Here you have the March edition of our monthly newsletter covering cognitive health and brain fitness topics. Please remember that you can subscribe to receive this Newsletter by email, using the box at the top of this page. I know I am biased – but do believe this Newsletter issue might well be our best so far. I hope you find the time to enjoy it!

Bird’s Eye View

Brain Fitness Survey: Over 2,000 thoughtful responses to our January survey (Thank You!) reinforce the need for public awareness initiatives and quality information to help evaluate and navigate lifestyle and product claims, as well as the need for more research, an expanded healthcare culture, as more. Given this context, we are publishing The SharpBrains Guide to Brain Fitness in May 2009, a book with 18 Interviews with Scientists, Practical Advice, and Product Reviews, in addition to our annual market report for professionals and executives (to be published in April). If you have ideas to help us promote the book, please reply to this email and let us know!

Lifelong Learning

There’s such a flood of very significant research studies, educational resources and articles related to brain health, it’s hard to keep track – even for us!

Let me introduce and quote some of the top Brain Health Studies, Articles and Resources published in March:

1) Cognitive Decline Begins In Late 20s, Study Suggests (Science Daily)

- “These patterns suggest that some types of mental flexibility decrease relatively early in adulthood, but that how much knowledge one has, and the effectiveness of integrating it with one’s abilities, may increase throughout all of adulthood if there are no pathological diseases,” Salthouse said.

- However, Salthouse points out that there is a great deal of variance from person to person

2) Cerebrum 2009: Emerging Ideas in Brain Science – new book by the Dana Foundation that “explores the cutting edge of brain research and its implications in our everyday lives, in language understandable to the general reader.”

A couple of excellent chapters of direct relevance to everyone’s brain health are:
- Chapter 4: A Road Paved by Reason, by Elizabeth Norton Lasley

- Chapter 10: Neural Health: Is It Facilitated by Work Force Participation?, by Denise Park, Ph.D

3) Staying Sharp DVD Program: “Dr. Jordan Grafman, chief of the Cognitive Neuroscience Section at the National Institute of Neurological Disorders and Stroke outside of Washington, DC, and a member of the Dana Alliance for Brain Initiatives, is your guide as we cover what to expect from the aging brain and what we can do to ’stay sharp.’

For a free DVD of this program you can contact stayingsharp@dana.org. (they say free in their website, I don’t know if that includes shipping & handling)

4) Drivers to be tested on cognitive ability starting at age 75 (Japan Times)

The outline of a cognitive test that drivers aged 75 or over will be required to take from June when renewing their licenses was released Thursday…The test is intended to reduce the number of traffic accidents involving elderly drivers by measuring their cognitive level.

5) Physical Fitness Improves Spatial Memory, Increases Size Of Brain Structure (Science Daily)

- “Now researchers have found that elderly adults who are more physically fit tend to have bigger hippocampi and better spatial memory than those who are less fit.”

6) Brain Trainers: A Workout for the Mind (Scientific American Mind)

“I recently tried out eight of the latest brain fitness programs, training with each for a week. The programs ranged widely in focus, quality and how fun they were to use. “Like physical exercise equipment, a brain exercise program doesn’t do you any good if you don’t use it,” says Andrew J. Carle, director of the Program in Assisted Living/Senior Housing Administration at George Mason University. And people tend not to use boring equipment. “I remember when NordicTrack was the biggest thing out there. Everyone ran out and bought one, and 90 percent of them ended up as a clothes rack in the back of your bedroom.”

The reporter used: Posit Science’s Brain Fitness Program Classic, HappyNeuron, Nintendo BrainAge, CogniFit’s MindFit/ CogniFit Personal Coach, Lumosity, MyBrainTrainer, BrainTwister, Cogmed Working Memory Training.

7) The Latest in Mental Health: Working Out at the ‘Brain Gym’ (Wall Street Journal)

- “Marshall Kahn, an 82-year-old family doctor in Fullerton, Calif., says he got such a boost from brain exercises he started doing at a “Nifty after Fifty” club that he decided to start seeing patients again part-time. “Doing all the mental exercise,” he says, “I realized I’ve still got it.”

Debate Over Drugs For ADHD Reignites (Washington Post)

- “New data from a large federal study have reignited a debate over the effectiveness of long-term drug treatment of children with hyperactivity or attention-deficit disorder, and have drawn accusations that some members of the research team have sought to play down evidence that medications do little good beyond 24 months.”

- “The study also indicated that long-term use of the drugs can stunt children’s growth.”

