Here you have the September edition of our monthly newsletter covering cognitive health and brain fitness topics. Please remember that you can subscribe to receive this Newsletter by email, using the box at the top of this page.

In the current edition of The Journal on Active Aging, I discuss why we need to Retool “Use it or lose it”, and why routine, doing things inside our comfort zones, is the most common enemy of the novelty, variety and challenge our brains need. You can read the full article for free Here.

Book Tour

We are glad to report that The SharpBrains Guide to Brain Fitness continues to obtain excellent endorsements:

“This is the only book that I know of that seamlessly integrates latest information about cognitive health across the lifespan. Very useful to anyone interested in brain care.”

–Arthur Kramer, Ph. D., Professor of Psychology at University of Illinois

“…we now have a rock solid primer on brain health that we can recommend with confidence…I found it particularly effective to start the book with a list of ten brain myths that need debunking.”
–Michael C. Patterson, former Manager NRTA/ Staying Sharp at AARP

The official book tour starts this week, and includes New York Public Library!
09/08: Club One Fitness Center, Petaluma, CA
09/09: San Francisco State University OLLI
09/11: ASA Brain Health Day, Oakland, CA
09/23: New York Public Library, Bronx Library Center
09/25: New York Public Library, Stephen Schwarzman Building
10/06, SmartSilvers MIT Northern California, Palo Alto, CA
10/14: UC-Berkeley OLLI, CA

You can find all the details here. If you haven’t read the book yet, you can order it via Amazon Here (print book) or Here (Kindle edition). Or ask your local bookstore or library.

Brain Reserve

Think about this: How can anyone take care of his or her brain when every week brings a new barrage of articles and studies which seem to contradict each other?

Do supplements improve memory? Do you need both physical and mental exercise –or is one of them enough? Which brain training approach, if any, is worth one’s time and money?

We tried to address these questions, and many others, in our recent book, The SharpBrains Guide to Brain Fitness (182 pages, $24.95), that we presented at Games for Health Conference last week. The book is the result of over two years of extensive research including more than a hundred interviews with scientists, professionals and consumers, and a deep review of the scientific literature, led by neuropsychologist Elkhonon Goldberg and myself with the help of cognitive scientist Pascale Michelon. As we wrote in the Introduction, what we wanted to do first of all was to debunks these 10 myths on brain health and brain training:

Myth 1. Genes determine the fate of our brains.
Facts: Lifelong neuroplasticity allows our lifestyles and actions to play a meaningful role in how our brains physically evolve, especially given longer life expectancy.

Myth 2. Aging means automatic decline.
Facts: There is nothing inherently fixed in the precise trajectory of how brain functions evolve as we age.

Myth 3. Medication is the main hope for cognitive enhancement.
Facts: Non-invasive interventions can have comparable and more durable effects, side effect-free.

Myth 4. We will soon have a Magic Pill or General Solution to solve all our cognitive challenges.
Facts: A multi-pronged approach is recommended, centered around nutrition, stress management, and both physical and mental exercise.

Myth 5. There is only one “it” in “Use It or Lose it”.
Facts: The brain is composed of a number of specialized units. Our life and productivity depend on a variety of brain functions, not just one.

Myth 6. All brain activities or exercises are equal.
Facts: Varied and targeted exercises are the necessary ingredients in brain training so that a wide range of brain functions can be stimulated.

Myth 7. There is only one way to train your brain.
Facts: Brain functions can be impacted in a number of ways: through meditation, cognitive therapy, cognitive training.

Myth 8. We all have something called “Brain Age”.
Facts: Brain age is a fiction. No two individuals have the same brain or expression of brain functions.

Myth 9. That “brain age” can be reversed by 10, 20, 30 years.
Facts: Brain training can improve specific brain functions, but, with research available today, cannot be said to roll back one’s “brain age” by a number of years.

Myth 10. All human brains need the same brain training.
Facts: As in physical fitness, users must ask themselves: What functions do I need to improve on? In what timeframe? What is my budget?

Do you have other myths in mind you would like  us to address?

We have started to receive great feedback from the healthcare community, such as this email from a neurosurgeon in Texas:

“I really like the book, it is comprehensive without being too technical. I have recommended it to several patients. There are some other books that I expected would be greeted with enthusiasm, but were too complex for most of my patients. I think this book is right in the sweet spot”.

