Eric Jensen alerted me to a research study published in the February 4th Journal of Neuroscience — Transgenerational Rescue of a Genetic Defect in Long-Term Potentiation and Memory Formation by Juvenile Enrichment. We both had the same initial WOW! feeling that we had experienced when we first read about the discovery of mirror neurons a decade+ ago.

The study’s findings seemed to suggest that acquired characteristics can be genetically transmitted, a Lamarckinan belief that had long been discarded by biologists. This seemed improbable, so we decided to check out what the scientific community thought. It’s the kind of research that educators certainly need to understand because the potential educational implications are profound, no matter how this particular study sorts out.

I’ve thus appended the following information below: (1) the abstract and reference of the original sttudy, (2) a link to a non-technical report in the current issue of New Scientist, (3) a link to a non- technical explanation of the research in Medical News Today, and (4) a link to a recent extended non-technical New Scientist article on the issue of non-genetic inheritance. Eric will post his commentary on the research in the March edition of his Brighter Brain Bulletin newsletter.

THE STUDY:

To put it simply: The researchers studied long-term potentiation (LTP), in which longer and more robust synaptic activation occurs. LTP is the basic mechanism for learning and memory formation.

Juvenile mice placed into an enriched environment (EE) developed enhanced LTP capabilities that they later transmitted to their own offspring during embryogenesis (rather than through later maternal instruction), and these effects persisted even when the offspring weren’t in an EE. The study concluded that a stimulating juvenile environment can thus influence the composition of signaling networks that influence synaptic plasticity and memory formation in the enriched mouse, and also in its future offspring.

The problem with this research appears to be over whether the transmitted effects occurred via genetic changes or through something else in the mother’s uterine environment. A female’s eggs develop early in life to be distributed later, so it’s improbable that a female’s juvenile experiences would alter the DNA in her eggs. A more probable explanation may be that any changes in the mother’s brain that occur via an EE are represented as currently ill- understood signaling molecules that pass through the placental barrier into the embryonic brain.

THE SIGNIFICANCE:

For educators, this research simply adds to our own strong belief that long-term benefits accrue from a stimulating early environment that encourages curiosity and exploration. The research builds on Read the rest of this entry »

As you may have noticed, we just changed a few things in our site, including preparing a more solid Resources section. Please take a look at the navigation bar at the top.

One of the new pages, that we will update often, is an expanded Books page. Here are the books that we are recommending now.

Fascinating books on neuroplasticity (the ability of the brain to rewire itself through experience):

Train Your Mind, Change Your Brain: How a New Science Reveals Our Extraordinary Potential to Transform Ourselves – by Sharon Begley.

 

The Brain That Changes Itself: Stories of Personal Triumph from the Frontiers of Brain Science – by Norman Doidge.

 

Great popular science books by Read the rest of this entry »

Here you are have the Monthly Digest of our Most Popular Blog Posts. You can consider it your monthly Brain Exercise Magazine.

Gratitude is a very important emotion to cultivate, as Professor Robert Emmons tells us in this interview, based on his last book. Please take some time to read it, and to find at least one thing you are thankful for-it will be good for your health.

We are grateful about a very stimulating November:

Brain Fitness Market News

10 Neurotechnology Trends: a leading industry organization released their Top 10 NeuroTrends for 2007, and brain fitness matters appeared in 3 of them.

Thank Boomers for Buffing Up Brain Market: great overview of the market from a technology point of view, quoting our market projections. To clarify the numbers mentioned: we project $225m in the US alone for the brain fitness software market (growing from $70m in 2003), broken-down as follows: $80m for the Consumer segment, $60m in K12 Education, $50m in Clinical applications, and $35m in the Corporate segment. The Consumer segment, with a healthy aging value proposition, is the most recent one but the most rapidly growing.

Exercise On the Brain: a NYT OpEd: a widely read opinion piece in the New York Times, written by 2 neuroscientists, that somehow seems to miss the research behind the value of mental stimulation and cognitive training. Other neuroscience teams and us write letters to the editor that go unpublished. Should you have any contacts with journalists, please ask them to contact us: we are always happy to serve as a resource to the media.

Posit Science @ GSA: well-designed Brain Training Works: a timely heads up on how well-designed computer-based programs can be a great complement to other interventions. We will be interviewing the leading researcher behind that study during the next 2 weeks, so keep tuned!

Brain and Mind News and Articles: a variety of links to good media reports, including a spectacular special on memory in National Geographic.

News You Can Use

Marian Diamond on the brain: leading neuroscientist Marian Diamond, now 81, shares her prescription for lifelong brain health- diet, exercise, challenge, newness and tender loving care.

From Meditation to MBSR (Mindfulness Based Stress Reduction): a report on the benefits of meditation and how it is becoming more mainstream in medicine.

Teasers

50 Mind and Brain Games for adults: you may have seen these teasers, but we want to alert you we have opened a new section in the site where you can easily find our growing collection of teasers

Your Haiku, please?: a friendly challenge to your brain.

Education and Lifelong Learning

Carol Dweck on Mindsets, Learning and Intelligence: we found a fascinating interview on the importance on having a growth and learning oriented mindset. Both for kids and adults.

Is Intelligence Innate and Fixed?: some reflections based on biology.

Corporate Training, Wellness and Leadership

Cognitive Fitness and The Future of Work: an excellent concept map on how neuroscience may influence the workplace of the future, drawn in real time as I spoke at an Institute for the Future event.

