Here you have the February edition of our monthly newsletter covering cognitive health and brain fitness topics. Please remember that you can subscribe to receive this Newsletter by email, simply by submitting your email at the top of this page.

Cognitive training (or structured mental exercise) definitely seems to work – as long as we define properly what “work” means, don’t expect magic cures, and help navigate options. Please keep reading…

Interview: Baycrest

Interview with Baycrest’s CEO Dr. William Reichman: Discussing the recent Centre for Brain Fitness at Baycrest, Dr. Reichman suggests that “we have an opportunity to make major progress in Brain Health in the XXI century, similar to what happened with Cardiovascular Health in the XXth, and technology will play a crucial role.” A major obstacle? We need a consensus on “widely accepted standards for outcome measures”.

Does It Work?

Does cognitive training work? (For Whom? For What?): The growing field of cognitive training (one of the tools for brain fitness) can appear very confusing as the media keeps reporting contradictory claims. These claims are often based on press releases, without a deeper understanding of the scientific evidence. Dr. Pascale Michelon, SharpBrains’ Research Manager for Educational Initiatives, analyzes a couple of recent studies, clarifying what they mean – and what they don’t mean.

It Works, and It Doesn’t Work: the IMPACT study (a major, multi-site study on the Posit Science auditory program) will be published at the Journal of the American Geriatrics Society in April. Results support that cognitive training works – but doesn’t support the grandiose “brain age” claims we see too often.

Cognitive Training can Influence Brain Biochemistry: Dr. David Rabiner discusses a recent scientific study that “shows that brain biochemistry can be modified by experience”, and that computerized cognitive training (Cogmed working memory training) can provide that experience.

The Big Picture

Making Healthy Choices – Primare Care and Prevention: a panel at the recent World Economic Forum explored why “New markets and industries are arising – “silver industries” such as financial services, health, housing and hospitality geared to senior citizens. Longevity needs to be linked to health – including cognitive health – and lifestyle choices play a major role in health.”

Enrich your environment now and benefit your future offspring: Dr. Robert Sylwester reports that “all sorts of long held-beliefs about our brain and cognition are being re- examined by cognitive neuroscientists” because of fascinating studies such as the one  he reviews (with mice): “The study’s findings seemed to suggest that acquired characteristics can be genetically transmitted…long-term benefits accrue from a stimulating early environment that encourages curiosity and exploration.”

Managing Emotions

From Distress to De-Stress: helping anxious, worried kids: In a detailed 2-part article, (Part 1, Part 2), Dr. Jerome Schultz provides great tips on how to help children learn to self-regulate emotions, adding that “Teachers, occupational therapists, physical education teachers and parents need to actually teach children (of all ages) how to get themselves into a physical state of being relaxed. This doesn’t happen automatically. If it did, there wouldn’t be so many adult yoga classes!”

Lie to Me, Paul Ekman and Biofeedback: You may have watched the new series Lie To Me, with Tim Roth, based on the work of Paul Ekman. The introduction to the second episode shows why what are called “lie detectors” are nothing but biofeedback systems that measure physiological anxiety.

 

News

Brain Games for Baby Boomers: round-up of other recent news, covering the effects of gaming, cognitive training for driving skills, and brain fitness classes.

Neurocognitive assessments and sports concussions: a new study and a new resource to understand and address the 1.6 to 3.8 million cases of sports-related concussions that occur annually in the United States.

 

Brain Teaser

How will you, your organization, your neighbors, participate in Brain Awareness Week, March 16th-22nd, organized by the Dana Foundation with the participation of thousands of outreach partners, including SharpBrains? You can find event ideas, excellent resources (yes, including puzzles), and a calendar of events, Here.

Have a great month of March!

 

 

 

The growing field of cognitive training (one of the tools for brain fitness) can appear very confusing as the media keeps reporting contradictory claims. These claims are often based on press releases, without a deeper evaluation of the scientific evidence.

Let’s take a couple of recent examples, in successive days:

“It doesn’t work!” type of headline:
Reuters (Feb. 10, 2009) — Formal brain exercise won’t help healthy seniors: research
“Healthy older people shouldn’t bother spending money on computer games and websites promising to ward off mental decline, the author of a review of scientific evidence for the benefits of these “brain exercise” programs says”.

“It works!” type of headline:
ScienceDaily (Feb. 11, 2009) — Computer Exercises Improve Memory And Attention, Study Suggests
“According to the researchers, participants who used the Brain Fitness Program also scored as well as those ten years younger, on average, on memory and attention tests for which they did not train.”

So… does structured brain exercise / cognitive training work or not?

The problem may in fact reside in asking this very question in the first place, as Alvaro pointed out a while ago in his article “Alzheimer’s Disease: too serious to play with headlines“.

We need a more nuanced set of questions.

Why? Because:
1. Cognition is made of several different abilities (working memory, attention, executive functions such as decision-making, etc)
2. Available training programs do not all train the same abilities
3. Users of training programs do not all have the same needs or goals
4. We need to differentiate between enhancing cognitive functions and delaying the onset of cognitive deficits such as Alzheimer’s.

