A few eternal questions:
- Is caffeine good for the brain?
- Does it boost cognitive functions?
- Does it protect against dementia?

There is little doubt that drinking that morning cup of coffee will likely increase alertness, but the main questions that research is trying to answer go beyond that. Basically: is there a sustained, lifetime, benefit or harm from drinking coffee regularly?

The answer, so far, contains good news and bad news. The good news for coffee drinkers is that most of the long-term results are directionally more positive than negative, so no clear harm seems to occur. The bad news is that it is not clear so far whether caffeine has beneficial effects on general brain functions, either short-term or long-term (aged-related decline or risks of dementia).

It is important to note that many of the studies showing an effect of coffee consumption on brain functions or risks of dementia report a correlation or association (they are not randomized clinical trials). As you know, correlation doesn’t prove causation: coffee drinkers may seem to do well in a number in these long-term studies, but there may be other reasons why coffee drinkers do better.

Q: How does caffeine affect my brain?
A: Caffeine is a stimulant.

It belongs to a chemical group called xanthine. Adenosine is a naturally occurring xanthine in the brain that slows down the activity of brain cells (neurons). To a neuron, caffeine looks like adenosine. It is therefore used by some neurons in place of adenosine. The result is that these neurons speed up instead of slowing down.

This increased neuronal activity triggers the release of the adrenaline hormone, which will affect your body Read the rest of this entry »

Have you already read The SharpBrains Guide to Brain Fitness?

Let’s see…

1. Pick the only part of your body that does not contain fat:

a. Arm
b. Thigh
c. Brain
d. None

Answer: d) Fats are also present in the brain: in neurons’ membranes to keep them flexible. These fats are the omega 3 and omega 6 fatty acids molecules. (Page 32 of the book)

2. Pick the only food product that doesn’t contain Omega-3 fatty acids

a. Tuna
b. Walnut
c. Kiwi
d. Jelly Beans

Answer: d) Fatty acids can be found in cold-water fish (such as mackerel, herring, salmon, and tuna), kiwi, and walnuts. (Page 33)

3. Pick the only food product that doesn’t contain antioxidants

a. Olive oil
b. Milk
c. Nuts
d. Berries

Answer: b) Antioxidants can be found in vegetable oils, nuts, green leafy vegetables (e.g., spinach), citrus fruit, and berries. (Page 33)

4. Chronic Stress cannot:

a. Prevent you from being creative
b. Kill brain cells
c. Prevent you from sleeping
d. Kill liver cells

Answer: d) Prolonged exposure to adrenal steroid hormones like cortisol, which is released into the blood stream when we are stressed, can lead to cell death and block the formation of new neurons. (Page 35)

5. What type of physical exercise is the best for your brain health?

a. Weight lifting
b. Aerobic exercises
c. Flexibility exercises Read the rest of this entry »

In a recently published scientific study (see Hall C, et al “Cognitive activities delay onset of memory decline in persons who develop dementia” Neurology 2009; 73: 356-361), Hall and colleagues examined how education and stimulating activities may interact to contribute to cognitive reserve. The study involved 488 initially healthy people, average age 79, who enrolled in the Bronx Aging Study between 1980 and 1983. These individuals were followed for 5 years with assessments every 12 to 18 months (starting in 1980). At the start of the study, all participants were asked how many cognitive activities (reading, writing, crossword puzzles, board or card games, group discussions, or playing music) they participated in and for how many days a week. Researchers were able to evaluate the impact of self-reported participation these activities on the onset of accelerated memory decline in 101 individuals who developed dementia during the study.

Results showed that for every “activity day” (participation in one activity for one day a week) the subjects engaged in, they delayed for about two months the onset of rapid memory loss associated with dementia. Interestingly, the positive effect of brain-stimulating activities in this study appeared to be independent of a person’s level of education.

This is great news as it suggests that it is never too late to try to build up brain reserve. The more brain stimulating activities one does and the more often, the better for a stronger cognitive reserve.

The cognitive reserve hypothesis suggests that individuals with more cognitive reserve can experience more Alzheimer’s disease pathology in the brain (more plaques and tangles) without developing Alzheimer’s disease symptoms.

How does that work? Scientists are not sure but two possibilities are considered.
1. One is that more cognitive reserve means more brain reserve, that is more neurons and connections between neurons.
2. Another possibility is that more cognitive reserve means more compensatory processes (see my previous post “Education builds Cognitive Reserve for Alzheimers Disease Protection” for more details.)

Now, one may wonder about the difference types of mental stimulation available, including not only puzzles and such, but structured activities such as brain fitness software and meditation. Do we exercise our brain every time we think about something? What can one do to exercise one’s brain in ways that enhance capacity? Does aerobic fitness training also exercise one’s brain? What types of methodologies and products are available? Do they “work”? Are all the same?

