In a recently published scientific study (see Hall C, et al “Cognitive activities delay onset of memory decline in persons who develop dementia” Neurology 2009; 73: 356-361), Hall and colleagues examined how education and stimulating activities may interact to contribute to cognitive reserve. The study involved 488 initially healthy people, average age 79, who enrolled in the Bronx Aging Study between 1980 and 1983. These individuals were followed for 5 years with assessments every 12 to 18 months (starting in 1980). At the start of the study, all participants were asked how many cognitive activities (reading, writing, crossword puzzles, board or card games, group discussions, or playing music) they participated in and for how many days a week. Researchers were able to evaluate the impact of self-reported participation these activities on the onset of accelerated memory decline in 101 individuals who developed dementia during the study.

Results showed that for every “activity day” (participation in one activity for one day a week) the subjects engaged in, they delayed for about two months the onset of rapid memory loss associated with dementia. Interestingly, the positive effect of brain-stimulating activities in this study appeared to be independent of a person’s level of education.

This is great news as it suggests that it is never too late to try to build up brain reserve. The more brain stimulating activities one does and the more often, the better for a stronger cognitive reserve.

The cognitive reserve hypothesis suggests that individuals with more cognitive reserve can experience more Alzheimer’s disease pathology in the brain (more plaques and tangles) without developing Alzheimer’s disease symptoms.

How does that work? Scientists are not sure but two possibilities are considered.
1. One is that more cognitive reserve means more brain reserve, that is more neurons and connections between neurons.
2. Another possibility is that more cognitive reserve means more compensatory processes (see my previous post “Education builds Cognitive Reserve for Alzheimers Disease Protection” for more details.)

Now, one may wonder about the difference types of mental stimulation available, including not only puzzles and such, but structured activities such as brain fitness software and meditation. Do we exercise our brain every time we think about something? What can one do to exercise one’s brain in ways that enhance capacity? Does aerobic fitness training also exercise one’s brain? What types of methodologies and products are available? Do they “work”? Are all the same?

Those are the types of questions we wanted to address in the book The SharpBrains Guide To Brain Fitness (available via Amazon.com). We are proud of the recognition the book has started to obtain, including endorsements by leading scientists:

“The SharpBrains Guide to Brain Fitness is the only book that I know of that seamlessly integrates latest information about cognitive health across the lifespan, with interviews with active researchers examining cognitive maintenance and enhancement, along with reviews of commercial products targeted to cognitive enhancement. The book should be very useful to anyone interested in brain care, both health care professionals and the public at large”.
– Arthur Kramer, Professor of Psychology at University of Illinois

“This SharpBrains book provides a very valuable service to a wide community interested in learning and brain topics. I found it interesting and helpful”
- Michael Posner, Emeritus Professor of Neuroscience at the University of Oregon, and first recipient of the Dogan Prize

– Pascale Michelon, Ph. D., is SharpBrains’ Research Manager for Educational Projects. Dr. Michelon has a Ph.D. in Cognitive Psychology and has worked as a Research Scientist at Washington University in Saint Louis, in the Psychology Department. She conducted several research projects to understand how the brain makes use of visual information and memorizes facts. She is now an Adjunct Faculty at Washington University.

References:

- Study: Hall C, et al “Cognitive activities delay onset of memory decline in persons who develop dementia” Neurology 2009; 73: 356-361

- Book: The SharpBrains Guide To Brain Fitness: 18 Interviews with Scientists, Practical Advice, and Product Reviews, to Keep Your Brain Sharp

Here you have the March edition of our monthly newsletter covering cognitive health and brain fitness topics. Please remember that you can subscribe to receive this Newsletter by email, using the box at the top of this page. I know I am biased – but do believe this Newsletter issue might well be our best so far. I hope you find the time to enjoy it!

