A few eternal questions:
- Is caffeine good for the brain?
- Does it boost cognitive functions?
- Does it protect against dementia?

There is little doubt that drinking that morning cup of coffee will likely increase alertness, but the main questions that research is trying to answer go beyond that. Basically: is there a sustained, lifetime, benefit or harm from drinking coffee regularly?

The answer, so far, contains good news and bad news. The good news for coffee drinkers is that most of the long-term results are directionally more positive than negative, so no clear harm seems to occur. The bad news is that it is not clear so far whether caffeine has beneficial effects on general brain functions, either short-term or long-term (aged-related decline or risks of dementia).

It is important to note that many of the studies showing an effect of coffee consumption on brain functions or risks of dementia report a correlation or association (they are not randomized clinical trials). As you know, correlation doesn’t prove causation: coffee drinkers may seem to do well in a number in these long-term studies, but there may be other reasons why coffee drinkers do better.

Q: How does caffeine affect my brain?
A: Caffeine is a stimulant.

It belongs to a chemical group called xanthine. Adenosine is a naturally occurring xanthine in the brain that slows down the activity of brain cells (neurons). To a neuron, caffeine looks like adenosine. It is therefore used by some neurons in place of adenosine. The result is that these neurons speed up instead of slowing down.

This increased neuronal activity triggers the release of the adrenaline hormone, which will affect your body Read the rest of this entry »

Think about this: How can anyone take care of his or her brain when every week brings a new barrage of articles and studies which seem to contradict each other?

Do supplements improve memory? Do you need both physical and mental exercise –or is one of them enough? Which brain training approach, if any, is worth one’s time and money?

We tried to address these questions, and many others, in our recent book, The SharpBrains Guide to Brain Fitness (182 pages, $24.95), that we presented at Games for Health Conference last week. The book is the result of over two years of extensive research including more than a hundred interviews with scientists, professionals and consumers, and a deep review of the scientific literature, led by neuropsychologist Elkhonon Goldberg and myself with the help of cognitive scientist Pascale Michelon. As we wrote in the Introduction, what we wanted to do first of all was to debunks these 10 myths on brain health and brain training:

Myth 1. Genes determine the fate of our brains.
Facts: Lifelong neuroplasticity allows our lifestyles and actions to play a meaningful role in how our brains physically evolve, especially given longer life expectancy.

Myth 2. Aging means automatic decline.
Facts: There is nothing inherently fixed in the precise trajectory of how brain functions evolve as we age.

Myth 3. Medication is the main hope for cognitive enhancement.
Facts: Non-invasive interventions can have comparable and more durable effects, side effect-free.

Myth 4. We will soon have a Magic Pill or General Solution to solve all our cognitive challenges.
Facts: A multi-pronged approach is recommended, centered around nutrition, stress management, and both physical and mental exercise.

Myth 5. There is only one “it” in “Use It or Lose it”.
Facts: The brain is composed of a number of specialized units. Our life and productivity depend on a variety of brain functions, not just one.

Myth 6. All brain activities or exercises are equal.
Facts: Varied and targeted exercises are the necessary ingredients in brain training so that a wide range of brain functions can be stimulated.

Myth 7. There is only one way to train your brain.
Facts: Brain functions can be impacted in a number of ways: through meditation, cognitive therapy, cognitive training.

Myth 8. We all have something called “Brain Age”.
Facts: Brain age is a fiction. No two individuals have the same brain or expression of brain functions.

Myth 9. That “brain age” can be reversed by 10, 20, 30 years.
Facts: Brain training can improve specific brain functions, but, with research available today, cannot be said to roll back one’s “brain age” by a number of years.

Myth 10. All human brains need the same brain training.
Facts: As in physical fitness, users must ask themselves: What functions do I need to improve on? In what timeframe? What is my budget?

Do you have other myths in mind you would like  us to address?

We have started to receive great feedback from the healthcare community, such as this email from a neurosurgeon in Texas:

“I really like the book, it is comprehensive without being too technical. I have recommended it to several patients. There are some other books that I expected would be greeted with enthusiasm, but were too complex for most of my patients. I think this book is right in the sweet spot”.

And this great book review by an Internist Physician and Robert Wood Johnson Foundation Fellow, titled Is Your Brain A Couch Potato?:

“…a short, sweet, entertaining read of a complex topic, with timely (written in 1/09) reviews of 21 top technology products, as well as informed and expert predictions of where this burgeoning brain-fitness field is headed. More importantly, after you read it, you’ll have a good, detailed sense of where you, personally, can act to improve your own couch-potato brain – and how to keep it fit and flexible your whole life. The SharpBrains Guide To Brain Fitness reminds of us all why books (and not just googling a topic) can be well worth your time and money. Two Stethoscopes Up – check it out. life.”

—Doc Gurley, book review for SFGate.com (06/08/09)

The book:  The SharpBrains Guide to Brain Fitness (available via Amazon.com Here, review copies available upon request).