And this great book review by an Internist Physician and Robert Wood Johnson Foundation Fellow, titled Is Your Brain A Couch Potato?:

“…a short, sweet, entertaining read of a complex topic, with timely (written in 1/09) reviews of 21 top technology products, as well as informed and expert predictions of where this burgeoning brain-fitness field is headed. More importantly, after you read it, you’ll have a good, detailed sense of where you, personally, can act to improve your own couch-potato brain – and how to keep it fit and flexible your whole life. The SharpBrains Guide To Brain Fitness reminds of us all why books (and not just googling a topic) can be well worth your time and money. Two Stethoscopes Up – check it out. life.”

—Doc Gurley, book review for SFGate.com (06/08/09)

The book:  The SharpBrains Guide to Brain Fitness (available via Amazon.com Here, review copies available upon request).

Description: While most of us have heard the phrase “use it or lose it,” very few understand what “it” means, or how to properly “use it” in order to maintain brain function and fitness. The SharpBrains Guide to Brain Fitness is an invaluable guide that helps readers navigate growing brain research and identify the lifestyle factors and products that contribute to brain health and fitness. By gathering insights from eighteen of the world’s top scientists and offering tools and detailed descriptions of over twenty products, this book is an essential guide to the field of brain fitness, neuroplasticity and cognitive health. An accessible and thought-provoking read, The SharpBrains Guide to Brain Fitness educates lifelong learners and professionals in healthcare, education, business, etc., on emerging trends and forecasts of what the future will hold.

Products Reviewed (we reviewed scientific studies published before January 2009, when the manuscript text was closed):

- Overall brain maintenance: Brain Age series (Nintendo), BrainWare Safari (Learning Enhancement Corporation), FitBrains.com (Vivity Labs), Happy-Neuron.com (Scientific Brain Training), Lumosity.com (Lumos Labs), MindFit (CogniFit), (m)Power (Dakim)

- Targeted brain workout: Classic and InSight (Posit Science), Working Memory Training JM and RM (Cogmed), DriveFit (CogniFit), Earobics (Houghton Mifflin), Fast ForWord (Scientific Learning), IntelliGym (Applied Cognitive Engineering), Vision Restpration Therapy (NovaVision)

- Emotional self-regulation: emWave PC and Personal Stress Reliever (HeartMath), Journey to the Wild Divine (Wild Divine), RESPeRATE (InterCure), StressEraser (Helicor)

Here you have the March edition of our monthly newsletter covering cognitive health and brain fitness topics. Please remember that you can subscribe to receive this Newsletter by email, using the box at the top of this page. I know I am biased – but do believe this Newsletter issue might well be our best so far. I hope you find the time to enjoy it!

Bird’s Eye View

Brain Fitness Survey: Over 2,000 thoughtful responses to our January survey (Thank You!) reinforce the need for public awareness initiatives and quality information to help evaluate and navigate lifestyle and product claims, as well as the need for more research, an expanded healthcare culture, as more. Given this context, we are publishing The SharpBrains Guide to Brain Fitness in May 2009, a book with 18 Interviews with Scientists, Practical Advice, and Product Reviews, in addition to our annual market report for professionals and executives (to be published in April). If you have ideas to help us promote the book, please reply to this email and let us know!

Lifelong Learning

There’s such a flood of very significant research studies, educational resources and articles related to brain health, it’s hard to keep track – even for us!

Let me introduce and quote some of the top Brain Health Studies, Articles and Resources published in March:

1) Cognitive Decline Begins In Late 20s, Study Suggests (Science Daily)

- “These patterns suggest that some types of mental flexibility decrease relatively early in adulthood, but that how much knowledge one has, and the effectiveness of integrating it with one’s abilities, may increase throughout all of adulthood if there are no pathological diseases,” Salthouse said.

- However, Salthouse points out that there is a great deal of variance from person to person

2) Cerebrum 2009: Emerging Ideas in Brain Science – new book by the Dana Foundation that “explores the cutting edge of brain research and its implications in our everyday lives, in language understandable to the general reader.”

A couple of excellent chapters of direct relevance to everyone’s brain health are:
- Chapter 4: A Road Paved by Reason, by Elizabeth Norton Lasley

- Chapter 10: Neural Health: Is It Facilitated by Work Force Participation?, by Denise Park, Ph.D

3) Staying Sharp DVD Program: “Dr. Jordan Grafman, chief of the Cognitive Neuroscience Section at the National Institute of Neurological Disorders and Stroke outside of Washington, DC, and a member of the Dana Alliance for Brain Initiatives, is your guide as we cover what to expect from the aging brain and what we can do to ’stay sharp.’

