SharpBrains

This is a partial list of the literature we reviewed during the research phase of our new book, The SharpBrains Guide to Brain Fitness.  We know many friends of SharpBrains are researchers, healthcare professionals, graduate/ Ph.D. students, who want have direct access to the references (perhaps PubMed should promote itself as a never ending source of mental stimulation?), so here you have this list, organized by relevant chapter. Please note that the list below appears in the book - whose manuscript we had to close in January 2009.

Introduction

• Basak, C. et al. (2008). Can training in a real-time strategy video game attenuate cognitive decline in older adults? Psychology and Aging.
• Begley, S. (2007). Train your mind, change your brain: How a new science reveals our extraordinary potential to transform ourselves. Ballantine Books.
• DeKosky, S. T., et al. (2008). Ginkgo biloba for prevention of dementia: a randomized controlled trial. Journal of the American Medical Association, 300, 2253-2262.
• Doidge, N. (2007). The Brain that changes itself: Stories of personal triumph from the frontiers of brain science. Viking Adult.

Chapter 1. The Brain and Brain Fitness 101

• Bunge, S. A., & Wright, S. B. (2007). Neurodevelopmental changes in working memory and cognitive control. Current Opinion In Neurobiology, 17(2), 243-50.
• Damasio, A. (1995). Descartes’ error: Emotion, reason, and the human brain. Penguin Press.
• David Kolb, D. (1983). Experiential learning: Experience as the source of learning and development. FT Press.
• Draganski, B., Gaser, C., Kempermann, G., Kuhn, H. G., Winkler, J., Buchel, C., & May A. (2006). Temporal and spatial dynamics of brain structure changes during extensive learning. The Journal of Neuroscience, 261231, 6314-6317.
• Gage, F. H., Kempermann, G., & Song, H. (2007). Adult Neurogenesis. Cold Spring Harbor Laboratory Press, NY.
• Gardner, H. (1983). Frames of Mind: The theory of multiple intelligences. New York: Basic Books.
• Gaser, C. & Schlaug, G. (2003). Brain structures differ between musicians and non-musicians. The Journal of Neuroscience, 23, 9240-9245. Continue Reading »

Working memory is our ability to store and manipulate information for a brief time. It is typically measured by dual-tasks, where the individual has to remember an item while simultaneously processing a sometimes unrelated piece of information. A widely used working memory task is the reading span task where the individual reads a sentence, verifies it, and then recalls the final word. Individual differences in working memory performance are closely related to a range of academic skills such as reading, spelling, comprehension, and mathematics. Crucially, there is emerging research that working memory predicts learning outcomes independently of IQ. One explanation for the importance of working memory in academic attainment is that because it appears to be relatively unaffected by environmental influences, such as parental educational level and financial background, it measures a student’s capacity to acquire knowledge rather than what they have already learned.

However little is known about the consequences of low working memory capacity per se, independent of other associated learning difficulties. In particular, it is not known either what proportion of students with low working memory capacities has significant learning difficulties or what their behavioral characteristics are. The aim of a recent study published in Child Development (reference below) was to provide the first systematic large-scale examination of the cognitive and behavioral characteristics of school-aged students who have been identified solely on the basis of very low working memory scores.

In screening of over 3000 school-aged students in mainstream schools, 1 in 10 was identified as having working memory difficulties. There were several key findings regarding their cognitive skills. The first is that the majority of them performed below age-expected levels in reading and mathematics. This suggests that Continue Reading »

There's such a flood of very significant research studies, educational resources and articles related to brain health, it's hard to keep track - even for us!

Let me introduce and quote some of the top Brain Health Studies, Articles and Resources published in March:

1) Cognitive Decline Begins In Late 20s, Study Suggests (Science Daily)

- "These patterns suggest that some types of mental flexibility decrease relatively early in adulthood, but that how much knowledge one has, and the effectiveness of integrating it with one's abilities, may increase throughout all of adulthood if there are no pathological diseases," Salthouse said.

- However, Salthouse points out that there is a great deal of variance from person to person

2) Cerebrum 2009: Emerging Ideas in Brain Science - new book by the Dana Foundation that "explores the cutting edge of brain research and its implications in our everyday lives, in language understandable to the general reader."