Those are the types of questions we wanted to address in the book The SharpBrains Guide To Brain Fitness (available via Amazon.com). We are proud of the recognition the book has started to obtain, including endorsements by leading scientists:

“The SharpBrains Guide to Brain Fitness is the only book that I know of that seamlessly integrates latest information about cognitive health across the lifespan, with interviews with active researchers examining cognitive maintenance and enhancement, along with reviews of commercial products targeted to cognitive enhancement. The book should be very useful to anyone interested in brain care, both health care professionals and the public at large”.
– Arthur Kramer, Professor of Psychology at University of Illinois

“This SharpBrains book provides a very valuable service to a wide community interested in learning and brain topics. I found it interesting and helpful”
- Michael Posner, Emeritus Professor of Neuroscience at the University of Oregon, and first recipient of the Dogan Prize

– Pascale Michelon, Ph. D., is SharpBrains’ Research Manager for Educational Projects. Dr. Michelon has a Ph.D. in Cognitive Psychology and has worked as a Research Scientist at Washington University in Saint Louis, in the Psychology Department. She conducted several research projects to understand how the brain makes use of visual information and memorizes facts. She is now an Adjunct Faculty at Washington University.

References:

- Study: Hall C, et al “Cognitive activities delay onset of memory decline in persons who develop dementia” Neurology 2009; 73: 356-361

- Book: The SharpBrains Guide To Brain Fitness: 18 Interviews with Scientists, Practical Advice, and Product Reviews, to Keep Your Brain Sharp

Learning can be incidental. We all memorize facts without paying much attention to these facts or without willing to memorize them. However, when one really wants to memorize a fact, it is crucial to pay attention. Many studies have shown that compared to full attention conditions, dividing attention during study time leads to poor memory performance.

This exercise will help you practice focusing your attention.

It may seem easy but make sure you count twice!

Count the number of “Y” in this text:

Yesterday, Lucy went all the way to Boston. She wanted to buy new shoes. She had to go in many shops before she found the shoes she wanted. She was happy to stop at a restaurant to have some tea and cookies before she took the train back home.

Count the number of “F” in this text:

Finished files are the result of years of scientific study combined with the experience of years.
Count the number of “E” in this text:

Last summer, Jean and Harriet spent their vacation in Michigan. They rented a cabin on the lake. The cabin had two bedrooms and a nice deck. They used to spend a lot of time on the deck, just looking at how the light would change on the water. Several times, they borrowed bikes from their neighbors and spent a few hours exploring the villages not far from their cabin.

—
Solutions

There are 7 “Y” in the first text.

There are 6 “F” in the second text (got them?)
There are 38 “E” in the third text.

—

For many other Brain Teasers, click Here.
For many other teasers and articles by Dr. Michelon, click Here.

– Pascale Michelon, Ph. D., is SharpBrains’ Research Manager for Educational Projects. Dr. Michelon has a Ph.D. in Cognitive Psychology and has worked as a Research Scientist at Washington University in Saint Louis, in the Psychology Department. She conducted several research projects to understand how the brain makes use of visual information and memorizes facts. She is now an Adjunct Faculty at Washington University.

The growing field of cognitive training (one of the tools for brain fitness) can appear very confusing as the media keeps reporting contradictory claims. These claims are often based on press releases, without a deeper evaluation of the scientific evidence.

Let’s take a couple of recent examples, in successive days:

“It doesn’t work!” type of headline:
Reuters (Feb. 10, 2009) — Formal brain exercise won’t help healthy seniors: research
“Healthy older people shouldn’t bother spending money on computer games and websites promising to ward off mental decline, the author of a review of scientific evidence for the benefits of these “brain exercise” programs says”.

“It works!” type of headline:
ScienceDaily (Feb. 11, 2009) — Computer Exercises Improve Memory And Attention, Study Suggests
“According to the researchers, participants who used the Brain Fitness Program also scored as well as those ten years younger, on average, on memory and attention tests for which they did not train.”

So… does structured brain exercise / cognitive training work or not?

The problem may in fact reside in asking this very question in the first place, as Alvaro pointed out a while ago in his article “Alzheimer’s Disease: too serious to play with headlines“.

We need a more nuanced set of questions.

Why? Because:
1. Cognition is made of several different abilities (working memory, attention, executive functions such as decision-making, etc)
2. Available training programs do not all train the same abilities
3. Users of training programs do not all have the same needs or goals
4. We need to differentiate between enhancing cognitive functions and delaying the onset of cognitive deficits such as Alzheimer’s.