For a free DVD of this program you can contact stayingsharp@dana.org. (they say free in their website, I don’t know if that includes shipping & handling)

4) Drivers to be tested on cognitive ability starting at age 75 (Japan Times)

The outline of a cognitive test that drivers aged 75 or over will be required to take from June when renewing their licenses was released Thursday…The test is intended to reduce the number of traffic accidents involving elderly drivers by measuring their cognitive level.

5) Physical Fitness Improves Spatial Memory, Increases Size Of Brain Structure (Science Daily)

- “Now researchers have found that elderly adults who are more physically fit tend to have bigger hippocampi and better spatial memory than those who are less fit.”

6) Brain Trainers: A Workout for the Mind (Scientific American Mind)

“I recently tried out eight of the latest brain fitness programs, training with each for a week. The programs ranged widely in focus, quality and how fun they were to use. “Like physical exercise equipment, a brain exercise program doesn’t do you any good if you don’t use it,” says Andrew J. Carle, director of the Program in Assisted Living/Senior Housing Administration at George Mason University. And people tend not to use boring equipment. “I remember when NordicTrack was the biggest thing out there. Everyone ran out and bought one, and 90 percent of them ended up as a clothes rack in the back of your bedroom.”

The reporter used: Posit Science’s Brain Fitness Program Classic, HappyNeuron, Nintendo BrainAge, CogniFit’s MindFit/ CogniFit Personal Coach, Lumosity, MyBrainTrainer, BrainTwister, Cogmed Working Memory Training.

7) The Latest in Mental Health: Working Out at the ‘Brain Gym’ (Wall Street Journal)

- “Marshall Kahn, an 82-year-old family doctor in Fullerton, Calif., says he got such a boost from brain exercises he started doing at a “Nifty after Fifty” club that he decided to start seeing patients again part-time. “Doing all the mental exercise,” he says, “I realized I’ve still got it.”

Debate Over Drugs For ADHD Reignites (Washington Post)

- “New data from a large federal study have reignited a debate over the effectiveness of long-term drug treatment of children with hyperactivity or attention-deficit disorder, and have drawn accusations that some members of the research team have sought to play down evidence that medications do little good beyond 24 months.”

- “The study also indicated that long-term use of the drugs can stunt children’s growth.”

Adaptive training leads to sustained enhancement of poor working memory in children (Developmental Science)

Abstract: Working memory plays a crucial role in supporting learning, with poor progress in reading and mathematics characterizing children with low memory skills. This study investigated whether these problems can be overcome by a training program designed to boost working memory. Children with low working memory skills were assessed on measures of working memory, IQ and academic attainment before and after training on either adaptive or non-adaptive versions of the program. Adaptive training that taxed working memory to its limits was associated with substantial and sustained gains in working memory, with age-appropriate levels achieved by the majority of children. Mathematical ability also improved significantly 6 months following adaptive training. These findings indicate that common impairments in working memory and associated learning difficulties may be overcome with this behavioral treatment.

9) Brain cortex thinning linked to inherited depression (Los Angeles Times)

- “On average, people with a family history of depression appear to have brains that are 28% thinner in the right cortex — the outermost layer of the brain — than those with no known family history of the disease. That cortical thinning, said the researchers, is on a scale similar to that seen in patients with Alzheimer’s disease or schizophrenia.”

Here you have the February edition of our monthly newsletter covering cognitive health and brain fitness topics. Please remember that you can subscribe to receive this Newsletter by email, simply by submitting your email at the top of this page.

Cognitive training (or structured mental exercise) definitely seems to work – as long as we define properly what “work” means, don’t expect magic cures, and help navigate options. Please keep reading…

Interview: Baycrest

Interview with Baycrest’s CEO Dr. William Reichman: Discussing the recent Centre for Brain Fitness at Baycrest, Dr. Reichman suggests that “we have an opportunity to make major progress in Brain Health in the XXI century, similar to what happened with Cardiovascular Health in the XXth, and technology will play a crucial role.” A major obstacle? We need a consensus on “widely accepted standards for outcome measures”.

Does It Work?

Does cognitive training work? (For Whom? For What?): The growing field of cognitive training (one of the tools for brain fitness) can appear very confusing as the media keeps reporting contradictory claims. These claims are often based on press releases, without a deeper understanding of the scientific evidence. Dr. Pascale Michelon, SharpBrains’ Research Manager for Educational Initiatives, analyzes a couple of recent studies, clarifying what they mean – and what they don’t mean.