A couple of excellent chapters of direct relevance to everyone's brain health are:
- Chapter 4: A Road Paved by Reason, by Elizabeth Norton Lasley

- Chapter 10: Neural Health: Is It Facilitated by Work Force Participation?, by Denise Park, Ph.D

3) Staying Sharp DVD Program: "Dr. Jordan Grafman, chief of the Cognitive Neuroscience Section at the National Institute of Neurological Disorders and Stroke outside of Washington, DC, and a member of the Dana Alliance for Brain Initiatives, is your guide as we cover what to expect from the aging brain and what we can do to 'stay sharp.'

For a free DVD of this program you can contact stayingsharp@dana.org. (they say free in their website, I don't know if that includes shipping & handling)

4) Drivers to be tested on cognitive ability starting at age 75 (Japan Times)

The outline of a cognitive test that drivers aged 75 or over will be required to take from June when renewing their licenses was released Thursday...The test is intended to reduce the number of traffic accidents involving elderly drivers by measuring their cognitive level.

5) Physical Fitness Improves Spatial Memory, Increases Size Of Brain Structure (Science Daily)

- "Now researchers have found that elderly adults who are more physically fit tend to have bigger hippocampi and better spatial memory than those who are less fit."

6) Brain Trainers: A Workout for the Mind (Scientific American Mind)

"I recently tried out eight of the latest brain fitness programs, training with each for a week. The programs ranged widely in focus, quality and how fun they were to use. “Like physical exercise equipment, a brain exercise program doesn’t do you any good if you don’t use it,” says Andrew J. Carle, director of the Program in Assisted Living/Senior Housing Administration at George Mason University. And people tend not to use boring equipment. “I remember when NordicTrack was the biggest thing out there. Everyone ran out and bought one, and 90 percent of them ended up as a clothes rack in the back of your bedroom.”

The reporter used: Posit Science's Brain Fitness Program Classic, HappyNeuron, Nintendo BrainAge, CogniFit's MindFit/ CogniFit Personal Coach, Lumosity, MyBrainTrainer, BrainTwister, Cogmed Working Memory Training.

7) The Latest in Mental Health: Working Out at the 'Brain Gym' (Wall Street Journal)

- "Marshall Kahn, an 82-year-old family doctor in Fullerton, Calif., says he got such a boost from brain exercises he started doing at a "Nifty after Fifty" club that he decided to start seeing patients again part-time. "Doing all the mental exercise," he says, "I realized I've still got it."

8) Debate Over Drugs For ADHD Reignites (Washington Post)

- "New data from a large federal study have reignited a debate over the effectiveness of long-term drug treatment of children with hyperactivity or attention-deficit disorder, and have drawn accusations that some members of the research team have sought to play down evidence that medications do little good beyond 24 months."

- "The study also indicated that long-term use of the drugs can stunt children's growth."

8) Adaptive training leads to sustained enhancement of poor working memory in children (Developmental Science)

Abstract: Working memory plays a crucial role in supporting learning, with poor progress in reading and mathematics characterizing children with low memory skills. This study investigated whether these problems can be overcome by a training program designed to boost working memory. Children with low working memory skills were assessed on measures of working memory, IQ and academic attainment before and after training on either adaptive or non-adaptive versions of the program. Adaptive training that taxed working memory to its limits was associated with substantial and sustained gains in working memory, with age-appropriate levels achieved by the majority of children. Mathematical ability also improved significantly 6 months following adaptive training. These findings indicate that common impairments in working memory and associated learning difficulties may be overcome with this behavioral treatment.

9) Brain cortex thinning linked to inherited depression (Los Angeles Times)

- "On average, people with a family history of depression appear to have brains that are 28% thinner in the right cortex --- the outermost layer of the brain --- than those with no known family history of the disease. That cortical thinning, said the researchers, is on a scale similar to that seen in patients with Alzheimer's disease or schizophrenia."

Today we continue the conversation with Maggie Jackson, author of Distracted: The Erosion of Attention and the Coming Dark Age.

You can read part 1 here.

Q - In your Harvard Management Update interview, you said that "When what we pay attention to is driven by the last email we received, the trivial and the crucial occupy the same plane." As well, it seems to be that a problem is our culture's over-idealization of "always on" and "road warrior" habits, which distract from the importance of executive functions such as paying attention to one's environment, setting up goals and plans, executing on them, measuring results, and internalizing learning. How can companies better equip their employees for future success? Can you offer some examples of companies who have positive cultures that encourage and reward employees fully put their frontal lobes into good use?

