into four groups, based on a proprietary Market and Research Momentum Matrix: SharpBrains finds 4 Leaders, 8 High Potentials, 3 Crosswords 2.0, and 6 Wait & See companies.

10) Increased differentiation: Leading companies are better defining their value proposition and distribution channels to reach specific segments such as retirement communities, schools, or healthcare providers.

Leading researchers prepared 10 Research Executive Briefs:
- Dr. Joshua Steinerman (Einstein-Montefiore): Neuroprotection via cognitive activities
- Dr. Jerri Edwards (South Florida): Assessments of driving fitness
- Dr. Susanne Jaeggi and Dr. Martin Buschkuehl (Bern, Michigan): Working memory training and fluid intelligence
- Dr. Torkel Klingberg (Karolinska): Working memory training, dopamine, and math
- Dr. Liz Zelinski (UC Davis): Auditory processing training
- Dr. David Vance (UAB): Speed-of-processing training
- Dr. Jerri Edwards (South Florida): Cognitive training for healthy aging
- Dr. Daphne Bavelier & Dr. Shawn Green (Rochester): Action videogames and attentional skills
- Dr. Arthur Kramer (Illinois): Strategy videogames and executive functions
- Dr. Yaakov Stern (Columbia): The cognitive reserve and neuroimaging
- Dr. David Rabiner (Duke): Objective assessments for ADHD

Table of Contents

Editorial
Executive Summary
Chapter 1. Bird’s-Eye View of the Growing Field
Chapter 2. Market Survey on Beliefs, Attitudes, Purchase Habits
Chapter 3. The Emerging Competitive Landscape
Chapter 4. The Science for Brain Fitness and Cognitive Health
Chapter 5. Consumers – Adopting Crosswords 2.0?
Chapter 6: Healthcare and Insurance Providers - A Culture of Cognitive Health
Chapter 7: K12 School Systems- Ready for Change?
Chapter 8: Military, Sports Teams, Companies – Brain-Performance Link
Chapter 9: Future Directions – Projections and Bottlenecks

Companies profiled include: Advanced Brain Technologies, Applied Cognitive Engineering, Brain Center America, Brain Resource, CNS Vital Signs, Cogmed, Cogstate, CogniFit, Cognitive Drug Research, Dakim, Houghton Mifflin, Learning Enhancement Corporation, LearningRx, Lumos Labs, Marbles: The Brain Store, Nintendo, NovaVision, Posit Science, Scientific Brain Training, Scientific Learning, TransAnalytics, vibrantBrains, Vigorous Mind, Vivity Labs.

More on the report by clicking on The State of the Brain Fitness Software Market 2009.

There's such a flood of very significant research studies, educational resources and articles related to brain health, it's hard to keep track - even for us!

Let me introduce and quote some of the top Brain Health Studies, Articles and Resources published in March:

1) Cognitive Decline Begins In Late 20s, Study Suggests (Science Daily)

- "These patterns suggest that some types of mental flexibility decrease relatively early in adulthood, but that how much knowledge one has, and the effectiveness of integrating it with one's abilities, may increase throughout all of adulthood if there are no pathological diseases," Salthouse said.

- However, Salthouse points out that there is a great deal of variance from person to person

2) Cerebrum 2009: Emerging Ideas in Brain Science - new book by the Dana Foundation that "explores the cutting edge of brain research and its implications in our everyday lives, in language understandable to the general reader."

A couple of excellent chapters of direct relevance to everyone's brain health are:
- Chapter 4: A Road Paved by Reason, by Elizabeth Norton Lasley

- Chapter 10: Neural Health: Is It Facilitated by Work Force Participation?, by Denise Park, Ph.D

3) Staying Sharp DVD Program: "Dr. Jordan Grafman, chief of the Cognitive Neuroscience Section at the National Institute of Neurological Disorders and Stroke outside of Washington, DC, and a member of the Dana Alliance for Brain Initiatives, is your guide as we cover what to expect from the aging brain and what we can do to 'stay sharp.'

For a free DVD of this program you can contact stayingsharp@dana.org. (they say free in their website, I don't know if that includes shipping & handling)

4) Drivers to be tested on cognitive ability starting at age 75 (Japan Times)

The outline of a cognitive test that drivers aged 75 or over will be required to take from June when renewing their licenses was released Thursday...The test is intended to reduce the number of traffic accidents involving elderly drivers by measuring their cognitive level.

5) Physical Fitness Improves Spatial Memory, Increases Size Of Brain Structure (Science Daily)

- "Now researchers have found that elderly adults who are more physically fit tend to have bigger hippocampi and better spatial memory than those who are less fit."

6) Brain Trainers: A Workout for the Mind (Scientific American Mind)

"I recently tried out eight of the latest brain fitness programs, training with each for a week. The programs ranged widely in focus, quality and how fun they were to use. “Like physical exercise equipment, a brain exercise program doesn’t do you any good if you don’t use it,” says Andrew J. Carle, director of the Program in Assisted Living/Senior Housing Administration at George Mason University. And people tend not to use boring equipment. “I remember when NordicTrack was the biggest thing out there. Everyone ran out and bought one, and 90 percent of them ended up as a clothes rack in the back of your bedroom.”