It Works, and It Doesn’t Work: the IMPACT study (a major, multi-site study on the Posit Science auditory program) will be published at the Journal of the American Geriatrics Society in April. Results support that cognitive training works – but doesn’t support the grandiose “brain age” claims we see too often.

Cognitive Training can Influence Brain Biochemistry: Dr. David Rabiner discusses a recent scientific study that “shows that brain biochemistry can be modified by experience”, and that computerized cognitive training (Cogmed working memory training) can provide that experience.

The Big Picture

Making Healthy Choices – Primare Care and Prevention: a panel at the recent World Economic Forum explored why “New markets and industries are arising – “silver industries” such as financial services, health, housing and hospitality geared to senior citizens. Longevity needs to be linked to health – including cognitive health – and lifestyle choices play a major role in health.”

Enrich your environment now and benefit your future offspring: Dr. Robert Sylwester reports that “all sorts of long held-beliefs about our brain and cognition are being re- examined by cognitive neuroscientists” because of fascinating studies such as the one  he reviews (with mice): “The study’s findings seemed to suggest that acquired characteristics can be genetically transmitted…long-term benefits accrue from a stimulating early environment that encourages curiosity and exploration.”

Managing Emotions

From Distress to De-Stress: helping anxious, worried kids: In a detailed 2-part article, (Part 1, Part 2), Dr. Jerome Schultz provides great tips on how to help children learn to self-regulate emotions, adding that “Teachers, occupational therapists, physical education teachers and parents need to actually teach children (of all ages) how to get themselves into a physical state of being relaxed. This doesn’t happen automatically. If it did, there wouldn’t be so many adult yoga classes!”

Lie to Me, Paul Ekman and Biofeedback: You may have watched the new series Lie To Me, with Tim Roth, based on the work of Paul Ekman. The introduction to the second episode shows why what are called “lie detectors” are nothing but biofeedback systems that measure physiological anxiety.

 

News

Brain Games for Baby Boomers: round-up of other recent news, covering the effects of gaming, cognitive training for driving skills, and brain fitness classes.

Neurocognitive assessments and sports concussions: a new study and a new resource to understand and address the 1.6 to 3.8 million cases of sports-related concussions that occur annually in the United States.

 

Brain Teaser

How will you, your organization, your neighbors, participate in Brain Awareness Week, March 16th-22nd, organized by the Dana Foundation with the participation of thousands of outreach partners, including SharpBrains? You can find event ideas, excellent resources (yes, including puzzles), and a calendar of events, Here.

Have a great month of March!

 

 

 

I wanted to alert you to a very interesting finding published in a recent issue of Science, one of the world’s leading scientific journals.

The study was led by Dr. Torkel Klingberg and his colleagues from the Karolinska Institute in Sweden. The goal was to learn whether Working Memory Training is associated with changes in brain biochemistry, thus suggesting a mechanism by which training may lead to enhanced working memory capacity and a reduction in attention problems. Thus, although Working Memory Training has previously shown promising results as a treatment for working memory and attention difficulties, this was a basic science study rather than a treatment study.

The major finding was that increased working memory capacity following training was associated with changes in brain biochemistry. Specifically, the researchers found changes in the density and binding potential of cortical D1 dopamine receptors in brain regions that are activated during working memory tasks.

Results from this study suggest a biological basis for the improvement in working memory capacity and reductions i Read the rest of this entry »

Cognitive Training Can Alter Biochemistry Of The Brain (Science Daily)

- “Researchers at the Swedish medical university Karolinska Institutet have shown for the first time that the active training of the working memory brings about visible changes in the number of dopamine receptors in the human brain.”

- “”Brain biochemistry doesn’t just underpin our mental activity; our mental activity and thinking process can also affect the biochemistry,” says Professor Torkel Klingberg, who led the study.”

- “Changes in the number of dopamine receptors in a person doesn’t give us the key to poor memory,” says Professor Lars Farde, one of the researchers who took part in the study. “We also have to ask if the differences could have been caused by a lack of memory training or other environmental factors. Maybe we’ll be able to find new, more effective treatments that combine medication and cognitive training, in which case we’re in extremely interesting territory.”

Comment:  couldn’t agree more with “Maybe we’ll be able to find new, more effective treatments that combine medication and cognitive training, in which case we’re in extremely interesting territory.” This study adds a very important angle to the growing literature on working memory training, showing a more fundamental, structural impact, that once thought (such as the well-known effect that “cells that fire together wire together”). The computerized cognitive program used in the study was Cogmed working memory training.