A – As I mentioned above, we are working and living in ways that undermine our ability to strategize, focus, reflect, innovate. Skimming, multitasking and speed all have a place in 21st-century life. But we can’t let go of deeper skills of focus and thinking and relating, or we’ll create a society of misunderstanding and shallow thinking.

To create workplaces that foster strategic thinking, deep social connection and innovation, we need to take three steps:

First, question the values that venerate McThinking and undermine attention. Recently, my morning paper carried a front-page story about efforts “in an age of impatience” to create a quick-boot computer. “It’s ridiculous to ask people to wait a couple of minutes to start up their computer,” explained one tech executive. The first hand up in the classroom, the hyper business-man or –woman who can’t sit still, much less listen – these are icons of success in American society. Still, many of us are beginning to question our adoration of instant gratification and hyper-mobility.

Second, we need to set the stage for focus individually and collectively by rewriting our climate of distraction and inattention. To help, some companies and business leaders are experimenting with “white space” – the creation of physical spaces or times on the calendar for uninterrupted, unwired thinking and Continue Reading »

Neurofeedback - also known as EEG Biofeedback - is an approach for treating ADHD in which individuals are provided real-time feedback on their brainwave patterns and taught to alter their typical EEG pattern to one that is consistent with a focused, attentive state. This is typically done by collecting EEG data from individuals as they focus on stimuli presented on a computer screen. Their ability to control the stimuli, for example, keeping the smile on a smiley face, is contingent on maintaining the particular EEG state being trained. According to neurofeedback proponents, learning how to do this during training generalizes to real world situations and this results in improved attention and reduced hyperactive/impulsive behavior.

Neurofeedback treatment for ADHD has been controversial in the field for many years and remains so today. Although a number of published studies have reported positive results many prominent ADHD researchers believe that problems with the design of these studies preclude concluding that neurofeedback is an effective treatment. These limitations have included the absence of random assignment, the lack of appropriate control groups, raters who are not 'blind' to children's treatment status, and small samples. For additional background, you can find a recent review I wrote on existing research support for neurofeedback treatment of ADHD - along with links to extensive reviews of several recently published studies -: How Strong is the Research Support for Neurofeedback in Attention Deficits?

- Results from a New Study of Neurofeedback -

Recently, a study of neurofeedback treatment for ADHD was published that addresses several limitations that have undermined prior research [Gevensleben, et al., (2009). Is neurofeedback an efficacious treatment for ADHD? A randomized controlled clinical trial. Journal of Child Psychology and Psychiatry.]

The study was conducted in Germany and began with 102 children aged 8 to 12. All had been carefully diagnosed with ADHD and approximately over 90% had never received medication treatment. About 80% were boys. Children were randomly assigned to Continue Reading »

Today we'll discuss some of the cognitive implications of "always on" workplaces and lifestyles via a fascinating interview with Maggie Jackson, an award-winning author and journalist. Her latest book, Distracted: The Erosion of Attention and the Coming Dark Age, describes the implications of our busy work and life environments and offers important reflections to help us thrive in them.

This is a 2-part interview conducted via e-mail: we will publish the continuation on Thursday March 12th.

Alvaro Fernandez: New York Times columnist David Brooks said last year that we live in a Cognitive Age, and encouraged readers to be aware of this change and try and adapt to the new reality. Can you explain the cognitive demands of today's workplaces that weren't there 30-40 years ago?

Maggie Jackson: Our workplaces have changed enormously in recent decades, and it’s easy to point to the Blackberry or the laptop as the sources of our culture of speed and overload and distraction. But it’s important to note first that our 24/7, fragmented work culture has deeper roots. With the first high-tech inventions, such as the cinema, phonograph, telegraph, rail, and car, came radical changes in human experience of time and space. Distance was shattered – long before email and red-eye flights. Telegraph operators – not online daters – experienced the first virtual love affairs, as evidenced by the 1890s novel Wired Love. Now, we wrestle with the effects of changes seeded long ago.

Today, the cognitive and physical demands on workers are steep. Consider 24/7 living. At great cost to our health, we operate in a sleepless, hurried world, ignoring cues of sun and season, the Industrial Age inventions of the weekend and vacation, and the rhythms of biology. We try to break the fetters of time – and live like perpetual motion machines. That’s one reason why we feel overloaded and stressed – conditions that are corrosive to problem-solving and clear thinking.

