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Physical Exercise and Brain Health

Posted By Dr. Pascale Michelon On June 26, 2008 @ 9:19 In Cognitive Neuroscience,Health & Wellness | Comments Disabled

Healthy Seniors

What is the con­nec­tion between phys­i­cal and men­tal exer­cises? Do they have addi­tive effects on brain health? Are they redundant?

Let’s start by review­ing what we know about the effects of phys­i­cal exer­cise on the brain.

The effect of phys­i­cal exer­cise on cog­ni­tive performance

Early stud­ies com­pared groups of peo­ple who exer­cised to groups of peo­ple who did not exer­cise much. Results showed that peo­ple who exer­cised usu­ally had bet­ter per­for­mance in a range of cog­ni­tive tasks com­pared to non-exercisers.

Lau­rin and col­leagues (2001) even sug­gested that mod­er­ate and high lev­els of phys­i­cal activ­ity were asso­ci­ated with lower risk for Alzheimer’s dis­ease and other dementias.

The prob­lem with these stud­ies is that the exer­cis­ers and the non-exercisers may dif­fer on other fac­tors than just exer­cise. The advan­tage that exer­ciser show may not come from exer­cis­ing but from other fac­tors such as more resources, bet­ter brain health to start with, bet­ter diet, etc.

The solu­tion to this prob­lem is to ran­domly assigned peo­ple to either an aer­o­bic train­ing group or a con­trol group. If the exer­ciser group and the non-exerciser group are very sim­i­lar to start with and if the exer­ciser group shows less decline or bet­ter per­for­mance over time than the non-exerciser group, then one can con­clude that phys­i­cal exer­cise is ben­e­fi­cial for brain health.

In 2003, Col­combe and Kramer, ana­lyzed the results of 18 sci­en­tific stud­ies pub­lished between 2000 and 2001 that were con­ducted in the way described above.

The results of this meta-analysis clearly showed that fit­ness train­ing increases cog­ni­tive per­for­mance in healthy adults between the ages of 55 and 80.

Another meta-analysis pub­lished in 2004 by Heyn and col­leagues shows sim­i­lar ben­e­fi­cial effects of fit­ness train­ing on peo­ple over 65 years old who had cog­ni­tive impair­ment or dementia.

What is the effect of fit­ness train­ing on the brain itself?

Research with ani­mals has shown that in mice, increased aer­o­bic fit­ness (run­ning) can increase the num­ber of new cells formed in the hip­pocam­pus (the hip­pocam­pus is cru­cial for learn­ing and mem­ory). Increased exer­cise also has a ben­e­fi­cial effect on mice’s vas­cu­lar system.

Only one study has used brain imag­ing to look at the effect of fit­ness on the human brain. In 2006, Col­combe and col­leagues ran­domly assigned 59 older adults to either a car­dio­vas­cu­lar exer­cise group, or a non­aer­o­bic exer­cise con­trol group (stretch­ing and ton­ing exer­cise). Par­tic­i­pants exer­cised 3h per week for 6 months. Col­combe et al. scanned the par­tic­i­pants’ brains before and after the train­ing period.

After 6 months, the brain vol­ume of the aer­o­bic exer­cis­ing group increased in sev­eral areas com­pared to the other group. Vol­ume increase occurred prin­ci­pally in frontal and tem­po­ral areas of the brain involved in exec­u­tive con­trol and mem­ory processes. The authors do not know what under­ly­ing cel­lu­lar changes might have caused these vol­ume changes. How­ever they sus­pect, based on ani­mal research, that vol­ume changes may be due to an increased num­ber of blood ves­sels and an increased num­ber of con­nec­tions between neurons.

How does phys­i­cal exer­cise com­pare to men­tal exercise?

Very few stud­ies have tried to com­pare the effect of phys­i­cal exer­cise and men­tal exer­cise on cog­ni­tive performance.brain books

When look­ing at each domain of research one notices the fol­low­ing differences:

- The effects of cog­ni­tive or men­tal exer­cise on per­for­mance seem to be very task spe­cific, that is trained tasks ben­e­fit from train­ing but the ben­e­fits do not trans­fer very well to tasks in which one was not trained.

- The effects of phys­i­cal exer­cise on per­for­mance seem broader. How­ever they do not gen­er­al­ize to all tasks. They ben­e­fit mostly tasks that involve executive-control com­po­nents (that is, tasks that require plan­ning, work­ing mem­ory, mul­ti­task­ing, resis­tance to distraction).

To my knowl­edge only one study tried to directly com­pare cog­ni­tive and fit­ness training:

Keep read­ing…

Fabre and col­leagues, in 1999, ran­domly assigned sub­jects to 4 groups: an aer­o­bic train­ing group (walk­ing or run­ning for 2 h per week for 2 months), a mem­ory train­ing group (one 90 min ses­sion a week for 2 months), a com­bined aer­o­bic and men­tal train­ing group, or a con­trol group (no training).

Results showed that com­pared to the con­trol group, the mem­ory per­for­mance of all 3 groups increased. The com­bined group showed greater increase than the other 2 train­ing groups.

This sug­gests that the effects of cog­ni­tive and fit­ness train­ing may be addi­tive. How­ever this study involved only 8 par­tic­i­pants per group! More research is clearly needed before any­thing can be safely concluded.

In the mean­time let’s play it safe and com­bine fit­ness and cog­ni­tive train­ing for bet­ter brain health.

Ref­er­ences

Col­combe, S. & Kramer, A. F. (2003). Fit­ness effects on the cog­ni­tive func­tion of older adults: A meta-analytic study. Psy­cho­log­i­cal Sci­ence, 14(2), 125–130.

Col­combe, S. J., Erick­son, K. I., Scalf, P. E., Kim, J. S., Prakash, R., McAuley, E., Elavsky, S., Mar­quez, D. X., Hu, L., & Kramer, A. F. (2006). Aer­o­bic exer­cise train­ing increases brain vol­ume in aging humans. Jour­nal of Geron­tol­ogy, 61A(11), 1166–1170.

Fabre, C., Msse-Biron, J., Chamari, K., Var­ray, A., Mucci, P., & Pre­faut, C. (1999). Eval­u­a­tion of qual­ity of life in elderly healthy sub­jects after aer­o­bic and/or men­tal train­ing. Archives of Geron­tol­ogy and Geri­atrics, 28, 9–22.

Heyn P.; Abreu B. C.; Otten­bacher K. J. (2004). The effects of exer­cise train­ing on elderly per­sons with cog­ni­tive impair­ment and demen­tia: a meta-analysis. Archives of phys­i­cal med­i­cine and reha­bil­i­ta­tion, 85(10), 1694–704.

Lau­rin, D., Ver­reault, R., Lind­say, J., MacPher­son, K., & Rock­wood, K. (2001). Phys­i­cal activ­ity and risk of cog­ni­tive impair­ment and demen­tia in elderly per­sons. Archives of Neu­rol­ogy, 58(3), 498–504.

Pascale Michelon— This arti­cle was writ­ten by Pas­cale Mich­e­lon, Ph. D. [1], for SharpBrains.com. Dr. Mich­e­lon, Copy­right 2008. Dr. Mich­e­lon has a Ph.D. in Cog­ni­tive Psy­chol­ogy and is a Research Sci­en­tist at Wash­ing­ton Uni­ver­sity in Saint Louis, in the Psy­chol­ogy Depart­ment. She con­ducted sev­eral research projects to under­stand how the brain makes use of visual infor­ma­tion and mem­o­rizes facts.

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