Here you have the November edition of our monthly newsletter covering cognitive health and brain fitness topics. Please remember that you can subscribe to receive this Newsletter by email, simply by submitting your email at the top of this page.

Thank you for your interest, attention and participation in our SharpBrains community. As always, we appreciate your comments and suggestions.

Summit of the Global Agenda

How can we persuade business leaders, policy-makers and researchers of the urgency to develop and promote an integrated “Healthy Living” agenda focused on maintaining lifelong physical and cognitive health, vs. the usual mindset focused on dealing with specific diseases and problems once they arise?

In The Future of the Aging Society: Burden or Human Capital?, I summarize some of the key themes discussed at the World Economic Forum event in Dubai on November 7-9th. The world is aging – and in healthier ways. But our healthcare and retirement systems are on track to go bankrupt – their premises are outdated. The current disease-based research agenda compounds the problem. Solutions? 1) Promote Healthy Lifestyles that help Maintain Physical and Cognitive Functional Abilities, 2) Redesign Environments to Foster Health, Engagement and Financial Security, 3) Develop an Integrated Healthy Living & Aging Research Agenda. Specifically, we could work with the UN and Global 2000 companies to move forward a new agenda.

Planet Earth 2.0: A New Operating System: Imagine seeing a top sheik in Dubai, wrapped in traditional Arab clothing, exclaim “Yes We Can” (a la Obama) in front of the 800 global experts, adding that “we build the future with our own hands”. Some of the attendants of the World Economic Forum’s Summit of the Global Agenda urged us to “reboot” the system. More than a “reboot”, we may have to upgrade to a new global “Yes We Can” operating system.

Brain Fitness Research

Neuroplasticity and the Brain That Changes Itself: Laurie Bartels reviews the excellent book by Norman Doidge, explaining that “the neuroscience behind Doidge’s book involves neuroplasticity, which is the brain’s ability to rewire itself. This means that the brain – our intelligence – is not something fixed in concrete but rather a changing, learning entity.”

Can We Pick Your Brain re: Cognitive Assessments?: In our view, a critical component in the maturity of the brain fitness market will be the availability of inexpensive, valid and reliable objective cognitive assessments,  to help measure how our brain functions change over time and identify priorities for targeted improvements. Dr. Joshua Steinerman asks if you would be up for them?

Use It (Properly) or Lose It

Physical and mental exercise to prevent cognitive decline: The American Medical News, a weekly newspaper for physicians published by the American Medical Association, just published an excellent article on the importance of physical and mental exercise. We are very happy to see efforts like these to train physicians and health professionals in general,  given that most of them were trained under a very different understanding of the brain than the one we have today.

Brain Fitness 2: Sight & Sound: PBS recently announced the second installment of their popular Brain Fitness Program show, to start airing soon.

MetaCarnival #1: a conversation across the blogosphere: We often insist on “Novelty, Variety and Challenge” as key ingredients for good “brain exercise”. There are many ways to mix those ingredients – you may enjoy this one, the first interdisciplinary gathering of blogs and blog carnivals covering health, science, anthropology, general advice and more.

Top 15 Brain Teasers and Games for Mental Exercise: Over the last 2 years we have published close to 100 puzzles, teasers, riddles, and every kind of mental exercise (without counting our in-depth interviews with top neuroscientists). Which ones have proven most stimulating for you. Let us know. Here is a selection of our Top 15 teasers.

Final Details

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Have a Happy Thanksgiving!

I just read a very interesting article in Newsweek: Executive Functions: The School Skill That May Matter More Than IQ. A few quotes:

- “But recent advances in psychology and brain science are now suggesting that a child’s ability to inhibit distracting thoughts and stay focused may be a fundamental cognitive skill, one that plays a big part in academic success from preschool on. Indeed, this and closely related skills may be more important than traditional IQ in predicting a child’s school performance.”

- “EF (executive functions) comprises not only effortful control and cognitive focus but also working memory and mental flexibility—the ability to adjust to change, to think outside the box.”

- “When the teacher holds up a circle they clap, with a triangle they hop, and so forth. The kids are taught to talk themselves through the mental exercise: “OK, now clap.” “Twirl now.” This has been shown to flex and enhance the brain’s ability to switch gears, to suppress one piece of information and sub in a new one. It takes discipline; it’s the elementary school equivalent of saying “I really need stop thinking about next week’s vacation and focus on this report.”

The main points: executive functions are crucial for success in life, AND they can be trained. I couldn’t agree more with the article in that cognitive training should be part of the education curriculum and receive more research dollars to determine exactly how to best do so.

I read another very interesting article on Alzheimer’s Disease. Which may look like a completely different topic than the one above…but please bear with me. Read the rest of this entry »

Roundup of several insightful articles and recent research:

Fish Oil May Help Prevent Alzheimer’s (Washington Post)

- “The omega-3 fatty acids found in fish oil might play an important role in preventing Alzheimer’s disease, according to a research team at the University of California, Los Angeles (UCLA).”

