SharpBrains

If you could, you would. You can, but prefer not to know it?

More than any other organ, your brain is up to you. You are what you think, not just what you eat. Here's some food for thought:

Design your Mind

Setting cognitive and behavioral goals raises challenging and worthy questions: What do you want from your brain? Will you know it when you achieve it?

To attain the brain of our choosing, we must understand our selves and current abilities. Introspection and curiosity are helpful if they trigger and sustain the effort to enrich the mind. However, objective information which leads to informed assessment of brain function is often lacking.

Mind your Brain

Honesty. Openness. Self-awareness.

Irrefutable virtues, but in practice most people fall short. Few regularly appraise their brain skills; even so, the ability to accurately judge one's own mental performance is not guaranteed. I believe the first step to minding the brain is shedding hang-ups while offering and soliciting frank feedback from family and close confidants. In the clinical setting, routine cognitive screening and "mental check ups" are not currently practiced, in part due to time constraints and limited utility of traditional paper-and-pencil tests. From a public health perspective, the U.S. Preventative Task Force reviewed Continue Reading »

The Neurotechnology Industry Organization (NIO) just announced the top ten emerging areas of neuroscience that will "impact the future of treatments for brain and nervous system": Top 10 Neuroscience Trends in 2007.

It provides superb food for thought. And some of them will sound familiar to readers of this blog:

* 6. Normal brain aging gets more attention: More research and development is being focused on thinking impairments that only partially limit independence and quality of life for senior citizens, adults and school aged children. Neurosoftware will penetrate nursing homes and schools, as brain fitness software becomes new first-line treatment strategy.
* 8. Prevention evidence grows: You are what you eat; smoking is as bad as we thought; and new studies reveal the effects of environmental substances on Alzheimer's disease, Parkinson's disease and others.
* 9. Emotional disorders research advances:  New research continues to link neurogenesis to treatment of depression.  A better understanding of PTSD should lead to new treatment regimes.

Want to read probably the best overview of the neurosoftware/ brain fitness software market? Check this article, fresh from the oven: Thank Boomers for Buffing Up Brain Market.

To clarify the numbers mentioned: we project $225m in the US alone (growing from $70m in 2003), broken-down as follows: $80m for the Consumer segment, $60m in K12 Education, $50m in Clinical applications, and $35m in the Corporate segment. The Consumer segment, with a healthy aging value proposition, is the most recent one but the most rapidly growing.

To all new readers-Welcome!. The Digg Tsunami has brought over 40,000 visitors so far...and it continues. We need to thank Andrey for his excellent technical work in helping us ride such a beautiful wave.

Let me give you an overview of what you can find in our blog, bridging neuroscience research and brain health/ "brain exercise" practice. First, here you have a few of my favorite quotes from the 10 interviews we have done with neuroscience and psychology experts in cognitive and emotional training in our Neuroscience Interview Series. You can read the in-depth interview notes for each if you want to stimulate those neurons...

• “Learning is physical. Learning means the modification, growth, and pruning of our neurons, connections–called synapses– and neuronal networks, through experience...we are cultivating our own neuronal networks.”- Dr. James Zull, Professor of Biology and Biochemistry at Case Western University: Read Interview Notes
• “Exercising our brains systematically ways is as important as exercising our bodies. In my experience, “Use it or lose it” should really be “Use it and get more of it”.- Dr. Elkhonon Goldberg, neuropsychologist, clinical professor of neurology at New York University School of Medicine, and disciple of the great neuropsychologist Alexander Luria: Read Interview Notes
• “Individuals who lead mentally stimulating lives, through education, occupation and leisure activities, have reduced risk of developing Alzheimer’s symptoms. Studies suggest that they have 35-40% less risk of manifesting the disease”- Dr. Yaakov Stern, Division Leader of the Cognitive Neuroscience Division of the Sergievsky Center at the College of Physicians and Surgeons of Columbia University, New York: Read Interview Notes

“What research has shown is that Continue Reading »

Dr. Yaakov Stern is the Division Leader of the Cognitive Neuroscience Division of the Sergievsky Center, and Professor of Clinical Neuropsychology, at the College of Physicians and Surgeons of Columbia University, New York.

He is one of the leading proponents of the Cognitive reserve theory, which aims to explain why some individuals with full Alzheimer's pathology (accumulation of plaques and tangles in their brains) can keep normal lives until they die, while others -with the same amount of plaques and tangles- display the severe symptoms we associate with Alzheimer’s Disease. He has published dozens of peer-reviewed scientific papers on the subject.

The concept of a Cognitive Reserve has been around since 1989, when a post mortem analysis of 137 people with Alzheimer's Disease showed that some patients exhibited fewer clinical symptoms than their actual pathology suggested. These patients also showed higher brain weights and greater number of neurons when compared to age-matched controls. The investigators hypothesized that the patients had a larger "reserve" of neurons and abilities that enable them to offset the losses caused by Alzheimer's. Since then, the concept of Cognitive Reserve has been defined as the ability of an individual to tolerate progressive brain pathology without demonstrating clinical cognitive symptoms. (You can check at the end of this interview a great clip on this).

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Key take-aways

- Lifetime experiences, like education, engaging occupation, and leisure activities, have been shown to have a major influence on how we age, specifically on whether we will develop Alzheimer's symptoms or not.

- This is so because stimulating activities, ideally combining physical exercise, learning and social interaction, help us build a Cognitive Reserve to protect us.

- The earlier we start building our Reserve, the better; but it is never too late to start. And, the more activities, the better: the effect is cumulative.

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The Cognitive Reserve

Alvaro Fernandez (AF): Dear Dr. Stern, it is a pleasure to have you here. Let me first ask you this: the implications of your research are pretty astounding, presenting major implications across sectors and age groups. What has been the most unexpected reaction so far?

YS: well...I was pretty surprised when Continue Reading »

Update: we now have an in-depth interview with Yaakov Stern, leading advocate of the cognitive reserve theory, and one of the authors of the paper we review below: click on Build Your Cognitive Reserve-Yaakov Stern. 

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In honor of the Week of Science presented at Just Science from Monday, February 5, through Sunday, February 11, we will be writing about "just science" this week. We thought we would take this time to discuss more deeply some of the key scientific publications in brain fitness.

Today, we will highlight the key points in an excellent review of cognitive reserve: Scarmeas, Nikolaos and Stern, Yaakov. Cognitive reserve and lifestyle. Journal of Clinical and Experimental Neuropsychology. 2003;25:625-33.

What is Cognitive Reserve?
The concept of a cognitive reserve has been around since 1998 when a post mortem analysis of 137 people with Alzheimer's Disease showed that the patients exhibited fewer clinical symptoms than their actual pathology suggested. (Katzman et al. 1988) They also showed higher brain weights and greater number of neurons when compared to age-matched controls. The investigators hypothesized that the patients had a larger "reserve" of neurons and abilities that offset the losses caused by Alzheimer's. Since then the concept of cognitive reserve has been defined as the ability of an individual to tolerate progressive brain pathology without demonstrating clinical cognitive symptoms.
Continue Reading »