Bird’s Eye View

Brain Fitness Survey: Over 2,000 thoughtful responses to our January survey (Thank You!) reinforce the need for public awareness initiatives and quality information to help evaluate and navigate lifestyle and product claims, as well as the need for more research, an expanded healthcare culture, as more. Given this context, we are publishing The SharpBrains Guide to Brain Fitness in May 2009, a book with 18 Interviews with Scientists, Practical Advice, and Product Reviews, in addition to our annual market report for professionals and executives (to be published in April). If you have ideas to help us promote the book, please reply to this email and let us know!

Lifelong Learning

“Whatever you struggle with in a sense as it stems from your neurology, the inherent plasticity of the brain gives you a basis for improvement. This is a way underutilized and under-appreciated resource that well all have.” Dr. Michael Merzenich on the Brain Science Podcast #54, 2/13/09.

Recently there has been growing controversy about the effectiveness of computer-based cognitive training programs. As a co-founder of Posit Science, Inc. Dr. Michael Merzenich is a staunch defender of the methods his company uses to validate the programs that they have developed. But for the purposes of this essay, I want to share some of the key ideas we discussed during his recent interview on the Brain Science Podcast.

First of all, I asked him to discuss some of the highlights of his long career. Since he was one of the first neuroscientists to embrace the concepts of neuroplasticity I was curious about how this came about. While he did have some exposure to the animal evidence as a graduate student, it was actually his experience with the invention of the cochlear implant that convinced Dr. Merzenich of the real-world, practical implications of brain plasticity. The quality of the Read the rest of this entry »

Here you have the twice-a-month newsletter with our most popular blog posts. Please remember that you can subscribe to receive this Newsletter by email, simply by submitting your email at the top of this page. 

First, I am pleased to report that I have been invited to participate in a new initiative by the World Economic Forum. Described as ”In a global environment marked by short-term orientation and silo-thinking, Global Agenda Councils will foster interdisciplinary and long-range thinking to address the prevailing challenges on the global agenda”, my specific Council will focus on the Challenges of Gerontology. More information on the Global Agenda Councils here. Will keep you updated via this blog.

In the News

Yes, It is Smart to Learn New Tricks: a recent Washington Post article presents a good overview of brain health trends, but framed around a highly artificial choice for consumers: either you a) do physical exercise, or b) take part in social interactions, or c) engage in mental exercise. What about switching off those TVs and having time for all a, b, c, and more? 

Mind Games: the August issue of Venture Capital Journal brings a very good piece on the emerging brain fitness software category (subscription required), which we enhance by providing a quick overview of the field.

CogniFit raises USD 5 million: if 2007 was the year of brain fitness media coverage, 2008 seems to be the year of serious investments. This CogniFit round follows other recent venture investments: Dakim ($10.6m), Lumos Labs ($3m). We hear all these companies are devoting part of these resources to fund clinical trials…never too late.

Brain Science and Lifelong Learning

Schools as Brain Training Hubs?: in a recent post we asked for suggestions to refine our predictions for the 2007-2015 period. A good number of readers contributed, and the winner of this informal contest is… Scott Spears, retired public schools superintendent, for his thoughts on the future implications of cognitive research on schooling.

Neurogenesis and Brain Plasticity in Adult Brains: while ”adults may have a tendency to get set in their ways – I’ve been doing it this way for a long time and it works, so why change?”, change itself is an excellent practice for healthy brain aging, as Laurie Bartels explains.  

A Farewell to Dementia?: a fascinating recent editorial in Archives of Neurology, titled Dementia: A Word to be Forgotten, calls for more constructive terminology. Dr. Joshua Steinerman weighs in.

Other Thought-Provoking Articles

To Think or to Blink?: should Hamlet be living with us now and reading bestsellers, he might be wondering: To Blink or not to Blink? To Think or not to Think? We are pleased to present an article by Madeleine Van Hecke, offering the ”on the other hand” to Malcolm Gladwell’s Blink argument. 

The impact of web 2.0 on healthcare: we hosted Medicine 2.0, a bi-weekly collection of articles that analyze the current and potential impact of web 2.0 technologies on medicine and healthcare.

Brain Teasers

Brain Teasers: Spot the Difference: how many differences can you spot (and how many cognitive functions can you engage with this simple exercise?)

I hope you are having a great August!