Description: While most of us have heard the phrase “use it or lose it,” very few understand what “it” means, or how to properly “use it” in order to maintain brain function and fitness. The SharpBrains Guide to Brain Fitness is an invaluable guide that helps readers navigate growing brain research and identify the lifestyle factors and products that contribute to brain health and fitness. By gathering insights from eighteen of the world’s top scientists and offering tools and detailed descriptions of over twenty products, this book is an essential guide to the field of brain fitness, neuroplasticity and cognitive health. An accessible and thought-provoking read, The SharpBrains Guide to Brain Fitness educates lifelong learners and professionals in healthcare, education, business, etc., on emerging trends and forecasts of what the future will hold.

Products Reviewed (we reviewed scientific studies published before January 2009, when the manuscript text was closed):

- Overall brain maintenance: Brain Age series (Nintendo), BrainWare Safari (Learning Enhancement Corporation), FitBrains.com (Vivity Labs), Happy-Neuron.com (Scientific Brain Training), Lumosity.com (Lumos Labs), MindFit (CogniFit), (m)Power (Dakim)

- Targeted brain workout: Classic and InSight (Posit Science), Working Memory Training JM and RM (Cogmed), DriveFit (CogniFit), Earobics (Houghton Mifflin), Fast ForWord (Scientific Learning), IntelliGym (Applied Cognitive Engineering), Vision Restpration Therapy (NovaVision)

- Emotional self-regulation: emWave PC and Personal Stress Reliever (HeartMath), Journey to the Wild Divine (Wild Divine), RESPeRATE (InterCure), StressEraser (Helicor)

You may be reading all about brain fitness and brain training. It seems every week brings a new barrage of articles and studies which often contradict what you read the month before: Does Gingko Biloba help delay Alzheimer’s Disease? Can physical exercise help you stay sharp as you age? Which computer-based “brain fitness programs”, if any, are worth your money?

All this coverage reflects very exciting scientific findings but also poses a key dilemma: How to become an informed lifelong learner and consumer when there are few and contradictory authoritative guidelines?

The SharpBrains Guide to Brain Fitness (to be published in May 2009; $24.95) aims to fill that void. This guide is the result of over a year of extensive research including more than a hundred interviews with scientists, professionals and consumers, and a deep literature review. Below you have some of the main findings from our effort. The guide not only covers these aspects in more depth and offers practical guidance, but also includes 18 interviews with prominent scientists to help you understand the research better.

Can we introduce you to your Brain?

The Guide will start at the obvious starting point: The Human Brain. In order to make informed decisions about brain health, one needs to first understand the basic organization of the human brain and how it tends to change as we get older.

• The brain is composed of a number of regions serving distinct functions. Forget IQ: our life and productivity depend on a variety of brain functions, not just one.

• There is nothing inherently fixed in the trajectory of how brain functions evolve as we age. Your lifestyle, actions, and even thoughts, do matter.

The 4 Pillars of Brain Maintenance

Neuroplasticity is the lifelong capacity of the brain to change and rewire itself in response to the stimulation of learning and experience. The latest scientific research shows that specific lifestyles and actions can, no matter our age, improve the health and level of functioning of our brains.

What factors seem to have the most influence? Read the rest of this entry »

Good article on the August edition of Military Officer magazine:

Mental Floss (August 2008) (link opens a PDF-life document, you can read the text by Zooming In).

My 2 favorite quotes, both by Dr. Molly Wagster, chief of the Neuropsychology of Aging Branch, National Institute on Aging (NIA) in Bethesda, Md:

- “Certainly as we age there are declines with brain functions and cognition. But there’s evidence that the aging brain can adapt and change more than we ever thought”.

- “We don’t know how it happens or how long changes last, but even in the face of these unanswered questions, there is the chance to maintain our cognitive function”.

Let me add a  reflection: who among us won’t be tomorrow one day older than he/she is today? The good news about the “aging brain” doesn’t only refer to adults over 70!

To explore these concepts in more depth, you may enjoy visiting our Neuroscience Interview Series.

Daniel Lende and Greg Downey run the though-provoking Neuroanthropology blog. Daniel also teaches a class at University of Notre Dame, and he asked his students to submit group-based blog posts in lieu of the traditional final essays. He explains more on Why A Final Essay When We Can Do This?.

Below you have a spectacular post written by 4 of his students. They show how brain imaging is starting to provide a window into the plasticity (glossary here) of our brains, and how our very own actions impact them. For good and for bad.

Understanding Brain Imaging

— By Chris Dudley, Matt Gasperetti, Mikey Narvaez, and Sarah Walorski

Do you remember the anti-drug public service announcement from the 1980s that showed an egg frying in a hot pan which represented your brain on drugs?

Read the rest of this entry »

Well, the idea that you can just pop a pill to improve your memory and attention lost some ground today.

The Associated Press released an article on DHEA, a steroid precursor to testosterone and estrogen used to improve athletic performance, increase sex drive, and reduce fat as well as fight diabetes and heart disease. The conclusion of a two-year study at the Mayo Clinic in Minnesota and University of Padua in Italy was that it did not improve strength, physical performance, or other measures of health. The positive news was: Read the rest of this entry »