The reporter used: Posit Science's Brain Fitness Program Classic, HappyNeuron, Nintendo BrainAge, CogniFit's MindFit/ CogniFit Personal Coach, Lumosity, MyBrainTrainer, BrainTwister, Cogmed Working Memory Training.

7) The Latest in Mental Health: Working Out at the 'Brain Gym' (Wall Street Journal)

- "Marshall Kahn, an 82-year-old family doctor in Fullerton, Calif., says he got such a boost from brain exercises he started doing at a "Nifty after Fifty" club that he decided to start seeing patients again part-time. "Doing all the mental exercise," he says, "I realized I've still got it."

8) Debate Over Drugs For ADHD Reignites (Washington Post)

- "New data from a large federal study have reignited a debate over the effectiveness of long-term drug treatment of children with hyperactivity or attention-deficit disorder, and have drawn accusations that some members of the research team have sought to play down evidence that medications do little good beyond 24 months."

- "The study also indicated that long-term use of the drugs can stunt children's growth."

8) Adaptive training leads to sustained enhancement of poor working memory in children (Developmental Science)

Abstract: Working memory plays a crucial role in supporting learning, with poor progress in reading and mathematics characterizing children with low memory skills. This study investigated whether these problems can be overcome by a training program designed to boost working memory. Children with low working memory skills were assessed on measures of working memory, IQ and academic attainment before and after training on either adaptive or non-adaptive versions of the program. Adaptive training that taxed working memory to its limits was associated with substantial and sustained gains in working memory, with age-appropriate levels achieved by the majority of children. Mathematical ability also improved significantly 6 months following adaptive training. These findings indicate that common impairments in working memory and associated learning difficulties may be overcome with this behavioral treatment.

9) Brain cortex thinning linked to inherited depression (Los Angeles Times)

- "On average, people with a family history of depression appear to have brains that are 28% thinner in the right cortex --- the outermost layer of the brain --- than those with no known family history of the disease. That cortical thinning, said the researchers, is on a scale similar to that seen in patients with Alzheimer's disease or schizophrenia."

Physical Fitness Improves Spatial Memory, Increases Size Of Brain Structure (Science Daily)

- "Now researchers have found that elderly adults who are more physically fit tend to have bigger hippocampi and better spatial memory than those who are less fit."

- "Certain activities are believed to modify hippocampus size in humans. For example, a study of London taxi drivers found that the posterior portion of the hippocampus was larger in experienced taxi drivers than in other subjects. And a study of German medical students found that the same region of the hippocampus increased in size as they studied for their final exams."

- "Studies also have found that the hippocampus shrinks with age, a process that coincides with small but significant cognitive declines. The rate at which this occurs, however, differs among individuals."

Related articles:

Physical Exercise and Brain Health

Brain Plasticity: How learning changes your brain

Increased longevity has generated many questions and much interest in healthy aging and retirement lifestyles over the recent decades. As Americans become educated regarding lifestyle choices that contribute to both physical and mental health, the definition of healthy aging has expanded to include brain health.

The notion of retirement as a time of withdrawal from society, to be spent on rest and repose reflected the thinking of a previous era when people expected shorter life spans. It is now known that the human brain benefits from environments rich in novel and complex stimuli, and that by actively participating in society and taking on personally relevant roles, people find meaning and purpose, which gives them a reason to get up in the morning and pursue new challenges.

This year, the MetLife Mature Market Institute® published a research study titled Discovering What Matters: Balancing Money, Medicine and Meaning. The study explored how people rebalance their priorities over time and juggle various competing aspects of life including money, medicine (a metaphor for health) and meaning, in order to live the “Good Life.” Having purpose was found to Continue Reading »

Here you have the February edition of our monthly newsletter covering cognitive health and brain fitness topics. Please remember that you can subscribe to receive this Newsletter by email, simply by submitting your email at the top of this page.

Cognitive training (or structured mental exercise) definitely seems to work - as long as we define properly what "work" means, don't expect magic cures, and help navigate options. Please keep reading...

Interview: Baycrest

Interview with Baycrest's CEO Dr. William Reichman: Discussing the recent Centre for Brain Fitness at Baycrest, Dr. Reichman suggests that "we have an opportunity to make major progress in Brain Health in the XXI century, similar to what happened with Cardiovascular Health in the XXth, and technology will play a crucial role." A major obstacle? We need a consensus on "widely accepted standards for outcome measures".

Does It Work?

Does cognitive training work? (For Whom? For What?): The growing field of cognitive training (one of the tools for brain fitness) can appear very confusing as the media keeps reporting contradictory claims. These claims are often based on press releases, without a deeper understanding of the scientific evidence. Dr. Pascale Michelon, SharpBrains' Research Manager for Educational Initiatives, analyzes a couple of recent studies, clarifying what they mean - and what they don't mean.