Let’s illustrate these points, by Read the rest of this entry »

In April 2008, Baycrest, a leading research institute focused on aging and brain function, received $10-million from the Ontario Government to create a groundbreaking Centre for Brain Fitness. Its stated goal was to “develop and commercialize a range of products designed to improve the brain health of aging Ontarians and others around the world”.

“Our government is proud to support Baycrest and its invaluable work, which is already leading to the discovery of important new tools and approaches to treating brain diseases associated with aging,” said Minister of Research and Innovation, John Wilkinson.

We have Baycrest’s CEO with us today, to explore why Ontario and Baycrest chose to become pioneers in this area, and discuss some of the main opportunities, and challenges. Dr. William E. Reichman is President and CEO of Baycrest. Dr. Reichman, an internationally-known expert in geriatric mental health and dementia, is also Professor of Psychiatry on the Faculty of Medicine at the University of Toronto.

Alvaro Fernandez: Bill, thank you for your time. Let me start by asking, given that you just spoke at the recent Consumer Electronic Show, what do you make of the growing brain fitness field?

Bill Reichman: it looks like a classic example of a very promising but still early stage field – a lot of opportunity and enthusiasm, but also a lot of product claims that are not backed by solid research. Think about the physical fitness analogy: even today, after decades of progress, you still see people buying research-based products such as treadmills but also all types of random machines they see on TV and have not been subject to any validation. Similarly, consumers today do not know what to make of growing brain fitness claims. As another speaker pointed out, for the industry to fulfill its promise, it will need to be careful with research and claims, not to end up like the nutraceuticals category.

By the way, let me recognize that the work you are doing with SharpBrains reports and your website is very important to offer quality information.

Thank you. Let’s step back for a moment. Taking a, say, 10 years view, what is the main opportunity that technology-based brain fitness can offer to society?

First of all, let me say that I think we have an opportunity to make major progress in Brain Health in the XXI century, similar to what happened with Cardiovascular Health in the XX, and technology will play a crucial role.

Given the rapid advances we are witnessing today in the research and technology arenas, I feel confident in saying that in less than 10 years we will have both valid and reliable assessments of cognitive functions, that will be used both by Read the rest of this entry »

I wanted to alert you to a very interesting finding published in a recent issue of Science, one of the world’s leading scientific journals.

The study was led by Dr. Torkel Klingberg and his colleagues from the Karolinska Institute in Sweden. The goal was to learn whether Working Memory Training is associated with changes in brain biochemistry, thus suggesting a mechanism by which training may lead to enhanced working memory capacity and a reduction in attention problems. Thus, although Working Memory Training has previously shown promising results as a treatment for working memory and attention difficulties, this was a basic science study rather than a treatment study.

The major finding was that increased working memory capacity following training was associated with changes in brain biochemistry. Specifically, the researchers found changes in the density and binding potential of cortical D1 dopamine receptors in brain regions that are activated during working memory tasks.

Results from this study suggest a biological basis for the improvement in working memory capacity and reductions i Read the rest of this entry »

Last week, in this article’s first part, we discussed the importance of actually teaching children how to get themselves into a physical state of being relaxed, explored several suggestions I hope you found useful.

Let’s continue.

Teachers can help student overcome stress by teaching them to identify the impediments they might encounter in doing a certain task.

The teacher can ask:

What’s going to get in the way of you doing this work?
He or she may have to jump-start the students’ thinking by suggesting such things as:
- competing events (family activities, friends call, IM-ing, new video game, etc.)
- lack of adequate place to study
- inadequate prior preparation or skills
- a negative attitude (this is not necessary, I can’t do math, I’ll never need to know this, etc).
- health factors (I’m sick; I’m tired)

Conversely, teachers have to teach students to identify the enhancers; What’s going to make it more likely that you will do this, and do this well?
(examples)
- I have confidence in my ability
- I feel competent in this skill
- I am committed to learning this because: I have the necessary resources to complete this task, such as materials, sources of information, people supports; parents, tutor, other kids

Teachers can turn distress into de-stress by using the Language of Success

The key is to de-emphasize PRAISE and emphasize SELF-APPRAISAL.

Teachers can encourage self-evaluation by Read the rest of this entry »

A couple of very well curated collections of recent blog posts:

Encephalon #64: hosted by Neurocritic, covering neuroscience and psychology. Please make sure to visit when you have some time to spare…because you will quickly become addicted to the quality content and superb presentation.

It’s Grand Rounds, What Do You Think? GOSH!: hosted by Kim at EmergiBlog,  with an interdisciplinary, “Napoleon Dynamite”, frame. Doesn’t seem to make sense? well, pay a visit.

Hiroshi Komiyama, President of the University of Tokyo and Chairperson of the Global Agenda Council on the Challenges of Gerontology I am a member of, just provided council members with a brief update of his participation in the recent World Economic Forum.