At the same time, our technologies allow us access to millions of information bites – producing an abundance of data that is both wondrous and dangerous. Unless we have the will, discipline and frameworks for turning this information into wisdom, we remain stuck on the surface of Continue Reading »

I wanted to alert you to a very interesting finding published in a recent issue of Science, one of the world's leading scientific journals.

The study was led by Dr. Torkel Klingberg and his colleagues from the Karolinska Institute in Sweden. The goal was to learn whether Working Memory Training is associated with changes in brain biochemistry, thus suggesting a mechanism by which training may lead to enhanced working memory capacity and a reduction in attention problems. Thus, although Working Memory Training has previously shown promising results as a treatment for working memory and attention difficulties, this was a basic science study rather than a treatment study.

The major finding was that increased working memory capacity following training was associated with changes in brain biochemistry. Specifically, the researchers found changes in the density and binding potential of cortical D1 dopamine receptors in brain regions that are activated during working memory tasks.

Results from this study suggest a biological basis for the improvement in working memory capacity and reductions i Continue Reading »

We have tracked for several years the scientific studies published by Torkel Klingberg and colleagues, often wondering aloud, "when will educators, health professionals, executives and mainstream society come to appreciate the potential we have in front of  us to enhance our brains and improve our cognitive functions?"

Dr. Klingberg has just published a very stimulating popular science book, The Overflowing Brain, that should help in precisely that direction. Given the importance of the topic, and the quality of the book, we have named  The Overflowing Brain: Information Overload and the Limits of Working Memory  The SharpBrains Most Important Book of 2008, and asked Dr. Klingberg to write a brief article to introduce his research and book to you. Below you have. Enjoy!

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Research and Tools to Thrive in the Cognitive Age

By Dr. Torkel Klingberg

Do we all have attention deficits?

The information age has provided us with high technology which fills our days with an ever increasing amount of information and distraction. We are constantly flooded with on-the-go emails, phone calls, advertisements and text-messages and we try to cope with the increasing pace by multi tasking. A survey of workplaces in the United States found that the personnel were interrupted and distracted roughly every three minutes and that people working on a computer had on average eight windows open at the same time. There is no tendency for this to slow down; the amount and complexity of information continually increases

The most pressing concerns with this environment are: how do we deal with the daily influx of information that our inundated mental capacities are faced with? At what point does our stone-age brain become insufficient? Will we be able to train our brains effectively to increase brain capacity in order to Continue Reading »

Like all psychiatric disorders, ADHD is diagnosed based on the presence of particular behavioral symptoms that are judged to cause significant impairment in an individual's functioning, and not on the results of a specific test. In fact, recently published ADHD evaluation guidelines from the American Academy of Pediatrics (AAP) explicitly state that no particular diagnostic test should be routinely used when evaluating a child for ADHD.

While most ADHD experts would agree that no single test could or should be used in isolation to diagnose ADHD, there are several important reasons why the availability of an accurate objective test would be useful.

First, many children do not receive a careful and comprehensive assessment for ADHD but are instead diagnosed with based on evaluation procedures that are far from optimal.

Second, although AAP guidelines indicate that specific diagnostic tests should not be routinely used, many parents are concerned about the lack of objective procedures in their child's evaluation. In fact, many families do not pursue treatment for ADHD because the the absence of objective evaluation procedures leads them to question the diagnosis. You can read a review of an interesting study on this issue at www.helpforadd.com/2006/january.htm

For these reasons an accurate and objective diagnostic test for ADHD could be of value in many clinical situations. Two important conditions would have to be met for such a test to be useful.

First, it would have to be highly sensitive to Continue Reading »

Great article in the New York Times titled Training Young Brains to Behave. A couple of quotes:

- "But just as biology shapes behavior, so behavior can accelerate biology. And a small group of educational and cognitive scientists now say that mental exercises of a certain kind can teach children to become more self-possessed at earlier ages, reducing stress levels at home and improving their experience in school. Researchers can test this ability, which they call executive function, and they say it is more strongly associated with school success than I.Q."

- “We know that the prefrontal cortex is not fully developed until the 20s, and some people will ask, Continue Reading »