 

A dreaded diagnosis, that dimmed and dooming dilemma. Feared, sometimes fought, too often forgotten. It is the grayest, ghastliest elephant in the room: dementia.

What is dementia? I, like many others who dedicate their professional efforts to its study and treatment, have no good answer. I believe we are lost in our lexicon, trying to define a brain state so vexing and elusive it drives us out of our minds.

I hope we can do better, and I am not alone. In a sensitive and forward-looking editorial entitled Dementia: A Word to be Forgotten, Drs. Trachtenberg and Trojanowski of the University of Pennsylvania argue that alternate terms are more appropriate for research, clinical, and everyday settings. From scientific and biological perspectives, dementia is unspecific and subjective. Within the walls of the physician’s office, delivering the diagnosis of dementia can erect unintended walls around patients and families; vulnerable individuals, assuming that the “cruel connotations in the lay language” actually apply to them, are unnecessarily isolated. Read the rest of this entry »

Cognitive training (the basis for what we call “brain fitness” these days) has a wide array of applications. The most recent one, which is capturing public’s imagination, monopolizing media coverage, and creating certain confusion, is Healthy Brain Aging. We are fortunate to have Dr. Joshua Steinerman, one of our new Expert Contributors, offer today his great voice to this conversation. Enjoy!

- Alvaro
—————————

Minding the Aging Brain

– By Joshua R. Steinerman, M.D.

Scientists, philosophers, artists, and experts from all fields of human endeavor lament: it ain’t easy getting older. It? Do they refer to frailty and disability? To bodily disease? To life at its essence?

It’s all in your head

The mind is not set in stone, but it is encased by bone. It’s really all about the brain, the hyphen in the mind-body conundrum. That squishy gray neuronal jungle is the interface between internal life and environmental sensations and stimulation. As expected, the brain shows signs of aging just as a wrinkled brow, a stooped posture, or an arthritic finger might. The most common brain changes observed in aging and in age-associated neuropsychiatric disease include:

Read the rest of this entry »

I hope you are having happy holidays, and are getting ready for New Year celebrations. Best wishes to you and your loved ones. 

Via MedJournalWatch we just found this interesting paper, 

Associations of job demands and intelligence with cognitive performance among men in late life. Guy G. Potter PhD^*, Michael J. Helms BS, and Brenda L. Plassman PhD Neurology 2007.

- CONCLUSIONS: “Intellectually demanding work was associated with greater benefit to cognitive performance in later life independent of related factors like education and intelligence. The fact that individuals with lower intellectual aptitude demonstrated a stronger positive association between work and higher cognitive performance during retirement suggests that behavior may enhance intellectual reserve, perhaps even years after peak intellectual activity.”

This is consistent with the Cognitive Reserve theory we discussed in the interview with neuroscientist Yaakov Stern:

- AF (Alvaro Fernandez): OK, so our goal is to build that Reserve of neurons, synapses, and skills. How can we do that? What defines “mentally stimulating activities” or good “brain exercise”?

- YS (Yaakov Stern): In summary, we could say that “stimulation” consists of engaging in activities. In our research almost all activities are seen to contribute to reserve. Some have challenging levels of cognitive complexity, and some have interpersonal or physical demands. In animal studies, exposure to an enriched environment or increased physical activity result in increased neurogenesis (the creation of new neurons). You can get that stimulation through education and/ or your occupation. There is clear research showing how those two elements reduce the risk. Now, what is very exciting is that, no matter one’s age, education and occupation, our level of participation in leisure activities has a significant and cumulative effect. A key message here is that different activities have independent, synergistic, contributions, which means the more things you do and the earlier you start, the better. But you are never stuck: better late than never.

- Read more on the Cognitive Reserve

In short, mentally and socially stimulating activities, through our education, occupation AND leisure activities, contribute to building a Cognitive Reserve in our brains that may help delay memory problems, Mild Cognitive Impairment, and Alzheimer’s related symptoms, and help maintain cognitive performance overall as we age.

If you are thinking about New Year Resolutions, this is one more area to consider. Happy 2008!