- “Publishing in the Dec. 26 issue of the Journal of Neuroscience, the scientists demonstrated that the omega-3 fatty acid docosahexaenoic acid (DHA) increases the production of LR11, a protein that is found at reduced levels in Alzheimer’s patients. LR11 is known to destroy the protein that forms the plaques associated with the disease, the researchers explained.” 

- “Alzheimer’s is a debilitating neurodegenerative disease that causes memory loss, dementia, personality change and ultimately death. The Alzheimer’s Association estimates that 5.1 million Americans are currently afflicted with the disease. The association predicts that may increase to between 11 million and 16 million people by 2050.”

 ‘Finding Alzheimer’s Before a Mind Fails’ (New York Times)

- “Ms. Kerley is part of an ambitious new scientific effort to find ways to detect Alzheimer’s disease at the earliest possible moment. Although the disease may seem like a calamity that strikes suddenly in old age, scientists now think it begins long before the mind fails.”

- “Many scientists believe the best hope of progress, maybe the only hope, lies in Read the rest of this entry »

I hope you are having happy holidays, and are getting ready for New Year celebrations. Best wishes to you and your loved ones. 

Via MedJournalWatch we just found this interesting paper, 

Associations of job demands and intelligence with cognitive performance among men in late life. Guy G. Potter PhD^*, Michael J. Helms BS, and Brenda L. Plassman PhD Neurology 2007.

- CONCLUSIONS: “Intellectually demanding work was associated with greater benefit to cognitive performance in later life independent of related factors like education and intelligence. The fact that individuals with lower intellectual aptitude demonstrated a stronger positive association between work and higher cognitive performance during retirement suggests that behavior may enhance intellectual reserve, perhaps even years after peak intellectual activity.”

This is consistent with the Cognitive Reserve theory we discussed in the interview with neuroscientist Yaakov Stern:

- AF (Alvaro Fernandez): OK, so our goal is to build that Reserve of neurons, synapses, and skills. How can we do that? What defines “mentally stimulating activities” or good “brain exercise”?

- YS (Yaakov Stern): In summary, we could say that “stimulation” consists of engaging in activities. In our research almost all activities are seen to contribute to reserve. Some have challenging levels of cognitive complexity, and some have interpersonal or physical demands. In animal studies, exposure to an enriched environment or increased physical activity result in increased neurogenesis (the creation of new neurons). You can get that stimulation through education and/ or your occupation. There is clear research showing how those two elements reduce the risk. Now, what is very exciting is that, no matter one’s age, education and occupation, our level of participation in leisure activities has a significant and cumulative effect. A key message here is that different activities have independent, synergistic, contributions, which means the more things you do and the earlier you start, the better. But you are never stuck: better late than never.

- Read more on the Cognitive Reserve

In short, mentally and socially stimulating activities, through our education, occupation AND leisure activities, contribute to building a Cognitive Reserve in our brains that may help delay memory problems, Mild Cognitive Impairment, and Alzheimer’s related symptoms, and help maintain cognitive performance overall as we age.

If you are thinking about New Year Resolutions, this is one more area to consider. Happy 2008!

Hi!
This is Andreas, the Norwegian MD/PhD in neuroscience candidate who worked as an intern at SharpBrains a few months ago. Now I’m back in chilly Oslo where I’ve just begun my PhD program on cognitive training for patients with memory problems.

Today I felt it was time to reflect upon my 3 month stay in San Francisco earlier this year. It all started when in April when the Norwegian school of entrepreneurship said: You’ve got a ticket to San Francisco, now you got to find the perfect start-up company to work for.

Being interested in brain training, I googled “Brain fitness San Francisco” and guess what I found? I got in touch with Alvaro Fernandez, the co-founder of SharpBrains.com and two months later I started working with him and his team.

As a scientist, being placed in an exciting start-up company in a novel market like brain fitness was a huge learning experience that gave me hands-on knowledge of business and entrepreneurial culture. Being a neuroscience student, I know that learning physically changes my brain, strengthening it.

Here’s a list of some of the key things I’ve learned:

1) First of all, one of key rules for brain fitness is learning. In SharpBrains I immediately got to experience what a great learning culture can be all about – from key insights in entrepreneurship to how to make creative videos and writing for the web. The urge for constant learning is both fun and stimulating – and I appreciate Alvaro’s suggestion to write this post.
Read the rest of this entry »

Here is question 14 of 25 from Brain Fitness 101: Answers to Your Top 25 Questions. To download the complete version, please click here.

Question:
Does a brain fitness program prevent Alzheimer’s disease and other forms of dementia?

Key Points:

• Studies have shown mentally active people have lower rates and later onset of symptoms for Alzheimer’s disease and other forms of dementia. These diseases involve a number of variables like family history, physical fitness, nutrition, and brain fitness.
• People who remain intellectually active and engage in hobbies reduce the risk of Alzheimer’s disease by one third.

Answer:
Read the rest of this entry »