Part of the proceedings are public – you may enjoy reading this panel write-up of the session Healthcare under Stress:

- “Japan has the world’s oldest population. Health and longevity create wealth and, thus, “health begets wealth”. It is documented that nations that develop a five-year life expectancy advantage also create a larger GDP. A healthy childhood and adulthood contribute to a more productive old age. New markets and industries are arising – “silver industries” such as financial services, health, housing and hospitality geared to senior citizens. Longevity needs to be linked to health – including cognitive health – and lifestyle choices play a major role in health.”

- “The public health focus is shifting from infections to cardiovascular diseases. Complex new models are necessary to develop better responses and improved health – with the primary emphasis on “really good primary healthcare” and prevention – to lower costs. Prevention increases the healthy years of a person’s life. The challenge is creating the incentive for prevention: how can people be encouraged to make healthy choices? Mobilized populations can drive the change. Finland has an 80% lower incidence of heart disease than 30 years ago due to such incentives.”

Full write-up: Healthcare under Stress

Related articles:

- The Future of the Aging Society: Burden or Human Capital?

- Update: Global Consortium for Neurocognitive Fitness Innovation

Eric Jensen alerted me to a research study published in the February 4th Journal of Neuroscience — Transgenerational Rescue of a Genetic Defect in Long-Term Potentiation and Memory Formation by Juvenile Enrichment. We both had the same initial WOW! feeling that we had experienced when we first read about the discovery of mirror neurons a decade+ ago.

The study’s findings seemed to suggest that acquired characteristics can be genetically transmitted, a Lamarckinan belief that had long been discarded by biologists. This seemed improbable, so we decided to check out what the scientific community thought. It’s the kind of research that educators certainly need to understand because the potential educational implications are profound, no matter how this particular study sorts out.

I’ve thus appended the following information below: (1) the abstract and reference of the original sttudy, (2) a link to a non-technical report in the current issue of New Scientist, (3) a link to a non- technical explanation of the research in Medical News Today, and (4) a link to a recent extended non-technical New Scientist article on the issue of non-genetic inheritance. Eric will post his commentary on the research in the March edition of his Brighter Brain Bulletin newsletter.

THE STUDY:

To put it simply: The researchers studied long-term potentiation (LTP), in which longer and more robust synaptic activation occurs. LTP is the basic mechanism for learning and memory formation.

Juvenile mice placed into an enriched environment (EE) developed enhanced LTP capabilities that they later transmitted to their own offspring during embryogenesis (rather than through later maternal instruction), and these effects persisted even when the offspring weren’t in an EE. The study concluded that a stimulating juvenile environment can thus influence the composition of signaling networks that influence synaptic plasticity and memory formation in the enriched mouse, and also in its future offspring.

The problem with this research appears to be over whether the transmitted effects occurred via genetic changes or through something else in the mother’s uterine environment. A female’s eggs develop early in life to be distributed later, so it’s improbable that a female’s juvenile experiences would alter the DNA in her eggs. A more probable explanation may be that any changes in the mother’s brain that occur via an EE are represented as currently ill- understood signaling molecules that pass through the placental barrier into the embryonic brain.

THE SIGNIFICANCE:

For educators, this research simply adds to our own strong belief that long-term benefits accrue from a stimulating early environment that encourages curiosity and exploration. The research builds on Read the rest of this entry »

Stronger Effort Needed To Prevent Mental, Emotional, And Behavioral Disorders in Young people, Experts Urge (Science Daily)

- “The federal government should make preventing mental, emotional, and behavioral disorders and promoting mental health in young people a national priority, says a new report from the National Research Council and Institute of Medicine.”

- “Research has shown that a number of programs are effective at preventing these problems and promoting mental health, the report says.  Such programs could be implemented more broadly, but currently there is no clear federal presence to lead these efforts.  The White House should create an entity that can coordinate agency initiatives in this area, set public goals for prevention, and provide needed research and funding to achieve them, said the committee that wrote the report.”

- “There is a substantial gap between what is known about preventing mental, emotional, and behavioral disorders and what is actually being done,” said Kenneth E. Warner, committee chair and dean of the University of Michigan School of Public Health.”

The IMPACT study which we reported on in December 2007, funded by Posit Science, conducted  by the Mayo Clinic and USC Davis, has just announced publication at the Journal of the American Geriatrics Society. Reference:

- Smith et al. A Cognitive Training Program Designed Based on Principles of Brain Plasticity: Results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training Study. Journal of the American Geriatrics Society, April 2009.

Computer Exercises Improve Memory And Attention, Study Suggests (Science Daily)

- “The Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study was funded by the Posit Science Corporation, which owns the rights to the Brain Fitness Program, tested in the study.”

- “Of the 487 healthy adults over the age of 65 who participated in a randomized controlled trial, half used the Brain Fitness Program for 40 hours over the course of eight weeks. The Brain Fitness Program consists of six audio exercises done on a computer, and is intended to “retrain the brain to discriminate fine distinctions in sound, and do it in a way that keeps the user engaged,” Zelinski explained.” The other half of participants spent an equal amount of time learning from educational DVDs followed by quizzes.

Comment: this is a very interesting study, in that it shows both that cognitive training works, and that it doesn’t work.

What do I mean? Read the rest of this entry »