It Works, and It Doesn't Work: the IMPACT study (a major, multi-site study on the Posit Science auditory program) will be published at the Journal of the American Geriatrics Society in April. Results support that cognitive training works - but doesn't support the grandiose "brain age" claims we see too often.

Cognitive Training can Influence Brain Biochemistry: Dr. David Rabiner discusses a recent scientific study that "shows that brain biochemistry can be modified by experience", and that computerized cognitive training (Cogmed working memory training) can provide that experience.

The Big Picture

Making Healthy Choices - Primare Care and Prevention: a panel at the recent World Economic Forum explored why "New markets and industries are arising – “silver industries” such as financial services, health, housing and hospitality geared to senior citizens. Longevity needs to be linked to health – including cognitive health – and lifestyle choices play a major role in health."

Enrich your environment now and benefit your future offspring: Dr. Robert Sylwester reports that "all sorts of long held-beliefs about our brain and cognition are being re- examined by cognitive neuroscientists" because of fascinating studies such as the one  he reviews (with mice): "The study's findings seemed to suggest that acquired characteristics can be genetically transmitted...long-term benefits accrue from a stimulating early environment that encourages curiosity and exploration."

Managing Emotions

From Distress to De-Stress: helping anxious, worried kids: In a detailed 2-part article, (Part 1, Part 2), Dr. Jerome Schultz provides great tips on how to help children learn to self-regulate emotions, adding that "Teachers, occupational therapists, physical education teachers and parents need to actually teach children (of all ages) how to get themselves into a physical state of being relaxed. This doesn’t happen automatically. If it did, there wouldn’t be so many adult yoga classes!"

Lie to Me, Paul Ekman and Biofeedback: You may have watched the new series Lie To Me, with Tim Roth, based on the work of Paul Ekman. The introduction to the second episode shows why what are called "lie detectors" are nothing but biofeedback systems that measure physiological anxiety.

News

Brain Games for Baby Boomers: round-up of other recent news, covering the effects of gaming, cognitive training for driving skills, and brain fitness classes.

Neurocognitive assessments and sports concussions: a new study and a new resource to understand and address the 1.6 to 3.8 million cases of sports-related concussions that occur annually in the United States.

Brain Teaser

How will you, your organization, your neighbors, participate in Brain Awareness Week, March 16th-22nd, organized by the Dana Foundation with the participation of thousands of outreach partners, including SharpBrains? You can find event ideas, excellent resources (yes, including puzzles), and a calendar of events, Here.

Have a great month of March!

In April 2008, Baycrest, a leading research institute focused on aging and brain function, received $10-million from the Ontario Government to create a groundbreaking Centre for Brain Fitness. Its stated goal was to “develop and commercialize a range of products designed to improve the brain health of aging Ontarians and others around the world”.

“Our government is proud to support Baycrest and its invaluable work, which is already leading to the discovery of important new tools and approaches to treating brain diseases associated with aging,” said Minister of Research and Innovation, John Wilkinson.

We have Baycrest’s CEO with us today, to explore why Ontario and Baycrest chose to become pioneers in this area, and discuss some of the main opportunities, and challenges. Dr. William E. Reichman is President and CEO of Baycrest. Dr. Reichman, an internationally-known expert in geriatric mental health and dementia, is also Professor of Psychiatry on the Faculty of Medicine at the University of Toronto.

Alvaro Fernandez: Bill, thank you for your time. Let me start by asking, given that you just spoke at the recent Consumer Electronic Show, what do you make of the growing brain fitness field?

Bill Reichman: it looks like a classic example of a very promising but still early stage field – a lot of opportunity and enthusiasm, but also a lot of product claims that are not backed by solid research. Think about the physical fitness analogy: even today, after decades of progress, you still see people buying research-based products such as treadmills but also all types of random machines they see on TV and have not been subject to any validation. Similarly, consumers today do not know what to make of growing brain fitness claims. As another speaker pointed out, for the industry to fulfill its promise, it will need to be careful with research and claims, not to end up like the nutraceuticals category.

By the way, let me recognize that the work you are doing with SharpBrains reports and your website is very important to offer quality information.

Thank you. Let’s step back for a moment. Taking a, say, 10 years view, what is the main opportunity that technology-based brain fitness can offer to society?

First of all, let me say that I think we have an opportunity to make major progress in Brain Health in the XXI century, similar to what happened with Cardiovascular Health in the XX, and technology will play a crucial role.

Given the rapid advances we are witnessing today in the research and technology arenas, I feel confident in saying that in less than 10 years we will have both valid and reliable assessments of cognitive functions, that will be used both by Continue Reading »

Welcome to the 8th edition of Hourglass, the blog carnival devoted to biogerontology. Enjoy!

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Use It or Lose It

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Cognitive Enhancement, Health and Assessments

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The Benefits of Caloric Restriction Continue Reading »