Emotional Intelligence and Faces: how many universal emotions and facial expressions are there?

Events

Use It or Lose It, and Cells that Fire together Wire together: I spoke at the Italian Consulate in San Francisco, where we explored some of the basic concepts we should all know about how our brains and mind work.

Let me practice the Gratitude concept…Thank You for your attention and participation!

You can also enjoy our previous editions of this monthly digest:

- October

- September

- August

- July

Quotes from a great article, Professor, 81, proves brain stays young:

- In 1960, Diamond became the first female faculty member in Cal’s science department, achieving full professorship in 1974. She still teaches anatomy with her 81st birthday two weeks away.

- Diamond, a professor of anatomy at UC Berkeley, determined that the brain can stay young through stimulation, which can be achieved through her five-point plan: diet, exercise, challenge, newness and tender loving care.

- Using her plan, how is she challenged?

- “Every student who sits in that chair,” she said, pointing across the desk in her fifth-floor office in the Life Sciences Building on campus. “They come in here asking questions, and you better have the answers.”

- What newness, then, is in her life?

- “I have grandchildren,” she said. “What could be better, deciding new things for them, to stimulate their brains.”

- She has four children, four grandchildren and a husband, Arnold Scheidel, who teaches anatomy at UCLA. They see each other on school weekends,

- Diamond feels her own brain growing.

Keep reading here.

 

Related resources

A previous post listing a number of her essays: Marian Diamond and the Brain Revolution

Her great book Magic Trees of the Mind: How to Nurture Your Child’s Intelligence, Creativity, and Healthy Emotions from Birth Through Adolescence, by Berkeley’s Marian Diamond and Janet L. Hopson.

We had a very fun session titled Teaching Brain Fitness in Your Community at an American Society on Aging (ASA) conference for health professionals a couple of weeks ago. Full house, with over 60 attendants and very good participation, showing great interest in the topic. I can’t wait to see the evaluations.

These are some of the resources I promised as a follow-up, which can be useful to everyone interested in our field:

Good general articles in the business and general media:

Change or Die

Want a sharp mind for your golden years? Start now

You’re Wiser Now

On how new neurons are born and grow in the adult brain:

Salk Scientists Demonstrate For The First Time That Newly Born Brain Cells Are Functional In The Adult Brain

Old Brains, New Tricks

On the surprising plasticity and development potential throughout life:

Brain Plasticity, Language Processing and Reading

Juggling Juggles the Brain

Successful Aging of the Healthy Brain

Other important aspects:

Stress and the Brain

Exercise and the Brain

Humor, Laughter and The Brain

On the importance and impact of mental stimulation and training: Read the rest of this entry »

Alvaro and I had the good fortune to attend a great conference last week called Learning & The Brain: Enhancing Cognition and Emotions for Learning. It was a fascinating mix of neuroscientists and educators talking with and listening to each other. Some topics were meant to be applied today, but many were food for thought – insight on where science and education are headed and how they influence each other.

Using dramatic new imaging techniques, such as fMRIs, PET, and SPECT, neuroscientists are gaining valuable information about learning. This pioneering knowledge is leading not only to new pedagogies, but also to new medications, brain enhancement technologies, and therapies…. The Conference creates an interdisciplinary forum — a meeting place for neuroscientists, educators, psychologists, clinicians, and parents — to examine these new research findings with respect to their applicability in the classroom and clinical practice.

Take-aways

• Humans are a mixture of cognition and emotion, and both elements are essential to function and learn properly
• Educators and public policy makers need to learn more about the brain, how it grows, and how to cultivate it
• Students of all ages need to be both challenged and nurtured in order to succeed
• People learn differently – try to teach and learn through as many different modalities as possible (engage language, motor skills, artistic creation, social interaction, sensory input, etc.)
• While short-term stress can heighten your cognitive abilities, long term stress kills you — you need to find balance and release
• Test anxiety and subsequent poor test results can be improved with behavioral training with feedback based on heart rate variability
• Dr. Robert Sapolsky is a very very enlightening and fun speaker
• Allow time for rest and consolidation of learned material
• Emotional memories are easier to remember
• Conferences like these perform a real service in fostering dialogues between scientists and educators

Read the rest of this entry »

Continuing with the theme of a Week of Science sponsored by Just Science, we will highlight some of the key points in: Appelhans BM, Luecken LJ. Heart Rate Variability as an Index of Regulated Emotional Responding. Review of General Psychology. 2006;10:229–240.

Defining Heart Rate Variability
Effective emotional regulation depends on being able to flexibly adjust your physiological response to a changing environment.

“… heart rate variability (HRV) is a measure of the continuous interplay between sympathetic and parasympathetic influences on heart rate that yields information about autonomic flexibility and thereby represents the capacity for regulated emotional responding.”

“HRV reflects the degree to which cardiac activity can be modulated to meet changing situational demands.”

The sympathetic (SNS) and parasympathetic (PNS) branches of the autonomic nervous system (ANS) antagonistically influence the lengths of time between consecutive heartbeats. Faster heart rates, which can be due to increased SNS and/or lower PNS activity, correspond to a shorter interbeat interval while slower heart rates have a longer interbeat interval, which can be attributed to increased PNS and/or decreased SNS activity.

The frequency-based HRV analyses are based on the fact that the variations in heart rate produced by SNS and PNS activity occur at different speeds, or frequencies. SNS is slow acting and mediated by norepinephrine while PNS influence is fast acting and mediated by acetylcholine.

Read the rest of this entry »