More on Torkel Klingberg’s research:

- Article written by Torkel Klingberg on The Overflowing Brain & Information Overload

- His recent book, which was The SharpBrains Most Important Book of 2008: The Overflowing Brain: Information Overload and the Limits of Working Memory

- 2006 Interview with Dr. Klingberg: Working Memory Training and RoboMemo: Interview with Dr. Torkel Klingberg

We have just announced an upcoming webinar to provide a market update:  Top 10 Cognitive Fitness Events of 2008 – A Market Update.

When: Thursday December 11th, from 12:00 to 1:00 pm Pacific Time. The same webinar will be repeated on Thursday December 18th, from 9:00 to 10:00 pm Pacific Time.

The Top 10 Cognitive Fitness Events that will be discussed include:

1) February: Dakim secures a $10.6m investment from Galen Partners. Jack LaLanne becomes spokesperson.
2) April: The Government of Ontario, Canada, invests $10m in Baycrest to develop and commercialize cognitive fitness technologies.
3) April: University of Michigan researchers reveal in the Proceedings of the National Academy of Sciences how computerized working memory training can generalize and improve fluid intelligence in healthy adults.
4) May: Humana unveils Games for Health initiatives, not renewing its agreement with Posit Science.
5) June: The US Army launches a new policy requiring cognitive screenings of all soldiers before deployment (in order to Read the rest of this entry »

Karolinska Institute’s Dr. Torkel Klingberg has just released in the US his excellent book The Overflowing Brain: Information Overload and the Limits of Working Memory 

The title was first released in Sweden with great success, and our co-founder Dr. Elkhonon Goldberg gave a Foreword to the new US edition.

Dr. Klingberg will be writing an essay for SharpBrains readers soon, so we can discuss the importance of this topic and his work in depth. Let me now link to two thought-provoking reviews of the book:

Attention Must Be Paid (Inside Higher Ed)

- “The weak link in the information age seems to be our human hard-wiring. So one gathers from The Overflowing Brain: Information Overload and the Limits of Working Memory (Oxford University Press) by Torkel Klingberg, who is a professor of developmental cognitive neuroscience at the Stockholm Brain Institute. A review of recent research on how attention and memory actually function within our gray matter, it is a work of scientific popularization rather than a handbook on how to minimize the cognitive drain of distraction.”

- “To simplify Klingberg’s already pared-down analysis, we can distinguish between two kinds of attention. One is controlled attention: the directed effort to apply one’s concentration to a particular task. The other is stimulus-driven attention, which is an involuntary response to something happening in the environment. (You can tune out the conversations going on around you in a restaurant. But if a waiter drops a tray full of dishes, it is going to impose itself on your awareness.)”

- “Klingberg reports that a two-year study in his lab showed that it was possible to increase working-memory capacity Read the rest of this entry »

Michael I. Posner is a prominent scientist in the field of cognitive neuroscience. He is currently an emeritus professor of neuroscience at the University of Oregon (Department of Psychology, Institute of Cognitive and Decision Sciences). In August 2008, the International Union of Psychological Science made him the first recipient of the Dogan Prize “in recognition of a contribution that represents a major advance in psychology by a scholar or team of scholars of high international reputation.”

Dr. Posner, many thanks for your time today. I really enjoyed the James Arthur Lecture monograph on Evolution and Development of Self-Regulation that you delivered last year. Could you provide a summary of the research you presented?

I would emphasize that we human beings can regulate our thoughts, emotions, and actions to a greater degree than other primates. For example, we can choose to pass up an immediate reward for a larger, delayed reward.

We can plan ahead, resist distractions, be goal-oriented. These human characteristics appear to depend upon what we often call “self-regulation.” What is exciting these days is that progress in neuroimaging and in genetics make it possible to think about self-regulation in terms of specific brain-based networks.

Can you explain what self-regulation is?

All parents have seen this in their kids. Parents can see the remarkable transformation as their children develop the ability to regulate emotions and to persist with goals in the face of distractions. That ability is usually labeled ‘‘self-regulation.’’

The other main area of your research is attention. Can you explain the brain-basis for what we usually call “attention”?

I have been interested in how the attention system develops in infancy and early childhood.

One of our major findings, thanks to neuroimaging, is that there is not one single “attention”, but three separate functions of attention with three separate underlying brain networks: alerting, orienting, and executive attention. Read the rest of this entry »