Let’s illustrate these points, by Read the rest of this entry »

As you may know, memory relies mostly on some temporal (in green) and frontal (in red) areas of the brain. These may be the areas that will get stimulated when you (assuming you are American or have lived in the US for long) try to remember the missing words in the American proverbs below.

However when it comes to internationals proverbs below you may have to use your reasoning skills more than your memory skills, as it is likely that you do not know these proverbs. In this case, the frontal exercise is more intense. Try to guess what the final words of each international proverb might be. Use your logical skills.

If you live outside the USA, your experience will probably be the reverse.

US proverbs

1. The early bird gets the ___________.
2. After all is _______ and done, more is said than __________.
3. From ___________ beginnings come great ____________. Read the rest of this entry »

Given the growing media coverage mentioning the terms Cognitive Reserve and Brain Reserve, you may be asking yourself, “What exactly is my Cognitive (or Brain) Reserve?”

The cognitive reserve hypothesis, tested in multiple studies, states that individuals with more cognitive reserve can experience more Alzheimer’s disease pathology in the brain (more plaques and tangles) without developing Alzheimer’s disease symptoms.

How does that work? Scientists are not sure but two possibilities are considered.
1. One is that more cognitive reserve means more brain reserve, that is more neurons and connections (synapses) between neurons. Individuals with more synapses would then have more synapses to lose before the critical threshold for Alzheimer’s Disease is reached.
2. Another possibility is that more cognitive reserve means more compensatory processes. The brain of individuals with more cognitive reserve would use more alternative networks to compensate for the damages caused by the pathology in previously used networks.

In a newly published study, Roe and colleagues from Washington University in St. Louis, used the number of years of education as a measure of cognitive reserve. Why years of education? Because previous studies have shown that people who have more education also exhibit a greater resistance to Alzheimer’s symptoms, even while pathological changes are occurring in the brain (see Bennett el al., 2003 or Roe, Xiong, et al., 2008).

Roe and her colleagues studied 198 individuals whose mean age was 67. Out of these 198 individuals, 161 were nondemented and 37 were diagnosed with Alzheimer’s Disease.

All the participants in the study took a Read the rest of this entry »

In other words, may some foods be specifically good for brain function?

For a great in-depth review of the effects of food on the brain you can check out Fernando Gomez-Pinilla’s recent article in Nature Reviews Neuroscience (reference below). Here is an overview of the state off the research.

Several components of diet seem to have a positive effect on brain function.

Omega-3 fatty acids

These acids are normal constituents of cell membranes and are essential for normal brain function. Omega-3 fatty acids can be found in fish (salmon), kiwi, and walnuts. Docosahexaenoic acid, or DHA, is the most abundant omega-3 fatty acid in cell membranes in the brain. The human body produces DHA but not enough. So we are dependent on the DHA that we get from what we eat.

A randomized double-blind controlled trial (which means seriously conducted scientific study) is currently looking at the effect of taking omega-3 fatty acids on children’s performance at school in England. Preliminary results (Portwood, 2006) suggest that Read the rest of this entry »

What is mental self rotation? It is the ability to imagine yourself in different locations in space and imagine your body moving in space. This is an ability that is used in different everyday activities such as navigating in an environment or reading a map.

- Ability involved: egocentric spatial transformations (yes, that is the scientific expression) or mental self rotation.

- Brain areas involved: mostly parietal lobes.

Let’s take an example. Imagine that you plan to go to a new Walgreens’ location. You wonder whether going North on Big Bend Avenue you would have to make a right or a left turn onto Forsyth Blvd to get to Walgreens. You then look at the map that your spouse has laid out on the table. It turns out that the map is upside down so your perspective is not aligned with the one shown on the map (see Figure 1 just below, Box A). How do you get the answer to your question? Read the rest of this entry »

We have all heard about children who have Attention Deficit/Hyperactivity Disorder (AD/HD). Indeed, this condition seems to affect 5 to 8% of school age children. Have you ever wondered what happen to these children? As many as 60% of them become adults presenting AD/HD symptoms! Ron de Graaf and colleagues recently published a study in which they found that an average of 3.5% of workers (in ten countries) meet the criteria for adult ADHD. As you can imagine, being an adult with AD/HD can be a challenge at work.

Before we explore this issue let’s start by describing the symptoms of ADHD.

What is adult AD/HD?

AD/HD is a disorder of the brain. Research clearly indicates that AD/HD is to a large extent genetic, that is it tends to run in families. However, AD/HD is a complex disorder and other causal factors may be at play.

Typically, the symptoms arise in early childhood, unless they are associated with some type of brain injury later in life. Some people have mild AD/HD with only a few symptoms while others have more serious AD/HD with more symptoms.

Symptoms of inattention (adapted from the DSM-IV)

Read the rest of this entry »