Adaptive training leads to sustained enhancement of poor working memory in children (Developmental Science)

Abstract: Working memory plays a crucial role in supporting learning, with poor progress in reading and mathematics characterizing children with low memory skills. This study investigated whether these problems can be overcome by a training program designed to boost working memory. Children with low working memory skills were assessed on measures of working memory, IQ and academic attainment before and after training on either adaptive or non-adaptive versions of the program. Adaptive training that taxed working memory to its limits was associated with substantial and sustained gains in working memory, with age-appropriate levels achieved by the majority of children. Mathematical ability also improved significantly 6 months following adaptive training. These findings indicate that common impairments in working memory and associated learning difficulties may be overcome with this behavioral treatment.

9) Brain cortex thinning linked to inherited depression (Los Angeles Times)

- “On average, people with a family history of depression appear to have brains that are 28% thinner in the right cortex — the outermost layer of the brain — than those with no known family history of the disease. That cortical thinning, said the researchers, is on a scale similar to that seen in patients with Alzheimer’s disease or schizophrenia.”

While travelling to several conferences recently, I realized how convenient it is to post quick updates and thoughts via Twitter.

I will continue to do so often, so you may want to follow my Twitter SharpBrains updates and engage in a conversation there.

URL is http://twitter.com/AlvaroF

What started as an academic dispute regarding disclosure of conflict of interest is now snowballing into the mainstream media, due to the over-reaction by JAMA editors as reported in this Wall Street Journal blog post, JAMA editor calls Critic a “Nobody and a Nothing”

In summary, Dr. Jonathan Leo, the “Critic”, dared to draw attention to 2 important points regarding a study comparing the efficacy of therapy vs. medication published in the Journal of the American Academy of Medicine (JAMA) – one of the most prestigious scientific publications:

1) The study results were presented and reported in a biased way, since they favored one specific intervention, a drug, while ignoring another one, therapy-based, that had equally statistically significant effects.

2) Both the lead author of the study and one of the main experts asked to comment on the study in several media outlets had undisclosed and unreported conflicts of interest. JAMA could have done a 5-minute Google search to identify and report the conflict of interest of the lead author (received a variety of revenues from the drugmaker).

Dr. Leo has summarized the continuing matter in several impressive letters. The 2 main ones, in chronological order:

Clinical Trials of Therapy vs. Medication: Even in a Tie, Medication Wins(BMJ)

- “Central to the idea of evidence-based medicine is that the choices made by patients and doctors to use a certain treatment should at least in part be based on scientific studies published in peer reviewed academic journals. For a patient diagnosed with Read the rest of this entry »

A person who helped reinvent “aging”, “retirement” and “learning”, contributing to the cognitive health of millions of individuals as a result:

Martin P. ‘Marty’ Knowlton dies at 88; co-founder of Elderhostel (Los Angeles Times)

- “Martin P. “Marty” Knowlton, a world traveler who fought ageism by co-founding Elderhostel, a program that pioneered learning vacations for mature adults, has died. He was 88.”

- “Knowlton died Thursday of natural causes at a nursing home in Ventura, said David Bianco, who started Elderhostel with his friend in 1975.”

- “When he was about 50, Knowlton became highly annoyed by two things: the prevailing wisdom that “as you got older, your mind automatically began to fail” and the government notifying him that “old age begins at 55,” he told the Ventura County Star in 2000.”

The article: Here

Elderhostel website: Here

(Alvaro’s note: one of the most common enemies of getting quality cognitive exercise is being on “mental autopilot”. I recently came across an excellent new book, titled The Daily Trading Coach: 101 Lessons for Becoming Your Own Trading Psychologist, by trading performance expert Dr. Brett Steenbarger, which explicitly calls for addressing the “mental autopilot” problem in his Lesson 4. Even for those of us who are not traders, Dr. Steenbarger advice provides excellent guidance for peak cognitive performance. Dr. Steenbarger graciously gave us permission to share with you, below, Lesson 4: Change Your Environment, Change Yourself. Enjoy!).

Human beings adapt to their environments. We draw on a range of skills and personality traits to fit into various settings. That is why we can behave one way in a social setting and then seem like a totally different human being at work. One of the enduring attractions of travel is that it takes us out of our native environments and forces us to adapt to new people, new cultures, and new ways. When we make those adaptations, we discover new facets of ourselves. As we’ll see shortly, discrepancy is the mother of all change: when we are in the same environments, we tend to draw upon the same, routine modes of thought and behavior.

A few months ago I had an attack of acute appendicitis while staying in a LaGuardia airport hotel awaiting a return flight to Chicago. When I went to the nearest emergency room at Elmhurst Hospital outside Jackson Heights, Queens, I found that I was seemingly the only native English speaker in a sea of people awaiting medical care. After some difficulty attracting attention, I was admitted to the hospital and spent the next several days of recuperation navigating my way through patients and staff of every conceivable nationality. By the end of the experience, I felt at home there. I’ve since stayed at the same airport hotel and routinely make visits into the surrounding neighborhoods—areas I would have never in my wildest dreams ventured into previously. In adapting to that environment, I discovered hidden strengths. I also overcame more than a few hidden prejudices and fears.

The greatest enemy of change is routine. When we lapse into routine and operate on autopilot, we are no longer fully and actively conscious of what we’re doing and why. That is why some of the most fertile situations for personal growth—those that occur within new environments—are those that force us to exit our routines and actively master unfamiliar challenges.

In familiar environments and routines, we operate on autopilot. Nothing changes.

When you act as your own trading coach, your challenge is to stay fully conscious, alert to risk and opportunity. One of your greatest threats will be the autopilot mode in which you act without thinking, without full awareness of your situation. If you shift your trading environment, you push yourself to adapt to new situations: you break routines. If your environment is always the same, you will find yourself gravitating to the same Read the rest of this entry »

Physical Fitness Improves Spatial Memory, Increases Size Of Brain Structure (Science Daily)

- “Now researchers have found that elderly adults who are more physically fit tend to have bigger hippocampi and better spatial memory than those who are less fit.”

- “Certain activities are believed to modify hippocampus size in humans. For example, a study of London taxi drivers found that the posterior portion of the hippocampus was larger in experienced taxi drivers than in other subjects. And a study of German medical students found that the same region of the hippocampus increased in size as they studied for their final exams.”

- “Studies also have found that the hippocampus shrinks with age, a process that coincides with small but significant cognitive declines. The rate at which this occurs, however, differs among individuals.”

Related articles:

Physical Exercise and Brain Health

Brain Plasticity: How learning changes your brain

If you subscribe to our monthly newsletter, you may remember we ran a survey in January. Well, the response rate and the quality of the responses were nothing short of spectacular, in many dimensions. The responses from over 2,000 participants (out of 21,000 subscribers) reinforce the need for public awareness initiatives and quality information to help evaluate and navigate product claims.

I have been presenting the results from one of the questions (see below), yesterday at the ASA/ NCOA (American Society on Aging) event, today at IHRSA (International Health, Racquet and Sportsclub Association), as part of more comprehensive presentations of what is going on in the brain fitness and cognitive health field.

An obvious implication for the survey result reinforces the need for brain-related public awareness campaigns such as the ongoing Brain Awareness Week. Every year, landmark research findings open new opportunities to help maintain lifelong cognitive health and brain fitness. The opportunity is immense – but we will need to ensure the marketplace matures in a rational and sustainable manner, helping consumers and professionals separate hope from hype and make informed decisions.

Robin Klaus, Chairman of Club One Fitness Centers (the company is a client, he is an advisor), just gave us a nice quote saying that “as our population ages the fields of physical fitness and brain fitness will naturally merge and, as this happens, a whole new field of valued added services will emerge for our members. High quality informational resources such as SharpBrains’ are crucial to the success of this merger.”

The Survey: Results to Key Question 

Asked, “What is the most important problem you see in the brain fitness field and how do you think it can be solved?” respondents identified the following six problems in rank order:

#1: Public Awareness (39%)
- “Getting people to understand that heredity alone does not decide brain functioning.”
- “An expectant public will first want to believe that a “miracle” drug is to be soon available (to prevent Alzheimer’s Disease).”

#2: Navigating Claims (21%)
- “How to separate marketing hype from stuff that really works?”
- “The lack of standards and clear definitions is very confusing, and makes a lot of people sceptical.”

#3: Research (15%)
- “Determining what activities are most beneficial to Read the rest of this entry »

Reminder: 2009 Brain Awareness Week started today. You can find excellent resources and a calendar of events, Here.

Next time you are in a public space (perhaps now you are at home, as I am as I write these lines), look left, look in front, look right. Perhaps you can see someone who would benefit from the awareness that he or she is endowed with that wonderful, unique, organ!

(Note: don’t watch TV, or you will spend your day calling all those 1-800 numbers…)

And, of course, what a better week to read some of our Neuroscience Interviews, discover a new brain book, and try a Brain Teaser? 

Increased longevity has generated many questions and much interest in healthy aging and retirement lifestyles over the recent decades. As Americans become educated regarding lifestyle choices that contribute to both physical and mental health, the definition of healthy aging has expanded to include brain health.

The notion of retirement as a time of withdrawal from society, to be spent on rest and repose reflected the thinking of a previous era when people expected shorter life spans. It is now known that the human brain benefits from environments rich in novel and complex stimuli, and that by actively participating in society and taking on personally relevant roles, people find meaning and purpose, which gives them a reason to get up in the morning and pursue new challenges.

This year, the MetLife Mature Market Institute® published a research study titled Discovering What Matters: Balancing Money, Medicine and Meaning. The study explored how people rebalance their priorities over time and juggle various competing aspects of life including money, medicine (a metaphor for health) and meaning, in order to live the “Good Life.” Having purpose was found to Read the rest of this entry »